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Volumn 67, Issue 2, 2015, Pages 4-17

Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy

Author keywords

Cancer; Immune evasion; Immunotherapy; PD 1; PD L1

Indexed keywords

BIOLOGICAL MARKER; BMS 936559; DURVALUMAB; ERLOTINIB; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; PIDILIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN BINDING;

EID: 84930730522     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.02.009     Document Type: Review
Times cited : (185)

References (131)
  • 1
    • 84875171283 scopus 로고    scopus 로고
    • PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction
    • Abiko K., Mandai M., Hamanishi J., et al. PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. Clin. Cancer Res. 2013, 19:1363-1374.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1363-1374
    • Abiko, K.1    Mandai, M.2    Hamanishi, J.3
  • 2
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M., Johnson L.A., Heemskerk B., et al. Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009, 114:1537-1544.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3
  • 3
    • 0033562695 scopus 로고    scopus 로고
    • BCG immunotherapy of bladder cancer: 20 years on
    • Alexandroff A.B., Jackson A.M., O'Donnell M.A., et al. BCG immunotherapy of bladder cancer: 20 years on. Lancet 1999, 353:1689-1694.
    • (1999) Lancet , vol.353 , pp. 1689-1694
    • Alexandroff, A.B.1    Jackson, A.M.2    O'Donnell, M.A.3
  • 4
    • 84914176528 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • Amin A., Plimack E.R., Infante J.R., et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). ASCO Meet. Abstr. 2014, 32:5010.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 5010
    • Amin, A.1    Plimack, E.R.2    Infante, J.R.3
  • 5
    • 79960318715 scopus 로고    scopus 로고
    • Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-associated T cells
    • Andorsky D.J., Yamada R.E., Said J., et al. Programmed death ligand 1 is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-associated T cells. Clin. Cancer Res. 2011, 17:4232-4244.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4232-4244
    • Andorsky, D.J.1    Yamada, R.E.2    Said, J.3
  • 6
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell S.M., Lesokhin A.M., Borrello I., et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 2015, 372:311-319.
    • (2015) N. Engl. J. Med. , vol.372 , pp. 311-319
    • Ansell, S.M.1    Lesokhin, A.M.2    Borrello, I.3
  • 7
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results
    • Antonia S.J., Gettinger S.N., Chow L.Q.M., et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. ASCO Meet. Abstr. 2014, 32:8023.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8023
    • Antonia, S.J.1    Gettinger, S.N.2    Chow, L.Q.M.3
  • 8
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
    • Antonia S.J., Brahmer J.R., Gettinger S.N., et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). ASCO Meet. Abstr. 2014, 32:8113.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8113
    • Antonia, S.J.1    Brahmer, J.R.2    Gettinger, S.N.3
  • 9
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large b-cell lymphoma: results of an international phase II trial
    • Armand P., Nagler A., Weller E.A., et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large b-cell lymphoma: results of an international phase II trial. J. Clin. Oncol. 2013, 31:4199-4206.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4199-4206
    • Armand, P.1    Nagler, A.2    Weller, E.A.3
  • 10
    • 84907613231 scopus 로고    scopus 로고
    • Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma
    • Atkins M.B., Kudchadkar R.R., Sznol M., et al. Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma. ASCO Meet. Abstr. 2014, 32:9001.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 9001
    • Atkins, M.B.1    Kudchadkar, R.R.2    Sznol, M.3
  • 11
    • 84871966600 scopus 로고    scopus 로고
    • PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer
    • Badoual C., Hans S., Merillon N., et al. PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res. 2013, 73:128-138.
    • (2013) Cancer Res. , vol.73 , pp. 128-138
    • Badoual, C.1    Hans, S.2    Merillon, N.3
  • 12
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8T cells during chronic viral infection
    • Barber D.L., Wherry E.J., Masopust D., et al. Restoring function in exhausted CD8T cells during chronic viral infection. Nature 2006, 439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 13
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson D.M., Bakan C.E., Mishra A., et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 2010, 116:2286-2294.
    • (2010) Blood , vol.116 , pp. 2286-2294
    • Benson, D.M.1    Bakan, C.E.2    Mishra, A.3
  • 14
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R., Rotem-Yehudar R., Slama G., et al. Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 2008, 14:3044-3051.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3
  • 15
    • 84891654921 scopus 로고    scopus 로고
    • PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL)
    • Berghoff A.S., Ricken G., Widhalm G., et al. PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL). Clin. Neuropathol. 2014, 33:42-49.
    • (2014) Clin. Neuropathol. , vol.33 , pp. 42-49
    • Berghoff, A.S.1    Ricken, G.2    Widhalm, G.3
  • 16
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism
    • Blazar B.R., Carreno B.M., Panoskaltsis-Mortari A., et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism. J. Immunol. 2003, 171:1272-1277.
    • (2003) J. Immunol. , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3
  • 17
    • 51049096135 scopus 로고    scopus 로고
    • T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival
    • (an official journal of the American Association for Cancer Research)
    • Boorjian S.A., Sheinin Y., Crispen P.L., et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin. Cancer Res. 2008, 14:4800-4808. (an official journal of the American Association for Cancer Research).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4800-4808
    • Boorjian, S.A.1    Sheinin, Y.2    Crispen, P.L.3
  • 18
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer J.R., Drake C.G., Wollner I., et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 2010, 28:3167-3175.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 19
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J.R., Tykodi S.S., Chow L.Q.M., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 2012, 366:2455-2465.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.M.3
  • 20
    • 84912130561 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis
    • Brahmer J.R., Horn L., Gandhi L., et al. Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. ASCO Meet. Abstr. 2014, 32:8112.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8112
    • Brahmer, J.R.1    Horn, L.2    Gandhi, L.3
  • 21
    • 84907651084 scopus 로고    scopus 로고
    • Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC
    • Brahmer J.R., Rizvi N.A., Lutzky J., et al. Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. ASCO Meet. Abstr. 2014, 32:8021.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8021
    • Brahmer, J.R.1    Rizvi, N.A.2    Lutzky, J.3
  • 22
    • 63049113299 scopus 로고    scopus 로고
    • High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
    • Carreras J., Lopez-Guillermo A., Roncador G., et al. High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma. J. Clin. Oncol. 2009, 27:1470-1476.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1470-1476
    • Carreras, J.1    Lopez-Guillermo, A.2    Roncador, G.3
  • 23
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
    • Chen D.S., Irving B.A., Hodi F.S. Molecular pathways: next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1. Clin. Cancer Res. 2012, 18:6580-6587.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6580-6587
    • Chen, D.S.1    Irving, B.A.2    Hodi, F.S.3
  • 24
    • 84879866976 scopus 로고    scopus 로고
    • PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
    • Chen B.J., Chapuy B., Ouyang J., et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clin. Cancer Res. 2013, 19:3462-3473.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3462-3473
    • Chen, B.J.1    Chapuy, B.2    Ouyang, J.3
  • 27
    • 0029925375 scopus 로고    scopus 로고
    • Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
    • Clemente C.G., Mihm M.C., Bufalino R., et al. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996, 77:1303-1310.
    • (1996) Cancer , vol.77 , pp. 1303-1310
    • Clemente, C.G.1    Mihm, M.C.2    Bufalino, R.3
  • 28
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel T.J., Wei S., Dong H., et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 2003, 9:562-567.
    • (2003) Nat. Med. , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3
  • 29
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran M.A., Montalvo W., Yagita H., et al. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:4275-4280.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3
  • 30
    • 84862236855 scopus 로고    scopus 로고
    • Immune alterations and emerging immunotherapeutic approaches in lung cancer
    • Dasanu C.A., Sethi N., Ahmed N. Immune alterations and emerging immunotherapeutic approaches in lung cancer. Expert Opin. Biol. Ther. 2012, 12:923-937.
    • (2012) Expert Opin. Biol. Ther. , vol.12 , pp. 923-937
    • Dasanu, C.A.1    Sethi, N.2    Ahmed, N.3
  • 31
    • 84905991829 scopus 로고    scopus 로고
    • Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome [abstract]
    • Daud A.I., Hamid O., Ribas A., et al. Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome [abstract]. Proc. Ann. Meeting AACR 2014, CT104.
    • (2014) Proc. Ann. Meeting AACR , vol.CT104
    • Daud, A.I.1    Hamid, O.2    Ribas, A.3
  • 32
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H., Zhu G., Tamada K., et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 1999, 5:1365-1369.
    • (1999) Nat. Med. , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3
  • 33
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H., Strome S.E., Salomao D.R., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002, 8:793-800.
    • (2002) Nat. Med. , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 34
    • 33746877544 scopus 로고    scopus 로고
    • Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
    • Dorfman D.M., Brown J.A., Shahsafaei A., et al. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am. J. Surg. Pathol. 2006, 30:802-810.
    • (2006) Am. J. Surg. Pathol. , vol.30 , pp. 802-810
    • Dorfman, D.M.1    Brown, J.A.2    Shahsafaei, A.3
  • 35
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
    • Duraiswamy J., Kaluza K.M., Freeman G.J., et al. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013, 73:3591-3603.
    • (2013) Cancer Res. , vol.73 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3
  • 36
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • Duraiswamy J., Freeman G.J., Coukos G. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res. 2013, 73:6900-6912.
    • (2013) Cancer Res. , vol.73 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 37
    • 34249785092 scopus 로고    scopus 로고
    • CD4+ CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model
    • Elpek K.G., Lacelle C., Singh N.P., et al. CD4+ CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model. J. Immunol. 2007, 178:6840-6848.
    • (2007) J. Immunol. , vol.178 , pp. 6840-6848
    • Elpek, K.G.1    Lacelle, C.2    Singh, N.P.3
  • 38
    • 84905090973 scopus 로고    scopus 로고
    • PD-L1 expression in non-clear cell renal cell carcinoma
    • Fay A.P., Callea M., Gray K.P., et al. PD-L1 expression in non-clear cell renal cell carcinoma. J. Clin. Oncol. 2014, 32.
    • (2014) J. Clin. Oncol. , vol.32
    • Fay, A.P.1    Callea, M.2    Gray, K.P.3
  • 39
    • 84857660324 scopus 로고    scopus 로고
    • Therapy for metastatic melanoma: the past, present, and future
    • Finn L., Markovic S.N., Joseph R.W. Therapy for metastatic melanoma: the past, present, and future. BMC Med. 2012, 10(23). http://www.biomedcentral.com/1741-7015/10/2.
    • (2012) BMC Med. , vol.10 , Issue.23
    • Finn, L.1    Markovic, S.N.2    Joseph, R.W.3
  • 40
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco L.M., Salinas V.H., Brown K.E., et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 2009, 206:3015-3029.
    • (2009) J. Exp. Med. , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 41
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman G.J., Long A.J., Iwai Y., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000, 192:1027-1034.
    • (2000) J. Exp. Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 42
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G., Fisher R.I., Rosenberg S.A., et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 1995, 13:688-696.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 43
    • 79955518331 scopus 로고    scopus 로고
    • Overall survival and PD-L1 expression in metastasized malignant melanoma
    • Gadiot J., Hooijkaas A.I., Kaiser A.D., et al. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 2011, 117:2192-2201.
    • (2011) Cancer , vol.117 , pp. 2192-2201
    • Gadiot, J.1    Hooijkaas, A.I.2    Kaiser, A.D.3
  • 44
    • 84971325923 scopus 로고    scopus 로고
    • MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): antitumor activity and association with tumor PD-L1 expression [abstract]
    • Gandhi L. MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): antitumor activity and association with tumor PD-L1 expression [abstract]. Proc. Ann. Meet. AACR 2014, CT105.
    • (2014) Proc. Ann. Meet. AACR , vol.CT105
    • Gandhi, L.1
  • 45
    • 84895904745 scopus 로고    scopus 로고
    • Mitigating the toxic effects of anticancer immunotherapy
    • Gangadhar T.C., Vonderheide R.H. Mitigating the toxic effects of anticancer immunotherapy. Nat. Rev. Clin. Oncol. 2014, 11:91-99.
    • (2014) Nat. Rev. Clin. Oncol. , vol.11 , pp. 91-99
    • Gangadhar, T.C.1    Vonderheide, R.H.2
  • 46
    • 84907614647 scopus 로고    scopus 로고
    • Safety and clinical activity of MK-3475 in previously treated patients (pts) with non-small cell lung cancer (NSCLC)
    • Garon E.B., Leighl N.B., Rizvi N.A., et al. Safety and clinical activity of MK-3475 in previously treated patients (pts) with non-small cell lung cancer (NSCLC). ASCO Meet. Abstr. 2014, 32:8020.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8020
    • Garon, E.B.1    Leighl, N.B.2    Rizvi, N.A.3
  • 47
    • 84907651086 scopus 로고    scopus 로고
    • First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status
    • Gettinger S.N., Shepherd F.A., Antonia S.J., et al. First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status. ASCO Meet. Abstr. 2014, 32:8024.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8024
    • Gettinger, S.N.1    Shepherd, F.A.2    Antonia, S.J.3
  • 48
    • 84873534154 scopus 로고    scopus 로고
    • The role of B7 family molecules in hematologic malignancy
    • Greaves P., Gribben J.G. The role of B7 family molecules in hematologic malignancy. Blood 2013, 121:734-744.
    • (2013) Blood , vol.121 , pp. 734-744
    • Greaves, P.1    Gribben, J.G.2
  • 49
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green M.R., Monti S., Rodig S.J., et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 2010, 116:3268-3277.
    • (2010) Blood , vol.116 , pp. 3268-3277
    • Green, M.R.1    Monti, S.2    Rodig, S.J.3
  • 50
    • 84859817335 scopus 로고    scopus 로고
    • Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia
    • Grzywnowicz M., Zaleska J., Mertens D., et al. Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia. PLoS ONE 2012, 7.
    • (2012) PLoS ONE , vol.7
    • Grzywnowicz, M.1    Zaleska, J.2    Mertens, D.3
  • 51
    • 79960218752 scopus 로고    scopus 로고
    • Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade
    • Hallett W.H.D., Jing W., Drobyski W.R., et al. Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade. Biol. Blood Marrow Transpl. 2011, 17:1133-1145.
    • (2011) Biol. Blood Marrow Transpl. , vol.17 , pp. 1133-1145
    • Hallett, W.H.D.1    Jing, W.2    Drobyski, W.R.3
  • 52
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J., Mandai M., Iwasaki M., et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:3360-3365.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 53
    • 84905753981 scopus 로고    scopus 로고
    • Efficacy and safety of anti-PD-1 antibody (nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer
    • Hamanishi J., Mandai M., Ikeda T., et al. Efficacy and safety of anti-PD-1 antibody (nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. ASCO Meet. Abstr. 2014, 32:5511.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 5511
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3
  • 54
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O., Robert C., Daud A., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 2013, 369:134-144.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 55
    • 84914148032 scopus 로고    scopus 로고
    • Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
    • Hammers H.J., Plimack E.R., Infante J.R., et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). ASCO Meet. Abstr. 2014, 32:4504.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 4504
    • Hammers, H.J.1    Plimack, E.R.2    Infante, J.R.3
  • 56
    • 0030903694 scopus 로고    scopus 로고
    • A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice
    • Hardy B., Kovjazin R., Raiter A., et al. A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:5756-5760.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 5756-5760
    • Hardy, B.1    Kovjazin, R.2    Raiter, A.3
  • 57
    • 84887262315 scopus 로고    scopus 로고
    • A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • Herbst R.S., Gordon M.S., Fine G.D., et al. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J. Clin. Oncol. 2013, 31.
    • (2013) J. Clin. Oncol. , vol.31
    • Herbst, R.S.1    Gordon, M.S.2    Fine, G.D.3
  • 58
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst R.S., Soria J-C., Kowanetz M., et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014, 515:563-567.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.-C.2    Kowanetz, M.3
  • 59
    • 0017125234 scopus 로고
    • Decreased ability of blood leukocytes from patients with tumors of the urinary bladder to act as stimulator cells in mixed leukocyte culture
    • Herr H.W., Bean M.A., Whitmore W.F. Decreased ability of blood leukocytes from patients with tumors of the urinary bladder to act as stimulator cells in mixed leukocyte culture. Cancer Res. 1976, 36:2754-2760.
    • (1976) Cancer Res. , vol.36 , pp. 2754-2760
    • Herr, H.W.1    Bean, M.A.2    Whitmore, W.F.3
  • 60
    • 84907543029 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma
    • Hersey P., Ribas A., Hodi F.S., et al. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma. Asia-Pac. J. Clin. Oncol. 2014, 10:48-49.
    • (2014) Asia-Pac. J. Clin. Oncol. , vol.10 , pp. 48-49
    • Hersey, P.1    Ribas, A.2    Hodi, F.S.3
  • 61
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano F., Kaneko K., Tamura H., et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005, 65:1089-1096.
    • (2005) Cancer Res. , vol.65 , pp. 1089-1096
    • Hirano, F.1    Kaneko, K.2    Tamura, H.3
  • 62
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi F.S., O'Day S.J., McDermott D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 2010, 363:711-723.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 63
    • 84907558390 scopus 로고    scopus 로고
    • Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial
    • Hodi F.S., Sznol M., Kluger H.M., et al. Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial. ASCO Meet. Abstr. 2014, 32:9002.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 9002
    • Hodi, F.S.1    Sznol, M.2    Kluger, H.M.3
  • 64
    • 78650929413 scopus 로고    scopus 로고
    • Immunotherapy as a strategy for the treatment of non-small-cell lung cancer
    • Holt G.E., Podack E.R., Raez L.E. Immunotherapy as a strategy for the treatment of non-small-cell lung cancer. Therapy 2011, 8:43-54.
    • (2011) Therapy , vol.8 , pp. 43-54
    • Holt, G.E.1    Podack, E.R.2    Raez, L.E.3
  • 65
    • 34247113727 scopus 로고    scopus 로고
    • PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression
    • Inman B.A., Sebo T.J., Frigola X., et al. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer 2007, 109:1499-1505.
    • (2007) Cancer , vol.109 , pp. 1499-1505
    • Inman, B.A.1    Sebo, T.J.2    Frigola, X.3
  • 66
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y., Ishida M., Tanaka Y., et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:12293-12297.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 67
    • 13844294372 scopus 로고    scopus 로고
    • PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
    • Iwai Y., Terawaki S., Honjo T. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int. Immunol. 2005, 17:133-144.
    • (2005) Int. Immunol. , vol.17 , pp. 133-144
    • Iwai, Y.1    Terawaki, S.2    Honjo, T.3
  • 68
    • 84864954385 scopus 로고    scopus 로고
    • Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention
    • Jadus M.R., Natividad J., Mai A., et al. Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention. Clin. Dev. Immunol. 2012, 2012. Article ID 160724, 21 pages. 10.1155/2012/160724.
    • (2012) Clin. Dev. Immunol. , vol.2012 , pp. 21
    • Jadus, M.R.1    Natividad, J.2    Mai, A.3
  • 69
    • 85006320672 scopus 로고    scopus 로고
    • Severe cutaneous and neurologic toxicity in melanoma patients during vemurafenib administration following anti-PD-1 therapy
    • Johnson D.B., Wallender E.K., Cohen D.N., et al. Severe cutaneous and neurologic toxicity in melanoma patients during vemurafenib administration following anti-PD-1 therapy. Cancer Immunol. Res. 2013, 1:373.
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 373
    • Johnson, D.B.1    Wallender, E.K.2    Cohen, D.N.3
  • 70
    • 79960427572 scopus 로고    scopus 로고
    • Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy
    • Joseph R.W., Peddareddigari V.R., Liu P., et al. Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy. Clin. Cancer Res. 2011, 17:4882-4891.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4882-4891
    • Joseph, R.W.1    Peddareddigari, V.R.2    Liu, P.3
  • 71
    • 85003055690 scopus 로고    scopus 로고
    • Inverse association between programmed death ligand 1 and genes in the VEGF pathway in primary clear cell renal cell carcinoma
    • Joseph R.W., Parasramka M., Eckel-Passow J.E., et al. Inverse association between programmed death ligand 1 and genes in the VEGF pathway in primary clear cell renal cell carcinoma. Cancer Immunol. Res. 2013, 1:378-385.
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 378-385
    • Joseph, R.W.1    Parasramka, M.2    Eckel-Passow, J.E.3
  • 73
    • 84904856532 scopus 로고    scopus 로고
    • Nonclinical evaluation of the combination of mouse IL-21 and anti- mouse CTLA-4 or PD-1 blocking antibodies in mouse tumor models
    • Jure-Kunkel M., Selby M., Lewis K., et al. Nonclinical evaluation of the combination of mouse IL-21 and anti- mouse CTLA-4 or PD-1 blocking antibodies in mouse tumor models. ASCO Meet. Abstr. 2013, 31:3019.
    • (2013) ASCO Meet. Abstr. , vol.31 , pp. 3019
    • Jure-Kunkel, M.1    Selby, M.2    Lewis, K.3
  • 74
    • 78751679810 scopus 로고    scopus 로고
    • PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells
    • Koestner W., Hapke M., Herbst J., et al. PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells. Blood 2011, 117:1030-1041.
    • (2011) Blood , vol.117 , pp. 1030-1041
    • Koestner, W.1    Hapke, M.2    Herbst, J.3
  • 75
    • 65449131740 scopus 로고    scopus 로고
    • The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    • Kong C.S., Narasimhan B., Cao H., et al. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 2009, 74:553-561.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.74 , pp. 553-561
    • Kong, C.S.1    Narasimhan, B.2    Cao, H.3
  • 76
    • 60149109928 scopus 로고    scopus 로고
    • PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients
    • Kozako T., Yoshimitsu M., Fujiwara H., et al. PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. Leukemia 2009, 23:375-382.
    • (2009) Leukemia , vol.23 , pp. 375-382
    • Kozako, T.1    Yoshimitsu, M.2    Fujiwara, H.3
  • 77
    • 34250209885 scopus 로고    scopus 로고
    • Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma
    • Krambeck A.E., Dong H., Thompson R.H., et al. Survivin and B7-H1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Clin. Cancer Res. 2007, 13:1749-1756.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1749-1756
    • Krambeck, A.E.1    Dong, H.2    Thompson, R.H.3
  • 78
    • 79959549102 scopus 로고    scopus 로고
    • Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer
    • Krempski J., Karyampudi L., Behrens M.D., et al. Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer. J. Immunol. 2011, 186:6905-6913.
    • (2011) J. Immunol. , vol.186 , pp. 6905-6913
    • Krempski, J.1    Karyampudi, L.2    Behrens, M.D.3
  • 79
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y., Wood C.R., Chernova T., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2001, 2:261-268.
    • (2001) Nat. Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 80
    • 34347400169 scopus 로고    scopus 로고
    • Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    • Liu J., Hamrouni A., Wolowiec D., et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 2007, 110:296-304.
    • (2007) Blood , vol.110 , pp. 296-304
    • Liu, J.1    Hamrouni, A.2    Wolowiec, D.3
  • 81
    • 84875475811 scopus 로고    scopus 로고
    • Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma
    • Lyford-Pike S., Peng S., Young G.D., et al. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013, 73:1733-1741.
    • (2013) Cancer Res. , vol.73 , pp. 1733-1741
    • Lyford-Pike, S.1    Peng, S.2    Young, G.D.3
  • 82
    • 77954938867 scopus 로고    scopus 로고
    • Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy
    • Mangsbo S.M., Sandin L.C., Anger K., et al. Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy. J. Immunother. 2010, 33:225-235.
    • (2010) J. Immunother. , vol.33 , pp. 225-235
    • Mangsbo, S.M.1    Sandin, L.C.2    Anger, K.3
  • 83
    • 0033991158 scopus 로고    scopus 로고
    • Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance
    • Marincola F.M., Jaffee E.M., Hicklin D.J., et al. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 2000, 181-273.
    • (2000) Adv. Immunol. , pp. 181-273
    • Marincola, F.M.1    Jaffee, E.M.2    Hicklin, D.J.3
  • 84
    • 0020030473 scopus 로고
    • Immunological profile of patients with transitional cell carcinoma of the bladder
    • Mukamel E., Shohat B., Servadio C. Immunological profile of patients with transitional cell carcinoma of the bladder. Br. J. Urol. 1982, 54:11-15.
    • (1982) Br. J. Urol. , vol.54 , pp. 11-15
    • Mukamel, E.1    Shohat, B.2    Servadio, C.3
  • 85
    • 84887316694 scopus 로고    scopus 로고
    • Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells
    • Munir S., Andersen G.H., Woetmann A., et al. Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells. Leukemia 2013, 27:2251-2253.
    • (2013) Leukemia , vol.27 , pp. 2251-2253
    • Munir, S.1    Andersen, G.H.2    Woetmann, A.3
  • 86
    • 84874442281 scopus 로고    scopus 로고
    • High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
    • Myklebust J.H., Irish J.M., Brody J., et al. High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood 2013, 121:1367-1376.
    • (2013) Blood , vol.121 , pp. 1367-1376
    • Myklebust, J.H.1    Irish, J.M.2    Brody, J.3
  • 87
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H., Nose M., Hiai H., et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999, 11:141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 88
    • 70449395259 scopus 로고    scopus 로고
    • Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model
    • Okudaira K., Hokari R., Tsuzuki Y., et al. Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. Int. J. Oncol 2009, 35:741-749.
    • (2009) Int. J. Oncol , vol.35 , pp. 741-749
    • Okudaira, K.1    Hokari, R.2    Tsuzuki, Y.3
  • 89
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012, 12:252-264.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 90
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa A.T., Waldron J.S., Panner A., et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat. Med. 2007, 13:84-88.
    • (2007) Nat. Med. , vol.13 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 91
    • 84928637112 scopus 로고    scopus 로고
    • LBA23-a phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced urothelial tract cancer
    • (Official journal of the European Society for Medical Oncology/ESMO)
    • Plimack E.R., Gupta S., Bellmunt J., et al. LBA23-a phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced urothelial tract cancer. Ann. Oncol. 2014, 25:1-41. (Official journal of the European Society for Medical Oncology/ESMO).
    • (2014) Ann. Oncol. , vol.25 , pp. 1-41
    • Plimack, E.R.1    Gupta, S.2    Bellmunt, J.3
  • 92
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • Powles T., Vogelzang N.J., Fine G.D., et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). ASCO Meet. Abstr. 2014, 32:5011.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 5011
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3
  • 93
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T., Eder J.P., Fine G.D., et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014, 515:558-562.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 94
    • 2442737061 scopus 로고    scopus 로고
    • Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
    • Pyrhönen S., Salminen E., Ruutu M., et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J. Clin. Oncol. 1999, 17:2859-2867.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2859-2867
    • Pyrhönen, S.1    Salminen, E.2    Ruutu, M.3
  • 95
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
    • Ramsay A.G., Clear A.J., Fatah R., et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood 2012, 120:1412-1421.
    • (2012) Blood , vol.120 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3
  • 96
    • 84880305809 scopus 로고    scopus 로고
    • Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity
    • Ramsay A.G. Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity. Br. J. Haematol. 2013, 162:313-325.
    • (2013) Br. J. Haematol. , vol.162 , pp. 313-325
    • Ramsay, A.G.1
  • 97
    • 73149111448 scopus 로고    scopus 로고
    • Do we need a different set of response assessment criteria for tumor immunotherapy?
    • Ribas A., Chmielowski B., Glaspy J.A. Do we need a different set of response assessment criteria for tumor immunotherapy?. Clin. Cancer Res. 2009, 15:7116-7118.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7116-7118
    • Ribas, A.1    Chmielowski, B.2    Glaspy, J.A.3
  • 98
    • 84907614647 scopus 로고    scopus 로고
    • Safety and clinical activity of MK-3475 as initial therapy in patients with advanced non-small cell lung cancer (NSCLC)
    • Rizvi N.A., Garon E.B., Patnaik A., et al. Safety and clinical activity of MK-3475 as initial therapy in patients with advanced non-small cell lung cancer (NSCLC). ASCO Meet. Abstr. 2014, 32:8007.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8007
    • Rizvi, N.A.1    Garon, E.B.2    Patnaik, A.3
  • 99
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
    • Rizvi N.A., Chow L.Q.M., Borghaei H., et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO Meet. Abstr. 2014, 32:8022.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 8022
    • Rizvi, N.A.1    Chow, L.Q.M.2    Borghaei, H.3
  • 101
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C., Long G.V., Brady B., et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 2015, 372:320-330.
    • (2015) N. Engl. J. Med. , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 102
    • 84907497893 scopus 로고    scopus 로고
    • High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial
    • Rossille D., Gressier M., Damotte D., et al. High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial. LID 2014, 10.1038/leu.2014.137.
    • (2014) LID
    • Rossille, D.1    Gressier, M.2    Damotte, D.3
  • 103
    • 4644256639 scopus 로고    scopus 로고
    • In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis
    • Saudemont A., Quesnel B. In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis. Blood 2004, 104:2124-2133.
    • (2004) Blood , vol.104 , pp. 2124-2133
    • Saudemont, A.1    Quesnel, B.2
  • 104
    • 0036736510 scopus 로고    scopus 로고
    • Gene transfer of CD154 and IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia
    • Saudemont A., Buffenoir G., Denys A., et al. Gene transfer of CD154 and IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia. Leukemia 2002, 16:1637-1644.
    • (2002) Leukemia , vol.16 , pp. 1637-1644
    • Saudemont, A.1    Buffenoir, G.2    Denys, A.3
  • 105
    • 84907521155 scopus 로고    scopus 로고
    • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer
    • Seiwert T.Y., Burtness B., Weiss J., et al. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer. ASCO Meet. Abstr. 2014, 32:6011.
    • (2014) ASCO Meet. Abstr. , vol.32 , pp. 6011
    • Seiwert, T.Y.1    Burtness, B.2    Weiss, J.3
  • 106
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • Spigel D.R., Gettinger S.N., Horn L., et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). ASCO Meet. Abstr. 2013, 31:8008.
    • (2013) ASCO Meet. Abstr. , vol.31 , pp. 8008
    • Spigel, D.R.1    Gettinger, S.N.2    Horn, L.3
  • 107
    • 79952816655 scopus 로고    scopus 로고
    • MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
    • Steidl C., Shah S.P., Woolcock B.W., et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 2011, 471:377-383.
    • (2011) Nature , vol.471 , pp. 377-383
    • Steidl, C.1    Shah, S.P.2    Woolcock, B.W.3
  • 108
    • 0141953992 scopus 로고    scopus 로고
    • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    • Strome S.E., Dong H., Tamura H., et al. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res. 2003, 63:6501-6505.
    • (2003) Cancer Res. , vol.63 , pp. 6501-6505
    • Strome, S.E.1    Dong, H.2    Tamura, H.3
  • 109
    • 84907498833 scopus 로고    scopus 로고
    • Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL)
    • Sznol M., Kluger H.M., Callahan M.K., et al. Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL). ASCO Meet. Abstr. 2014, 32:LBA9003.
    • (2014) ASCO Meet. Abstr. , vol.32
    • Sznol, M.1    Kluger, H.M.2    Callahan, M.K.3
  • 110
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube J.M., Anders R.A., Young G.D., et al. Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci. Transl. Med. 2012, 4(127):127-137.
    • (2012) Sci. Transl. Med. , vol.4 , Issue.127 , pp. 127-137
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3
  • 111
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
    • Thompson R.H., Gillett M.D., Cheville J.C., et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:17174-17179.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 17174-17179
    • Thompson, R.H.1    Gillett, M.D.2    Cheville, J.C.3
  • 112
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson R.H., Kuntz S.M., Leibovich B.C., et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 2006, 66:3381-3385.
    • (2006) Cancer Res. , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3
  • 113
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian S.L., Hodi F.S., Brahmer J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 2012, 366:2443-2454.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 114
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian S.L., Sznol M., McDermott D.F., et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 2014, 32:1020-1030.
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 115
    • 84930934581 scopus 로고    scopus 로고
    • Effect of PDL-1 expression on prognosis in head and neck squamous cell carcinoma
    • Vasilakopoulou M., Velcheti V., Rampias T., et al. Effect of PDL-1 expression on prognosis in head and neck squamous cell carcinoma. ASCO Meet. Abstr. 2013, 31:6012.
    • (2013) ASCO Meet. Abstr. , vol.31 , pp. 6012
    • Vasilakopoulou, M.1    Velcheti, V.2    Rampias, T.3
  • 116
    • 69749106159 scopus 로고    scopus 로고
    • PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells
    • Wang W., Lau R., Yu D., et al. PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells. Int. Immunol. 2009, 21:1065-1077.
    • (2009) Int. Immunol. , vol.21 , pp. 1065-1077
    • Wang, W.1    Lau, R.2    Yu, D.3
  • 117
    • 84880747587 scopus 로고    scopus 로고
    • Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells
    • Wang L., Qian J., Lu Y., et al. Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells. Haematologica 2013, 98:1458-1466.
    • (2013) Haematologica , vol.98 , pp. 1458-1466
    • Wang, L.1    Qian, J.2    Lu, Y.3
  • 118
    • 38449107219 scopus 로고    scopus 로고
    • Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine
    • Webster W.S., Thompson R.H., Harris K.J., et al. Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. J. Immunol. 2007, 179:2860-2869.
    • (2007) J. Immunol. , vol.179 , pp. 2860-2869
    • Webster, W.S.1    Thompson, R.H.2    Harris, K.J.3
  • 119
    • 84878585947 scopus 로고    scopus 로고
    • PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
    • West E.E., Jin H.T., Rasheed A.U., et al. PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J. Clin. Investig. 2013, 123:2604-2615.
    • (2013) J. Clin. Investig. , vol.123 , pp. 2604-2615
    • West, E.E.1    Jin, H.T.2    Rasheed, A.U.3
  • 120
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
    • Westin J.R., Chu F., Zhang M., et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol. 2014, 15:69-77.
    • (2014) Lancet Oncol. , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3
  • 121
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
    • Wolchok J.D., Hoos A., O'Day S., et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 2009, 15:7412-7420.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 122
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok J.D., Kluger H., Callahan M.K., et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 2013, 369:122-133.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 123
    • 34848900497 scopus 로고    scopus 로고
    • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
    • Wong R.M., Scotland R.R., Lau R.L., et al. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int. Immunol. 2007, 19:1223-1234.
    • (2007) Int. Immunol. , vol.19 , pp. 1223-1234
    • Wong, R.M.1    Scotland, R.R.2    Lau, R.L.3
  • 124
    • 0036569127 scopus 로고    scopus 로고
    • Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
    • Woo E.Y., Yeh H., Chu C.S., et al. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 2002, 168:4272-4276.
    • (2002) J. Immunol. , vol.168 , pp. 4272-4276
    • Woo, E.Y.1    Yeh, H.2    Chu, C.S.3
  • 125
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo S.R., Turnis M.E., Goldberg M.V., et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012, 72:917-927.
    • (2012) Cancer Res. , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 126
    • 45049087313 scopus 로고    scopus 로고
    • Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
    • Xerri L., Chetaille B., Seriari N., et al. Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum. Pathol. 2008, 39:1050-1058.
    • (2008) Hum. Pathol. , vol.39 , pp. 1050-1058
    • Xerri, L.1    Chetaille, B.2    Seriari, N.3
  • 127
    • 84892544676 scopus 로고    scopus 로고
    • Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder
    • (The journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
    • Xylinas E., Robinson B.D., Kluth L.A., et al. Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder. Eur. J. Surg. Oncol. 2014, 40:121-127. (The journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology).
    • (2014) Eur. J. Surg. Oncol. , vol.40 , pp. 121-127
    • Xylinas, E.1    Robinson, B.D.2    Kluth, L.A.3
  • 128
    • 42449147063 scopus 로고    scopus 로고
    • PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    • Yamamoto R., Nishikori M., Kitawaki T., et al. PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood 2008, 111:3220-3224.
    • (2008) Blood , vol.111 , pp. 3220-3224
    • Yamamoto, R.1    Nishikori, M.2    Kitawaki, T.3
  • 129
    • 34247260551 scopus 로고    scopus 로고
    • Immunotherapy for renal cell cancer
    • Yang J.C., Childs R. Immunotherapy for renal cell cancer. J. Clin. Oncol. 2006, 24:5576-5583.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5576-5583
    • Yang, J.C.1    Childs, R.2
  • 130
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    • Zhang Y., Huang S., Gong D., et al. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. Cell. Mol. Immunol. 2010, 7:389-395.
    • (2010) Cell. Mol. Immunol. , vol.7 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3
  • 131
    • 78149491097 scopus 로고    scopus 로고
    • Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization
    • Zhou Q., Xiao H., Liu Y., et al. Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization. J. Immunol. 2010, 185:5082-5092.
    • (2010) J. Immunol. , vol.185 , pp. 5082-5092
    • Zhou, Q.1    Xiao, H.2    Liu, Y.3


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