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Volumn 7, Issue 12, 2016, Pages

Microfabricated physiological models for in vitro drug screening applications

Author keywords

Drug screening; Microfluidics; Organ on chips; Physiological models

Indexed keywords

CELL CULTURE; MICROFABRICATION; MICROFLUIDICS; PHYSIOLOGY;

EID: 85007357011     PISSN: None     EISSN: 2072666X     Source Type: Journal    
DOI: 10.3390/mi7120233     Document Type: Review
Times cited : (21)

References (186)
  • 1
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, J.A.; Hansen, R.W.; Grabowski, H.G. The price of innovation: New estimates of drug development costs. J. Health Econ. 2003, 22, 151-185
    • (2003) J. Health Econ , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 2
    • 84959128138 scopus 로고    scopus 로고
    • Innovation in the pharmaceutical industry: New estimates of R&D costs
    • DiMasi, J.A.; Grabowski, H.G.; Hansen, R.W. Innovation in the pharmaceutical industry: New estimates of R&D costs. J. Health Econ. 2016, 47, 20-33
    • (2016) J. Health Econ , vol.47 , pp. 20-33
    • DiMasi, J.A.1    Grabowski, H.G.2    Hansen, R.W.3
  • 3
    • 0035462130 scopus 로고    scopus 로고
    • From idea to market: The drug approval process FDA: A historical perspective
    • Lipsky, M.S.; Sharp, L.K. From idea to market: The drug approval process FDA: A historical perspective. Development 2001, 14, 362-367
    • (2001) Development , vol.14 , pp. 362-367
    • Lipsky, M.S.1    Sharp, L.K.2
  • 4
    • 84890346695 scopus 로고    scopus 로고
    • An evaluation of the latest in vitro tools for drug metabolism studies
    • Costa, A.; Sarmento, B.; Seabra, V. An evaluation of the latest in vitro tools for drug metabolism studies. Expert Opin. Drug Metab. Toxicol 2014, 10, 103-119
    • (2014) Expert Opin. Drug Metab. Toxicol , vol.10 , pp. 103-119
    • Costa, A.1    Sarmento, B.2    Seabra, V.3
  • 5
    • 27644596457 scopus 로고    scopus 로고
    • Predicting in vivo drug interactions from in vitro drug discovery data
    • Wienkers, L.C.; Heath, T.G. Predicting in vivo drug interactions from in vitro drug discovery data. Nat. Rev. Drug Discov. 2005, 4, 825-833
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 825-833
    • Wienkers, L.C.1    Heath, T.G.2
  • 6
    • 84857995039 scopus 로고    scopus 로고
    • Predictive in vivo animal models and translation to clinical trials
    • Cook, N.; Jodrell, D.I.; Tuveson, D.A. Predictive in vivo animal models and translation to clinical trials. Drug Discov. Today 2012, 17, 253-260
    • (2012) Drug Discov. Today , vol.17 , pp. 253-260
    • Cook, N.1    Jodrell, D.I.2    Tuveson, D.A.3
  • 8
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I.; Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 2004, 3, 1-5
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 1-5
    • Kola, I.1    Landis, J.2
  • 10
    • 84892960440 scopus 로고    scopus 로고
    • Lost in translation: Animal models and clinical trials in cancer treatment
    • Mak, I.W.; Evaniew, N.; Ghert, M. Lost in translation: Animal models and clinical trials in cancer treatment. Am. J. Transl. Res. 2014, 6, 114-118
    • (2014) Am. J. Transl. Res , vol.6 , pp. 114-118
    • Mak, I.W.1    Evaniew, N.2    Ghert, M.3
  • 11
    • 1842510682 scopus 로고    scopus 로고
    • Trials, tribulations, and trends in tumor modeling in mice
    • Schuh, J.C.L. Trials, tribulations, and trends in tumor modeling in mice. Toxicol. Pathol. 2004, 32 (Suppl. 1), 53-66
    • (2004) Toxicol. Pathol , vol.32 , pp. 53-66
    • Schuh, J.C.L.1
  • 13
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides, G.M. The origins and the future of microfluidics. Nature 2006, 442, 368-373
    • (2006) Nature , vol.442 , pp. 368-373
    • Whitesides, G.M.1
  • 14
    • 84896284039 scopus 로고    scopus 로고
    • The present and future role of microfluidics in biomedical research
    • Sackmann, E.K.; Fulton, A.L.; Beebe, D.J. The present and future role of microfluidics in biomedical research. Nature 2014, 507, 181-189
    • (2014) Nature , vol.507 , pp. 181-189
    • Sackmann, E.K.1    Fulton, A.L.2    Beebe, D.J.3
  • 15
    • 81355146382 scopus 로고    scopus 로고
    • From 3D cell culture to organs-on-chips
    • Huh, D.; Hamilton, G.A.; Ingber, D.E. From 3D cell culture to organs-on-chips. Trends Cell Biol. 2011, 21, 745-754
    • (2011) Trends Cell Biol , vol.21 , pp. 745-754
    • Huh, D.1    Hamilton, G.A.2    Ingber, D.E.3
  • 16
    • 84862186471 scopus 로고    scopus 로고
    • Microengineered physiological biomimicry: Organs-on-Chips
    • Huh, D.; Torisawa, Y.; Hamilton, G.A.; Kim, H.J.; Ingber, D.E. Microengineered physiological biomimicry: Organs-on-Chips. Lab Chip 2012, 12, 2156-2164
    • (2012) Lab Chip , vol.12 , pp. 2156-2164
    • Huh, D.1    Torisawa, Y.2    Hamilton, G.A.3    Kim, H.J.4    Ingber, D.E.5
  • 17
    • 84905754409 scopus 로고    scopus 로고
    • Microfluidic organs-on-chips
    • Bhatia, S.N.; Ingber, D.E. Microfluidic organs-on-chips. Nat. Biotechnol. 2014, 32, 760-772
    • (2014) Nat. Biotechnol , vol.32 , pp. 760-772
    • Bhatia, S.N.1    Ingber, D.E.2
  • 18
  • 19
    • 84959184483 scopus 로고    scopus 로고
    • Organ-on-a-Chip Systems: Microengineering to biomimic living systems
    • Zheng, F.; Fu, F.; Cheng, Y.; Wang, C.; Zhao, Y.; Gu, Z. Organ-on-a-Chip Systems: Microengineering to biomimic living systems. Small 2016, 12, 2253-2282
    • (2016) Small , vol.12 , pp. 2253-2282
    • Zheng, F.1    Fu, F.2    Cheng, Y.3    Wang, C.4    Zhao, Y.5    Gu, Z.6
  • 20
    • 84949883901 scopus 로고    scopus 로고
    • Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering
    • Perestrelo, A.R.; Águas, A.C.P.; Rainer, A.; Forte, G. Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering. Sensors 2015, 15, 29848
    • (2015) Sensors , vol.15 , pp. 29848
    • Perestrelo, A.R.1    Águas, A.C.P.2    Rainer, A.3    Forte, G.4
  • 21
    • 0032968777 scopus 로고    scopus 로고
    • Cryopreserved human hepatocytes: Characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
    • Li, A.P.; Lu, C.; Brent, J.A.; Pham, C.; Fackett, A.; Ruegg, C.E.; Silber, P.M. Cryopreserved human hepatocytes: Characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem. Biol. Interact. 1999, 121, 17-35
    • (1999) Chem. Biol. Interact , vol.121 , pp. 17-35
    • Li, A.P.1    Lu, C.2    Brent, J.A.3    Pham, C.4    Fackett, A.5    Ruegg, C.E.6    Silber, P.M.7
  • 22
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrighton, S.A.; Stevens, J.C. The human hepatic cytochromes P450 involved in drug metabolism. Crit. Rev. Toxicol. 1992, 22, 1-21
    • (1992) Crit. Rev. Toxicol , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 23
    • 84859163249 scopus 로고    scopus 로고
    • Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
    • Gerets, H.H.J.; Tilmant, K.; Gerin, B.; Chanteux, H.; Depelchin, B.O.; Dhalluin, S.; Atienzar, F.A. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol. Toxicol. 2012, 28, 69-87
    • (2012) Cell Biol. Toxicol , vol.28 , pp. 69-87
    • Gerets, H.H.J.1    Tilmant, K.2    Gerin, B.3    Chanteux, H.4    Depelchin, B.O.5    Dhalluin, S.6    Atienzar, F.A.7
  • 25
    • 67650169752 scopus 로고    scopus 로고
    • Hydrogels as extracellular matrix mimics for 3D cell culture
    • Tibbitt, M.W.; Anseth, K.S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 2009, 103, 655-663
    • (2009) Biotechnol. Bioeng , vol.103 , pp. 655-663
    • Tibbitt, M.W.1    Anseth, K.S.2
  • 30
    • 67349277662 scopus 로고    scopus 로고
    • The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system
    • Zhang, C.; Chia, S.M.; Ong, S.M.; Zhang, S.; Toh, Y.C.; van Noort, D.; Yu, H. The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system. Biomaterials 2009, 30, 3847-3853
    • (2009) Biomaterials , vol.30 , pp. 3847-3853
    • Zhang, C.1    Chia, S.M.2    Ong, S.M.3    Zhang, S.4    Toh, Y.C.5    van Noort, D.6    Yu, H.7
  • 31
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Toh, Y.-C.; Lim, T.C.; Tai, D.; Xiao, G.; van Noort, D.; Yu, H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip 2009, 9, 2026-2035
    • (2009) Lab Chip , vol.9 , pp. 2026-2035
    • Toh, Y.-C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    van Noort, D.5    Yu, H.6
  • 32
    • 33846032329 scopus 로고    scopus 로고
    • A microfluidic platform for 3-dimensional cell culture and cell-based assays
    • Kim, M.S.; Yeon, J.H.; Park, J.-K. A microfluidic platform for 3-dimensional cell culture and cell-based assays. Biomed. Microdevices 2007, 9, 25-34
    • (2007) Biomed. Microdevices , vol.9 , pp. 25-34
    • Kim, M.S.1    Yeon, J.H.2    Park, J.-K.3
  • 36
    • 84889026967 scopus 로고    scopus 로고
    • Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: Toward engineering the liver sinusoid
    • Kang, Y.B.A.; Rawat, S.; Cirillo, J.; Bouchard, M.; Noh, H.M. Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: Toward engineering the liver sinusoid. Biofabrication 2013, 5, 45008
    • (2013) Biofabrication , vol.5 , pp. 45008
    • Kang, Y.B.A.1    Rawat, S.2    Cirillo, J.3    Bouchard, M.4    Noh, H.M.5
  • 37
    • 54949146528 scopus 로고    scopus 로고
    • Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells
    • Ohno, M.; Motojima, K.; Okano, T.; Taniguchi, A. Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells. Tissue Eng. Part A 2008, 14, 1861-1869
    • (2008) Tissue Eng. Part A , vol.14 , pp. 1861-1869
    • Ohno, M.1    Motojima, K.2    Okano, T.3    Taniguchi, A.4
  • 39
    • 84946845089 scopus 로고    scopus 로고
    • Liver injury-on-a-chip: Microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury
    • Zhou, Q.; Patel, D.; Kwa, T.; Haque, A.; Matharu, Z.; Stybayeva, G.; Gao, Y.; Diehl, A.M.; Revzin, A. Liver injury-on-a-chip: Microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury. Lab Chip 2015, 15, 4467-4478
    • (2015) Lab Chip , vol.15 , pp. 4467-4478
    • Zhou, Q.1    Patel, D.2    Kwa, T.3    Haque, A.4    Matharu, Z.5    Stybayeva, G.6    Gao, Y.7    Diehl, A.M.8    Revzin, A.9
  • 41
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • Khetani, S.R.; Bhatia, S.N. Microscale culture of human liver cells for drug development. Nat. Biotechnol. 2008, 26, 120-126
    • (2008) Nat. Biotechnol , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 42
    • 84957603856 scopus 로고    scopus 로고
    • On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay
    • Ma, C.; Zhao, L.; Zhou, E.M.; Xu, J.; Shen, S.; Wang, J. On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay. Anal. Chem. 2016, 88, 1719-1727
    • (2016) Anal. Chem , vol.88 , pp. 1719-1727
    • Ma, C.1    Zhao, L.2    Zhou, E.M.3    Xu, J.4    Shen, S.5    Wang, J.6
  • 44
    • 84895922881 scopus 로고    scopus 로고
    • Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats
    • Baudoin, R.; Legendre, A.; Jacques, S.; Cotton, J.; Bois, F.; Leclerc, E. Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats. J. Pharm. Sci. 2014, 103, 706-718
    • (2014) J. Pharm. Sci , vol.103 , pp. 706-718
    • Baudoin, R.1    Legendre, A.2    Jacques, S.3    Cotton, J.4    Bois, F.5    Leclerc, E.6
  • 46
    • 79953243156 scopus 로고    scopus 로고
    • A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening
    • Prot, J.M.; Videau, O.; Brochot, C.; Legallais, C.; Bénech, H.; Leclerc, E. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. Int. J. Pharm. 2011, 408, 67-75
    • (2011) Int. J. Pharm , vol.408 , pp. 67-75
    • Prot, J.M.1    Videau, O.2    Brochot, C.3    Legallais, C.4    Bénech, H.5    Leclerc, E.6
  • 48
    • 34547581758 scopus 로고    scopus 로고
    • An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
    • Lee, P.J.; Hung, P.J.; Lee, L.P. An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 2007, 97, 1340-1346
    • (2007) Biotechnol. Bioeng , vol.97 , pp. 1340-1346
    • Lee, P.J.1    Hung, P.J.2    Lee, L.P.3
  • 51
    • 77449119885 scopus 로고    scopus 로고
    • A microfluidic hepatic coculture platform for cell-based drug metabolism studies
    • Novik, E.; Maguire, T.J.; Chao, P.; Cheng, K.C.; Yarmush, M.L. A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem. Pharmacol. 2010, 79, 1036-1044
    • (2010) Biochem. Pharmacol , vol.79 , pp. 1036-1044
    • Novik, E.1    Maguire, T.J.2    Chao, P.3    Cheng, K.C.4    Yarmush, M.L.5
  • 53
    • 54449093310 scopus 로고    scopus 로고
    • CNS disorders-current treatment options and the prospects for advanced therapies
    • DiNunzio, J.C.; Williams, R.O. CNS disorders-current treatment options and the prospects for advanced therapies. Drug Dev. Ind. Pharm. 2008, 34, 1141-1167
    • (2008) Drug Dev. Ind. Pharm , vol.34 , pp. 1141-1167
    • DiNunzio, J.C.1    Williams, R.O.2
  • 54
    • 17144398875 scopus 로고    scopus 로고
    • Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
    • Chung, B.G.; Flanagan, L.A.; Rhee, S.W.; Schwartz, P.H.; Lee, A.P.; Monuki, E.S.; Jeon, N.L. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 2005, 5, 401-406
    • (2005) Lab Chip , vol.5 , pp. 401-406
    • Chung, B.G.1    Flanagan, L.A.2    Rhee, S.W.3    Schwartz, P.H.4    Lee, A.P.5    Monuki, E.S.6    Jeon, N.L.7
  • 55
    • 1942485769 scopus 로고    scopus 로고
    • Immobilized concentration gradients of nerve growth factor guide neurite outgrowth
    • Kapur, T.A.; Shoichet, M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J. Biomed. Mater. Res. A 2004, 68, 235-243
    • (2004) J. Biomed. Mater. Res. A , vol.68 , pp. 235-243
    • Kapur, T.A.1    Shoichet, M.S.2
  • 56
    • 84922842049 scopus 로고    scopus 로고
    • Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities
    • Romano, N.H.; Lampe, K.J.; Xu, H.; Ferreira, M.M.; Heilshorn, S.C. Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities. Small 2015, 11, 722-730
    • (2015) Small , vol.11 , pp. 722-730
    • Romano, N.H.1    Lampe, K.J.2    Xu, H.3    Ferreira, M.M.4    Heilshorn, S.C.5
  • 57
    • 79960473407 scopus 로고    scopus 로고
    • Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies
    • Kunze, A.; Meissner, R.; Brando, S.; Renaud, P. Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies. Biotechnol. Bioeng. 2011, 108, 2241-2245
    • (2011) Biotechnol. Bioeng , vol.108 , pp. 2241-2245
    • Kunze, A.1    Meissner, R.2    Brando, S.3    Renaud, P.4
  • 58
    • 84882605442 scopus 로고    scopus 로고
    • Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response
    • Xiao, R.R.; Zeng, W.J.; Li, Y.T.; Zou, W.; Wang, L.; Pei, X.F.; Xie, M.; Huang, W.H. Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response. Anal. Chem. 2013, 85, 7842-7850
    • (2013) Anal. Chem , vol.85 , pp. 7842-7850
    • Xiao, R.R.1    Zeng, W.J.2    Li, Y.T.3    Zou, W.4    Wang, L.5    Pei, X.F.6    Xie, M.7    Huang, W.H.8
  • 59
    • 38849122821 scopus 로고    scopus 로고
    • A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues
    • Joanne, W.C.; Li, X.; Lin, B.; Shim, S.; Ming, G.-L.; Levchenko, A. A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip 2008, 8, 227-237
    • (2008) Lab Chip , vol.8 , pp. 227-237
    • Joanne, W.C.1    Li, X.2    Lin, B.3    Shim, S.4    Ming, G.-L.5    Levchenko, A.6
  • 60
    • 84925005451 scopus 로고    scopus 로고
    • Using microfluidic chip to form brain-derived neurotrophic factor concentration gradient for studying neuron axon guidance
    • Huang, H.; Jiang, L.; Li, S.; Deng, J.; Li, Y.; Yao, J.; Li, B.; Zheng, J. Using microfluidic chip to form brain-derived neurotrophic factor concentration gradient for studying neuron axon guidance. Biomicrofluidics 2014, 8, 014108
    • (2014) Biomicrofluidics , vol.8
    • Huang, H.1    Jiang, L.2    Li, S.3    Deng, J.4    Li, Y.5    Yao, J.6    Li, B.7    Zheng, J.8
  • 61
    • 84933046165 scopus 로고    scopus 로고
    • Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
    • Taylor, A.M.; Menon, S.; Gupton, S.L. Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab Chip 2015, 15, 2781-2789
    • (2015) Lab Chip , vol.15 , pp. 2781-2789
    • Taylor, A.M.1    Menon, S.2    Gupton, S.L.3
  • 64
    • 77951883483 scopus 로고    scopus 로고
    • Microfluidic local perfusion chambers for the visualization and manipulation of synapses
    • Taylor, A.M.; Dieterich, D.C.; Ito, H.T.; Kim, S.A.; Schuman, E.M. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 2010, 66, 57-68
    • (2010) Neuron , vol.66 , pp. 57-68
    • Taylor, A.M.1    Dieterich, D.C.2    Ito, H.T.3    Kim, S.A.4    Schuman, E.M.5
  • 65
    • 77954961916 scopus 로고    scopus 로고
    • Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection
    • Hellman, A.N.; Vahidi, B.; Kim, H.J.; Mismar, W.; Steward, O.; Jeon, N.L.; Venugopalan, V. Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip 2010, 10, 2083-2092
    • (2010) Lab Chip , vol.10 , pp. 2083-2092
    • Hellman, A.N.1    Vahidi, B.2    Kim, H.J.3    Mismar, W.4    Steward, O.5    Jeon, N.L.6    Venugopalan, V.7
  • 66
    • 70449088618 scopus 로고    scopus 로고
    • Quantitative analysis of CNS axon regeneration using a microfluidic neuron culture device
    • Park, J.W.; Vahidi, B.; Kim, H.J.; Rhee, S.W.; Jeon, N.L. Quantitative analysis of CNS axon regeneration using a microfluidic neuron culture device. Biochip J. 2008, 2, 44-51
    • (2008) Biochip J , vol.2 , pp. 44-51
    • Park, J.W.1    Vahidi, B.2    Kim, H.J.3    Rhee, S.W.4    Jeon, N.L.5
  • 67
    • 85007398062 scopus 로고    scopus 로고
    • Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device
    • Gao, Y.; Broussard, J.; Haque, A.; Revzin, A.; Lin, T. Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst. Nanoeng. 2016, 2, 15045
    • (2016) Microsyst. Nanoeng , vol.2 , pp. 15045
    • Gao, Y.1    Broussard, J.2    Haque, A.3    Revzin, A.4    Lin, T.5
  • 69
    • 58649114243 scopus 로고    scopus 로고
    • Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture
    • Dworak, B.J.; Wheeler, B.C. Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip 2009, 9, 404-410
    • (2009) Lab Chip , vol.9 , pp. 404-410
    • Dworak, B.J.1    Wheeler, B.C.2
  • 70
    • 33847632492 scopus 로고    scopus 로고
    • Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration
    • Ravula, S.K.; Wang, M.S.; McClain, M.A.; Asress, S.A.; Frazier, B.; Glass, J.D. Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neurosci. Lett. 2007, 415, 34-39
    • (2007) Neurosci. Lett , vol.415 , pp. 34-39
    • Ravula, S.K.1    Wang, M.S.2    McClain, M.A.3    Asress, S.A.4    Frazier, B.5    Glass, J.D.6
  • 72
    • 81455143852 scopus 로고    scopus 로고
    • Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates
    • Biffi, E.; Menegon, A.; Piraino, F.; Pedrocchi, A.; Fiore, G.B.; Rasponi, M. Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates. Biotechnol. Bioeng. 2012, 109, 166-175
    • (2012) Biotechnol. Bioeng , vol.109 , pp. 166-175
    • Biffi, E.1    Menegon, A.2    Piraino, F.3    Pedrocchi, A.4    Fiore, G.B.5    Rasponi, M.6
  • 73
    • 84875794834 scopus 로고    scopus 로고
    • A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices
    • Scott, A.; Weir, K.; Easton, C.; Huynh, W.; Moody, W.J.; Folch, A. A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices. Lab Chip 2013, 13, 527-535
    • (2013) Lab Chip , vol.13 , pp. 527-535
    • Scott, A.1    Weir, K.2    Easton, C.3    Huynh, W.4    Moody, W.J.5    Folch, A.6
  • 74
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • Pardridge, W.M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow Metab. 2012, 32, 1959-1972
    • (2012) J. Cereb. Blood Flow Metab , vol.32 , pp. 1959-1972
    • Pardridge, W.M.1
  • 75
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2005, 2, 3-14
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 76
    • 0036205158 scopus 로고    scopus 로고
    • Nanoparticle technology for drug delivery across the blood-brain barrier
    • Lockman, P.R.; Mumper, R.J.; Khan, M.A.; Allen, D.D. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 2002, 28, 1-13
    • (2002) Drug Dev. Ind. Pharm , vol.28 , pp. 1-13
    • Lockman, P.R.1    Mumper, R.J.2    Khan, M.A.3    Allen, D.D.4
  • 80
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
    • Booth, R.; Kim, H. Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). Lab Chip 2012, 12, 1784-1792
    • (2012) Lab Chip , vol.12 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 82
    • 84960888901 scopus 로고    scopus 로고
    • Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip
    • Herland, A.; van der Meer, A.D.; FitzGerald, E.A.; Park, T.E.; Sleeboom, J.J.F.; Ingber, D.E. Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip. PLoS ONE 2016, 11, e0150360
    • (2016) PLoS ONE , vol.11
    • Herland, A.1    van der Meer, A.D.2    FitzGerald, E.A.3    Park, T.E.4    Sleeboom, J.J.F.5    Ingber, D.E.6
  • 83
    • 84960121035 scopus 로고    scopus 로고
    • Organization of endothelial cells, pericytes, and astrocytes into a 3D microfluidic in vitro model of the blood-brain barrier
    • Wang, J.D.; Khafagy, E.S.; Khanafer, K.; Takayama, S.; Elsayed, M.E.H. Organization of endothelial cells, pericytes, and astrocytes into a 3D microfluidic in vitro model of the blood-brain barrier. Mol. Pharm. 2016, 13, 895-906
    • (2016) Mol. Pharm , vol.13 , pp. 895-906
    • Wang, J.D.1    Khafagy, E.S.2    Khanafer, K.3    Takayama, S.4    Elsayed, M.E.H.5
  • 84
  • 85
    • 84876526111 scopus 로고    scopus 로고
    • Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
    • Liang, P.; Lan, F.; Lee, A.S.; Gong, T.; Sanchez-Freire, V.; Wang, Y.; Diecke, S.; Sallam, K.; Knowles, J.W.; Wang, P.J.; et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 2013, 127, 1677-1691
    • (2013) Circulation , vol.127 , pp. 1677-1691
    • Liang, P.1    Lan, F.2    Lee, A.S.3    Gong, T.4    Sanchez-Freire, V.5    Wang, Y.6    Diecke, S.7    Sallam, K.8    Knowles, J.W.9    Wang, P.J.10
  • 86
    • 84959457881 scopus 로고    scopus 로고
    • On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain
    • Ugolini, G.S.; Rasponi, M.; Pavesi, A.; Santoro, R.; Kamm, R.; Fiore, G.B.; Pesce, M.; Soncini, M. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnol. Bioeng. 2016, 113, 859-869
    • (2016) Biotechnol. Bioeng , vol.113 , pp. 859-869
    • Ugolini, G.S.1    Rasponi, M.2    Pavesi, A.3    Santoro, R.4    Kamm, R.5    Fiore, G.B.6    Pesce, M.7    Soncini, M.8
  • 89
    • 84863116827 scopus 로고    scopus 로고
    • Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
    • Abassi, Y.A.; Xi, B.; Li, N.; Ouyang, W.; Seiler, A.; Watzele, M.; Kettenhofen, R.; Bohlen, H.; Ehlich, A.; Kolossov, E.; et al. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br. J. Pharmacol. 2012, 165, 1424-1441
    • (2012) Br. J. Pharmacol , vol.165 , pp. 1424-1441
    • Abassi, Y.A.1    Xi, B.2    Li, N.3    Ouyang, W.4    Seiler, A.5    Watzele, M.6    Kettenhofen, R.7    Bohlen, H.8    Ehlich, A.9    Kolossov, E.10
  • 90
    • 82855168014 scopus 로고    scopus 로고
    • Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System
    • Xi, B.; Wang, T.; Li, N.; Ouyang, W.; Zhang, W.; Wu, J.; Xu, X.; Wang, X.; Abassi, Y.A. Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System. J. Lab. Autom. 2011, 16, 415-421
    • (2011) J. Lab. Autom , vol.16 , pp. 415-421
    • Xi, B.1    Wang, T.2    Li, N.3    Ouyang, W.4    Zhang, W.5    Wu, J.6    Xu, X.7    Wang, X.8    Abassi, Y.A.9
  • 91
    • 84922273996 scopus 로고    scopus 로고
    • High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition
    • Hu, N.; Wang, T.; Wang, Q.; Zhou, J.; Zou, L.; Su, K.; Wu, J.; Wang, P. High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition. Biosens. Bioelectron. 2015, 67, 146-153
    • (2015) Biosens. Bioelectron , vol.67 , pp. 146-153
    • Hu, N.1    Wang, T.2    Wang, Q.3    Zhou, J.4    Zou, L.5    Su, K.6    Wu, J.7    Wang, P.8
  • 92
    • 84878376886 scopus 로고    scopus 로고
    • A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating
    • Wang, T.; Hu, N.; Cao, J.; Wu, J.; Su, K.; Wang, P. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens. Bioelectron. 2013, 49, 9-13
    • (2013) Biosens. Bioelectron , vol.49 , pp. 9-13
    • Wang, T.1    Hu, N.2    Cao, J.3    Wu, J.4    Su, K.5    Wang, P.6
  • 93
    • 4344654280 scopus 로고    scopus 로고
    • A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings
    • Werdich, A.A.; Lima, E.A.; Ivanov, B.; Ges, I.; Anderson, M.E.; Wikswo, J.P.; Baudenbacher, F.J. A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Lab Chip 2004, 4, 357-362
    • (2004) Lab Chip , vol.4 , pp. 357-362
    • Werdich, A.A.1    Lima, E.A.2    Ivanov, B.3    Ges, I.4    Anderson, M.E.5    Wikswo, J.P.6    Baudenbacher, F.J.7
  • 94
    • 33747587891 scopus 로고    scopus 로고
    • Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers
    • Ganitkevich, V.; Reil, S.; Schwethelm, B.; Schroeter, T.; Benndorf, K. Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers. Circ. Res. 2006, 99, 165-171
    • (2006) Circ. Res , vol.99 , pp. 165-171
    • Ganitkevich, V.1    Reil, S.2    Schwethelm, B.3    Schroeter, T.4    Benndorf, K.5
  • 95
    • 77951201263 scopus 로고    scopus 로고
    • Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes
    • Cheng, W.; Klauke, N.; Smith, G.; Cooper, J.M. Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis 2010, 31, 1405-1413
    • (2010) Electrophoresis , vol.31 , pp. 1405-1413
    • Cheng, W.1    Klauke, N.2    Smith, G.3    Cooper, J.M.4
  • 96
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
    • Grosberg, A.; Alford, P.W.; McCain, M.L.; Parker, K.K. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip 2011, 11, 4165-4173
    • (2011) Lab Chip , vol.11 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 97
    • 59649107048 scopus 로고    scopus 로고
    • Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes
    • Heidi Au, H.T.; Cui, B.; Chu, Z.E.; Veres, T.; Radisic, M. Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes. Lab Chip 2009, 9, 564-575
    • (2009) Lab Chip , vol.9 , pp. 564-575
    • Heidi Au, H.T.1    Cui, B.2    Chu, Z.E.3    Veres, T.4    Radisic, M.5
  • 98
    • 84882240631 scopus 로고    scopus 로고
    • Microfluidic heart on a chip for higher throughput pharmacological studies
    • Agarwal, A.; Goss, J.A.; Cho, A.; McCain, M.L.; Parker, K.K. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip 2013, 13, 3599-3608
    • (2013) Lab Chip , vol.13 , pp. 3599-3608
    • Agarwal, A.1    Goss, J.A.2    Cho, A.3    McCain, M.L.4    Parker, K.K.5
  • 99
    • 84902087268 scopus 로고    scopus 로고
    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
    • Wang, G.; McCain, M.L.; Yang, L.; He, A.; Pasqualini, F.S.; Agarwal, A.; Yuan, H.; Jiang, D.; Zhang, D.; Zangi, L.; et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat. Med. 2014, 20, 616-623
    • (2014) Nat. Med , vol.20 , pp. 616-623
    • Wang, G.1    McCain, M.L.2    Yang, L.3    He, A.4    Pasqualini, F.S.5    Agarwal, A.6    Yuan, H.7    Jiang, D.8    Zhang, D.9    Zangi, L.10
  • 101
    • 84949683733 scopus 로고    scopus 로고
    • Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes
    • Sun, X.; Nunes, S.S. Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Methods 2016, 101, 21-26
    • (2016) Methods , vol.101 , pp. 21-26
    • Sun, X.1    Nunes, S.S.2
  • 104
    • 84896752543 scopus 로고    scopus 로고
    • Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses
    • Li, M.; Hotaling, N.A.; Ku, D.N.; Forest, C.R. Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. PLoS ONE 2014, 9, e82493
    • (2014) PLoS ONE , vol.9
    • Li, M.1    Hotaling, N.A.2    Ku, D.N.3    Forest, C.R.4
  • 105
    • 84863286346 scopus 로고    scopus 로고
    • Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood
    • Li, M.; Ku, D.N.; Forest, C.R. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 2012, 12, 1355-1362
    • (2012) Lab Chip , vol.12 , pp. 1355-1362
    • Li, M.1    Ku, D.N.2    Forest, C.R.3
  • 108
    • 33646943472 scopus 로고    scopus 로고
    • Formation of perfused, functional microvascular tubes in vitro
    • Chrobak, K.M.; Potter, D.R.; Tien, J. Formation of perfused, functional microvascular tubes in vitro. Microvasc. Res. 2006, 71, 185-196
    • (2006) Microvasc. Res , vol.71 , pp. 185-196
    • Chrobak, K.M.1    Potter, D.R.2    Tien, J.3
  • 109
    • 84892372328 scopus 로고    scopus 로고
    • A bioengineered array of 3D microvessels for vascular permeability assay
    • Lee, H.; Kim, S.; Chung, M.; Kim, J.H.; Jeon, N.L. A bioengineered array of 3D microvessels for vascular permeability assay. Microvasc. Res. 2014, 91, 90-98
    • (2014) Microvasc. Res , vol.91 , pp. 90-98
    • Lee, H.1    Kim, S.2    Chung, M.3    Kim, J.H.4    Jeon, N.L.5
  • 110
    • 84947803121 scopus 로고    scopus 로고
    • Microcirculation-on-a-chip: A microfluidic platform for assaying blood-and lymphatic-vessel permeability
    • Sato, M.; Sasaki, N.; Ato, M.; Hirakawa, S.; Sato, K.; Sato, K. Microcirculation-on-a-chip: A microfluidic platform for assaying blood-and lymphatic-vessel permeability. PLoS ONE 2015, 10, e0137301
    • (2015) PLoS ONE , vol.10
    • Sato, M.1    Sasaki, N.2    Ato, M.3    Hirakawa, S.4    Sato, K.5    Sato, K.6
  • 112
    • 84934882141 scopus 로고    scopus 로고
    • Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function
    • Yasotharan, S.; Pinto, S.; Sled, J.G.; Bolz, S.-S.; Günther, A. Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function. Lab Chip 2015, 15, 2660-2669
    • (2015) Lab Chip , vol.15 , pp. 2660-2669
    • Yasotharan, S.1    Pinto, S.2    Sled, J.G.3    Bolz, S.-S.4    Günther, A.5
  • 113
    • 77955113600 scopus 로고    scopus 로고
    • Reconstructing the lung
    • Wagner, W.R.; Griffith, B.P. Reconstructing the lung. Science 2010, 329, 520-522
    • (2010) Science , vol.329 , pp. 520-522
    • Wagner, W.R.1    Griffith, B.P.2
  • 115
    • 75349108981 scopus 로고    scopus 로고
    • Preclinical models for pulmonary drug delivery
    • Fernandes, C.A.; Vanbever, R. Preclinical models for pulmonary drug delivery. Expert Opin. Drug Deliv. 2009, 6, 1231-1245
    • (2009) Expert Opin. Drug Deliv , vol.6 , pp. 1231-1245
    • Fernandes, C.A.1    Vanbever, R.2
  • 116
    • 79952129858 scopus 로고    scopus 로고
    • Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices
    • Hakkinen, K.M.; Harunaga, J.S.; Doyle, A.D.; Yamada, K.M. Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng. Part A 2011, 17, 713-724
    • (2011) Tissue Eng. Part A , vol.17 , pp. 713-724
    • Hakkinen, K.M.1    Harunaga, J.S.2    Doyle, A.D.3    Yamada, K.M.4
  • 118
  • 120
    • 84907016366 scopus 로고    scopus 로고
    • Modeling the lung: Design and development of tissue engineered macro-and micro-physiologic lung models for research use
    • Nichols, J.E.; Niles, J.A.; Vega, S.P.; Argueta, L.B.; Eastaway, A.; Cortiella, J. Modeling the lung: Design and development of tissue engineered macro-and micro-physiologic lung models for research use. Exp. Biol. Med. 2014, 239, 1135-1169
    • (2014) Exp. Biol. Med , vol.239 , pp. 1135-1169
    • Nichols, J.E.1    Niles, J.A.2    Vega, S.P.3    Argueta, L.B.4    Eastaway, A.5    Cortiella, J.6
  • 123
    • 84928723734 scopus 로고    scopus 로고
    • A human breathing lung-on-a-chip
    • Huh, D. A human breathing lung-on-a-chip. Ann. Am. Thorac. Soc. 2015, 12, S42-S44
    • (2015) Ann. Am. Thorac. Soc , vol.12 , pp. S42-S44
    • Huh, D.1
  • 125
    • 39149103052 scopus 로고    scopus 로고
    • The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia
    • Kudlacz, E.; Conklyn, M.; Andresen, C.; Whitney-Pickett, C.; Changelian, P. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582, 154-161
    • (2008) Eur. J. Pharmacol , vol.582 , pp. 154-161
    • Kudlacz, E.1    Conklyn, M.2    Andresen, C.3    Whitney-Pickett, C.4    Changelian, P.5
  • 126
    • 84907818816 scopus 로고    scopus 로고
    • Human airway musculature on a chip: An in vitro model of allergic asthmatic bronchoconstriction and bronchodilation
    • Nesmith, A.P.; Agarwal, A.; McCain, M.L.; Parker, K.K. Human airway musculature on a chip: An in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip 2014, 14, 3925-3936
    • (2014) Lab Chip , vol.14 , pp. 3925-3936
    • Nesmith, A.P.1    Agarwal, A.2    McCain, M.L.3    Parker, K.K.4
  • 127
    • 0030933944 scopus 로고    scopus 로고
    • Airways remodeling is a distinctive feature of asthma and is related to severity of disease
    • Chetta, A.; Foresi, A.; del Donno, M.; Bertorelli, G.; Pesci, A.; Olivieri, D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997, 111, 852-857
    • (1997) Chest , vol.111 , pp. 852-857
    • Chetta, A.1    Foresi, A.2    del Donno, M.3    Bertorelli, G.4    Pesci, A.5    Olivieri, D.6
  • 128
    • 0026612959 scopus 로고
    • M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle
    • Fernandes, L.B.; Fryer, A.D.; Hirshman, C.A. M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle. J. Pharmacol. Exp. Ther. 1992, 262, 119-126
    • (1992) J. Pharmacol. Exp. Ther , vol.262 , pp. 119-126
    • Fernandes, L.B.1    Fryer, A.D.2    Hirshman, C.A.3
  • 130
    • 61449197656 scopus 로고    scopus 로고
    • Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance
    • Wang, S.; Yue, F.; Zhang, L.; Wang, J.; Wang, Y.; Li, J.; Lin, B.; Qi, W. Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance. J. Pharm. Biomed. Anal. 2009, 49, 806-810
    • (2009) J. Pharm. Biomed. Anal , vol.49 , pp. 806-810
    • Wang, S.1    Yue, F.2    Zhang, L.3    Wang, J.4    Wang, Y.5    Li, J.6    Lin, B.7    Qi, W.8
  • 131
    • 84938347800 scopus 로고    scopus 로고
    • Cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer A549 cells by up-regulating the PI3K/Akt and GRP78 signaling on a microfluidic platform
    • Ying, L.; Zhu, Z.; Xu, Z.; He, T.; Li, E.; Guo, Z.; Liu, F.; Jiang, C.; Wang, Q. Cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer A549 cells by up-regulating the PI3K/Akt and GRP78 signaling on a microfluidic platform. PLoS ONE 2015, 10, 1-15
    • (2015) PLoS ONE , vol.10 , pp. 1-15
    • Ying, L.1    Zhu, Z.2    Xu, Z.3    He, T.4    Li, E.5    Guo, Z.6    Liu, F.7    Jiang, C.8    Wang, Q.9
  • 133
    • 45149094559 scopus 로고    scopus 로고
    • Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
    • Barbone, D.; Yang, T.M.; Morgan, J.R.; Gaudino, G.; Broaddus, V.C. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J. Biol. Chem. 2008, 283, 13021-13030
    • (2008) J. Biol. Chem , vol.283 , pp. 13021-13030
    • Barbone, D.1    Yang, T.M.2    Morgan, J.R.3    Gaudino, G.4    Broaddus, V.C.5
  • 134
    • 84875781499 scopus 로고    scopus 로고
    • Construction of oxygen and chemical concentration gradients in a single microfluidic device for studying tumor cell-drug interactions in a dynamic hypoxia microenvironment
    • Wang, L.; Liu, W.; Wang, Y.; Wang, J.; Tu, Q.; Liu, R.; Wang, J. Construction of oxygen and chemical concentration gradients in a single microfluidic device for studying tumor cell-drug interactions in a dynamic hypoxia microenvironment. Lab Chip 2013, 13, 695-705
    • (2013) Lab Chip , vol.13 , pp. 695-705
    • Wang, L.1    Liu, W.2    Wang, Y.3    Wang, J.4    Tu, Q.5    Liu, R.6    Wang, J.7
  • 136
    • 84874964737 scopus 로고    scopus 로고
    • Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer
    • Xu, Z.; Gao, Y.; Hao, Y.; Li, E.; Wang, Y.; Zhang, J.; Wang, W.; Gao, Z.; Wang, Q. Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer. Biomaterials 2013, 34, 4109-4117
    • (2013) Biomaterials , vol.34 , pp. 4109-4117
    • Xu, Z.1    Gao, Y.2    Hao, Y.3    Li, E.4    Wang, Y.5    Zhang, J.6    Wang, W.7    Gao, Z.8    Wang, Q.9
  • 137
    • 77951884924 scopus 로고    scopus 로고
    • A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells
    • Jang, K.-J.; Suh, K.-Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip 2010, 10, 36-42
    • (2010) Lab Chip , vol.10 , pp. 36-42
    • Jang, K.-J.1    Suh, K.-Y.2
  • 138
    • 0031832902 scopus 로고    scopus 로고
    • Intrarenal blood flow: Microvascular anatomy and the regulation of medullary perfusion
    • Pallone, T.L.; Silldorff, E.P.; Turner, M.R. Intrarenal blood flow: Microvascular anatomy and the regulation of medullary perfusion. Clin. Exp. Pharmacol. Physiol. 1998, 25, 383-392
    • (1998) Clin. Exp. Pharmacol. Physiol , vol.25 , pp. 383-392
    • Pallone, T.L.1    Silldorff, E.P.2    Turner, M.R.3
  • 139
    • 84903973480 scopus 로고    scopus 로고
    • Drug-induced nephrotoxicity: Clinical impact and preclinical in vitro models
    • Tiong, H.Y.; Huang, P.; Xiong, S.; Li, Y.; Vathsala, A.; Zink, D. Drug-induced nephrotoxicity: Clinical impact and preclinical in vitro models. Mol. Pharm. 2014, 11, 1933-1948
    • (2014) Mol. Pharm , vol.11 , pp. 1933-1948
    • Tiong, H.Y.1    Huang, P.2    Xiong, S.3    Li, Y.4    Vathsala, A.5    Zink, D.6
  • 140
    • 67549145035 scopus 로고    scopus 로고
    • Drug-induced nephrotoxicity
    • Naughton, C.A. Drug-induced nephrotoxicity. Am. Fam. Phys. 2008, 78, 743-750
    • (2008) Am. Fam. Phys , vol.78 , pp. 743-750
    • Naughton, C.A.1
  • 141
    • 70349303831 scopus 로고    scopus 로고
    • Renal vulnerability to drug toxicity
    • Perazella, M.A. Renal vulnerability to drug toxicity. Clin. J. Am. Soc. Nephrol. 2009, 4, 1275-1283
    • (2009) Clin. J. Am. Soc. Nephrol , vol.4 , pp. 1275-1283
    • Perazella, M.A.1
  • 143
    • 85027933239 scopus 로고    scopus 로고
    • The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule
    • Jenkinson, S.E.; Chung, G.W.; van Loon, E.; Bakar, N.S.; Dalzell, A.M.; Brown, C.D.A. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. Pflugers Arch. Eur. J. Physiol. 2012, 464, 601-611
    • (2012) Pflugers Arch. Eur. J. Physiol , vol.464 , pp. 601-611
    • Jenkinson, S.E.1    Chung, G.W.2    van Loon, E.3    Bakar, N.S.4    Dalzell, A.M.5    Brown, C.D.A.6
  • 144
    • 84859635020 scopus 로고    scopus 로고
    • Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip
    • Snouber, L.C.; Letourneur, F.; Chafey, P.; Broussard, C.; Monge, M.; Legallais, C.; Leclerc, E. Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip. Biotechnol. Prog. 2012, 28, 474-484
    • (2012) Biotechnol. Prog , vol.28 , pp. 474-484
    • Snouber, L.C.1    Letourneur, F.2    Chafey, P.3    Broussard, C.4    Monge, M.5    Legallais, C.6    Leclerc, E.7
  • 145
    • 0034796171 scopus 로고    scopus 로고
    • Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells
    • Essig, M.; Terzi, F.; Burtin, M.; Friedlander, G. Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells. Am. J. Physiol. Ren. Physiol. 2001, 281, F751-F762
    • (2001) Am. J. Physiol. Ren. Physiol , vol.281 , pp. F751-F762
    • Essig, M.1    Terzi, F.2    Burtin, M.3    Friedlander, G.4
  • 146
    • 0029360777 scopus 로고
    • Fluctuating shear stress effects on stress fiber architecture and energy metabolism of cultured renal cells
    • Bhat, V.D.; Windridge, P.A.; Cherry, R.S.; Mandel, L.J. Fluctuating shear stress effects on stress fiber architecture and energy metabolism of cultured renal cells. Biotechnol. Prog. 1995, 11, 596-600
    • (1995) Biotechnol. Prog , vol.11 , pp. 596-600
    • Bhat, V.D.1    Windridge, P.A.2    Cherry, R.S.3    Mandel, L.J.4
  • 147
    • 33644855811 scopus 로고    scopus 로고
    • Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments
    • Du, Z.; Yan, Q.; Duan, Y.; Weinbaum, S.; Weinstein, A.M.; Wang, T. Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments. Am. J. Physiol. Ren. Physiol. 2006, 290, F289-F296
    • (2006) Am. J. Physiol. Ren. Physiol , vol.290 , pp. F289-F296
    • Du, Z.1    Yan, Q.2    Duan, Y.3    Weinbaum, S.4    Weinstein, A.M.5    Wang, T.6
  • 149
    • 2942709867 scopus 로고    scopus 로고
    • Microfluidic PDMS (Polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes
    • Leclerc, E.; Sakai, Y.; Fujii, T. Microfluidic PDMS (Polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol. Prog. 2004, 20, 750-755
    • (2004) Biotechnol. Prog , vol.20 , pp. 750-755
    • Leclerc, E.1    Sakai, Y.2    Fujii, T.3
  • 150
    • 35348827791 scopus 로고    scopus 로고
    • Development of a renal microchip for in vitro distal tubule models
    • Baudoin, R.; Griscom, L.; Monge, M.; Legallais, C.; Leclerc, E. Development of a renal microchip for in vitro distal tubule models. Biotechnol. Prog. 2007, 23, 1245-1253
    • (2007) Biotechnol. Prog , vol.23 , pp. 1245-1253
    • Baudoin, R.1    Griscom, L.2    Monge, M.3    Legallais, C.4    Leclerc, E.5
  • 151
    • 0029937194 scopus 로고    scopus 로고
    • The importance of ammonia in mammalian cell culture
    • Schneider, M.; Marison, I.W.; von Stockar, U. The importance of ammonia in mammalian cell culture. J. Biotechnol. 1996, 46, 161-185
    • (1996) J. Biotechnol , vol.46 , pp. 161-185
    • Schneider, M.1    Marison, I.W.2    von Stockar, U.3
  • 152
    • 84862773705 scopus 로고    scopus 로고
    • Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips
    • Choucha Snouber, L.; Jacques, S.; Monge, M.; Legallais, C.; Leclerc, E. Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips. Genomics 2012, 100, 27-34
    • (2012) Genomics , vol.100 , pp. 27-34
    • Choucha Snouber, L.1    Jacques, S.2    Monge, M.3    Legallais, C.4    Leclerc, E.5
  • 153
    • 40249109853 scopus 로고    scopus 로고
    • The IkappaB kinase-A bridge between inflammation and cancer
    • Karin, M. The IkappaB kinase-A bridge between inflammation and cancer. Cell Res. 2008, 18, 334-342
    • (2008) Cell Res , vol.18 , pp. 334-342
    • Karin, M.1
  • 154
    • 66449120238 scopus 로고    scopus 로고
    • ransepithelial fluxes of adenosine and 20-deoxyadenosine across human renal proximal tubule cells: Roles of nucleoside transporters hENT1, hENT2, and hCNT
    • Elwi, A.N.; Damaraju, V.L.; Kuzma, M.L.; Mowles, D.A.; Baldwin, S.A.; Young, J.D.; Sawyer, M.B.; Cass, C.E. ransepithelial fluxes of adenosine and 20-deoxyadenosine across human renal proximal tubule cells: Roles of nucleoside transporters hENT1, hENT2, and hCNT. Am. J. Physiol. Ren. Physiol. 2009, 296, F1439-F1451
    • (2009) Am. J. Physiol. Ren. Physiol , vol.296 , pp. F1439-F1451
    • Elwi, A.N.1    Damaraju, V.L.2    Kuzma, M.L.3    Mowles, D.A.4    Baldwin, S.A.5    Young, J.D.6    Sawyer, M.B.7    Cass, C.E.8
  • 155
    • 0026529989 scopus 로고
    • Redistribution of microvilli and membrane enzymes in isolated rat proximal tubule cells
    • Rebelo, L.; Carmo-Fonseca, M.; Moura, T.F. Redistribution of microvilli and membrane enzymes in isolated rat proximal tubule cells. Biol. Cell 1992, 74, 203-209
    • (1992) Biol. Cell , vol.74 , pp. 203-209
    • Rebelo, L.1    Carmo-Fonseca, M.2    Moura, T.F.3
  • 156
    • 79951474125 scopus 로고    scopus 로고
    • Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells
    • Jang, K.-J.; Cho, H.S.; Kang, D.H.; Bae, W.G.; Kwon, T.-H.; Suh, K.-Y. Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr. Biol. 2011, 3, 134-141
    • (2011) Integr. Biol , vol.3 , pp. 134-141
    • Jang, K.-J.1    Cho, H.S.2    Kang, D.H.3    Bae, W.G.4    Kwon, T.-H.5    Suh, K.-Y.6
  • 157
    • 79957949200 scopus 로고    scopus 로고
    • Investigation into modification of mass transfer kinetics by acrolein in a renal biochip
    • Ramello, C.; Paullier, P.; Ould-Dris, A.; Monge, M.; Legallais, C.; Leclerc, E. Investigation into modification of mass transfer kinetics by acrolein in a renal biochip. Toxicol. In Vitro 2011, 25, 1123-1131
    • (2011) Toxicol. In Vitro , vol.25 , pp. 1123-1131
    • Ramello, C.1    Paullier, P.2    Ould-Dris, A.3    Monge, M.4    Legallais, C.5    Leclerc, E.6
  • 159
    • 78651449264 scopus 로고    scopus 로고
    • Once versus multiple daily dosing of aminoglycosides for patients with febrile neutropenia: A systematic review and meta-analysis
    • Mavros, M.N.; Polyzos, K.A.; Rafailidis, P.I.; Falagas, M.E. Once versus multiple daily dosing of aminoglycosides for patients with febrile neutropenia: A systematic review and meta-analysis. J. Antimicrob. Chemother. 2011, 66, 251-259
    • (2011) J. Antimicrob. Chemother , vol.66 , pp. 251-259
    • Mavros, M.N.1    Polyzos, K.A.2    Rafailidis, P.I.3    Falagas, M.E.4
  • 160
    • 49649114844 scopus 로고    scopus 로고
    • Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
    • Duan, Y.; Gotoh, N.; Yan, Q.; Du, Z.; Weinstein, A.M.; Wang, T.; Weinbaum, S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proc. Natl. Acad. Sci. USA 2008, 105, 11418-11423
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 11418-11423
    • Duan, Y.1    Gotoh, N.2    Yan, Q.3    Du, Z.4    Weinstein, A.M.5    Wang, T.6    Weinbaum, S.7
  • 161
    • 0036226940 scopus 로고    scopus 로고
    • Animal model pharmacokinetics and pharmacodynamics: A critical review
    • Andes, D.; Craig, W.A. Animal model pharmacokinetics and pharmacodynamics: A critical review. Int. J. Antimicrob. Agents 2002, 19, 261-268
    • (2002) Int. J. Antimicrob. Agents , vol.19 , pp. 261-268
    • Andes, D.1    Craig, W.A.2
  • 162
    • 79956123094 scopus 로고    scopus 로고
    • Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption
    • Paine, S.W.; Ménochet, K.; Denton, R.; McGinnity, D.F.; Riley, R.J. Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption. Drug Metab. Dispos. 2011, 39, 1008-1013
    • (2011) Drug Metab. Dispos , vol.39 , pp. 1008-1013
    • Paine, S.W.1    Ménochet, K.2    Denton, R.3    McGinnity, D.F.4    Riley, R.J.5
  • 163
    • 85007300025 scopus 로고    scopus 로고
    • Species differences in drug transporters and implications for translating preclinical findings to humans
    • Chu, X.; Bleasby, K.; Evers, R. Species differences in drug transporters and implications for translating preclinical findings to humans. Expert Opin. Drug Metab. Toxicol. 2012, 5255, 1-16
    • (2012) Expert Opin. Drug Metab. Toxicol , vol.5255 , pp. 1-16
    • Chu, X.1    Bleasby, K.2    Evers, R.3
  • 164
    • 0031834028 scopus 로고    scopus 로고
    • Nephrotoxicity testing in vitro-What we know and what we need to know
    • Pfaller, W.; Gstraunthaler, G. Nephrotoxicity testing in vitro-What we know and what we need to know. Environ. Health Perspect. 1998, 106 (Suppl. 2), 559-569
    • (1998) Environ. Health Perspect , vol.106 , pp. 559-569
    • Pfaller, W.1    Gstraunthaler, G.2
  • 169
    • 85003286532 scopus 로고    scopus 로고
    • Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs
    • Madden, L.; Juhas, M.; Kraus, W.E.; Truskey, G.A.; Bursac, N. Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. eLife 2015, 4, e04885
    • (2015) eLife , vol.4
    • Madden, L.1    Juhas, M.2    Kraus, W.E.3    Truskey, G.A.4    Bursac, N.5
  • 170
    • 84929991052 scopus 로고    scopus 로고
    • High-throughput microfluidic platform for 3D cultures of mesenchymal stem cells, towards engineering developmental processes
    • Occhetta, P.; Centola, M.; Tonnarelli, B.; Redaelli, A.; Martin, I.; Rasponi, M. High-throughput microfluidic platform for 3D cultures of mesenchymal stem cells, towards engineering developmental processes. Sci. Rep. 2015, 5, 10288
    • (2015) Sci. Rep , vol.5 , pp. 10288
    • Occhetta, P.1    Centola, M.2    Tonnarelli, B.3    Redaelli, A.4    Martin, I.5    Rasponi, M.6
  • 173
    • 84995906303 scopus 로고    scopus 로고
    • Red blood cell phase separation in symmetric and asymmetric microchannel networks: Effect of capillary dilation and inflow velocity
    • Clavica, F.; Homsy, A.; Jeandupeux, L.; Obrist, D. Red blood cell phase separation in symmetric and asymmetric microchannel networks: Effect of capillary dilation and inflow velocity. Sci. Rep. 2016, 6, 36763
    • (2016) Sci. Rep , vol.6 , pp. 36763
    • Clavica, F.1    Homsy, A.2    Jeandupeux, L.3    Obrist, D.4
  • 174
    • 84971351772 scopus 로고    scopus 로고
    • Rapid, low-cost fabrication of circular microchannels by air expansion into partially cured polymer
    • Nguyen, T.Q.; Park, W.T. Rapid, low-cost fabrication of circular microchannels by air expansion into partially cured polymer. Sens. Actuators B Chem. 2016, 235, 302-308
    • (2016) Sens. Actuators B Chem , vol.235 , pp. 302-308
    • Nguyen, T.Q.1    Park, W.T.2
  • 177
    • 84891348288 scopus 로고    scopus 로고
    • HeLiVa platform: Integrated heart-liver-vascular systems for drug testing in human health and disease
    • Vunjak-Novakovic, G.; Bhatia, S.; Chen, C.; Hirschi, K. HeLiVa platform: Integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res. Ther. 2013, 4, 1-6
    • (2013) Stem Cell Res. Ther , vol.4 , pp. 1-6
    • Vunjak-Novakovic, G.1    Bhatia, S.2    Chen, C.3    Hirschi, K.4
  • 178
    • 77957671875 scopus 로고    scopus 로고
    • A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
    • Van Midwoud, P.M.; Merema, M.T.; Verpoorte, E.; Groothuis, G.M.M. A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip 2010, 10, 2778-2786
    • (2010) Lab Chip , vol.10 , pp. 2778-2786
    • Van Midwoud, P.M.1    Merema, M.T.2    Verpoorte, E.3    Groothuis, G.M.M.4
  • 180
    • 84873579795 scopus 로고    scopus 로고
    • "Human-on-a-chip" developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
    • Marx, U.; Walles, H.; Hoffmann, S.; Lindner, G.; Horland, R.; Sonntag, F.; Klotzbach, U.; Sakharov, D.; Tonevitsky, A.; Lauster, R. "Human-on-a-chip" developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? ATLA Altern. Lab. Anim. 2012, 40, 235-257
    • (2012) ATLA Altern. Lab. Anim , vol.40 , pp. 235-257
    • Marx, U.1    Walles, H.2    Hoffmann, S.3    Lindner, G.4    Horland, R.5    Sonntag, F.6    Klotzbach, U.7    Sakharov, D.8    Tonevitsky, A.9    Lauster, R.10
  • 181
    • 84874894377 scopus 로고    scopus 로고
    • Microfabricated mammalian organ systems and their integration into models of whole animals and humans
    • Sung, J.H.; Esch, M.B.; Prot, J.-M.; Long, C.J.; Smith, A.; Hickman, J.J.; Shuler, M.L. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 2013, 13, 1201-1212
    • (2013) Lab Chip , vol.13 , pp. 1201-1212
    • Sung, J.H.1    Esch, M.B.2    Prot, J.-M.3    Long, C.J.4    Smith, A.5    Hickman, J.J.6    Shuler, M.L.7
  • 182
    • 75749153235 scopus 로고    scopus 로고
    • A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
    • Sung, J.H.; Kam, C.; Shuler, M.L. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 2010, 10, 446-455
    • (2010) Lab Chip , vol.10 , pp. 446-455
    • Sung, J.H.1    Kam, C.2    Shuler, M.L.3
  • 184
  • 185
    • 1142305959 scopus 로고    scopus 로고
    • Development of a microscale cell culture analog to probe naphthalene toxicity
    • Viravaidya, K.; Sin, A.; Shuler, M.L. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol. Prog. 2004, 20, 316-323
    • (2004) Biotechnol. Prog , vol.20 , pp. 316-323
    • Viravaidya, K.1    Sin, A.2    Shuler, M.L.3
  • 186
    • 84927592484 scopus 로고    scopus 로고
    • Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
    • Abaci, H.E.; Shuler, M.L. Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr. Biol. 2015, 7, 383-391
    • (2015) Integr. Biol , vol.7 , pp. 383-391
    • Abaci, H.E.1    Shuler, M.L.2


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