-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi, J.A.; Hansen, R.W.; Grabowski, H.G. The price of innovation: New estimates of drug development costs. J. Health Econ. 2003, 22, 151-185
-
(2003)
J. Health Econ
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
2
-
-
84959128138
-
Innovation in the pharmaceutical industry: New estimates of R&D costs
-
DiMasi, J.A.; Grabowski, H.G.; Hansen, R.W. Innovation in the pharmaceutical industry: New estimates of R&D costs. J. Health Econ. 2016, 47, 20-33
-
(2016)
J. Health Econ
, vol.47
, pp. 20-33
-
-
DiMasi, J.A.1
Grabowski, H.G.2
Hansen, R.W.3
-
3
-
-
0035462130
-
From idea to market: The drug approval process FDA: A historical perspective
-
Lipsky, M.S.; Sharp, L.K. From idea to market: The drug approval process FDA: A historical perspective. Development 2001, 14, 362-367
-
(2001)
Development
, vol.14
, pp. 362-367
-
-
Lipsky, M.S.1
Sharp, L.K.2
-
4
-
-
84890346695
-
An evaluation of the latest in vitro tools for drug metabolism studies
-
Costa, A.; Sarmento, B.; Seabra, V. An evaluation of the latest in vitro tools for drug metabolism studies. Expert Opin. Drug Metab. Toxicol 2014, 10, 103-119
-
(2014)
Expert Opin. Drug Metab. Toxicol
, vol.10
, pp. 103-119
-
-
Costa, A.1
Sarmento, B.2
Seabra, V.3
-
5
-
-
27644596457
-
Predicting in vivo drug interactions from in vitro drug discovery data
-
Wienkers, L.C.; Heath, T.G. Predicting in vivo drug interactions from in vitro drug discovery data. Nat. Rev. Drug Discov. 2005, 4, 825-833
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, pp. 825-833
-
-
Wienkers, L.C.1
Heath, T.G.2
-
6
-
-
84857995039
-
Predictive in vivo animal models and translation to clinical trials
-
Cook, N.; Jodrell, D.I.; Tuveson, D.A. Predictive in vivo animal models and translation to clinical trials. Drug Discov. Today 2012, 17, 253-260
-
(2012)
Drug Discov. Today
, vol.17
, pp. 253-260
-
-
Cook, N.1
Jodrell, D.I.2
Tuveson, D.A.3
-
7
-
-
79957889347
-
The productivity crisis in pharmaceutical R&D
-
Pammolli, F.; Magazzini, L.; Riccaboni, M. The productivity crisis in pharmaceutical R&D. Nat. Rev. Drug Discov. 2011, 10, 428-438
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, pp. 428-438
-
-
Pammolli, F.1
Magazzini, L.2
Riccaboni, M.3
-
8
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I.; Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 2004, 3, 1-5
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 1-5
-
-
Kola, I.1
Landis, J.2
-
9
-
-
84930008613
-
The cost of drug development
-
DiMasi, J.A.; Grabowski, H.G.; Hansen, R.W. The cost of drug development. N. Engl. J. Med. 2015, 372, 1972
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 1972
-
-
DiMasi, J.A.1
Grabowski, H.G.2
Hansen, R.W.3
-
10
-
-
84892960440
-
Lost in translation: Animal models and clinical trials in cancer treatment
-
Mak, I.W.; Evaniew, N.; Ghert, M. Lost in translation: Animal models and clinical trials in cancer treatment. Am. J. Transl. Res. 2014, 6, 114-118
-
(2014)
Am. J. Transl. Res
, vol.6
, pp. 114-118
-
-
Mak, I.W.1
Evaniew, N.2
Ghert, M.3
-
11
-
-
1842510682
-
Trials, tribulations, and trends in tumor modeling in mice
-
Schuh, J.C.L. Trials, tribulations, and trends in tumor modeling in mice. Toxicol. Pathol. 2004, 32 (Suppl. 1), 53-66
-
(2004)
Toxicol. Pathol
, vol.32
, pp. 53-66
-
-
Schuh, J.C.L.1
-
12
-
-
84874457770
-
Genomic responses in mouse models poorly mimic human inflammatory diseases
-
Seok, J.; Warren, H.S.; Cuenca, A.G.; Mindrinos, M.N.; Baker, H.V.; Xu, W.; Richards, D.R.; McDonald-Smith, G.P.; Gao, H.; Hennessy, L.; et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 2013, 110, 3507-3512
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3507-3512
-
-
Seok, J.1
Warren, H.S.2
Cuenca, A.G.3
Mindrinos, M.N.4
Baker, H.V.5
Xu, W.6
Richards, D.R.7
McDonald-Smith, G.P.8
Gao, H.9
Hennessy, L.10
-
13
-
-
33747117373
-
The origins and the future of microfluidics
-
Whitesides, G.M. The origins and the future of microfluidics. Nature 2006, 442, 368-373
-
(2006)
Nature
, vol.442
, pp. 368-373
-
-
Whitesides, G.M.1
-
14
-
-
84896284039
-
The present and future role of microfluidics in biomedical research
-
Sackmann, E.K.; Fulton, A.L.; Beebe, D.J. The present and future role of microfluidics in biomedical research. Nature 2014, 507, 181-189
-
(2014)
Nature
, vol.507
, pp. 181-189
-
-
Sackmann, E.K.1
Fulton, A.L.2
Beebe, D.J.3
-
15
-
-
81355146382
-
From 3D cell culture to organs-on-chips
-
Huh, D.; Hamilton, G.A.; Ingber, D.E. From 3D cell culture to organs-on-chips. Trends Cell Biol. 2011, 21, 745-754
-
(2011)
Trends Cell Biol
, vol.21
, pp. 745-754
-
-
Huh, D.1
Hamilton, G.A.2
Ingber, D.E.3
-
16
-
-
84862186471
-
Microengineered physiological biomimicry: Organs-on-Chips
-
Huh, D.; Torisawa, Y.; Hamilton, G.A.; Kim, H.J.; Ingber, D.E. Microengineered physiological biomimicry: Organs-on-Chips. Lab Chip 2012, 12, 2156-2164
-
(2012)
Lab Chip
, vol.12
, pp. 2156-2164
-
-
Huh, D.1
Torisawa, Y.2
Hamilton, G.A.3
Kim, H.J.4
Ingber, D.E.5
-
17
-
-
84905754409
-
Microfluidic organs-on-chips
-
Bhatia, S.N.; Ingber, D.E. Microfluidic organs-on-chips. Nat. Biotechnol. 2014, 32, 760-772
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 760-772
-
-
Bhatia, S.N.1
Ingber, D.E.2
-
18
-
-
84891930814
-
Physiologically relevant organs on chips
-
Yum, K.; Hong, S.G.; Healy, K.E.; Lee, L.P. Physiologically relevant organs on chips. Biotechnol. J. 2014, 9, 16-27
-
(2014)
Biotechnol. J
, vol.9
, pp. 16-27
-
-
Yum, K.1
Hong, S.G.2
Healy, K.E.3
Lee, L.P.4
-
19
-
-
84959184483
-
Organ-on-a-Chip Systems: Microengineering to biomimic living systems
-
Zheng, F.; Fu, F.; Cheng, Y.; Wang, C.; Zhao, Y.; Gu, Z. Organ-on-a-Chip Systems: Microengineering to biomimic living systems. Small 2016, 12, 2253-2282
-
(2016)
Small
, vol.12
, pp. 2253-2282
-
-
Zheng, F.1
Fu, F.2
Cheng, Y.3
Wang, C.4
Zhao, Y.5
Gu, Z.6
-
20
-
-
84949883901
-
Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering
-
Perestrelo, A.R.; Águas, A.C.P.; Rainer, A.; Forte, G. Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering. Sensors 2015, 15, 29848
-
(2015)
Sensors
, vol.15
, pp. 29848
-
-
Perestrelo, A.R.1
Águas, A.C.P.2
Rainer, A.3
Forte, G.4
-
21
-
-
0032968777
-
Cryopreserved human hepatocytes: Characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
-
Li, A.P.; Lu, C.; Brent, J.A.; Pham, C.; Fackett, A.; Ruegg, C.E.; Silber, P.M. Cryopreserved human hepatocytes: Characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem. Biol. Interact. 1999, 121, 17-35
-
(1999)
Chem. Biol. Interact
, vol.121
, pp. 17-35
-
-
Li, A.P.1
Lu, C.2
Brent, J.A.3
Pham, C.4
Fackett, A.5
Ruegg, C.E.6
Silber, P.M.7
-
22
-
-
0026750647
-
The human hepatic cytochromes P450 involved in drug metabolism
-
Wrighton, S.A.; Stevens, J.C. The human hepatic cytochromes P450 involved in drug metabolism. Crit. Rev. Toxicol. 1992, 22, 1-21
-
(1992)
Crit. Rev. Toxicol
, vol.22
, pp. 1-21
-
-
Wrighton, S.A.1
Stevens, J.C.2
-
23
-
-
84859163249
-
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
-
Gerets, H.H.J.; Tilmant, K.; Gerin, B.; Chanteux, H.; Depelchin, B.O.; Dhalluin, S.; Atienzar, F.A. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol. Toxicol. 2012, 28, 69-87
-
(2012)
Cell Biol. Toxicol
, vol.28
, pp. 69-87
-
-
Gerets, H.H.J.1
Tilmant, K.2
Gerin, B.3
Chanteux, H.4
Depelchin, B.O.5
Dhalluin, S.6
Atienzar, F.A.7
-
24
-
-
84910072170
-
3D cell culture systems: Advantages and applications
-
Ravi, M.; Paramesh, V.; Kaviya, S.R.; Anuradha, E.; Paul Solomon, F.D. 3D cell culture systems: Advantages and applications. J. Cell. Physiol. 2015, 230, 16-26
-
(2015)
J. Cell. Physiol
, vol.230
, pp. 16-26
-
-
Ravi, M.1
Paramesh, V.2
Kaviya, S.R.3
Anuradha, E.4
Paul Solomon, F.D.5
-
25
-
-
67650169752
-
Hydrogels as extracellular matrix mimics for 3D cell culture
-
Tibbitt, M.W.; Anseth, K.S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 2009, 103, 655-663
-
(2009)
Biotechnol. Bioeng
, vol.103
, pp. 655-663
-
-
Tibbitt, M.W.1
Anseth, K.S.2
-
26
-
-
84934942592
-
Microfluidic 3D cell culture: From tools to tissue models
-
Van Duinen, V.; Trietsch, S.J.; Joore, J.; Vulto, P.; Hankemeier, T. Microfluidic 3D cell culture: From tools to tissue models. Curr. Opin. Biotechnol. 2015, 35, 118-126
-
(2015)
Curr. Opin. Biotechnol
, vol.35
, pp. 118-126
-
-
Van Duinen, V.1
Trietsch, S.J.2
Joore, J.3
Vulto, P.4
Hankemeier, T.5
-
27
-
-
84867486363
-
Microfluidic hydrogels for tissue engineering
-
Huang, G.Y.; Zhou, L.H.; Zhang, Q.C.; Chen, Y.M.; Sun, W.; Xu, F.; Lu, T.J. Microfluidic hydrogels for tissue engineering. Biofabrication 2011, 3, 12001
-
(2011)
Biofabrication
, vol.3
, pp. 12001
-
-
Huang, G.Y.1
Zhou, L.H.2
Zhang, Q.C.3
Chen, Y.M.4
Sun, W.5
Xu, F.6
Lu, T.J.7
-
28
-
-
33847356130
-
A novel 3D mammalian cell perfusion-culture system in microfluidic channels
-
Toh, Y.-C.; Zhang, C.; Zhang, J.; Khong, Y.M.; Chang, S.; Samper, V.D.; van Noort, D.; Hutmacher, D.W.; Yu, H. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip 2007, 7, 302-309
-
(2007)
Lab Chip
, vol.7
, pp. 302-309
-
-
Toh, Y.-C.1
Zhang, C.2
Zhang, J.3
Khong, Y.M.4
Chang, S.5
Samper, V.D.6
van Noort, D.7
Hutmacher, D.W.8
Yu, H.9
-
29
-
-
84905457028
-
Hepatic organoids for microfluidic drug screening
-
Au, S.H.; Chamberlain, M.D.; Mahesh, S.; Sefton, M.V.; Wheeler, A.R. Hepatic organoids for microfluidic drug screening. Lab Chip 2014, 14, 3290-3299
-
(2014)
Lab Chip
, vol.14
, pp. 3290-3299
-
-
Au, S.H.1
Chamberlain, M.D.2
Mahesh, S.3
Sefton, M.V.4
Wheeler, A.R.5
-
30
-
-
67349277662
-
The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system
-
Zhang, C.; Chia, S.M.; Ong, S.M.; Zhang, S.; Toh, Y.C.; van Noort, D.; Yu, H. The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system. Biomaterials 2009, 30, 3847-3853
-
(2009)
Biomaterials
, vol.30
, pp. 3847-3853
-
-
Zhang, C.1
Chia, S.M.2
Ong, S.M.3
Zhang, S.4
Toh, Y.C.5
van Noort, D.6
Yu, H.7
-
31
-
-
67650481611
-
A microfluidic 3D hepatocyte chip for drug toxicity testing
-
Toh, Y.-C.; Lim, T.C.; Tai, D.; Xiao, G.; van Noort, D.; Yu, H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip 2009, 9, 2026-2035
-
(2009)
Lab Chip
, vol.9
, pp. 2026-2035
-
-
Toh, Y.-C.1
Lim, T.C.2
Tai, D.3
Xiao, G.4
van Noort, D.5
Yu, H.6
-
32
-
-
33846032329
-
A microfluidic platform for 3-dimensional cell culture and cell-based assays
-
Kim, M.S.; Yeon, J.H.; Park, J.-K. A microfluidic platform for 3-dimensional cell culture and cell-based assays. Biomed. Microdevices 2007, 9, 25-34
-
(2007)
Biomed. Microdevices
, vol.9
, pp. 25-34
-
-
Kim, M.S.1
Yeon, J.H.2
Park, J.-K.3
-
33
-
-
84958985967
-
A liver-on-a-chip platform with bioprinted hepatic spheroids
-
Bhise, N.S.; Manoharan, V.; Massa, S.; Tamayol, A.; Ghaderi, M.; Miscuglio, M.; Lang, Q.; Zhang, Y.S.; Shin, S.R.; Calzone, G.; et al. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 2016, 8, 14101
-
(2016)
Biofabrication
, vol.8
, pp. 14101
-
-
Bhise, N.S.1
Manoharan, V.2
Massa, S.3
Tamayol, A.4
Ghaderi, M.5
Miscuglio, M.6
Lang, Q.7
Zhang, Y.S.8
Shin, S.R.9
Calzone, G.10
-
34
-
-
70349399012
-
Liver tissue engineering in the evaluation of drug safety
-
Dash, A.; Inman, W.; Hoffmaster, K.; Sevidal, S.; Kelly, J.; Obach, R.S.; Griffith, L.G.; Tannenbaum, S.R. Liver tissue engineering in the evaluation of drug safety. Expert Opin. Drug Metab. Toxicol. 2009, 5, 1159-1174
-
(2009)
Expert Opin. Drug Metab. Toxicol
, vol.5
, pp. 1159-1174
-
-
Dash, A.1
Inman, W.2
Hoffmaster, K.3
Sevidal, S.4
Kelly, J.5
Obach, R.S.6
Griffith, L.G.7
Tannenbaum, S.R.8
-
35
-
-
84877931182
-
In vitro models for liver toxicity testing
-
Soldatow, V.Y.; LeCluyse, E.L.; Griffith, L.G.; Rusyn, I. In vitro models for liver toxicity testing. Toxicol. Res. (Camb.) 2013, 2, 23-39
-
(2013)
Toxicol. Res. (Camb.)
, vol.2
, pp. 23-39
-
-
Soldatow, V.Y.1
LeCluyse, E.L.2
Griffith, L.G.3
Rusyn, I.4
-
36
-
-
84889026967
-
Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: Toward engineering the liver sinusoid
-
Kang, Y.B.A.; Rawat, S.; Cirillo, J.; Bouchard, M.; Noh, H.M. Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: Toward engineering the liver sinusoid. Biofabrication 2013, 5, 45008
-
(2013)
Biofabrication
, vol.5
, pp. 45008
-
-
Kang, Y.B.A.1
Rawat, S.2
Cirillo, J.3
Bouchard, M.4
Noh, H.M.5
-
37
-
-
54949146528
-
Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells
-
Ohno, M.; Motojima, K.; Okano, T.; Taniguchi, A. Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells. Tissue Eng. Part A 2008, 14, 1861-1869
-
(2008)
Tissue Eng. Part A
, vol.14
, pp. 1861-1869
-
-
Ohno, M.1
Motojima, K.2
Okano, T.3
Taniguchi, A.4
-
38
-
-
84891364200
-
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans
-
Bhushan, A.; Senutovitch, N.; Bale, S.S.; McCarty, W.J.; Hegde, M.; Jindal, R.; Golberg, I.; Berk Usta, O.; Yarmush, M.L.; Vernetti, L.; et al. Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Stem Cell Res. Ther. 2013, 4 (Suppl. 1), S16
-
(2013)
Stem Cell Res Ther
, vol.4
, pp. S16
-
-
Bhushan, A.1
Senutovitch, N.2
Bale, S.S.3
McCarty, W.J.4
Hegde, M.5
Jindal, R.6
Golberg, I.7
Berk Usta, O.8
Yarmush, M.L.9
Vernetti, L.10
-
39
-
-
84946845089
-
Liver injury-on-a-chip: Microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury
-
Zhou, Q.; Patel, D.; Kwa, T.; Haque, A.; Matharu, Z.; Stybayeva, G.; Gao, Y.; Diehl, A.M.; Revzin, A. Liver injury-on-a-chip: Microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury. Lab Chip 2015, 15, 4467-4478
-
(2015)
Lab Chip
, vol.15
, pp. 4467-4478
-
-
Zhou, Q.1
Patel, D.2
Kwa, T.3
Haque, A.4
Matharu, Z.5
Stybayeva, G.6
Gao, Y.7
Diehl, A.M.8
Revzin, A.9
-
40
-
-
84941560577
-
A microfluidically perfused three dimensional human liver model
-
Rennert, K.; Steinborn, S.; Gröger, M.; Ungerböck, B.; Jank, A.M.; Ehgartner, J.; Nietzsche, S.; Dinger, J.; Kiehntopf, M.; Funke, H.; et al. A microfluidically perfused three dimensional human liver model. Biomaterials 2015, 71, 119-131
-
(2015)
Biomaterials
, vol.71
, pp. 119-131
-
-
Rennert, K.1
Steinborn, S.2
Gröger, M.3
Ungerböck, B.4
Jank, A.M.5
Ehgartner, J.6
Nietzsche, S.7
Dinger, J.8
Kiehntopf, M.9
Funke, H.10
-
41
-
-
38049011979
-
Microscale culture of human liver cells for drug development
-
Khetani, S.R.; Bhatia, S.N. Microscale culture of human liver cells for drug development. Nat. Biotechnol. 2008, 26, 120-126
-
(2008)
Nat. Biotechnol
, vol.26
, pp. 120-126
-
-
Khetani, S.R.1
Bhatia, S.N.2
-
42
-
-
84957603856
-
On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay
-
Ma, C.; Zhao, L.; Zhou, E.M.; Xu, J.; Shen, S.; Wang, J. On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay. Anal. Chem. 2016, 88, 1719-1727
-
(2016)
Anal. Chem
, vol.88
, pp. 1719-1727
-
-
Ma, C.1
Zhao, L.2
Zhou, E.M.3
Xu, J.4
Shen, S.5
Wang, J.6
-
43
-
-
79953236870
-
Improvement of HepG2/C3a cell functions in a microfluidic biochip
-
Prot, J.M.; Aninat, C.; Griscom, L.; Razan, F.; Brochot, C.; Guillouzo, C.G.; Legallais, C.; Corlu, A.; Leclerc, E. Improvement of HepG2/C3a cell functions in a microfluidic biochip. Biotechnol. Bioeng. 2011, 108, 1704-1715
-
(2011)
Biotechnol. Bioeng
, vol.108
, pp. 1704-1715
-
-
Prot, J.M.1
Aninat, C.2
Griscom, L.3
Razan, F.4
Brochot, C.5
Guillouzo, C.G.6
Legallais, C.7
Corlu, A.8
Leclerc, E.9
-
44
-
-
84895922881
-
Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats
-
Baudoin, R.; Legendre, A.; Jacques, S.; Cotton, J.; Bois, F.; Leclerc, E. Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats. J. Pharm. Sci. 2014, 103, 706-718
-
(2014)
J. Pharm. Sci
, vol.103
, pp. 706-718
-
-
Baudoin, R.1
Legendre, A.2
Jacques, S.3
Cotton, J.4
Bois, F.5
Leclerc, E.6
-
45
-
-
79961194518
-
Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip
-
Prot, J.M.; Briffaut, A.S.; Letourneur, F.; Chafey, P.; Merlier, F.; Grandvalet, Y.; Legallais, C.; Leclerc, E. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PLoS ONE 2011, 6, e21268
-
(2011)
PLoS ONE
, vol.6
-
-
Prot, J.M.1
Briffaut, A.S.2
Letourneur, F.3
Chafey, P.4
Merlier, F.5
Grandvalet, Y.6
Legallais, C.7
Leclerc, E.8
-
46
-
-
79953243156
-
A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening
-
Prot, J.M.; Videau, O.; Brochot, C.; Legallais, C.; Bénech, H.; Leclerc, E. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening. Int. J. Pharm. 2011, 408, 67-75
-
(2011)
Int. J. Pharm
, vol.408
, pp. 67-75
-
-
Prot, J.M.1
Videau, O.2
Brochot, C.3
Legallais, C.4
Bénech, H.5
Leclerc, E.6
-
47
-
-
78649912552
-
Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor
-
Baudoin, R.; Griscom, L.; Prot, J.M.; Legallais, C.; Leclerc, E. Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor. Biochem. Eng. J. 2011, 53, 172-181
-
(2011)
Biochem. Eng. J
, vol.53
, pp. 172-181
-
-
Baudoin, R.1
Griscom, L.2
Prot, J.M.3
Legallais, C.4
Leclerc, E.5
-
48
-
-
34547581758
-
An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
-
Lee, P.J.; Hung, P.J.; Lee, L.P. An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 2007, 97, 1340-1346
-
(2007)
Biotechnol. Bioeng
, vol.97
, pp. 1340-1346
-
-
Lee, P.J.1
Hung, P.J.2
Lee, L.P.3
-
49
-
-
84928957146
-
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow
-
Esch, M.B.; Prot, J.-M.; Wang, Y.I.; Miller, P.; Llamas-Vidales, J.R.; Naughton, B.A.; Applegate, D.R.; Shuler, M.L.; Facility, C.N. Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Lab Chip 2015, 15, 2269-2277
-
(2015)
Lab Chip
, vol.15
, pp. 2269-2277
-
-
Esch, M.B.1
Prot, J.-M.2
Wang, Y.I.3
Miller, P.4
Llamas-Vidales, J.R.5
Naughton, B.A.6
Applegate, D.R.7
Shuler, M.L.8
Facility, C.N.9
-
50
-
-
52449122645
-
In vitro analysis of a hepatic device with intrinsic microvascular-based channels
-
Carraro, A.; Hsu, W.M.; Kulig, K.M.; Cheung, W.S.; Miller, M.L.; Weinberg, E.J.; Swart, E.F.; Kaazempur-Mofrad, M.; Borenstein, J.T.; Vacanti, J.P.; et al. In vitro analysis of a hepatic device with intrinsic microvascular-based channels. Biomed. Microdevices 2008, 10, 795-805
-
(2008)
Biomed. Microdevices
, vol.10
, pp. 795-805
-
-
Carraro, A.1
Hsu, W.M.2
Kulig, K.M.3
Cheung, W.S.4
Miller, M.L.5
Weinberg, E.J.6
Swart, E.F.7
Kaazempur-Mofrad, M.8
Borenstein, J.T.9
Vacanti, J.P.10
-
51
-
-
77449119885
-
A microfluidic hepatic coculture platform for cell-based drug metabolism studies
-
Novik, E.; Maguire, T.J.; Chao, P.; Cheng, K.C.; Yarmush, M.L. A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem. Pharmacol. 2010, 79, 1036-1044
-
(2010)
Biochem. Pharmacol
, vol.79
, pp. 1036-1044
-
-
Novik, E.1
Maguire, T.J.2
Chao, P.3
Cheng, K.C.4
Yarmush, M.L.5
-
52
-
-
84892921738
-
Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis
-
Kim, Y.; Lobatto, M.E.; Kawahara, T.; Lee Chung, B.; Mieszawska, A.J.; Sanchez-Gaytan, B.L.; Fay, F.; Senders, M.L.; Calcagno, C.; Becraft, J.; et al. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proc. Natl. Acad. Sci. USA 2014, 111, 1078-1083
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 1078-1083
-
-
Kim, Y.1
Lobatto, M.E.2
Kawahara, T.3
Lee Chung, B.4
Mieszawska, A.J.5
Sanchez-Gaytan, B.L.6
Fay, F.7
Senders, M.L.8
Calcagno, C.9
Becraft, J.10
-
53
-
-
54449093310
-
CNS disorders-current treatment options and the prospects for advanced therapies
-
DiNunzio, J.C.; Williams, R.O. CNS disorders-current treatment options and the prospects for advanced therapies. Drug Dev. Ind. Pharm. 2008, 34, 1141-1167
-
(2008)
Drug Dev. Ind. Pharm
, vol.34
, pp. 1141-1167
-
-
DiNunzio, J.C.1
Williams, R.O.2
-
54
-
-
17144398875
-
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
-
Chung, B.G.; Flanagan, L.A.; Rhee, S.W.; Schwartz, P.H.; Lee, A.P.; Monuki, E.S.; Jeon, N.L. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 2005, 5, 401-406
-
(2005)
Lab Chip
, vol.5
, pp. 401-406
-
-
Chung, B.G.1
Flanagan, L.A.2
Rhee, S.W.3
Schwartz, P.H.4
Lee, A.P.5
Monuki, E.S.6
Jeon, N.L.7
-
55
-
-
1942485769
-
Immobilized concentration gradients of nerve growth factor guide neurite outgrowth
-
Kapur, T.A.; Shoichet, M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J. Biomed. Mater. Res. A 2004, 68, 235-243
-
(2004)
J. Biomed. Mater. Res. A
, vol.68
, pp. 235-243
-
-
Kapur, T.A.1
Shoichet, M.S.2
-
56
-
-
84922842049
-
Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities
-
Romano, N.H.; Lampe, K.J.; Xu, H.; Ferreira, M.M.; Heilshorn, S.C. Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities. Small 2015, 11, 722-730
-
(2015)
Small
, vol.11
, pp. 722-730
-
-
Romano, N.H.1
Lampe, K.J.2
Xu, H.3
Ferreira, M.M.4
Heilshorn, S.C.5
-
57
-
-
79960473407
-
Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies
-
Kunze, A.; Meissner, R.; Brando, S.; Renaud, P. Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies. Biotechnol. Bioeng. 2011, 108, 2241-2245
-
(2011)
Biotechnol. Bioeng
, vol.108
, pp. 2241-2245
-
-
Kunze, A.1
Meissner, R.2
Brando, S.3
Renaud, P.4
-
58
-
-
84882605442
-
Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response
-
Xiao, R.R.; Zeng, W.J.; Li, Y.T.; Zou, W.; Wang, L.; Pei, X.F.; Xie, M.; Huang, W.H. Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response. Anal. Chem. 2013, 85, 7842-7850
-
(2013)
Anal. Chem
, vol.85
, pp. 7842-7850
-
-
Xiao, R.R.1
Zeng, W.J.2
Li, Y.T.3
Zou, W.4
Wang, L.5
Pei, X.F.6
Xie, M.7
Huang, W.H.8
-
59
-
-
38849122821
-
A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues
-
Joanne, W.C.; Li, X.; Lin, B.; Shim, S.; Ming, G.-L.; Levchenko, A. A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip 2008, 8, 227-237
-
(2008)
Lab Chip
, vol.8
, pp. 227-237
-
-
Joanne, W.C.1
Li, X.2
Lin, B.3
Shim, S.4
Ming, G.-L.5
Levchenko, A.6
-
60
-
-
84925005451
-
Using microfluidic chip to form brain-derived neurotrophic factor concentration gradient for studying neuron axon guidance
-
Huang, H.; Jiang, L.; Li, S.; Deng, J.; Li, Y.; Yao, J.; Li, B.; Zheng, J. Using microfluidic chip to form brain-derived neurotrophic factor concentration gradient for studying neuron axon guidance. Biomicrofluidics 2014, 8, 014108
-
(2014)
Biomicrofluidics
, vol.8
-
-
Huang, H.1
Jiang, L.2
Li, S.3
Deng, J.4
Li, Y.5
Yao, J.6
Li, B.7
Zheng, J.8
-
61
-
-
84933046165
-
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
-
Taylor, A.M.; Menon, S.; Gupton, S.L. Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients. Lab Chip 2015, 15, 2781-2789
-
(2015)
Lab Chip
, vol.15
, pp. 2781-2789
-
-
Taylor, A.M.1
Menon, S.2
Gupton, S.L.3
-
62
-
-
78751542982
-
A high-throughput microfluidic assay to study neurite response to growth factor gradients
-
Kothapalli, C.R.; van Veen, E.; de Valence, S.; Chung, S.; Zervantonakis, I.K.; Gertler, F.B.; Kamm, R.D. A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab Chip 2011, 11, 497-507
-
(2011)
Lab Chip
, vol.11
, pp. 497-507
-
-
Kothapalli, C.R.1
van Veen, E.2
de Valence, S.3
Chung, S.4
Zervantonakis, I.K.5
Gertler, F.B.6
Kamm, R.D.7
-
63
-
-
23144439234
-
A microfluidic culture platform for CNS axonal injury, regeneration and transport
-
Taylor, A.M.; Blurton-Jones, M.; Rhee, S.W.; Cribbs, D.H.; Cotman, C.W.; Jeon, N.L. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat. Methods 2005, 2, 599-605
-
(2005)
Nat. Methods
, vol.2
, pp. 599-605
-
-
Taylor, A.M.1
Blurton-Jones, M.2
Rhee, S.W.3
Cribbs, D.H.4
Cotman, C.W.5
Jeon, N.L.6
-
64
-
-
77951883483
-
Microfluidic local perfusion chambers for the visualization and manipulation of synapses
-
Taylor, A.M.; Dieterich, D.C.; Ito, H.T.; Kim, S.A.; Schuman, E.M. Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 2010, 66, 57-68
-
(2010)
Neuron
, vol.66
, pp. 57-68
-
-
Taylor, A.M.1
Dieterich, D.C.2
Ito, H.T.3
Kim, S.A.4
Schuman, E.M.5
-
65
-
-
77954961916
-
Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection
-
Hellman, A.N.; Vahidi, B.; Kim, H.J.; Mismar, W.; Steward, O.; Jeon, N.L.; Venugopalan, V. Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip 2010, 10, 2083-2092
-
(2010)
Lab Chip
, vol.10
, pp. 2083-2092
-
-
Hellman, A.N.1
Vahidi, B.2
Kim, H.J.3
Mismar, W.4
Steward, O.5
Jeon, N.L.6
Venugopalan, V.7
-
66
-
-
70449088618
-
Quantitative analysis of CNS axon regeneration using a microfluidic neuron culture device
-
Park, J.W.; Vahidi, B.; Kim, H.J.; Rhee, S.W.; Jeon, N.L. Quantitative analysis of CNS axon regeneration using a microfluidic neuron culture device. Biochip J. 2008, 2, 44-51
-
(2008)
Biochip J
, vol.2
, pp. 44-51
-
-
Park, J.W.1
Vahidi, B.2
Kim, H.J.3
Rhee, S.W.4
Jeon, N.L.5
-
67
-
-
85007398062
-
Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device
-
Gao, Y.; Broussard, J.; Haque, A.; Revzin, A.; Lin, T. Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst. Nanoeng. 2016, 2, 15045
-
(2016)
Microsyst. Nanoeng
, vol.2
, pp. 15045
-
-
Gao, Y.1
Broussard, J.2
Haque, A.3
Revzin, A.4
Lin, T.5
-
68
-
-
77953538605
-
Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century
-
Johnstone, A.F.M.; Gross, G.W.; Weiss, D.G.; Schroeder, O.H.U.; Gramowski, A.; Shafer, T.J. Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century. Neurotoxicology 2010, 31, 331-350
-
(2010)
Neurotoxicology
, vol.31
, pp. 331-350
-
-
Johnstone, A.F.M.1
Gross, G.W.2
Weiss, D.G.3
Schroeder, O.H.U.4
Gramowski, A.5
Shafer, T.J.6
-
69
-
-
58649114243
-
Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture
-
Dworak, B.J.; Wheeler, B.C. Novel MEA platform with PDMS microtunnels enables the detection of action potential propagation from isolated axons in culture. Lab Chip 2009, 9, 404-410
-
(2009)
Lab Chip
, vol.9
, pp. 404-410
-
-
Dworak, B.J.1
Wheeler, B.C.2
-
70
-
-
33847632492
-
Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration
-
Ravula, S.K.; Wang, M.S.; McClain, M.A.; Asress, S.A.; Frazier, B.; Glass, J.D. Spatiotemporal localization of injury potentials in DRG neurons during vincristine-induced axonal degeneration. Neurosci. Lett. 2007, 415, 34-39
-
(2007)
Neurosci. Lett
, vol.415
, pp. 34-39
-
-
Ravula, S.K.1
Wang, M.S.2
McClain, M.A.3
Asress, S.A.4
Frazier, B.5
Glass, J.D.6
-
71
-
-
84863207551
-
A microfluidic platform for controlled biochemical stimulation of twin neuronal networks
-
Biffi, E.; Piraino, F.; Pedrocchi, A.; Fiore, G.B.; Ferrigno, G.; Redaelli, A.; Menegon, A.; Rasponi, M. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks. Biomicrofluidics 2012, 6
-
(2012)
Biomicrofluidics
, pp. 6
-
-
Biffi, E.1
Piraino, F.2
Pedrocchi, A.3
Fiore, G.B.4
Ferrigno, G.5
Redaelli, A.6
Menegon, A.7
Rasponi, M.8
-
72
-
-
81455143852
-
Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates
-
Biffi, E.; Menegon, A.; Piraino, F.; Pedrocchi, A.; Fiore, G.B.; Rasponi, M. Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates. Biotechnol. Bioeng. 2012, 109, 166-175
-
(2012)
Biotechnol. Bioeng
, vol.109
, pp. 166-175
-
-
Biffi, E.1
Menegon, A.2
Piraino, F.3
Pedrocchi, A.4
Fiore, G.B.5
Rasponi, M.6
-
73
-
-
84875794834
-
A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices
-
Scott, A.; Weir, K.; Easton, C.; Huynh, W.; Moody, W.J.; Folch, A. A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices. Lab Chip 2013, 13, 527-535
-
(2013)
Lab Chip
, vol.13
, pp. 527-535
-
-
Scott, A.1
Weir, K.2
Easton, C.3
Huynh, W.4
Moody, W.J.5
Folch, A.6
-
74
-
-
84868573143
-
Drug transport across the blood-brain barrier
-
Pardridge, W.M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow Metab. 2012, 32, 1959-1972
-
(2012)
J. Cereb. Blood Flow Metab
, vol.32
, pp. 1959-1972
-
-
Pardridge, W.M.1
-
75
-
-
12344273726
-
The blood-brain barrier: Bottleneck in brain drug development
-
Pardridge, W.M. The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2005, 2, 3-14
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
76
-
-
0036205158
-
Nanoparticle technology for drug delivery across the blood-brain barrier
-
Lockman, P.R.; Mumper, R.J.; Khan, M.A.; Allen, D.D. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 2002, 28, 1-13
-
(2002)
Drug Dev. Ind. Pharm
, vol.28
, pp. 1-13
-
-
Lockman, P.R.1
Mumper, R.J.2
Khan, M.A.3
Allen, D.D.4
-
77
-
-
84872610509
-
BBB on CHIP: Microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
-
Griep, L.M.; Wolbers, F.; de Wagenaar, B.; Ter Braak, P.M.; Weksler, B.B.; Romero, I.A.; Couraud, P.O.; Vermes, I.; van der Meer, A.D.; van den Berg, A. BBB on CHIP: Microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomed. Microdevices 2013, 15, 145-150
-
(2013)
Biomed. Microdevices
, vol.15
, pp. 145-150
-
-
Griep, L.M.1
Wolbers, F.2
de Wagenaar, B.3
Ter Braak, P.M.4
Weksler, B.B.5
Romero, I.A.6
Couraud, P.O.7
Vermes, I.8
van der Meer, A.D.9
van den Berg, A.10
-
78
-
-
84875833460
-
SyM-BBB: A microfluidic blood brain barrier model
-
Prabhakarpandian, B.; Shen, M.-C.; Nichols, J.B.; Mills, I.R.; Sidoryk-Wegrzynowicz, M.; Aschner, M.; Pant, K. SyM-BBB: A microfluidic blood brain barrier model. Lab Chip 2013, 13, 1093-1101
-
(2013)
Lab Chip
, vol.13
, pp. 1093-1101
-
-
Prabhakarpandian, B.1
Shen, M.-C.2
Nichols, J.B.3
Mills, I.R.4
Sidoryk-Wegrzynowicz, M.5
Aschner, M.6
Pant, K.7
-
79
-
-
84875775289
-
A modular approach to create a neurovascular unit-on-a-chip
-
Achyuta, A.K.H.; Conway, A.J.; Crouse, R.B.; Bannister, E.C.; Lee, R.N.; Katnik, C.P.; Behensky, A.A.; Cuevas, J.; Sundaram, S.S. A modular approach to create a neurovascular unit-on-a-chip. Lab Chip 2013, 542-553
-
(2013)
Lab Chip
, pp. 542-553
-
-
Achyuta, A.K.H.1
Conway, A.J.2
Crouse, R.B.3
Bannister, E.C.4
Lee, R.N.5
Katnik, C.P.6
Behensky, A.A.7
Cuevas, J.8
Sundaram, S.S.9
-
80
-
-
84860366574
-
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
-
Booth, R.; Kim, H. Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). Lab Chip 2012, 12, 1784-1792
-
(2012)
Lab Chip
, vol.12
, pp. 1784-1792
-
-
Booth, R.1
Kim, H.2
-
81
-
-
84946070945
-
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
-
Brown, J.A.; Pensabene, V.; Markov, D.A.; Allwardt, V.; Diana Neely, M.; Shi, M.; Britt, C.M.; Hoilett, O.S.; Yang, Q.; Brewer, B.M.; et al. Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Biomicrofluidics 2015, 9, 054124
-
(2015)
Biomicrofluidics
, vol.9
-
-
Brown, J.A.1
Pensabene, V.2
Markov, D.A.3
Allwardt, V.4
Diana Neely, M.5
Shi, M.6
Britt, C.M.7
Hoilett, O.S.8
Yang, Q.9
Brewer, B.M.10
-
82
-
-
84960888901
-
Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip
-
Herland, A.; van der Meer, A.D.; FitzGerald, E.A.; Park, T.E.; Sleeboom, J.J.F.; Ingber, D.E. Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3D human blood-brain barrier on a chip. PLoS ONE 2016, 11, e0150360
-
(2016)
PLoS ONE
, vol.11
-
-
Herland, A.1
van der Meer, A.D.2
FitzGerald, E.A.3
Park, T.E.4
Sleeboom, J.J.F.5
Ingber, D.E.6
-
83
-
-
84960121035
-
Organization of endothelial cells, pericytes, and astrocytes into a 3D microfluidic in vitro model of the blood-brain barrier
-
Wang, J.D.; Khafagy, E.S.; Khanafer, K.; Takayama, S.; Elsayed, M.E.H. Organization of endothelial cells, pericytes, and astrocytes into a 3D microfluidic in vitro model of the blood-brain barrier. Mol. Pharm. 2016, 13, 895-906
-
(2016)
Mol. Pharm
, vol.13
, pp. 895-906
-
-
Wang, J.D.1
Khafagy, E.S.2
Khanafer, K.3
Takayama, S.4
Elsayed, M.E.H.5
-
84
-
-
84946040793
-
Three-dimensional blood-brain barrier model for in vitro studies of neurovascular pathology
-
Cho, H.; Seo, J.H.; Wong, K.H.K.; Terasaki, Y.; Park, J.; Bong, K.; Arai, K.; Lo, E.H.; Irimia, D. Three-dimensional blood-brain barrier model for in vitro studies of neurovascular pathology. Sci. Rep. 2015, 5, 15222
-
(2015)
Sci. Rep
, vol.5
, pp. 15222
-
-
Cho, H.1
Seo, J.H.2
Wong, K.H.K.3
Terasaki, Y.4
Park, J.5
Bong, K.6
Arai, K.7
Lo, E.H.8
Irimia, D.9
-
85
-
-
84876526111
-
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity
-
Liang, P.; Lan, F.; Lee, A.S.; Gong, T.; Sanchez-Freire, V.; Wang, Y.; Diecke, S.; Sallam, K.; Knowles, J.W.; Wang, P.J.; et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation 2013, 127, 1677-1691
-
(2013)
Circulation
, vol.127
, pp. 1677-1691
-
-
Liang, P.1
Lan, F.2
Lee, A.S.3
Gong, T.4
Sanchez-Freire, V.5
Wang, Y.6
Diecke, S.7
Sallam, K.8
Knowles, J.W.9
Wang, P.J.10
-
86
-
-
84959457881
-
On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain
-
Ugolini, G.S.; Rasponi, M.; Pavesi, A.; Santoro, R.; Kamm, R.; Fiore, G.B.; Pesce, M.; Soncini, M. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnol. Bioeng. 2016, 113, 859-869
-
(2016)
Biotechnol. Bioeng
, vol.113
, pp. 859-869
-
-
Ugolini, G.S.1
Rasponi, M.2
Pavesi, A.3
Santoro, R.4
Kamm, R.5
Fiore, G.B.6
Pesce, M.7
Soncini, M.8
-
87
-
-
84962320853
-
Beating heart on a chip: A novel microfluidic platform to generate functional 3D cardiac microtissues
-
Marsano, A.; Conficconi, C.; Lemme, M.; Occhetta, P.; Gaudiello, E.; Votta, E.; Cerino, G.; Redaelli, A.; Rasponi, M. Beating heart on a chip: A novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 2015, 16, 599-610
-
(2015)
Lab Chip
, vol.16
, pp. 599-610
-
-
Marsano, A.1
Conficconi, C.2
Lemme, M.3
Occhetta, P.4
Gaudiello, E.5
Votta, E.6
Cerino, G.7
Redaelli, A.8
Rasponi, M.9
-
88
-
-
84944209336
-
Controlled electromechanical cell stimulation on-a-chip
-
Pavesi, A.; Adriani, G.; Rasponi, M.; Zervantonakis, I.; Fiore, G.; Kamm, R. Controlled electromechanical cell stimulation on-a-chip. Sci. Rep. 2015, 5, 11800
-
(2015)
Sci. Rep
, vol.5
, pp. 11800
-
-
Pavesi, A.1
Adriani, G.2
Rasponi, M.3
Zervantonakis, I.4
Fiore, G.5
Kamm, R.6
-
89
-
-
84863116827
-
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
-
Abassi, Y.A.; Xi, B.; Li, N.; Ouyang, W.; Seiler, A.; Watzele, M.; Kettenhofen, R.; Bohlen, H.; Ehlich, A.; Kolossov, E.; et al. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br. J. Pharmacol. 2012, 165, 1424-1441
-
(2012)
Br. J. Pharmacol
, vol.165
, pp. 1424-1441
-
-
Abassi, Y.A.1
Xi, B.2
Li, N.3
Ouyang, W.4
Seiler, A.5
Watzele, M.6
Kettenhofen, R.7
Bohlen, H.8
Ehlich, A.9
Kolossov, E.10
-
90
-
-
82855168014
-
Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System
-
Xi, B.; Wang, T.; Li, N.; Ouyang, W.; Zhang, W.; Wu, J.; Xu, X.; Wang, X.; Abassi, Y.A. Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System. J. Lab. Autom. 2011, 16, 415-421
-
(2011)
J. Lab. Autom
, vol.16
, pp. 415-421
-
-
Xi, B.1
Wang, T.2
Li, N.3
Ouyang, W.4
Zhang, W.5
Wu, J.6
Xu, X.7
Wang, X.8
Abassi, Y.A.9
-
91
-
-
84922273996
-
High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition
-
Hu, N.; Wang, T.; Wang, Q.; Zhou, J.; Zou, L.; Su, K.; Wu, J.; Wang, P. High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition. Biosens. Bioelectron. 2015, 67, 146-153
-
(2015)
Biosens. Bioelectron
, vol.67
, pp. 146-153
-
-
Hu, N.1
Wang, T.2
Wang, Q.3
Zhou, J.4
Zou, L.5
Su, K.6
Wu, J.7
Wang, P.8
-
92
-
-
84878376886
-
A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating
-
Wang, T.; Hu, N.; Cao, J.; Wu, J.; Su, K.; Wang, P. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens. Bioelectron. 2013, 49, 9-13
-
(2013)
Biosens. Bioelectron
, vol.49
, pp. 9-13
-
-
Wang, T.1
Hu, N.2
Cao, J.3
Wu, J.4
Su, K.5
Wang, P.6
-
93
-
-
4344654280
-
A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings
-
Werdich, A.A.; Lima, E.A.; Ivanov, B.; Ges, I.; Anderson, M.E.; Wikswo, J.P.; Baudenbacher, F.J. A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Lab Chip 2004, 4, 357-362
-
(2004)
Lab Chip
, vol.4
, pp. 357-362
-
-
Werdich, A.A.1
Lima, E.A.2
Ivanov, B.3
Ges, I.4
Anderson, M.E.5
Wikswo, J.P.6
Baudenbacher, F.J.7
-
94
-
-
33747587891
-
Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers
-
Ganitkevich, V.; Reil, S.; Schwethelm, B.; Schroeter, T.; Benndorf, K. Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers. Circ. Res. 2006, 99, 165-171
-
(2006)
Circ. Res
, vol.99
, pp. 165-171
-
-
Ganitkevich, V.1
Reil, S.2
Schwethelm, B.3
Schroeter, T.4
Benndorf, K.5
-
95
-
-
77951201263
-
Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes
-
Cheng, W.; Klauke, N.; Smith, G.; Cooper, J.M. Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes. Electrophoresis 2010, 31, 1405-1413
-
(2010)
Electrophoresis
, vol.31
, pp. 1405-1413
-
-
Cheng, W.1
Klauke, N.2
Smith, G.3
Cooper, J.M.4
-
96
-
-
84857964726
-
Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
-
Grosberg, A.; Alford, P.W.; McCain, M.L.; Parker, K.K. Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip 2011, 11, 4165-4173
-
(2011)
Lab Chip
, vol.11
, pp. 4165-4173
-
-
Grosberg, A.1
Alford, P.W.2
McCain, M.L.3
Parker, K.K.4
-
97
-
-
59649107048
-
Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes
-
Heidi Au, H.T.; Cui, B.; Chu, Z.E.; Veres, T.; Radisic, M. Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes. Lab Chip 2009, 9, 564-575
-
(2009)
Lab Chip
, vol.9
, pp. 564-575
-
-
Heidi Au, H.T.1
Cui, B.2
Chu, Z.E.3
Veres, T.4
Radisic, M.5
-
98
-
-
84882240631
-
Microfluidic heart on a chip for higher throughput pharmacological studies
-
Agarwal, A.; Goss, J.A.; Cho, A.; McCain, M.L.; Parker, K.K. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip 2013, 13, 3599-3608
-
(2013)
Lab Chip
, vol.13
, pp. 3599-3608
-
-
Agarwal, A.1
Goss, J.A.2
Cho, A.3
McCain, M.L.4
Parker, K.K.5
-
99
-
-
84902087268
-
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
-
Wang, G.; McCain, M.L.; Yang, L.; He, A.; Pasqualini, F.S.; Agarwal, A.; Yuan, H.; Jiang, D.; Zhang, D.; Zangi, L.; et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat. Med. 2014, 20, 616-623
-
(2014)
Nat. Med
, vol.20
, pp. 616-623
-
-
Wang, G.1
McCain, M.L.2
Yang, L.3
He, A.4
Pasqualini, F.S.5
Agarwal, A.6
Yuan, H.7
Jiang, D.8
Zhang, D.9
Zangi, L.10
-
100
-
-
84881480907
-
Biowire: A platform for maturation of human pluripotent stem cell-derived cardiomyocytes
-
Nunes, S.S.; Miklas, J.W.; Liu, J.; Aschar-Sobbi, R.; Xiao, Y.; Zhang, B.; Jiang, J.; Massé, S.; Gagliardi, M.; Hsieh, A.; et al. Biowire: A platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat. Methods 2013, 10, 781-787
-
(2013)
Nat. Methods
, vol.10
, pp. 781-787
-
-
Nunes, S.S.1
Miklas, J.W.2
Liu, J.3
Aschar-Sobbi, R.4
Xiao, Y.5
Zhang, B.6
Jiang, J.7
Massé, S.8
Gagliardi, M.9
Hsieh, A.10
-
101
-
-
84949683733
-
Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes
-
Sun, X.; Nunes, S.S. Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Methods 2016, 101, 21-26
-
(2016)
Methods
, vol.101
, pp. 21-26
-
-
Sun, X.1
Nunes, S.S.2
-
102
-
-
84893513035
-
Microfabricated perfusable cardiac biowire: A platform that mimics native cardiac bundle
-
Xiao, Y.; Zhang, B.; Liu, H.; Miklas, J.W.; Gagliardi, M.; Pahnke, A.; Thavandiran, N.; Sun, Y.; Simmons, C.; Keller, G.; et al. Microfabricated perfusable cardiac biowire: A platform that mimics native cardiac bundle. Lab Chip 2014, 14, 869-882
-
(2014)
Lab Chip
, vol.14
, pp. 869-882
-
-
Xiao, Y.1
Zhang, B.2
Liu, H.3
Miklas, J.W.4
Gagliardi, M.5
Pahnke, A.6
Thavandiran, N.7
Sun, Y.8
Simmons, C.9
Keller, G.10
-
103
-
-
84924405787
-
Human iPSC-based cardiac microphysiological system for drug screening applications
-
Mathur, A.; Loskill, P.; Shao, K.; Huebsch, N.; Hong, S.; Marcus, S.G.; Marks, N.; Mandegar, M.; Conklin, B.R.; Lee, L.P.; et al. Human iPSC-based cardiac microphysiological system for drug screening applications. Sci. Rep. 2015, 5, 8883
-
(2015)
Sci. Rep
, vol.5
, pp. 8883
-
-
Mathur, A.1
Loskill, P.2
Shao, K.3
Huebsch, N.4
Hong, S.5
Marcus, S.G.6
Marks, N.7
Mandegar, M.8
Conklin, B.R.9
Lee, L.P.10
-
104
-
-
84896752543
-
Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses
-
Li, M.; Hotaling, N.A.; Ku, D.N.; Forest, C.R. Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. PLoS ONE 2014, 9, e82493
-
(2014)
PLoS ONE
, vol.9
-
-
Li, M.1
Hotaling, N.A.2
Ku, D.N.3
Forest, C.R.4
-
105
-
-
84863286346
-
Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood
-
Li, M.; Ku, D.N.; Forest, C.R. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 2012, 12, 1355-1362
-
(2012)
Lab Chip
, vol.12
, pp. 1355-1362
-
-
Li, M.1
Ku, D.N.2
Forest, C.R.3
-
106
-
-
84947439952
-
Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation
-
Dimasi, A.; Rasponi, M.; Sheriff, J.; Chiu, W.C.; Bluestein, D.; Tran, P.L.; Slepian, M.J.; Redaelli, A. Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation. Biomed. Microdevices 2015, 17, 1-11
-
(2015)
Biomed. Microdevices
, vol.17
, pp. 1-11
-
-
Dimasi, A.1
Rasponi, M.2
Sheriff, J.3
Chiu, W.C.4
Bluestein, D.5
Tran, P.L.6
Slepian, M.J.7
Redaelli, A.8
-
107
-
-
84864832183
-
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels
-
Korin, N.; Kanapathipillai, M.; Matthews, B.D.; Crescente, M.; Brill, A.; Mammoto, T.; Ghosh, K.; Jurek, S.; Bencherif, S.A.; Bhatta, D.; et al. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science 2012, 337, 738-742
-
(2012)
Science
, vol.337
, pp. 738-742
-
-
Korin, N.1
Kanapathipillai, M.2
Matthews, B.D.3
Crescente, M.4
Brill, A.5
Mammoto, T.6
Ghosh, K.7
Jurek, S.8
Bencherif, S.A.9
Bhatta, D.10
-
108
-
-
33646943472
-
Formation of perfused, functional microvascular tubes in vitro
-
Chrobak, K.M.; Potter, D.R.; Tien, J. Formation of perfused, functional microvascular tubes in vitro. Microvasc. Res. 2006, 71, 185-196
-
(2006)
Microvasc. Res
, vol.71
, pp. 185-196
-
-
Chrobak, K.M.1
Potter, D.R.2
Tien, J.3
-
109
-
-
84892372328
-
A bioengineered array of 3D microvessels for vascular permeability assay
-
Lee, H.; Kim, S.; Chung, M.; Kim, J.H.; Jeon, N.L. A bioengineered array of 3D microvessels for vascular permeability assay. Microvasc. Res. 2014, 91, 90-98
-
(2014)
Microvasc. Res
, vol.91
, pp. 90-98
-
-
Lee, H.1
Kim, S.2
Chung, M.3
Kim, J.H.4
Jeon, N.L.5
-
110
-
-
84947803121
-
Microcirculation-on-a-chip: A microfluidic platform for assaying blood-and lymphatic-vessel permeability
-
Sato, M.; Sasaki, N.; Ato, M.; Hirakawa, S.; Sato, K.; Sato, K. Microcirculation-on-a-chip: A microfluidic platform for assaying blood-and lymphatic-vessel permeability. PLoS ONE 2015, 10, e0137301
-
(2015)
PLoS ONE
, vol.10
-
-
Sato, M.1
Sasaki, N.2
Ato, M.3
Hirakawa, S.4
Sato, K.5
Sato, K.6
-
111
-
-
77956112678
-
A microfluidic platform for probing small artery structure and function
-
Günther, A.; Yasotharan, S.; Vagaon, A.; Lochovsky, C.; Pinto, S.; Yang, J.; Lau, C.; Voigtlaender-Bolz, J.; Bolz, S.-S. A microfluidic platform for probing small artery structure and function. Lab Chip 2010, 10, 2341-2349
-
(2010)
Lab Chip
, vol.10
, pp. 2341-2349
-
-
Günther, A.1
Yasotharan, S.2
Vagaon, A.3
Lochovsky, C.4
Pinto, S.5
Yang, J.6
Lau, C.7
Voigtlaender-Bolz, J.8
Bolz, S.-S.9
-
112
-
-
84934882141
-
Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function
-
Yasotharan, S.; Pinto, S.; Sled, J.G.; Bolz, S.-S.; Günther, A. Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function. Lab Chip 2015, 15, 2660-2669
-
(2015)
Lab Chip
, vol.15
, pp. 2660-2669
-
-
Yasotharan, S.1
Pinto, S.2
Sled, J.G.3
Bolz, S.-S.4
Günther, A.5
-
113
-
-
77955113600
-
Reconstructing the lung
-
Wagner, W.R.; Griffith, B.P. Reconstructing the lung. Science 2010, 329, 520-522
-
(2010)
Science
, vol.329
, pp. 520-522
-
-
Wagner, W.R.1
Griffith, B.P.2
-
114
-
-
84930082170
-
Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models
-
Hittinger, M.; Juntke, J.; Kletting, S.; Schneider-Daum, N.; de Souza Carvalho, C.; Lehr, C.-M. Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models. Adv. Drug Deliv. Rev. 2015, 85, 44-56
-
(2015)
Adv. Drug Deliv. Rev
, vol.85
, pp. 44-56
-
-
Hittinger, M.1
Juntke, J.2
Kletting, S.3
Schneider-Daum, N.4
de Souza Carvalho, C.5
Lehr, C.-M.6
-
115
-
-
75349108981
-
Preclinical models for pulmonary drug delivery
-
Fernandes, C.A.; Vanbever, R. Preclinical models for pulmonary drug delivery. Expert Opin. Drug Deliv. 2009, 6, 1231-1245
-
(2009)
Expert Opin. Drug Deliv
, vol.6
, pp. 1231-1245
-
-
Fernandes, C.A.1
Vanbever, R.2
-
116
-
-
79952129858
-
Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices
-
Hakkinen, K.M.; Harunaga, J.S.; Doyle, A.D.; Yamada, K.M. Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng. Part A 2011, 17, 713-724
-
(2011)
Tissue Eng. Part A
, vol.17
, pp. 713-724
-
-
Hakkinen, K.M.1
Harunaga, J.S.2
Doyle, A.D.3
Yamada, K.M.4
-
117
-
-
84905440393
-
Approaching the in vitro clinical trial: Engineering organs on chips
-
Capulli, A.K.; Tian, K.; Mehandru, N.; Bukhta, A.; Choudhury, S.F.; Suchyta, M.; Parker, K.K. Approaching the in vitro clinical trial: Engineering organs on chips. Lab Chip 2014, 14, 3181-3186
-
(2014)
Lab Chip
, vol.14
, pp. 3181-3186
-
-
Capulli, A.K.1
Tian, K.2
Mehandru, N.3
Bukhta, A.4
Choudhury, S.F.5
Suchyta, M.6
Parker, K.K.7
-
119
-
-
77950679333
-
Can animal models of disease reliably inform human studies?
-
Van der Worp, H.B.; Howells, D.W.; Sena, E.S.; Porritt, M.J.; Rewell, S.; O'Collins, V.; Macleod, M.R. Can animal models of disease reliably inform human studies? PLoS Med. 2010, 7, 1-8
-
(2010)
PLoS Med
, vol.7
, pp. 1-8
-
-
Van der Worp, H.B.1
Howells, D.W.2
Sena, E.S.3
Porritt, M.J.4
Rewell, S.5
O'Collins, V.6
Macleod, M.R.7
-
120
-
-
84907016366
-
Modeling the lung: Design and development of tissue engineered macro-and micro-physiologic lung models for research use
-
Nichols, J.E.; Niles, J.A.; Vega, S.P.; Argueta, L.B.; Eastaway, A.; Cortiella, J. Modeling the lung: Design and development of tissue engineered macro-and micro-physiologic lung models for research use. Exp. Biol. Med. 2014, 239, 1135-1169
-
(2014)
Exp. Biol. Med
, vol.239
, pp. 1135-1169
-
-
Nichols, J.E.1
Niles, J.A.2
Vega, S.P.3
Argueta, L.B.4
Eastaway, A.5
Cortiella, J.6
-
121
-
-
77954038080
-
Reconstituting organ level lung functions on a chip
-
Dongeun, H.; Benjamin, D.M.; Akiko, M.; Martín, M.-Z.; Hong, Y.H.; Donald, E.I. Reconstituting organ level lung functions on a chip. Science 2010, 328, 1662-1668
-
(2010)
Science
, vol.328
, pp. 1662-1668
-
-
Dongeun, H.1
Benjamin, D.M.2
Akiko, M.3
Martín, M.-Z.4
Hong, Y.H.5
Donald, E.I.6
-
122
-
-
84869126274
-
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice
-
Huh, D.; Leslie, D.C.; Matthews, B.D.; Fraser, J.P.; Jurek, S.; Hamilton, G.A.; Thorneloe, K.S.; McAlexander, M.A.; Ingber, D.E. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci. Transl. Med. 2012, 4, 159ra147
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Huh, D.1
Leslie, D.C.2
Matthews, B.D.3
Fraser, J.P.4
Jurek, S.5
Hamilton, G.A.6
Thorneloe, K.S.7
McAlexander, M.A.8
Ingber, D.E.9
-
123
-
-
84928723734
-
A human breathing lung-on-a-chip
-
Huh, D. A human breathing lung-on-a-chip. Ann. Am. Thorac. Soc. 2015, 12, S42-S44
-
(2015)
Ann. Am. Thorac. Soc
, vol.12
, pp. S42-S44
-
-
Huh, D.1
-
124
-
-
84956654664
-
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
-
Benam, K.H.; Villenave, R.; Lucchesi, C.; Varone, A.; Hubeau, C.; Lee, H.-H.; Alves, S.E.; Salmon, M.; Ferrante, T.C.; Weaver, J.C.; et al. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat. Methods 2016, 13, 151-157
-
(2016)
Nat. Methods
, vol.13
, pp. 151-157
-
-
Benam, K.H.1
Villenave, R.2
Lucchesi, C.3
Varone, A.4
Hubeau, C.5
Lee, H.-H.6
Alves, S.E.7
Salmon, M.8
Ferrante, T.C.9
Weaver, J.C.10
-
125
-
-
39149103052
-
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia
-
Kudlacz, E.; Conklyn, M.; Andresen, C.; Whitney-Pickett, C.; Changelian, P. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582, 154-161
-
(2008)
Eur. J. Pharmacol
, vol.582
, pp. 154-161
-
-
Kudlacz, E.1
Conklyn, M.2
Andresen, C.3
Whitney-Pickett, C.4
Changelian, P.5
-
126
-
-
84907818816
-
Human airway musculature on a chip: An in vitro model of allergic asthmatic bronchoconstriction and bronchodilation
-
Nesmith, A.P.; Agarwal, A.; McCain, M.L.; Parker, K.K. Human airway musculature on a chip: An in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip 2014, 14, 3925-3936
-
(2014)
Lab Chip
, vol.14
, pp. 3925-3936
-
-
Nesmith, A.P.1
Agarwal, A.2
McCain, M.L.3
Parker, K.K.4
-
127
-
-
0030933944
-
Airways remodeling is a distinctive feature of asthma and is related to severity of disease
-
Chetta, A.; Foresi, A.; del Donno, M.; Bertorelli, G.; Pesci, A.; Olivieri, D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997, 111, 852-857
-
(1997)
Chest
, vol.111
, pp. 852-857
-
-
Chetta, A.1
Foresi, A.2
del Donno, M.3
Bertorelli, G.4
Pesci, A.5
Olivieri, D.6
-
128
-
-
0026612959
-
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle
-
Fernandes, L.B.; Fryer, A.D.; Hirshman, C.A. M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle. J. Pharmacol. Exp. Ther. 1992, 262, 119-126
-
(1992)
J. Pharmacol. Exp. Ther
, vol.262
, pp. 119-126
-
-
Fernandes, L.B.1
Fryer, A.D.2
Hirshman, C.A.3
-
129
-
-
84923127772
-
A lung-on-a-chip array with an integrated bio-inspired respiration mechanism
-
Stucki, A.O.; Stucki, J.D.; Hall, S.R.R.; Felder, M.; Mermoud, Y.; Schmid, R.A.; Geiser, T.; Guenat, O.T. A lung-on-a-chip array with an integrated bio-inspired respiration mechanism. Lab Chip 2015, 15, 1302-1310
-
(2015)
Lab Chip
, vol.15
, pp. 1302-1310
-
-
Stucki, A.O.1
Stucki, J.D.2
Hall, S.R.R.3
Felder, M.4
Mermoud, Y.5
Schmid, R.A.6
Geiser, T.7
Guenat, O.T.8
-
130
-
-
61449197656
-
Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance
-
Wang, S.; Yue, F.; Zhang, L.; Wang, J.; Wang, Y.; Li, J.; Lin, B.; Qi, W. Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance. J. Pharm. Biomed. Anal. 2009, 49, 806-810
-
(2009)
J. Pharm. Biomed. Anal
, vol.49
, pp. 806-810
-
-
Wang, S.1
Yue, F.2
Zhang, L.3
Wang, J.4
Wang, Y.5
Li, J.6
Lin, B.7
Qi, W.8
-
131
-
-
84938347800
-
Cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer A549 cells by up-regulating the PI3K/Akt and GRP78 signaling on a microfluidic platform
-
Ying, L.; Zhu, Z.; Xu, Z.; He, T.; Li, E.; Guo, Z.; Liu, F.; Jiang, C.; Wang, Q. Cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer A549 cells by up-regulating the PI3K/Akt and GRP78 signaling on a microfluidic platform. PLoS ONE 2015, 10, 1-15
-
(2015)
PLoS ONE
, vol.10
, pp. 1-15
-
-
Ying, L.1
Zhu, Z.2
Xu, Z.3
He, T.4
Li, E.5
Guo, Z.6
Liu, F.7
Jiang, C.8
Wang, Q.9
-
132
-
-
77953916745
-
Multicellular tumor spheroids: An underestimated tool is catching up again
-
Hirschhaeuser, F.; Menne, H.; Dittfeld, C.; West, J.; Mueller-Klieser, W.; Kunz-Schughart, L.A. Multicellular tumor spheroids: An underestimated tool is catching up again. J. Biotechnol. 2010, 148, 3-15
-
(2010)
J. Biotechnol
, vol.148
, pp. 3-15
-
-
Hirschhaeuser, F.1
Menne, H.2
Dittfeld, C.3
West, J.4
Mueller-Klieser, W.5
Kunz-Schughart, L.A.6
-
133
-
-
45149094559
-
Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
-
Barbone, D.; Yang, T.M.; Morgan, J.R.; Gaudino, G.; Broaddus, V.C. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J. Biol. Chem. 2008, 283, 13021-13030
-
(2008)
J. Biol. Chem
, vol.283
, pp. 13021-13030
-
-
Barbone, D.1
Yang, T.M.2
Morgan, J.R.3
Gaudino, G.4
Broaddus, V.C.5
-
134
-
-
84875781499
-
Construction of oxygen and chemical concentration gradients in a single microfluidic device for studying tumor cell-drug interactions in a dynamic hypoxia microenvironment
-
Wang, L.; Liu, W.; Wang, Y.; Wang, J.; Tu, Q.; Liu, R.; Wang, J. Construction of oxygen and chemical concentration gradients in a single microfluidic device for studying tumor cell-drug interactions in a dynamic hypoxia microenvironment. Lab Chip 2013, 13, 695-705
-
(2013)
Lab Chip
, vol.13
, pp. 695-705
-
-
Wang, L.1
Liu, W.2
Wang, Y.3
Wang, J.4
Tu, Q.5
Liu, R.6
Wang, J.7
-
135
-
-
84894255591
-
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids
-
Ruppen, J.; Cortes-Dericks, L.; Marconi, E.; Karoubi, G.; Schmid, R.A.; Peng, R.; Marti, T.M.; Guenat, O.T. A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids. Lab Chip 2014, 14, 1198-1205
-
(2014)
Lab Chip
, vol.14
, pp. 1198-1205
-
-
Ruppen, J.1
Cortes-Dericks, L.2
Marconi, E.3
Karoubi, G.4
Schmid, R.A.5
Peng, R.6
Marti, T.M.7
Guenat, O.T.8
-
136
-
-
84874964737
-
Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer
-
Xu, Z.; Gao, Y.; Hao, Y.; Li, E.; Wang, Y.; Zhang, J.; Wang, W.; Gao, Z.; Wang, Q. Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer. Biomaterials 2013, 34, 4109-4117
-
(2013)
Biomaterials
, vol.34
, pp. 4109-4117
-
-
Xu, Z.1
Gao, Y.2
Hao, Y.3
Li, E.4
Wang, Y.5
Zhang, J.6
Wang, W.7
Gao, Z.8
Wang, Q.9
-
137
-
-
77951884924
-
A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells
-
Jang, K.-J.; Suh, K.-Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip 2010, 10, 36-42
-
(2010)
Lab Chip
, vol.10
, pp. 36-42
-
-
Jang, K.-J.1
Suh, K.-Y.2
-
138
-
-
0031832902
-
Intrarenal blood flow: Microvascular anatomy and the regulation of medullary perfusion
-
Pallone, T.L.; Silldorff, E.P.; Turner, M.R. Intrarenal blood flow: Microvascular anatomy and the regulation of medullary perfusion. Clin. Exp. Pharmacol. Physiol. 1998, 25, 383-392
-
(1998)
Clin. Exp. Pharmacol. Physiol
, vol.25
, pp. 383-392
-
-
Pallone, T.L.1
Silldorff, E.P.2
Turner, M.R.3
-
139
-
-
84903973480
-
Drug-induced nephrotoxicity: Clinical impact and preclinical in vitro models
-
Tiong, H.Y.; Huang, P.; Xiong, S.; Li, Y.; Vathsala, A.; Zink, D. Drug-induced nephrotoxicity: Clinical impact and preclinical in vitro models. Mol. Pharm. 2014, 11, 1933-1948
-
(2014)
Mol. Pharm
, vol.11
, pp. 1933-1948
-
-
Tiong, H.Y.1
Huang, P.2
Xiong, S.3
Li, Y.4
Vathsala, A.5
Zink, D.6
-
140
-
-
67549145035
-
Drug-induced nephrotoxicity
-
Naughton, C.A. Drug-induced nephrotoxicity. Am. Fam. Phys. 2008, 78, 743-750
-
(2008)
Am. Fam. Phys
, vol.78
, pp. 743-750
-
-
Naughton, C.A.1
-
141
-
-
70349303831
-
Renal vulnerability to drug toxicity
-
Perazella, M.A. Renal vulnerability to drug toxicity. Clin. J. Am. Soc. Nephrol. 2009, 4, 1275-1283
-
(2009)
Clin. J. Am. Soc. Nephrol
, vol.4
, pp. 1275-1283
-
-
Perazella, M.A.1
-
142
-
-
28144463388
-
Drug-induced acute kidney injury
-
Schetz, M.; Dasta, J.; Goldstein, S.; Golper, T. Drug-induced acute kidney injury. Curr. Opin. Crit. Care 2005, 11, 555-565
-
(2005)
Curr. Opin. Crit. Care
, vol.11
, pp. 555-565
-
-
Schetz, M.1
Dasta, J.2
Goldstein, S.3
Golper, T.4
-
143
-
-
85027933239
-
The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule
-
Jenkinson, S.E.; Chung, G.W.; van Loon, E.; Bakar, N.S.; Dalzell, A.M.; Brown, C.D.A. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. Pflugers Arch. Eur. J. Physiol. 2012, 464, 601-611
-
(2012)
Pflugers Arch. Eur. J. Physiol
, vol.464
, pp. 601-611
-
-
Jenkinson, S.E.1
Chung, G.W.2
van Loon, E.3
Bakar, N.S.4
Dalzell, A.M.5
Brown, C.D.A.6
-
144
-
-
84859635020
-
Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip
-
Snouber, L.C.; Letourneur, F.; Chafey, P.; Broussard, C.; Monge, M.; Legallais, C.; Leclerc, E. Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip. Biotechnol. Prog. 2012, 28, 474-484
-
(2012)
Biotechnol. Prog
, vol.28
, pp. 474-484
-
-
Snouber, L.C.1
Letourneur, F.2
Chafey, P.3
Broussard, C.4
Monge, M.5
Legallais, C.6
Leclerc, E.7
-
145
-
-
0034796171
-
Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells
-
Essig, M.; Terzi, F.; Burtin, M.; Friedlander, G. Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells. Am. J. Physiol. Ren. Physiol. 2001, 281, F751-F762
-
(2001)
Am. J. Physiol. Ren. Physiol
, vol.281
, pp. F751-F762
-
-
Essig, M.1
Terzi, F.2
Burtin, M.3
Friedlander, G.4
-
146
-
-
0029360777
-
Fluctuating shear stress effects on stress fiber architecture and energy metabolism of cultured renal cells
-
Bhat, V.D.; Windridge, P.A.; Cherry, R.S.; Mandel, L.J. Fluctuating shear stress effects on stress fiber architecture and energy metabolism of cultured renal cells. Biotechnol. Prog. 1995, 11, 596-600
-
(1995)
Biotechnol. Prog
, vol.11
, pp. 596-600
-
-
Bhat, V.D.1
Windridge, P.A.2
Cherry, R.S.3
Mandel, L.J.4
-
147
-
-
33644855811
-
Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments
-
Du, Z.; Yan, Q.; Duan, Y.; Weinbaum, S.; Weinstein, A.M.; Wang, T. Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments. Am. J. Physiol. Ren. Physiol. 2006, 290, F289-F296
-
(2006)
Am. J. Physiol. Ren. Physiol
, vol.290
, pp. F289-F296
-
-
Du, Z.1
Yan, Q.2
Duan, Y.3
Weinbaum, S.4
Weinstein, A.M.5
Wang, T.6
-
148
-
-
84960177173
-
Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
-
Wilmer, M.J.; Ng, C.P.; Lanz, H.L.; Vulto, P.; Suter-Dick, L.; Masereeuw, R. Kidney-on-a-chip technology for drug-induced nephrotoxicity screening. Trends Biotechnol. 2016, 34, 156-170
-
(2016)
Trends Biotechnol
, vol.34
, pp. 156-170
-
-
Wilmer, M.J.1
Ng, C.P.2
Lanz, H.L.3
Vulto, P.4
Suter-Dick, L.5
Masereeuw, R.6
-
149
-
-
2942709867
-
Microfluidic PDMS (Polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes
-
Leclerc, E.; Sakai, Y.; Fujii, T. Microfluidic PDMS (Polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol. Prog. 2004, 20, 750-755
-
(2004)
Biotechnol. Prog
, vol.20
, pp. 750-755
-
-
Leclerc, E.1
Sakai, Y.2
Fujii, T.3
-
150
-
-
35348827791
-
Development of a renal microchip for in vitro distal tubule models
-
Baudoin, R.; Griscom, L.; Monge, M.; Legallais, C.; Leclerc, E. Development of a renal microchip for in vitro distal tubule models. Biotechnol. Prog. 2007, 23, 1245-1253
-
(2007)
Biotechnol. Prog
, vol.23
, pp. 1245-1253
-
-
Baudoin, R.1
Griscom, L.2
Monge, M.3
Legallais, C.4
Leclerc, E.5
-
151
-
-
0029937194
-
The importance of ammonia in mammalian cell culture
-
Schneider, M.; Marison, I.W.; von Stockar, U. The importance of ammonia in mammalian cell culture. J. Biotechnol. 1996, 46, 161-185
-
(1996)
J. Biotechnol
, vol.46
, pp. 161-185
-
-
Schneider, M.1
Marison, I.W.2
von Stockar, U.3
-
152
-
-
84862773705
-
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips
-
Choucha Snouber, L.; Jacques, S.; Monge, M.; Legallais, C.; Leclerc, E. Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips. Genomics 2012, 100, 27-34
-
(2012)
Genomics
, vol.100
, pp. 27-34
-
-
Choucha Snouber, L.1
Jacques, S.2
Monge, M.3
Legallais, C.4
Leclerc, E.5
-
153
-
-
40249109853
-
The IkappaB kinase-A bridge between inflammation and cancer
-
Karin, M. The IkappaB kinase-A bridge between inflammation and cancer. Cell Res. 2008, 18, 334-342
-
(2008)
Cell Res
, vol.18
, pp. 334-342
-
-
Karin, M.1
-
154
-
-
66449120238
-
ransepithelial fluxes of adenosine and 20-deoxyadenosine across human renal proximal tubule cells: Roles of nucleoside transporters hENT1, hENT2, and hCNT
-
Elwi, A.N.; Damaraju, V.L.; Kuzma, M.L.; Mowles, D.A.; Baldwin, S.A.; Young, J.D.; Sawyer, M.B.; Cass, C.E. ransepithelial fluxes of adenosine and 20-deoxyadenosine across human renal proximal tubule cells: Roles of nucleoside transporters hENT1, hENT2, and hCNT. Am. J. Physiol. Ren. Physiol. 2009, 296, F1439-F1451
-
(2009)
Am. J. Physiol. Ren. Physiol
, vol.296
, pp. F1439-F1451
-
-
Elwi, A.N.1
Damaraju, V.L.2
Kuzma, M.L.3
Mowles, D.A.4
Baldwin, S.A.5
Young, J.D.6
Sawyer, M.B.7
Cass, C.E.8
-
155
-
-
0026529989
-
Redistribution of microvilli and membrane enzymes in isolated rat proximal tubule cells
-
Rebelo, L.; Carmo-Fonseca, M.; Moura, T.F. Redistribution of microvilli and membrane enzymes in isolated rat proximal tubule cells. Biol. Cell 1992, 74, 203-209
-
(1992)
Biol. Cell
, vol.74
, pp. 203-209
-
-
Rebelo, L.1
Carmo-Fonseca, M.2
Moura, T.F.3
-
156
-
-
79951474125
-
Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells
-
Jang, K.-J.; Cho, H.S.; Kang, D.H.; Bae, W.G.; Kwon, T.-H.; Suh, K.-Y. Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr. Biol. 2011, 3, 134-141
-
(2011)
Integr. Biol
, vol.3
, pp. 134-141
-
-
Jang, K.-J.1
Cho, H.S.2
Kang, D.H.3
Bae, W.G.4
Kwon, T.-H.5
Suh, K.-Y.6
-
157
-
-
79957949200
-
Investigation into modification of mass transfer kinetics by acrolein in a renal biochip
-
Ramello, C.; Paullier, P.; Ould-Dris, A.; Monge, M.; Legallais, C.; Leclerc, E. Investigation into modification of mass transfer kinetics by acrolein in a renal biochip. Toxicol. In Vitro 2011, 25, 1123-1131
-
(2011)
Toxicol. In Vitro
, vol.25
, pp. 1123-1131
-
-
Ramello, C.1
Paullier, P.2
Ould-Dris, A.3
Monge, M.4
Legallais, C.5
Leclerc, E.6
-
158
-
-
85003053593
-
Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip
-
Kim, S.; LesherPerez, S.C.; Kim, B.C.C.; Yamanishi, C.; Labuz, J.M.; Leung, B.; Takayama, S. Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip. Biofabrication 2016, 8, 015021
-
(2016)
Biofabrication
, vol.8
-
-
Kim, S.1
LesherPerez, S.C.2
Kim, B.C.C.3
Yamanishi, C.4
Labuz, J.M.5
Leung, B.6
Takayama, S.7
-
159
-
-
78651449264
-
Once versus multiple daily dosing of aminoglycosides for patients with febrile neutropenia: A systematic review and meta-analysis
-
Mavros, M.N.; Polyzos, K.A.; Rafailidis, P.I.; Falagas, M.E. Once versus multiple daily dosing of aminoglycosides for patients with febrile neutropenia: A systematic review and meta-analysis. J. Antimicrob. Chemother. 2011, 66, 251-259
-
(2011)
J. Antimicrob. Chemother
, vol.66
, pp. 251-259
-
-
Mavros, M.N.1
Polyzos, K.A.2
Rafailidis, P.I.3
Falagas, M.E.4
-
160
-
-
49649114844
-
Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
-
Duan, Y.; Gotoh, N.; Yan, Q.; Du, Z.; Weinstein, A.M.; Wang, T.; Weinbaum, S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proc. Natl. Acad. Sci. USA 2008, 105, 11418-11423
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11418-11423
-
-
Duan, Y.1
Gotoh, N.2
Yan, Q.3
Du, Z.4
Weinstein, A.M.5
Wang, T.6
Weinbaum, S.7
-
161
-
-
0036226940
-
Animal model pharmacokinetics and pharmacodynamics: A critical review
-
Andes, D.; Craig, W.A. Animal model pharmacokinetics and pharmacodynamics: A critical review. Int. J. Antimicrob. Agents 2002, 19, 261-268
-
(2002)
Int. J. Antimicrob. Agents
, vol.19
, pp. 261-268
-
-
Andes, D.1
Craig, W.A.2
-
162
-
-
79956123094
-
Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption
-
Paine, S.W.; Ménochet, K.; Denton, R.; McGinnity, D.F.; Riley, R.J. Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption. Drug Metab. Dispos. 2011, 39, 1008-1013
-
(2011)
Drug Metab. Dispos
, vol.39
, pp. 1008-1013
-
-
Paine, S.W.1
Ménochet, K.2
Denton, R.3
McGinnity, D.F.4
Riley, R.J.5
-
163
-
-
85007300025
-
Species differences in drug transporters and implications for translating preclinical findings to humans
-
Chu, X.; Bleasby, K.; Evers, R. Species differences in drug transporters and implications for translating preclinical findings to humans. Expert Opin. Drug Metab. Toxicol. 2012, 5255, 1-16
-
(2012)
Expert Opin. Drug Metab. Toxicol
, vol.5255
, pp. 1-16
-
-
Chu, X.1
Bleasby, K.2
Evers, R.3
-
164
-
-
0031834028
-
Nephrotoxicity testing in vitro-What we know and what we need to know
-
Pfaller, W.; Gstraunthaler, G. Nephrotoxicity testing in vitro-What we know and what we need to know. Environ. Health Perspect. 1998, 106 (Suppl. 2), 559-569
-
(1998)
Environ. Health Perspect
, vol.106
, pp. 559-569
-
-
Pfaller, W.1
Gstraunthaler, G.2
-
165
-
-
84882590738
-
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
-
Jang, K.-J.; Mehr, A.P.; Hamilton, G.A.; McPartlin, L.A.; Chung, S.; Suh, K.-Y.; Ingber, D.E. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr. Biol. (Camb.) 2013, 5, 1119-1129
-
(2013)
Integr. Biol. (Camb.)
, vol.5
, pp. 1119-1129
-
-
Jang, K.-J.1
Mehr, A.P.2
Hamilton, G.A.3
McPartlin, L.A.4
Chung, S.5
Suh, K.-Y.6
Ingber, D.E.7
-
166
-
-
85017054630
-
A quantitative approach to screen for nephrotoxic compounds in vitro
-
Adler, M.; Ramm, S.; Hafner, M.; Muhlich, J.L.; Gottwald, E.M.; Weber, E.; Jaklic, A.; Ajay, A.K.; Svoboda, D.; Auerbach, S.; et al. A quantitative approach to screen for nephrotoxic compounds in vitro. J. Am. Soc. Nephrol. 2016, 27, 1015-1028
-
(2016)
J. Am. Soc. Nephrol
, vol.27
, pp. 1015-1028
-
-
Adler, M.1
Ramm, S.2
Hafner, M.3
Muhlich, J.L.4
Gottwald, E.M.5
Weber, E.6
Jaklic, A.7
Ajay, A.K.8
Svoboda, D.9
Auerbach, S.10
-
167
-
-
84891362516
-
Innovations in preclinical biology: Ex vivo engineering of a human kidney tissue microperfusion system
-
Kelly, E.J.; Wang, Z.; Voellinger, J.L.; Yeung, C.K.; Shen, D.D.; Thummel, K.E.; Zheng, Y.; Ligresti, G.; Eaton, D.L.; Muczynski, K.A.; et al. Innovations in preclinical biology: Ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Res. Ther. 2013, 4 (Suppl. 1), S17
-
(2013)
Stem Cell Res. Ther
, vol.4
, pp. S17
-
-
Kelly, E.J.1
Wang, Z.2
Voellinger, J.L.3
Yeung, C.K.4
Shen, D.D.5
Thummel, K.E.6
Zheng, Y.7
Ligresti, G.8
Eaton, D.L.9
Muczynski, K.A.10
-
168
-
-
84994236238
-
Development of a microphysiological model of human kidney proximal tubule function
-
Weber, E.J.; Chapron, A.; Chapron, B.D.; Voellinger, J.L.; Lidberg, K.A.; Yeung, C.K.; Wang, Z.; Yamaura, Y.; Hailey, D.W.; Neumann, T.; et al. Development of a microphysiological model of human kidney proximal tubule function. Kidney Int. 2016, 90, 627-637
-
(2016)
Kidney Int
, vol.90
, pp. 627-637
-
-
Weber, E.J.1
Chapron, A.2
Chapron, B.D.3
Voellinger, J.L.4
Lidberg, K.A.5
Yeung, C.K.6
Wang, Z.7
Yamaura, Y.8
Hailey, D.W.9
Neumann, T.10
-
169
-
-
85003286532
-
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs
-
Madden, L.; Juhas, M.; Kraus, W.E.; Truskey, G.A.; Bursac, N. Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. eLife 2015, 4, e04885
-
(2015)
eLife
, vol.4
-
-
Madden, L.1
Juhas, M.2
Kraus, W.E.3
Truskey, G.A.4
Bursac, N.5
-
170
-
-
84929991052
-
High-throughput microfluidic platform for 3D cultures of mesenchymal stem cells, towards engineering developmental processes
-
Occhetta, P.; Centola, M.; Tonnarelli, B.; Redaelli, A.; Martin, I.; Rasponi, M. High-throughput microfluidic platform for 3D cultures of mesenchymal stem cells, towards engineering developmental processes. Sci. Rep. 2015, 5, 10288
-
(2015)
Sci. Rep
, vol.5
, pp. 10288
-
-
Occhetta, P.1
Centola, M.2
Tonnarelli, B.3
Redaelli, A.4
Martin, I.5
Rasponi, M.6
-
171
-
-
84946910471
-
Retina-on-a-chip: A microfluidic platform for point access signaling studies
-
Dodson, K.H.; Echevarria, F.D.; Li, D.; Sappington, R.M.; Edd, J.F. Retina-on-a-chip: A microfluidic platform for point access signaling studies. Biomed. Microdevices 2015, 17, 1-10
-
(2015)
Biomed. Microdevices
, vol.17
, pp. 1-10
-
-
Dodson, K.H.1
Echevarria, F.D.2
Li, D.3
Sappington, R.M.4
Edd, J.F.5
-
172
-
-
84898920410
-
A functional microengineered model of the human splenon-on-a-chip
-
Rigat-Brugarolas, L.G.; Elizalde-Torrent, A.; Bernabeu, M.; de Niz, M.; Martin-Jaular, L.; Fernandez-Becerra, C.; Homs-Corbera, A.; Samitier, J.; del Portillo, H.A. A functional microengineered model of the human splenon-on-a-chip. Lab Chip 2014, 14, 1715-1724
-
(2014)
Lab Chip
, vol.14
, pp. 1715-1724
-
-
Rigat-Brugarolas, L.G.1
Elizalde-Torrent, A.2
Bernabeu, M.3
de Niz, M.4
Martin-Jaular, L.5
Fernandez-Becerra, C.6
Homs-Corbera, A.7
Samitier, J.8
del Portillo, H.A.9
-
173
-
-
84995906303
-
Red blood cell phase separation in symmetric and asymmetric microchannel networks: Effect of capillary dilation and inflow velocity
-
Clavica, F.; Homsy, A.; Jeandupeux, L.; Obrist, D. Red blood cell phase separation in symmetric and asymmetric microchannel networks: Effect of capillary dilation and inflow velocity. Sci. Rep. 2016, 6, 36763
-
(2016)
Sci. Rep
, vol.6
, pp. 36763
-
-
Clavica, F.1
Homsy, A.2
Jeandupeux, L.3
Obrist, D.4
-
174
-
-
84971351772
-
Rapid, low-cost fabrication of circular microchannels by air expansion into partially cured polymer
-
Nguyen, T.Q.; Park, W.T. Rapid, low-cost fabrication of circular microchannels by air expansion into partially cured polymer. Sens. Actuators B Chem. 2016, 235, 302-308
-
(2016)
Sens. Actuators B Chem
, vol.235
, pp. 302-308
-
-
Nguyen, T.Q.1
Park, W.T.2
-
175
-
-
84930959624
-
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
-
Maschmeyer, I.; Lorenz, A.K.; Schimek, K.; Hasenberg, T.; Ramme, A.P.; Hübner, J.; Lindner, M.; Drewell, C.; Bauer, S.; Thomas, A.; et al. A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents. Lab Chip 2015, 15, 2688-2699
-
(2015)
Lab Chip
, vol.15
, pp. 2688-2699
-
-
Maschmeyer, I.1
Lorenz, A.K.2
Schimek, K.3
Hasenberg, T.4
Ramme, A.P.5
Hübner, J.6
Lindner, M.7
Drewell, C.8
Bauer, S.9
Thomas, A.10
-
176
-
-
84930957041
-
A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing
-
Materne, E.M.; Ramme, A.P.; Terrasso, A.P.; Serra, M.; Alves, P.M.; Brito, C.; Sakharov, D.A.; Tonevitsky, A.G.; Lauster, R.; Marx, U. A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing. J. Biotechnol. 2014, 205, 36-46
-
(2014)
J. Biotechnol
, vol.205
, pp. 36-46
-
-
Materne, E.M.1
Ramme, A.P.2
Terrasso, A.P.3
Serra, M.4
Alves, P.M.5
Brito, C.6
Sakharov, D.A.7
Tonevitsky, A.G.8
Lauster, R.9
Marx, U.10
-
177
-
-
84891348288
-
HeLiVa platform: Integrated heart-liver-vascular systems for drug testing in human health and disease
-
Vunjak-Novakovic, G.; Bhatia, S.; Chen, C.; Hirschi, K. HeLiVa platform: Integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res. Ther. 2013, 4, 1-6
-
(2013)
Stem Cell Res. Ther
, vol.4
, pp. 1-6
-
-
Vunjak-Novakovic, G.1
Bhatia, S.2
Chen, C.3
Hirschi, K.4
-
178
-
-
77957671875
-
A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
-
Van Midwoud, P.M.; Merema, M.T.; Verpoorte, E.; Groothuis, G.M.M. A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip 2010, 10, 2778-2786
-
(2010)
Lab Chip
, vol.10
, pp. 2778-2786
-
-
Van Midwoud, P.M.1
Merema, M.T.2
Verpoorte, E.3
Groothuis, G.M.M.4
-
179
-
-
84882252041
-
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
-
Wagner, I.; Materne, E.-M.; Brincker, S.; Süssbier, U.; Frädrich, C.; Busek, M.; Sonntag, F.; Sakharov, D.A.; Trushkin, E.V.; Tonevitsky, A.G.; et al. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip 2013, 13, 3538-3547
-
(2013)
Lab Chip
, vol.13
, pp. 3538-3547
-
-
Wagner, I.1
Materne, E.-M.2
Brincker, S.3
Süssbier, U.4
Frädrich, C.5
Busek, M.6
Sonntag, F.7
Sakharov, D.A.8
Trushkin, E.V.9
Tonevitsky, A.G.10
-
180
-
-
84873579795
-
"Human-on-a-chip" developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
-
Marx, U.; Walles, H.; Hoffmann, S.; Lindner, G.; Horland, R.; Sonntag, F.; Klotzbach, U.; Sakharov, D.; Tonevitsky, A.; Lauster, R. "Human-on-a-chip" developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? ATLA Altern. Lab. Anim. 2012, 40, 235-257
-
(2012)
ATLA Altern. Lab. Anim
, vol.40
, pp. 235-257
-
-
Marx, U.1
Walles, H.2
Hoffmann, S.3
Lindner, G.4
Horland, R.5
Sonntag, F.6
Klotzbach, U.7
Sakharov, D.8
Tonevitsky, A.9
Lauster, R.10
-
181
-
-
84874894377
-
Microfabricated mammalian organ systems and their integration into models of whole animals and humans
-
Sung, J.H.; Esch, M.B.; Prot, J.-M.; Long, C.J.; Smith, A.; Hickman, J.J.; Shuler, M.L. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 2013, 13, 1201-1212
-
(2013)
Lab Chip
, vol.13
, pp. 1201-1212
-
-
Sung, J.H.1
Esch, M.B.2
Prot, J.-M.3
Long, C.J.4
Smith, A.5
Hickman, J.J.6
Shuler, M.L.7
-
182
-
-
75749153235
-
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
-
Sung, J.H.; Kam, C.; Shuler, M.L. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 2010, 10, 446-455
-
(2010)
Lab Chip
, vol.10
, pp. 446-455
-
-
Sung, J.H.1
Kam, C.2
Shuler, M.L.3
-
183
-
-
84882245384
-
Scaling and systems biology for integrating multiple organs-on-a-chip
-
Wikswo, J.P.; Curtis, E.L.; Eagleton, Z.E.; Evans, B.C.; Kole, A.; Hofmeister, L.H.; Matloff, W.J. Scaling and systems biology for integrating multiple organs-on-a-chip. Lab Chip 2013, 13, 3496-3511
-
(2013)
Lab Chip
, vol.13
, pp. 3496-3511
-
-
Wikswo, J.P.1
Curtis, E.L.2
Eagleton, Z.E.3
Evans, B.C.4
Kole, A.5
Hofmeister, L.H.6
Matloff, W.J.7
-
184
-
-
84882683226
-
On being the right size: Scaling effects in designing a human-on-a-chip
-
Moraes, C.; Labuz, J.M.; Leung, B.M.; Inoue, M.; Chun, T.-H.; Takayama, S. On being the right size: Scaling effects in designing a human-on-a-chip. Integr. Biol. 2013, 5, 1149-1161
-
(2013)
Integr. Biol
, vol.5
, pp. 1149-1161
-
-
Moraes, C.1
Labuz, J.M.2
Leung, B.M.3
Inoue, M.4
Chun, T.-H.5
Takayama, S.6
-
185
-
-
1142305959
-
Development of a microscale cell culture analog to probe naphthalene toxicity
-
Viravaidya, K.; Sin, A.; Shuler, M.L. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol. Prog. 2004, 20, 316-323
-
(2004)
Biotechnol. Prog
, vol.20
, pp. 316-323
-
-
Viravaidya, K.1
Sin, A.2
Shuler, M.L.3
-
186
-
-
84927592484
-
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
-
Abaci, H.E.; Shuler, M.L. Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr. Biol. 2015, 7, 383-391
-
(2015)
Integr. Biol
, vol.7
, pp. 383-391
-
-
Abaci, H.E.1
Shuler, M.L.2
|