-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DOI 10.1016/S0167-6296(02)00126-1
-
The price of innovation: new estimates of drug development costs. DiMasi JA, Hansen RW, Grabowski HG, J Health Econ 2003 22 151 185 10.1016/S0167- 6296(02)00126-1 12606142 (Pubitemid 36279392)
-
(2003)
Journal of Health Economics
, vol.22
, Issue.2
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
2
-
-
80155205233
-
Artificial niche microarrays for probing single stem cell fate in high throughput
-
10.1038/nmeth.1732 21983923
-
Artificial niche microarrays for probing single stem cell fate in high throughput. Gobaa S, Hoehnel S, Roccio M, Negro A, Kobel S, Lutolf MP, Nat Methods 2011 8 949 955 10.1038/nmeth.1732 21983923
-
(2011)
Nat Methods
, vol.8
, pp. 949-955
-
-
Gobaa, S.1
Hoehnel, S.2
Roccio, M.3
Negro, A.4
Kobel, S.5
Lutolf, M.P.6
-
4
-
-
68949149740
-
Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative
-
10.1016/j.ahj.2009.06.007 19699852
-
Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative. Piccini JP, Whellan DJ, Berridge BR, Finkle JK, Pettit SD, Stockbridge N, Valentin JP, Vargas HM, Krucoff MW, CSRC/HESI Writing Group, Am Heart J 2009 158 317 326 10.1016/j.ahj.2009.06.007 19699852
-
(2009)
Am Heart J
, vol.158
, pp. 317-326
-
-
Piccini, J.P.1
Whellan, D.J.2
Berridge, B.R.3
Finkle, J.K.4
Pettit, S.D.5
Stockbridge, N.6
Valentin, J.P.7
Vargas, H.M.8
Krucoff, M.W.9
Writing Group, C.10
-
5
-
-
13444263619
-
Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: Nested case-control study
-
DOI 10.1016/S0140-6736(05)17864-7
-
Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study. Graham DJ, Campen D, Hui R, Spence M, Cheetham C, Levy G, Shoor S, Ray WA, Lancet 2005 365 475 481 15705456 (Pubitemid 40215729)
-
(2005)
Lancet
, vol.365
, Issue.9458
, pp. 475-481
-
-
Graham, D.J.1
Campen, D.2
Hui, R.3
Spence, M.4
Cheetham, C.5
Levy, G.6
Shoor, S.7
Ray, W.A.8
-
6
-
-
20844444779
-
Idiosyncratic drug hepatotoxicity
-
DOI 10.1038/nrd1750
-
Idiosyncratic drug hepatotoxicity. Kaplowitz N, Nat Rev Drug Discov 2005 4 489 499 10.1038/nrd1750 15931258 (Pubitemid 40861991)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.6
, pp. 489-499
-
-
Kaplowitz, N.1
-
7
-
-
70849112627
-
Inspiration and application in the evolution of biomaterials
-
10.1038/nature08601 19940912
-
Inspiration and application in the evolution of biomaterials. Huebsch N, Mooney DJ, Nature 2009 462 426 432 10.1038/nature08601 19940912
-
(2009)
Nature
, vol.462
, pp. 426-432
-
-
Huebsch, N.1
Mooney, D.J.2
-
8
-
-
77649262300
-
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
-
10.1073/pnas.0915130107 20133632
-
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, Mu K, Ritola K, Rice CM, Bhatia SN, Proc Natl Acad Sci USA 2010 107 3141 3145 10.1073/pnas.0915130107 20133632
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3141-3145
-
-
Ploss, A.1
Khetani, S.R.2
Jones, C.T.3
Syder, A.J.4
Trehan, K.5
Gaysinskaya, V.A.6
Mu, K.7
Ritola, K.8
Rice, C.M.9
Bhatia, S.N.10
-
9
-
-
75749153235
-
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
-
10.1039/b917763a 20126684
-
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Sung JH, Kam C, Shuler ML, Lab Chip 2010 10 446 455 10.1039/b917763a 20126684
-
(2010)
Lab Chip
, vol.10
, pp. 446-455
-
-
Sung, J.H.1
Kam, C.2
Shuler, M.L.3
-
10
-
-
38049011979
-
Microscale culture of human liver cells for drug development
-
10.1038/nbt1361 18026090
-
Microscale culture of human liver cells for drug development. Khetani SR, Bhatia SN, Nat Biotechnol 2008 26 120 126 10.1038/nbt1361 18026090
-
(2008)
Nat Biotechnol
, vol.26
, pp. 120-126
-
-
Khetani, S.R.1
Bhatia, S.N.2
-
11
-
-
79959881819
-
Engineering a stem cell house into a home
-
10.1186/scrt44 21345268
-
Engineering a stem cell house into a home. Gilbert P, Blau H, Stem Cell Res Ther 2011 2 3 10.1186/scrt44 21345268
-
(2011)
Stem Cell Res Ther
, vol.2
, pp. 3
-
-
Gilbert, P.1
Blau, H.2
-
12
-
-
84872090939
-
Dynamic regulation of early mesodermal commitment in human pluripotent stem cells using microfluidic technologies
-
10.1039/c2lc40836h 23232509
-
Dynamic regulation of early mesodermal commitment in human pluripotent stem cells using microfluidic technologies. Cimetta E, Sirabella D, Yeager K, Davidson K, Simon J, Moon RT, Vunjak-Novakovic G, Lab on a Chip 2013 13 355 364 10.1039/c2lc40836h 23232509
-
(2013)
Lab on A Chip
, vol.13
, pp. 355-364
-
-
Cimetta, E.1
Sirabella, D.2
Yeager, K.3
Davidson, K.4
Simon, J.5
Moon, R.T.6
Vunjak-Novakovic, G.7
-
13
-
-
81855176227
-
Hydrogel derived from native heart matrix induces cardiac differentiation of human embryonic stem cells without supplemental growth factors
-
10.1007/s12265-011-9304-0 21744185
-
Hydrogel derived from native heart matrix induces cardiac differentiation of human embryonic stem cells without supplemental growth factors. Duan Y, Liu Z, O'Neill J, Wan L, Freytes DO, Vunjak-Novakovic G, J Cardiovasc Transl Res 2011 4 605 615 10.1007/s12265-011-9304-0 21744185
-
(2011)
J Cardiovasc Transl Res
, vol.4
, pp. 605-615
-
-
Duan, Y.1
Liu, Z.2
O'Neill, J.3
Wan, L.4
Freytes, D.O.5
Vunjak-Novakovic, G.6
-
14
-
-
84875258119
-
Engineering complex three-dimensional cell microenvironments using docking hydrogel shapes
-
10.1073/pnas.1300569110 23487790
-
Engineering complex three-dimensional cell microenvironments using docking hydrogel shapes. Eng GM, Lee WB, Parsa H, Chin C, Schneider J, Linkov G, Vunjak-Novakovic G, Proc Natl Acad Sci USA 2013 110 4551 4556 10.1073/pnas.1300569110 23487790
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 4551-4556
-
-
Eng, G.M.1
Lee, W.B.2
Parsa, H.3
Chin, C.4
Schneider, J.5
Linkov, G.6
Vunjak-Novakovic, G.7
-
15
-
-
84871755759
-
Multiscale modeling of multicellular systems: Application to tissue engineering
-
10.1103/RevModPhys.84.1791
-
Multiscale modeling of multicellular systems: Application to tissue engineering. Kosztin I, Vunjak-Novakovic G, Forgacs G, Rev Mod Phys 2012 84 1791 1805 10.1103/RevModPhys.84.1791
-
(2012)
Rev Mod Phys
, vol.84
, pp. 1791-1805
-
-
Kosztin, I.1
Vunjak-Novakovic, G.2
Forgacs, G.3
-
16
-
-
84880916761
-
Identification of small molecules for human hepatocyte expansion and iPS differentiation
-
10.1038/nchembio.1270 23728495
-
Identification of small molecules for human hepatocyte expansion and iPS differentiation. Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN, Nat Chem Biol 2013 9 514 520 10.1038/nchembio.1270 23728495
-
(2013)
Nat Chem Biol
, vol.9
, pp. 514-520
-
-
Shan, J.1
Schwartz, R.E.2
Ross, N.T.3
Logan, D.J.4
Thomas, D.5
Duncan, S.A.6
North, T.E.7
Goessling, W.8
Carpenter, A.E.9
Bhatia, S.N.10
-
17
-
-
84886784880
-
Bioreactor engineering of stem cell environments
-
10.1016/j.biotechadv.2013.03.007 23531529
-
Bioreactor engineering of stem cell environments. Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G, Biotechnol Adv 2013 31 1020 1031 10.1016/j.biotechadv.2013.03.007 23531529
-
(2013)
Biotechnol Adv
, vol.31
, pp. 1020-1031
-
-
Tandon, N.1
Marolt, D.2
Cimetta, E.3
Vunjak-Novakovic, G.4
-
18
-
-
84884412620
-
Patterning pluripotency of embryonic stem cells
-
10.1002/stem.1468 23843329
-
Patterning pluripotency of embryonic stem cells. Zhang Y, Sevilla A, Wan LQ, Lemischka I, Vunjak-Novakovic G, Stem Cells 2013 31 1806 1815 10.1002/stem.1468 23843329
-
(2013)
Stem Cells
, vol.31
, pp. 1806-1815
-
-
Zhang, Y.1
Sevilla, A.2
Wan, L.Q.3
Lemischka, I.4
Vunjak-Novakovic, G.5
-
20
-
-
84866355664
-
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
-
10.1038/nmat3357 22751181
-
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Miller JS, Stevens KR, Yang MT, Baker BM, Nguyen DT, Cohen DM, Toro E, Chen SS, Galie PA, Yu X, Chaturvedi R, Bhatia SN, Chen CS, Nat Mater 2012 11 768 774 10.1038/nmat3357 22751181
-
(2012)
Nat Mater
, vol.11
, pp. 768-774
-
-
Miller, J.S.1
Stevens, K.R.2
Yang, M.T.3
Baker, B.M.4
Nguyen, D.T.5
Cohen, D.M.6
Toro, E.7
Chen, S.S.8
Galie, P.A.9
Yu, X.10
Chaturvedi, R.11
Bhatia, S.N.12
Chen, C.S.13
-
21
-
-
84877348134
-
Geometric control of vascular networks to enhance engineered tissue integration and function
-
10.1073/pnas.1217796110 23610423
-
Geometric control of vascular networks to enhance engineered tissue integration and function. Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS, Proc Natl Acad Sci USA 2013 110 7586 7591 10.1073/pnas.1217796110 23610423
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7586-7591
-
-
Baranski, J.D.1
Chaturvedi, R.R.2
Stevens, K.R.3
Eyckmans, J.4
Carvalho, B.5
Solorzano, R.D.6
Yang, M.T.7
Miller, J.S.8
Bhatia, S.N.9
Chen, C.S.10
-
22
-
-
84880346720
-
Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients
-
10.1039/c3lc50493j 23787488
-
Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS, Lab Chip 2013 13 3246 3252 10.1039/c3lc50493j 23787488
-
(2013)
Lab Chip
, vol.13
, pp. 3246-3252
-
-
Baker, B.M.1
Trappmann, B.2
Stapleton, S.C.3
Toro, E.4
Chen, C.S.5
-
23
-
-
84876872941
-
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro
-
10.1073/pnas.1221526110 23569284
-
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Nguyen DHT, Stapleton SC, Yang MT, Cha SS, Choi CK, Galie PA, Chen CS, Proc Natl Acad Sci USA 2013 110 6712 6717 10.1073/pnas.1221526110 23569284
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 6712-6717
-
-
Nguyen, D.H.T.1
Stapleton, S.C.2
Yang, M.T.3
Cha, S.S.4
Choi, C.K.5
Galie, P.A.6
Chen, C.S.7
-
24
-
-
84878682762
-
InVERT molding for scalable control of tissue microarchitecture
-
23673632
-
InVERT molding for scalable control of tissue microarchitecture. Stevens KR, Ungrin MD, Schwartz RE, Ng S, Carvalho B, Christine KS, Chaturvedi RR, Li CY, Zandstra PW, Chen CS, Bhatia SN, Nat Commun 2013 4 1847 23673632
-
(2013)
Nat Commun
, vol.4
, pp. 1847
-
-
Stevens, K.R.1
Ungrin, M.D.2
Schwartz, R.E.3
Ng, S.4
Carvalho, B.5
Christine, K.S.6
Chaturvedi, R.R.7
Li, C.Y.8
Zandstra, P.W.9
Chen, C.S.10
Bhatia, S.N.11
-
25
-
-
84857125662
-
Modeling hepatitis C virus infection using human induced pluripotent stem cells
-
10.1073/pnas.1121400109 22308485
-
Modeling hepatitis C virus infection using human induced pluripotent stem cells. Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN, Proc Natl Acad Sci USA 2012 109 2544 2548 10.1073/pnas.1121400109 22308485
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2544-2548
-
-
Schwartz, R.E.1
Trehan, K.2
Andrus, L.3
Sheahan, T.P.4
Ploss, A.5
Duncan, S.A.6
Rice, C.M.7
Bhatia, S.N.8
-
26
-
-
84877259309
-
Endothelial cell differentiation and specification
-
10.1161/CIRCRESAHA.113.300506 23620236
-
Endothelial cell differentiation and specification. Marcelo KL, Goldie LC, Hirschi KK, Circ Res 2013 112 1272 1287 10.1161/CIRCRESAHA.113.300506 23620236
-
(2013)
Circ Res
, vol.112
, pp. 1272-1287
-
-
Marcelo, K.L.1
Goldie, L.C.2
Hirschi, K.K.3
-
27
-
-
84884419048
-
Bioengineering heart tissue for in vitro testing
-
10.1016/j.copbio.2013.07.002 23932513
-
Bioengineering heart tissue for in vitro testing. Cimetta E, Godier-Furnémont A, Vunjak-Novakovic G, Curr Opin Biotechnol 2013 24 926 932 10.1016/j.copbio.2013.07.002 23932513
-
(2013)
Curr Opin Biotechnol
, vol.24
, pp. 926-932
-
-
Cimetta, E.1
Godier-Furnémont, A.2
Vunjak-Novakovic, G.3
-
28
-
-
79960836456
-
Genetic engineering of human pluripotent cells using TALE nucleases
-
10.1038/nbt.1927 21738127
-
Genetic engineering of human pluripotent cells using TALE nucleases. Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R, Nat Biotechnol 2011 29 731 734 10.1038/nbt.1927 21738127
-
(2011)
Nat Biotechnol
, vol.29
, pp. 731-734
-
-
Hockemeyer, D.1
Wang, H.2
Kiani, S.3
Lai, C.S.4
Gao, Q.5
Cassady, J.P.6
Cost, G.J.7
Zhang, L.8
Santiago, Y.9
Miller, J.C.10
Zeitler, B.11
Cherone, J.M.12
Meng, X.13
Hinkley, S.J.14
Rebar, E.J.15
Gregory, P.D.16
Urnov, F.D.17
Jaenisch, R.18
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