Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Prot, Jean Matthieu ^a   Briffaut, Anne Sophie ^a   Letourneur, Franck ^b   Chafey, Philippe ^b   Merlier, Franck ^a   Grandvalet, Yves ^a   Legallais, Cécile ^a   Leclerc, Eric ^a  

^a UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^b INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PARACETAMOL; TRANSCRIPTION FACTOR NRF2; ANALGESIC AGENT; TRANSCRIPTOME;

ARTICLE; BIOCHIP; CALCIUM METABOLISM; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; CYTOSKELETON; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; DRUG METABOLISM; FUNCTIONAL PROTEOMICS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; INTERMETHOD COMPARISON; LIPID METABOLISM; LIVER CELL; LIVER TOXICITY; MICROFLUIDIC BIOCHIP; MICROFLUIDICS; TOXICOGENETICS; TRANSCRIPTOMICS; APOPTOSIS; CELL CYCLE; CELL CYCLE S PHASE; CELL STRAIN HEPG2; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; INSTRUMENTATION; LIVER; METABOLISM; METHODOLOGY; MICROFLUIDIC ANALYSIS; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROTEOMICS; TOXIC HEPATITIS; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL PROLIFERATION; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; HEP G2 CELLS; HUMANS; LIVER; MICROFLUIDIC ANALYTICAL TECHNIQUES; PRINCIPAL COMPONENT ANALYSIS; PROTEOMICS; S PHASE; TRANSCRIPTOME; TWO-DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

EID: 79961194518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021268     Document Type: Article

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