'Human-on-a-chip' developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?

Alternatives to Laboratory Animals

Volumn 40, Issue 5, 2012, Pages 235-257

  Marx, Uwe ^a   Walles, Heike ^b   Hoffmann, Silke ^a   Lindner, Gerd ^a   Horland, Reyk ^a   Sonntag, Frank ^c   Klotzbach, Udo ^c   Sakharov, Dmitry ^d   Tonevitsky, Alexander ^e   Lauster, Roland ^a  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c FRAUNHOFER INSTITUTE FOR MATERIAL AND BEAM TECHNOLOGY IWS   (Germany)

^d Scientific Research Center Bioclinicum (SRC Bioclinicum)   (Russian Federation)

^e MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

3 D culture; Dynamic bioreactors; Microfluidics; Microsystems; Organ on a chip; Toxicity pathway

Indexed keywords

ADENOVIRUS VECTOR; CHLORPHENOTANE; DIOXIN; DOXORUBICIN; ORNITHINE CARBAMOYLTRANSFERASE; POLYCHLORINATED BIPHENYL; ROFECOXIB; TEGAFUR; TGN 1412; THALIDOMIDE;

ADULT STEM CELL; ANIMAL WELFARE; ARTICLE; CARCINOMA CELL; COMPUTER MODEL; DEVICE SAFETY; DRUG INDUSTRY; EMBRYONIC STEM CELL; EMBRYOTOXICITY; EPITHELIAL MESENCHYMAL TRANSITION; EXPERIMENTAL ANIMAL; EYE IRRITATION; GENE THERAPY; GOVERNMENT; HAZARD ASSESSMENT; HOMEOSTASIS; HUMAN; HUMAN ON A CHIP; IMMUNOGENICITY; IN VITRO STUDY; INTESTINE ABSORPTION; LAB ON A CHIP; LIVER CELL; LIVER METABOLISM; MECHANICAL STRESS; MICROELECTROMECHANICAL SYSTEM; MICROTECHNOLOGY; MULTIPLE ORGAN FAILURE; NONHUMAN; ORGAN ON A CHIP; ORGANOGENESIS; ORNITHINE TRANSCARBAMYLASE DEFICIENCY; PHYLOGENY; PRIORITY JOURNAL; RISK; RISK ASSESSMENT; RISK MANAGEMENT; SHEAR STRESS; STEM CELL NICHE; TISSUE ENGINEERING; TOXICITY TESTING; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION; VIRAL GENE DELIVERY SYSTEM;

EID: 84873579795     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291204000504     Document Type: Article

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