High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition

Biosensors and Bioelectronics

Volumn 67, Issue , 2015, Pages 146-153

  Hu, Ning ^a   Wang, Tianxing ^a   Wang, Qin ^a   Zhou, Jie ^a   Zou, Ling ^a   Su, Kaiqi ^a   Wu, Jieying ^b   Wang, Ping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ACEA BIO (Hangzhou) Co Ltd   (China)

Author keywords

Beating pattern function; Drug cardiotoxicity assessment; HERG inhibitor recognition; Human iPSC CM based biosensor array; Impedance detection technology

Indexed keywords

STEM CELLS; THROUGHPUT;

BIOSENSOR ARRAYS; BIOTECHNOLOGY INDUSTRY; CARDIOTOXICITY; HERG INHIBITOR RECOGNITION; HIGH THROUGHPUT; HUMAN-INDUCED PLURIPOTENT STEM CELLS; IMPEDANCE DETECTION; IMPEDANCE SENSOR ARRAYS;

BIOSENSORS;

ASTEMIZOLE; CISAPRIDE; DROPERIDOL; POTASSIUM CHANNEL HERG; SERTINDOLE; ERG1 POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ARTICLE; BIOSENSOR; CARDIOTOXICITY; CELL GROWTH; CONTROLLED STUDY; HEART MUSCLE CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMPEDANCE; MOLECULAR RECOGNITION; PATCH CLAMP TECHNIQUE; PLURIPOTENT STEM CELL; PROCESS DESIGN; ANTAGONISTS AND INHIBITORS; BIOASSAY; CELL CULTURE; CELL DIFFERENTIATION; CONDUCTOMETRY; CYTOLOGY; DEVICE FAILURE ANALYSIS; DEVICES; DRUG EFFECTS; EQUIPMENT DESIGN; GENETIC PROCEDURES; HEART RATE; PHYSIOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BIOLOGICAL ASSAY; BIOSENSING TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CONDUCTOMETRY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART RATE; HUMANS; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; POTASSIUM CHANNEL BLOCKERS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84922273996     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2014.07.080     Document Type: Article

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