Quantitative analysis of CNS axon regeneration using a microfluidic neuron culture device

Biochip Journal

Volumn 2, Issue 1, 2008, Pages 44-51

  Park, Jeong Won ^a,c   Vahidi, Behrad ^a   Kim, Hyung Joon ^a   Rhee, Seog Woo ^b   Jeon, Noo Li ^a  

^a University of California at Irvine   (United States)

^b Kongju National University   (South Korea)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Cortical neurons; MAG; Microfluidics; Nogo

Indexed keywords

EID: 70449088618     PISSN: 19760280     EISSN: 20927843     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Schwab, M.E. & Bartholdi, D. Degeneration and regeneration of axons in the lesioned spinal cord. Phyisol. Rev. 76, 319-70 (1996).
2. Fitch, M.T. & Silver, J. Beyond the glial scar, in CNS regeneration. Tuszynski, M.H., and Kordower J.H., Editors. Academic press: San Diego, 55-88 (1999).
3. Filbin, M.T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat. Rev. Neurosci. 4, 703-13 (2003).
4. Raper, J.A. & Kapfhammer, J.P. The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain. Neuron 2, 21-29 (1990).
5. GrandPre, T., Nakamura, F., Vartanian, T. & Strittmatter, S.M. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 23, 1416-1432 (2000).
6. Huber, A.B. & Schwab, M.E. Nogo-A, a protein inhibitor of neurite outgrowth and regeneration. Biol. Chem. 381, 407-419 (2000).
7. Prinjha, R. et al. Inhibitor of neurite outgrowth in humans. Nature 403, 383-384 (2000).
8. McKerracher, L. et al. Identification of myelin-associated gylcoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13, 805-811 (1994).
9. Mukhopadhy, G., Doherty, P., Walsh, F.S., Crocker, P.R. & Filbin, M.T. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767 (1994).
10. Wang, K.C. et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941-944 (2002a).
11. Quilty, M.C., Gai, W.P., Pountney, D.L., West, A.K. & Vickers, J.C. Localization of alpha-, beta-, and gamma-synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma. Exp. Neurol. 182, 195-207 (2003).
12. Mandolesi, G., Madeddu, F., Bozzi, Y., Maffei, L. & Ratto, G.M. Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity. FASEB J. 18, 1934-1936 (2004).
13. Fayaz, I. & Tator, C.H. Modeling axonal injury in vitro: injury and regeneration following acute neuritic trauma. J. Neurosci. Methods. 102, 69-79 (2000).
14. Campenot, R.B. Development of sympathetic neurons in compartmentalized cultures. II. Local control of neurite survival by nerve growth factor. Dev. Biol. 93, 1-12 (1982).
15. Taylor, A.M. et al. Microfluidic Multicompartment Device for Neuroscience Research. Langmuir 19, 1551-1556 (2003).
16. Taylor, A.M. et al. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat. Methods 2, 599-605 (2005).
17. Fournier, A.E., GrandPre, T. & Strittmatter, S.M. Identification of a receptor mediating NOGO-66 inhibition of axonal regeneration. Nature 409, 341-346 (2001).
18. Domeniconi, M. et al. Myelin-associated glycoprotein interacts with the Nogo-66 receptor to inhibit neurite outgrowth. Neuron. 35, 283-290 (2002).
19. Liu, B.P., Fournier, A., GrandPre, T. & Strittmatter, S.M. Myelin-associated glycoprotein as a functional ligand for the NOGO-66 receptor. Science 297, 1190-1193 (2002).
20. Wang, K.C., Kim, J., Sivasankaran, R., Segal, R. & He, Z. P75 interacts with the Nogo receptor as a co- receptor for Nogo, MAG and OMgp. Nature 420, 74-78 (2002b).
21. Shewan, D., Berry, M. & Cohen, J. Extensive regeneration in vitro by early embryonic neurons on immature and adult CNS tissue. J. Neurosci. 15, 2057-2062 (1995).
22. Bandtlow, C.E. Regeneration in the central nervous system. Exp. Gerontol. 38, 79-86 (2003).
23. Al Halabiah, H.A., Delezoide, A.L., Cardona, A., Moalic, J.M. & Simonneau, M. Expression pattern of NOGO and NgR genes during human development. Gene Expr. Patterns. 5, 561-568 (2005).
24. Schwab, J.M., Failli, V. & Chedotal, A. Injury-related dynamic myelin/oligodendrocyte axon-outgrowth inhibition in the central nervous system. Lancet. 365, 2055-2057 (2005).
25. Duffy, D.C., McDonald, J.C., Schueller, OJ. A. & Whitesides, G.M. Rapid prototyping of microfluidic systems in poly (dimethylsiloxane. Anal. Chem. 70, 4974-4984 (1998).
26. Ivins, K.J., Bui, E.T. & Cotman, C.W. Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neurite apoptosis. Neurobiol. Dis. 5, 365-378 (1998).
27. Park, J.W., Vahidi, B., Taylor, A.M., Rhee, S.W. & Jeon, N.L. Microfluidic culture platform for neuroscience research. Nat. Protoc. 1, 2128-2136 (2006).