메뉴 건너뛰기




Volumn 17, Issue 12, 2016, Pages

Cell death in Chondrocytes, osteoblasts, and osteocytes

Author keywords

Apoptosis; ATP; BCLXL; DAMPs; FoxO; Necrosis; Osteoarthritis; P53; Rankl; Rb

Indexed keywords

BCL2 RELATED PROTEIN A1; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; GLUCOCORTICOID; PARATHYROID HORMONE; PROTEIN BCL XL; PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR RUNX3; ALARMIN;

EID: 85005952109     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17122045     Document Type: Review
Times cited : (140)

References (122)
  • 1
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • Yoshida, C.A., Yamamoto, H., Fujita, T., Furuichi, T., Ito, K., Inoue, K., Yamana, K., Zanma, A., Takada, K., Ito, Y., et al. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004, 18, 952-963. [CrossRef] [PubMed]
    • (2004) Genes Dev , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5    Inoue, K.6    Yamana, K.7    Zanma, A.8    Takada, K.9    Ito, Y.10
  • 3
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., Hammerschmidt, M., McMahon, A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999, 13, 2072-2086. [CrossRef] [PubMed]
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 5
    • 4043062888 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway
    • Li, T.F., Dong, Y., Ionescu, A.M., Rosier, R.N., Zuscik, M.J., Schwarz, E.M., O’Keefe, R.J., Drissi, H. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp. Cell Res. 2004, 299, 128-136. [CrossRef] [PubMed]
    • (2004) Exp. Cell Res , vol.299 , pp. 128-136
    • Li, T.F.1    Dong, Y.2    Ionescu, A.M.3    Rosier, R.N.4    Zuscik, M.J.5    Schwarz, E.M.6    O’Keefe, R.J.7    Drissi, H.8
  • 6
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M., Tabin, C.J. Regulation of rate of cartilage differentiation by indian hedgehog and PTH-related protein. Science 1996, 273, 613-622. [CrossRef] [PubMed]
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 8
    • 0034914814 scopus 로고    scopus 로고
    • Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
    • Zelzer, E., Glotzer, D.J., Hartmann, C., Thomas, D., Fukai, N., Soker, S., Olsen, B.R. Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech. Dev. 2001, 106, 97-106. [CrossRef]
    • (2001) Mech. Dev , vol.106 , pp. 97-106
    • Zelzer, E.1    Glotzer, D.J.2    Hartmann, C.3    Thomas, D.4    Fukai, N.5    Soker, S.6    Olsen, B.R.7
  • 9
    • 72449129934 scopus 로고    scopus 로고
    • Regulation of bone development and extracellular matrix protein genes by Runx2
    • Komori, T. Regulation of bone development and extracellular matrix protein genes by Runx2. Cell Tissue Res. 2010, 339, 189-195. [CrossRef] [PubMed]
    • (2010) Cell Tissue Res , vol.339 , pp. 189-195
    • Komori, T.1
  • 10
    • 84906319227 scopus 로고    scopus 로고
    • Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
    • Yang, L., Tsang, K.Y., Tang, H.C., Chan, D., Cheah, K.S. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc. Natl. Acad. Sci. USA 2014, 111, 12097-12102. [CrossRef] [PubMed]
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 12097-12102
    • Yang, L.1    Tsang, K.Y.2    Tang, H.C.3    Chan, D.4    Cheah, K.S.5
  • 11
    • 84919667212 scopus 로고    scopus 로고
    • Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice
    • Zhou, X., von der Mark, K., Henry, S., Norton, W., Adams, H., de Crombrugghe, B. Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice. PLoS Genet. 2014, 10, e1004820. [CrossRef] [PubMed]
    • (2014) Plos Genet , vol.10
    • Zhou, X.1    Von Der Mark, K.2    Henry, S.3    Norton, W.4    Adams, H.5    De Crombrugghe, B.6
  • 12
    • 25444483052 scopus 로고    scopus 로고
    • Revisiting the “Cdk-centric” view of the mammalian cell cycle
    • Malumbres, M. Revisiting the “Cdk-centric” view of the mammalian cell cycle. Cell Cycle 2005, 4, 206-210. [CrossRef] [PubMed]
    • (2005) Cell Cycle , vol.4 , pp. 206-210
    • Malumbres, M.1
  • 14
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X.M., Karp, S., Yang, Y., McMahon, A.P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 2001, 128, 5099-5108. [PubMed]
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 15
    • 0037347909 scopus 로고    scopus 로고
    • Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    • Yang, Y., Topol, L., Lee, H., Wu, J. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 2003, 130, 1003-1015. [CrossRef] [PubMed]
    • (2003) Development , vol.130 , pp. 1003-1015
    • Yang, Y.1    Topol, L.2    Lee, H.3    Wu, J.4
  • 17
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl, V., Stamp, G., Andrews, A., Rosewell, I., Dickson, C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 1995, 9, 2364-2372. [CrossRef] [PubMed]
    • (1995) Genes Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Rews, A.3    Rosewell, I.4    Dickson, C.5
  • 20
    • 0036308935 scopus 로고    scopus 로고
    • P107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development
    • Rossi, F., MacLean, H.E., Yuan, W., Francis, R.O., Semenova, E., Lin, C.S., Kronenberg, H.M., Cobrinik, D. p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev. Biol. 2002, 247, 271-285. [CrossRef] [PubMed]
    • (2002) Dev. Biol , vol.247 , pp. 271-285
    • Rossi, F.1    Maclean, H.E.2    Yuan, W.3    Francis, R.O.4    Semenova, E.5    Lin, C.S.6    Kronenberg, H.M.7    Cobrinik, D.8
  • 21
    • 84897968837 scopus 로고    scopus 로고
    • Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation
    • Ito, K., Maruyama, Z., Sakai, A., Izumi, S., Moriishi, T., Yoshida, C.A., Miyazaki, T., Komori, H., Takada, K., Kawaguchi, H., et al. Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation. Oncogene 2013, 33, 1862-1871. [CrossRef] [PubMed]
    • (2013) Oncogene , vol.33 , pp. 1862-1871
    • Ito, K.1    Maruyama, Z.2    Sakai, A.3    Izumi, S.4    Moriishi, T.5    Yoshida, C.A.6    Miyazaki, T.7    Komori, H.8    Takada, K.9    Kawaguchi, H.10
  • 22
    • 0028243879 scopus 로고
    • Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    • Wang, T.C., Cardiff, R.D., Zukerberg, L., Lees, E., Arnold, A., Schmidt, E.V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 1994, 369, 669-671. [CrossRef] [PubMed]
    • (1994) Nature , vol.369 , pp. 669-671
    • Wang, T.C.1    Cardiff, R.D.2    Zukerberg, L.3    Lees, E.4    Arnold, A.5    Schmidt, E.V.6
  • 23
    • 0031454664 scopus 로고    scopus 로고
    • A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities
    • Mueller, A., Odze, R., Jenkins, T.D., Shahsesfaei, A., Nakagawa, H., Inomoto, T., Rustgi, A.K. A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities. Cancer Res. 1997, 57, 5542-5549. [PubMed]
    • (1997) Cancer Res , vol.57 , pp. 5542-5549
    • Mueller, A.1    Odze, R.2    Jenkins, T.D.3    Shahsesfaei, A.4    Nakagawa, H.5    Inomoto, T.6    Rustgi, A.K.7
  • 24
    • 0029054133 scopus 로고
    • Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins
    • Zhu, L., Xie, E., Chang, L.S. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol. 1995, 15, 3552-3562. [CrossRef] [PubMed]
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3552-3562
    • Zhu, L.1    Xie, E.2    Chang, L.S.3
  • 25
    • 77954157980 scopus 로고    scopus 로고
    • Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions
    • Burkhart, D.L., Wirt, S.E., Zmoos, A.F., Kareta, M.S., Sage, J. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010, 6, e1001003. [CrossRef] [PubMed]
    • (2010) Plos Genet , vol.6
    • Burkhart, D.L.1    Wirt, S.E.2    Zmoos, A.F.3    Kareta, M.S.4    Sage, J.5
  • 26
    • 15444353328 scopus 로고    scopus 로고
    • PRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
    • Hurford, R.K., Jr., Cobrinik, D., Lee, M.H., Dyson, N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 1997, 11, 1447-1463. [CrossRef] [PubMed]
    • (1997) Genes Dev , vol.11 , pp. 1447-1463
    • Hurford, R.K.1    Cobrinik, D.2    Lee, M.H.3    Dyson, N.4
  • 27
    • 84885183132 scopus 로고    scopus 로고
    • Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation
    • Landman, A.S., Danielian, P.S., Lees, J.A. Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation. Oncogene 2012, 32, 4798-4805. [CrossRef] [PubMed]
    • (2012) Oncogene , vol.32 , pp. 4798-4805
    • Landman, A.S.1    Danielian, P.S.2    Lees, J.A.3
  • 28
    • 84880408475 scopus 로고    scopus 로고
    • Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates
    • Komori, T. Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates. Cell Cycle 2013, 12, 2161-2162. [CrossRef] [PubMed]
    • (2013) Cell Cycle , vol.12 , pp. 2161-2162
    • Komori, T.1
  • 29
    • 0037184608 scopus 로고    scopus 로고
    • G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression
    • Calbo, J., Parreno, M., Sotillo, E., Yong, T., Mazo, A., Garriga, J., Grana, X. G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. J. Biol. Chem. 2002, 277, 50263-50274. [CrossRef] [PubMed]
    • (2002) J. Biol. Chem , vol.277 , pp. 50263-50274
    • Calbo, J.1    Parreno, M.2    Sotillo, E.3    Yong, T.4    Mazo, A.5    Garriga, J.6    Grana, X.7
  • 30
    • 84926363933 scopus 로고    scopus 로고
    • Emerging regulators of the inflammatory process in osteoarthritis
    • Liu-Bryan, R., Terkeltaub, R. Emerging regulators of the inflammatory process in osteoarthritis. Nat. Rev. Rheumatol. 2015, 11, 35-44. [CrossRef] [PubMed]
    • (2015) Nat. Rev. Rheumatol , vol.11 , pp. 35-44
    • Liu-Bryan, R.1    Terkeltaub, R.2
  • 31
    • 79955141040 scopus 로고    scopus 로고
    • Chondrocyte apoptosis: A cause or consequence of osteoarthritis
    • Zamli, Z., Sharif, M. Chondrocyte apoptosis: A cause or consequence of osteoarthritis? Int. J. Rheum. Dis. 2011, 14, 159-166. [CrossRef] [PubMed]
    • (2011) Int. J. Rheum. Dis , vol.14 , pp. 159-166
    • Zamli, Z.1    Sharif, M.2
  • 33
    • 84880573739 scopus 로고    scopus 로고
    • Functions of the osteocyte network in the regulation of bone mass
    • Komori, T. Functions of the osteocyte network in the regulation of bone mass. Cell Tissue Res. 2013, 352, 191-198. [CrossRef] [PubMed]
    • (2013) Cell Tissue Res , vol.352 , pp. 191-198
    • Komori, T.1
  • 34
    • 3142722961 scopus 로고    scopus 로고
    • Chondroptosis: A variant of apoptotic cell death in chondrocytes?
    • Roach, H.I., Aigner, T., Kouri, J.B. Chondroptosis: A variant of apoptotic cell death in chondrocytes? Apoptosis 2004, 9, 265-277. [CrossRef] [PubMed]
    • (2004) Apoptosis , vol.9 , pp. 265-277
    • Roach, H.I.1    Aigner, T.2    Kouri, J.B.3
  • 35
    • 84995877254 scopus 로고    scopus 로고
    • Glucocorticoid signaling and bone biology
    • Komori, T. Glucocorticoid signaling and bone biology. Horm. Metab. Res. 2016, 48, 755-763. [CrossRef] [PubMed]
    • (2016) Horm. Metab. Res , vol.48 , pp. 755-763
    • Komori, T.1
  • 36
    • 34548488448 scopus 로고    scopus 로고
    • PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate
    • Bohensky, J., Shapiro, I.M., Leshinsky, S., Watanabe, H., Srinivas, V. PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate. J. Cell. Physiol. 2007, 213, 246-251. [CrossRef] [PubMed]
    • (2007) J. Cell. Physiol , vol.213 , pp. 246-251
    • Bohensky, J.1    Shapiro, I.M.2    Leshinsky, S.3    Watanabe, H.4    Srinivas, V.5
  • 38
    • 33846293992 scopus 로고    scopus 로고
    • Chondrocyte death by apoptosis is associated with cartilage matrix degradation
    • Thomas, C.M., Fuller, C.J., Whittles, C.E., Sharif, M. Chondrocyte death by apoptosis is associated with cartilage matrix degradation. Osteoarthr. Cartil. 2007, 15, 27-34. [CrossRef] [PubMed]
    • (2007) Osteoarthr. Cartil , vol.15 , pp. 27-34
    • Thomas, C.M.1    Fuller, C.J.2    Whittles, C.E.3    Sharif, M.4
  • 39
    • 0031658981 scopus 로고    scopus 로고
    • Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis
    • Hashimoto, S., Ochs, R.L., Komiya, S., Lotz, M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum. 1998, 41, 1632-1638. [CrossRef]
    • (1998) Arthritis Rheum , vol.41 , pp. 1632-1638
    • Hashimoto, S.1    Ochs, R.L.2    Komiya, S.3    Lotz, M.4
  • 40
    • 0031886742 scopus 로고    scopus 로고
    • Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology
    • Blanco, F.J., Guitian, R., Vazquez-Martul, E., de Toro, F.J., Galdo, F. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum. 1998, 41, 284-289. [CrossRef]
    • (1998) Arthritis Rheum , vol.41 , pp. 284-289
    • Blanco, F.J.1    Guitian, R.2    Vazquez-Martul, E.3    De Toro, F.J.4    Galdo, F.5
  • 41
    • 1042278739 scopus 로고    scopus 로고
    • Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3
    • Sharif, M., Whitehouse, A., Sharman, P., Perry, M., Adams, M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum. 2004, 50, 507-515. [CrossRef] [PubMed]
    • (2004) Arthritis Rheum , vol.50 , pp. 507-515
    • Sharif, M.1    Whitehouse, A.2    Sharman, P.3    Perry, M.4    Adams, M.5
  • 42
    • 0037523033 scopus 로고    scopus 로고
    • Apoptotic chondrocyte death in human osteoarthritis
    • Kim, H.A., Lee, Y.J., Seong, S.C., Choe, K.W., Song, Y.W. Apoptotic chondrocyte death in human osteoarthritis. J. Rheumatol. 2000, 27, 455-462. [PubMed]
    • (2000) J. Rheumatol , vol.27 , pp. 455-462
    • Kim, H.A.1    Lee, Y.J.2    Seong, S.C.3    Choe, K.W.4    Song, Y.W.5
  • 43
    • 0031837375 scopus 로고    scopus 로고
    • Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis
    • Hashimoto, S., Takahashi, K., Amiel, D., Coutts, R.D., Lotz, M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum. 1998, 41, 1266-1274. [CrossRef]
    • (1998) Arthritis Rheum , vol.41 , pp. 1266-1274
    • Hashimoto, S.1    Takahashi, K.2    Amiel, D.3    Coutts, R.D.4    Lotz, M.5
  • 44
    • 7744229575 scopus 로고    scopus 로고
    • Characterization of mature vs. Aged rabbit articular cartilage: Analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis
    • Todd Allen, R., Robertson, C.M., Harwood, F.L., Sasho, T., Williams, S.K., Pomerleau, A.C., Amiel, D. Characterization of mature vs. aged rabbit articular cartilage: Analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis. Osteoarthr. Cartil. 2004, 12, 917-923. [CrossRef] [PubMed]
    • (2004) Osteoarthr. Cartil , vol.12 , pp. 917-923
    • Todd Allen, R.1    Robertson, C.M.2    Harwood, F.L.3    Sasho, T.4    Williams, S.K.5    Pomerleau, A.C.6    Amiel, D.7
  • 45
    • 0031915678 scopus 로고    scopus 로고
    • Chondrocyte apoptosis increases with age in the articular cartilage of adult animals
    • Adams, C.S., Horton, W.E., Jr. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat. Rec. 1998, 250, 418-425. [CrossRef]
    • (1998) Anat. Rec , vol.250 , pp. 418-425
    • Adams, C.S.1    Horton, W.E.2
  • 46
    • 33745041925 scopus 로고    scopus 로고
    • Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis
    • D’Lima, D., Hermida, J., Hashimoto, S., Colwell, C., Lotz, M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum. 2006, 54, 1814-1821. [CrossRef] [PubMed]
    • (2006) Arthritis Rheum , vol.54 , pp. 1814-1821
    • D’Lima, D.1    Hermida, J.2    Hashimoto, S.3    Colwell, C.4    Lotz, M.5
  • 47
    • 33646859080 scopus 로고    scopus 로고
    • Beneficial effects of intra-articular caspase inhibition therapy following osteochondral injury
    • Dang, A.C., Warren, A.P., Kim, H.T. Beneficial effects of intra-articular caspase inhibition therapy following osteochondral injury. Osteoarthr. Cartil. 2006, 14, 526-532. [CrossRef] [PubMed]
    • (2006) Osteoarthr. Cartil , vol.14 , pp. 526-532
    • Dang, A.C.1    Warren, A.P.2    Kim, H.T.3
  • 48
    • 84987776649 scopus 로고    scopus 로고
    • Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis
    • Zhang, M., Mani, S.B., He, Y., Hall, A.M., Xu, L., Li, Y., Zurakowski, D., Jay, G.D., Warman, M.L. Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. J. Clin. Investig. 2016, 126, 2893-2902. [CrossRef] [PubMed]
    • (2016) J. Clin. Investig , vol.126 , pp. 2893-2902
    • Zhang, M.1    Mani, S.B.2    He, Y.3    Hall, A.M.4    Xu, L.5    Li, Y.6    Zurakowski, D.7    Jay, G.D.8    Warman, M.L.9
  • 49
    • 44949140678 scopus 로고    scopus 로고
    • Cell death in osteoarthritis
    • Del Carlo, M., Jr., Loeser, R.F. Cell death in osteoarthritis. Curr. Rheumatol. Rep. 2008, 10, 37-42. [CrossRef] [PubMed]
    • (2008) Curr. Rheumatol. Rep , vol.10 , pp. 37-42
    • Del Carlo, M.1    Loeser, R.F.2
  • 50
    • 0034897419 scopus 로고    scopus 로고
    • How severe must repetitive loading be to kill chondrocytes in articular cartilage?
    • Clements, K.M., Bee, Z.C., Crossingham, G.V., Adams, M.A., Sharif, M. How severe must repetitive loading be to kill chondrocytes in articular cartilage? Osteoarthr. Cartil. 2001, 9, 499-507. [CrossRef] [PubMed]
    • (2001) Osteoarthr. Cartil , vol.9 , pp. 499-507
    • Clements, K.M.1    Bee, Z.C.2    Crossingham, G.V.3    Adams, M.A.4    Sharif, M.5
  • 51
    • 0035173327 scopus 로고    scopus 로고
    • Human chondrocyte apoptosis in response to mechanical injury. Osteoarthr
    • D’Lima, D.D., Hashimoto, S., Chen, P.C., Colwell, C.W., Jr., Lotz, M.K. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthr. Cartil. 2001, 9, 712-719. [CrossRef] [PubMed]
    • (2001) Cartil , vol.9 , pp. 712-719
    • D’Lima, D.D.1    Hashimoto, S.2    Chen, P.C.3    Colwell, C.W.4    Lotz, M.K.5
  • 52
    • 7244245657 scopus 로고    scopus 로고
    • Cyclic loading can denature type II collagen in articular cartilage
    • Clements, K.M., Hollander, A.P., Sharif, M., Adams, M.A. Cyclic loading can denature type II collagen in articular cartilage. Connect. Tissue Res. 2004, 45, 174-180. [CrossRef] [PubMed]
    • (2004) Connect. Tissue Res , vol.45 , pp. 174-180
    • Clements, K.M.1    Hollander, A.P.2    Sharif, M.3    Adams, M.A.4
  • 53
    • 0142072319 scopus 로고    scopus 로고
    • Accelerated, aging-dependent development of osteoarthritis in β1 integrin-deficient mice
    • Zemmyo, M., Meharra, E.J., Kuhn, K., Creighton-Achermann, L., Lotz, M. Accelerated, aging-dependent development of osteoarthritis in β1 integrin-deficient mice. Arthritis Rheum. 2003, 48, 2873-2880. [CrossRef] [PubMed]
    • (2003) Arthritis Rheum , vol.48 , pp. 2873-2880
    • Zemmyo, M.1    Meharra, E.J.2    Kuhn, K.3    Creighton-Achermann, L.4    Lotz, M.5
  • 54
    • 0031572309 scopus 로고    scopus 로고
    • Apoptosis of chondrocytes in transgenic mice lacking collagen II
    • Yang, C., Li, S.W., Helminen, H.J., Khillan, J.S., Bao, Y., Prockop, D.J. Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp. Cell Res. 1997, 235, 370-373. [CrossRef] [PubMed]
    • (1997) Exp. Cell Res , vol.235 , pp. 370-373
    • Yang, C.1    Li, S.W.2    Helminen, H.J.3    Khillan, J.S.4    Bao, Y.5    Prockop, D.J.6
  • 57
    • 0033939459 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization
    • Johnson, K., Jung, A., Murphy, A., Andreyev, A., Dykens, J., Terkeltaub, R. Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum. 2000, 43, 1560-1570. [CrossRef]
    • (2000) Arthritis Rheum , vol.43 , pp. 1560-1570
    • Johnson, K.1    Jung, A.2    Murphy, A.3    Reyev, A.4    Dykens, J.5    Terkeltaub, R.6
  • 58
    • 79952451523 scopus 로고    scopus 로고
    • The role of mitochondria in osteoarthritis. Nat
    • Blanco, F.J., Rego, I., Ruiz-Romero, C. The role of mitochondria in osteoarthritis. Nat. Rev. Rheumatol. 2011, 7, 161-169. [CrossRef] [PubMed]
    • (2011) Rev. Rheumatol , vol.7 , pp. 161-169
    • Blanco, F.J.1    Rego, I.2    Ruiz-Romero, C.3
  • 59
    • 0347088927 scopus 로고    scopus 로고
    • Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression
    • Kurz, B., Lemke, A., Kehn, M., Domm, C., Patwari, P., Frank, E.H., Grodzinsky, A.J., Schunke, M. Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum. 2004, 50, 123-130. [CrossRef] [PubMed]
    • (2004) Arthritis Rheum , vol.50 , pp. 123-130
    • Kurz, B.1    Lemke, A.2    Kehn, M.3    Domm, C.4    Patwari, P.5    Frank, E.H.6    Grodzinsky, A.J.7    Schunke, M.8
  • 61
    • 33645452703 scopus 로고    scopus 로고
    • Chondrocyte cell death mediated by reactive oxygen species-dependent activation of pkc-betai
    • DelCarlo, M., Loeser, R.F. Chondrocyte cell death mediated by reactive oxygen species-dependent activation of pkc-betai. Am. J. Physiol. Cell physiol. 2006, 290, 802-811. [CrossRef] [PubMed]
    • (2006) Am. J. Physiol. Cell Physiol , vol.290 , pp. 802-811
    • Delcarlo, M.1    Loeser, R.F.2
  • 64
    • 84903773914 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein
    • Uehara, Y., Hirose, J., Yamabe, S., Okamoto, N., Okada, T., Oyadomari, S., Mizuta, H. Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein. Osteoarthr. Cartil. 2014, 22, 1007-1017. [CrossRef] [PubMed]
    • (2014) Osteoarthr. Cartil , vol.22 , pp. 1007-1017
    • Uehara, Y.1    Hirose, J.2    Yamabe, S.3    Okamoto, N.4    Okada, T.5    Oyadomari, S.6    Mizuta, H.7
  • 66
    • 77951717549 scopus 로고    scopus 로고
    • SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    • Gagarina, V., Gabay, O., Dvir-Ginzberg, M., Lee, E.J., Brady, J.K., Quon, M.J., Hall, D.J. SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum. 2010, 62, 1383-1392. [CrossRef] [PubMed]
    • (2010) Arthritis Rheum , vol.62 , pp. 1383-1392
    • Gagarina, V.1    Gabay, O.2    Dvir-Ginzberg, M.3    Lee, E.J.4    Brady, J.K.5    Quon, M.J.6    Hall, D.J.7
  • 67
    • 85027953113 scopus 로고    scopus 로고
    • Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice
    • Gabay, O., Oppenhiemer, H., Meir, H., Zaal, K., Sanchez, C., Dvir-Ginzberg, M. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice. Ann. Rheum. Dis. 2012, 71, 613-616. [CrossRef] [PubMed]
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 613-616
    • Gabay, O.1    Oppenhiemer, H.2    Meir, H.3    Zaal, K.4    Sanchez, C.5    Dvir-Ginzberg, M.6
  • 68
    • 1642546419 scopus 로고    scopus 로고
    • Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength
    • O’Brien, C.A., Jia, D., Plotkin, L.I., Bellido, T., Powers, C.C., Stewart, S.A., Manolagas, S.C., Weinstein, R.S. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 2004, 145, 1835-1841. [CrossRef] [PubMed]
    • (2004) Endocrinology , vol.145 , pp. 1835-1841
    • O’Brien, C.A.1    Jia, D.2    Plotkin, L.I.3    Bellido, T.4    Powers, C.C.5    Stewart, S.A.6    Manolagas, S.C.7    Weinstein, R.S.8
  • 70
    • 18144452145 scopus 로고    scopus 로고
    • In vivo regulation of apoptosis in metaphyseal trabecular bone of young rats by synthetic human parathyroid hormone (1-34) fragment
    • Stanislaus, D., Yang, X., Liang, J.D., Wolfe, J., Cain, R.L., Onyia, J.E., Falla, N., Marder, P., Bidwell, J.P., Queener, S.W., et al. In vivo regulation of apoptosis in metaphyseal trabecular bone of young rats by synthetic human parathyroid hormone (1-34) fragment. Bone 2000, 27, 209-218. [CrossRef]
    • (2000) Bone , vol.27 , pp. 209-218
    • Stanislaus, D.1    Yang, X.2    Liang, J.D.3    Wolfe, J.4    Cain, R.L.5    Onyia, J.E.6    Falla, N.7    Marder, P.8    Bidwell, J.P.9    Queener, S.W.10
  • 71
    • 0033303829 scopus 로고    scopus 로고
    • Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro
    • Gohel, A., McCarthy, M.B., Gronowicz, G. Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro. Endocrinology 1999, 140, 5339-5347. [CrossRef] [PubMed]
    • (1999) Endocrinology , vol.140 , pp. 5339-5347
    • Gohel, A.1    McCarthy, M.B.2    Gronowicz, G.3
  • 72
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    • Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J. Clin. Investig. 1998, 102, 274-282. [CrossRef] [PubMed]
    • (1998) J. Clin. Investig , vol.102 , pp. 274-282
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 75
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
    • Tomkinson, A., Reeve, J., Shaw, R.W., Noble, B.S. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J. Clin. Endocrinol. Metab. 1997, 82, 3128-3135. [CrossRef] [PubMed]
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 3128-3135
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 76
    • 84977547580 scopus 로고    scopus 로고
    • Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength
    • Moriishi, T., Fukuyama, R., Miyazaki, T., Furuichi, T., Ito, M., Komori, T. Overexpression of BCLXL in osteoblasts inhibits osteoblast apoptosis and increases bone volume and strength. J. Bone Miner. Res. 2016, 31, 1366-1380. [CrossRef] [PubMed]
    • (2016) J. Bone Miner. Res , vol.31 , pp. 1366-1380
    • Moriishi, T.1    Fukuyama, R.2    Miyazaki, T.3    Furuichi, T.4    Ito, M.5    Komori, T.6
  • 77
    • 84890899395 scopus 로고    scopus 로고
    • Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age
    • Jilka, R.L., O’Brien, C.A., Roberson, P.K., Bonewald, L.F., Weinstein, R.S., Manolagas, S.C. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age. J. Bone Miner. Res. 2014, 29, 103-117. [CrossRef] [PubMed]
    • (2014) J. Bone Miner. Res. , vol.29 , pp. 103-117
    • Jilka, R.L.1    O’Brien, C.A.2    Roberson, P.K.3    Bonewald, L.F.4    Weinstein, R.S.5    Manolagas, S.C.6
  • 79
    • 73649107266 scopus 로고    scopus 로고
    • Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts
    • Nagase, Y., Iwasawa, M., Akiyama, T., Kadono, Y., Nakamura, M., Oshima, Y., Yasui, T., Matsumoto, T., Hirose, J., Nakamura, H., et al. Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts. J. Biol. Chem. 2009, 284, 36659-36669. [CrossRef] [PubMed]
    • (2009) J. Biol. Chem , vol.284 , pp. 36659-36669
    • Nagase, Y.1    Iwasawa, M.2    Akiyama, T.3    Kadono, Y.4    Nakamura, M.5    Oshima, Y.6    Yasui, T.7    Matsumoto, T.8    Hirose, J.9    Nakamura, H.10
  • 80
    • 84925224023 scopus 로고    scopus 로고
    • Bcl2 deficiency activates foxo through akt inactivation and accelerates osteoblast differentiation
    • Moriishi, T., Kawai, Y., Komori, H., Rokutanda, S., Eguchi, Y., Tsujimoto, Y., Asahina, I., Komori, T. Bcl2 deficiency activates foxo through akt inactivation and accelerates osteoblast differentiation. PLoS ONE 2014, 9, e86629. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Moriishi, T.1    Kawai, Y.2    Komori, H.3    Rokutanda, S.4    Eguchi, Y.5    Tsujimoto, Y.6    Asahina, I.7    Komori, T.8
  • 82
    • 77957258122 scopus 로고    scopus 로고
    • Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis
    • Teixeira, C.C., Liu, Y., Thant, L.M., Pang, J., Palmer, G., Alikhani, M. Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J. Biol. Chem. 2010, 285, 31055-31065. [CrossRef] [PubMed]
    • (2010) J. Biol. Chem , vol.285 , pp. 31055-31065
    • Teixeira, C.C.1    Liu, Y.2    Thant, L.M.3    Pang, J.4    Palmer, G.5    Alikhani, M.6
  • 85
    • 80052970809 scopus 로고    scopus 로고
    • FoxO transcription factors, regulation by AKT and 14-3-3 proteins
    • Tzivion, G., Dobson, M., Ramakrishnan, G. FoxO transcription factors, regulation by AKT and 14-3-3 proteins. Biochim. Biophys. Acta 2011, 1813, 1938-1945. [CrossRef] [PubMed]
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1938-1945
    • Tzivion, G.1    Dobson, M.2    Ramakrishnan, G.3
  • 88
    • 0036133378 scopus 로고    scopus 로고
    • Disruption of the p53 gene results in preserved trabecular bone mass and bone formation after mechanical unloading
    • Sakai, A., Sakata, T., Tanaka, S., Okazaki, R., Kunugita, N., Norimura, T., Nakamura, T. Disruption of the p53 gene results in preserved trabecular bone mass and bone formation after mechanical unloading. J. Bone Miner. Res. 2002, 17, 119-127. [CrossRef] [PubMed]
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 119-127
    • Sakai, A.1    Sakata, T.2    Tanaka, S.3    Okazaki, R.4    Kunugita, N.5    Norimura, T.6    Nakamura, T.7
  • 89
    • 1842505620 scopus 로고    scopus 로고
    • Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice
    • Okazaki, R., Sakai, A., Ootsuyama, A., Sakata, T., Nakamura, T., Norimura, T. Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice. Ann. Rheum. Dis. 2004, 63, 453-456. [CrossRef] [PubMed]
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 453-456
    • Okazaki, R.1    Sakai, A.2    Ootsuyama, A.3    Sakata, T.4    Nakamura, T.5    Norimura, T.6
  • 90
    • 29944437296 scopus 로고    scopus 로고
    • P53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
    • Wang, X. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J. Cell Biol. 2006, 172, 115-125. [CrossRef] [PubMed]
    • (2006) J. Cell Biol , vol.172 , pp. 115-125
    • Wang, X.1
  • 91
    • 0032991451 scopus 로고    scopus 로고
    • P53 transactivity during in vitro osteoblast differentiation in a rat osteosarcoma cell line
    • Schwartz, K.A., Lanciloti, N.J., Moore, M.K., Campione, A.L., Chandar, N. p53 transactivity during in vitro osteoblast differentiation in a rat osteosarcoma cell line. Mol. Carcinog. 1999, 25, 132-138. [CrossRef]
    • (1999) Mol. Carcinog , vol.25 , pp. 132-138
    • Schwartz, K.A.1    Lanciloti, N.J.2    Moore, M.K.3    Campione, A.L.4    Chandar, N.5
  • 94
    • 62549143109 scopus 로고    scopus 로고
    • Connexins, pannexins, innexins: Novel roles of “hemi-channels”
    • Scemes, E., Spray, D.C., Meda, P. Connexins, pannexins, innexins: Novel roles of “hemi-channels”. Pflugers Arch. 2009, 457, 1207-1226. [CrossRef] [PubMed]
    • (2009) Pflugers Arch , vol.457 , pp. 1207-1226
    • Scemes, E.1    Spray, D.C.2    Meda, P.3
  • 95
    • 84870054442 scopus 로고    scopus 로고
    • The biochemistry and function of pannexin channels
    • Penuela, S., Gehi, R., Laird, D.W. The biochemistry and function of pannexin channels. Biochim. Biophys. Acta 2013, 1828, 15-22. [CrossRef] [PubMed]
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 15-22
    • Penuela, S.1    Gehi, R.2    Laird, D.W.3
  • 97
    • 3042856490 scopus 로고    scopus 로고
    • ATP P2 receptors and regulation of bone effector cells
    • Gallagher, J.A. ATP P2 receptors and regulation of bone effector cells. J. Musculoskelet. Neuronal Interact. 2004, 4, 125-127. [PubMed]
    • (2004) J. Musculoskelet. Neuronal Interact , vol.4 , pp. 125-127
    • Gallagher, J.A.1
  • 98
    • 0036861712 scopus 로고    scopus 로고
    • Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand
    • Buckley, K.A., Hipskind, R.A., Gartland, A., Bowler, W.B., Gallagher, J.A. Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone 2002, 31, 582-590. [CrossRef]
    • (2002) Bone , vol.31 , pp. 582-590
    • Buckley, K.A.1    Hipskind, R.A.2    Gartland, A.3    Bowler, W.B.4    Gallagher, J.A.5
  • 99
    • 20444458308 scopus 로고    scopus 로고
    • P2Y6 nucleotide receptors activate NF
    • Korcok, J., Raimundo, L.N., Du, X., Sims, S.M., Dixon, S.J. P2Y6 nucleotide receptors activate NF-βB and increase survival of osteoclasts. J. Biol. Chem. 2005, 280, 16909-16915. [CrossRef] [PubMed]
    • (2005) J. Biol. Chem , vol.280 , pp. 16909-16915
    • Korcok, J.1    Raimundo, L.N.2    Du, X.3    Sims, S.M.4    Dixon, S.J.5
  • 100
    • 80053475754 scopus 로고    scopus 로고
    • The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF
    • Lemaire, I., Falzoni, S., Zhang, B., Pellegatti, P., di Virgilio, F. The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF. J. Immunol. 2011, 187, 3878-3887. [CrossRef] [PubMed]
    • (2011) J. Immunol , vol.187 , pp. 3878-3887
    • Lemaire, I.1    Falzoni, S.2    Zhang, B.3    Pellegatti, P.4    Di Virgilio, F.5
  • 102
    • 0033977796 scopus 로고    scopus 로고
    • Osteocyte function, osteocyte death and bone fracture resistance
    • Noble, B.S., Reeve, J. Osteocyte function, osteocyte death and bone fracture resistance. Mol. Cell. Endocrinol. 2000, 159, 7-13. [CrossRef]
    • (2000) Mol. Cell. Endocrinol , vol.159 , pp. 7-13
    • Noble, B.S.1    Reeve, J.2
  • 103
    • 65549087003 scopus 로고    scopus 로고
    • Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue
    • Cardoso, L., Herman, B.C., Verborgt, O., Laudier, D., Majeska, R.J., Schaffler, M.B. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J. Bone Miner. Res. 2009, 24, 597-605. [CrossRef] [PubMed]
    • (2009) J. Bone Miner. Res , vol.24 , pp. 597-605
    • Cardoso, L.1    Herman, B.C.2    Verborgt, O.3    Laudier, D.4    Majeska, R.J.5    Schaffler, M.B.6
  • 105
    • 0033981552 scopus 로고    scopus 로고
    • Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo
    • Verborgt, O., Gibson, G.J., Schaffler, M.B. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J. Bone Miner. Res. 2000, 15, 60-67. [CrossRef] [PubMed]
    • (2000) J. Bone Miner. Res , vol.15 , pp. 60-67
    • Verborgt, O.1    Gibson, G.J.2    Schaffler, M.B.3
  • 106
    • 3042793422 scopus 로고    scopus 로고
    • Bone microdamage and cell apoptosis
    • Noble, B. Bone microdamage and cell apoptosis. Eur. Cells Mater. 2003, 6, 46-55, discusssion 55. [PubMed]
    • (2003) Eur. Cells Mater , vol.6 , pp. 46-55
    • Noble, B.1
  • 108
    • 0034948738 scopus 로고    scopus 로고
    • The autophagosomal-lysosomal compartment in programmed cell death
    • Bursch, W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ. 2001, 8, 569-581. [CrossRef] [PubMed]
    • (2001) Cell Death Differ , vol.8 , pp. 569-581
    • Bursch, W.1
  • 109
    • 84899135231 scopus 로고    scopus 로고
    • Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo
    • Kennedy, O.D., Laudier, D.M., Majeska, R.J., Sun, H.B., Schaffler, M.B. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone 2014, 64, 132-137. [CrossRef] [PubMed]
    • (2014) Bone , vol.64 , pp. 132-137
    • Kennedy, O.D.1    Laudier, D.M.2    Majeska, R.J.3    Sun, H.B.4    Schaffler, M.B.5
  • 111
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong, W.X. Necrotic death as a cell fate. Genes Dev. 2006, 20, 1-15. [CrossRef] [PubMed]
    • (2006) Genes Dev , vol.20 , pp. 1-15
    • Zong, W.X.1
  • 112
    • 2942700201 scopus 로고    scopus 로고
    • High mobility group box protein 1: An endogenous signal for dendritic cell maturation and Th1 polarization
    • Messmer, D., Yang, H., Telusma, G., Knoll, F., Li, J., Messmer, B., Tracey, K.J., Chiorazzi, N. High mobility group box protein 1: An endogenous signal for dendritic cell maturation and Th1 polarization. J. Immunol. 2004, 173, 307-313. [CrossRef] [PubMed]
    • (2004) J. Immunol , vol.173 , pp. 307-313
    • Messmer, D.1    Yang, H.2    Telusma, G.3    Knoll, F.4    Li, J.5    Messmer, B.6    Tracey, K.J.7    Chiorazzi, N.8
  • 113
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park, J.S., Svetkauskaite, D., He, Q., Kim, J.Y., Strassheim, D., Ishizaka, A., Abraham, E. Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 2004, 279, 7370-7377. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 114
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze, M.T., Tracey, K.J. High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat. Rev. Immunol. 2005, 5, 331-342. [CrossRef] [PubMed]
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 115
    • 84882785076 scopus 로고    scopus 로고
    • RAGE and TLRs: Relatives, friends or neighbours?
    • Ibrahim, Z.A., Armour, C.L., Phipps, S., Sukkar, M.B. RAGE and TLRs: Relatives, friends or neighbours? Mol. Immunol. 2013, 56, 739-744. [CrossRef] [PubMed]
    • (2013) Mol. Immunol , vol.56 , pp. 739-744
    • Ibrahim, Z.A.1    Armour, C.L.2    Phipps, S.3    Sukkar, M.B.4
  • 116
    • 77950537989 scopus 로고    scopus 로고
    • Control of RANKL gene expression
    • O’Brien, C.A. Control of RANKL gene expression. Bone 2010, 46, 911-919. [CrossRef] [PubMed]
    • (2010) Bone , vol.46 , pp. 911-919
    • O’Brien, C.A.1
  • 117
    • 84856160446 scopus 로고    scopus 로고
    • Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
    • Bivi, N., Condon, K.W., Allen, M.R., Farlow, N., Passeri, G., Brun, L.R., Rhee, Y., Bellido, T., Plotkin, L.I. Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation. J. Bone Miner. Res. 2012, 27, 374-389. [CrossRef] [PubMed]
    • (2012) J. Bone Miner. Res , vol.27 , pp. 374-389
    • Bivi, N.1    Condon, K.W.2    Allen, M.R.3    Farlow, N.4    Passeri, G.5    Brun, L.R.6    Rhee, Y.7    Bellido, T.8    Plotkin, L.I.9
  • 119
    • 77950531312 scopus 로고    scopus 로고
    • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization
    • Ke, H., Parron, V.I., Reece, J., Zhang, J.Y., Akiyama, S.K., French, J.E. BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. Cell Res. 2010, 20, 458-469. [CrossRef] [PubMed]
    • (2010) Cell Res , vol.20 , pp. 458-469
    • Ke, H.1    Parron, V.I.2    Reece, J.3    Zhang, J.Y.4    Akiyama, S.K.5    French, J.E.6
  • 120
    • 84863111789 scopus 로고    scopus 로고
    • Osteocyte network, a negative regulatory system for bone mass augmented by the induction of rankl in osteoblasts and sost in osteocytes at unloading
    • Moriishi, T., Fukuyama, R., Ito, M., Miyazaki, T., Maeno, T., Kawai, Y., Komori, H., Komori, T. Osteocyte network, a negative regulatory system for bone mass augmented by the induction of rankl in osteoblasts and sost in osteocytes at unloading. PLoS ONE 2012, 7, e40143. [CrossRef] [PubMed]
    • (2012) Plos ONE , vol.7
    • Moriishi, T.1    Fukuyama, R.2    Ito, M.3    Miyazaki, T.4    Maeno, T.5    Kawai, Y.6    Komori, H.7    Komori, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.