Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

Journal of Bone and Mineral Research

Volumn 31, Issue 4, 2016, Pages 890-899

  Cheung, Wing Yee ^a   Fritton, J Christopher ^b   Morgan, Stacy Ann ^a   Seref Ferlengez, Zeynep ^a   Basta Pljakic, Jelena ^a   Thi, Mia M ^c   Suadicani, Sylvia O ^c   Spray, David C ^c   Majeska, Robert J ^a   Schaffler, Mitchell B ^a  

^a City College of New York   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Bystander Signaling; Fatigue Microdamage; Osteocyte Apoptosis; P2X7 Receptor; Pannexin 1; Rankl

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRILLIANT BLUE; CELL PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PANNEXIN 1; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; GAP JUNCTION PROTEIN; NERVE PROTEIN; PANX1 PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE DEFECT; CELL DAMAGE; CONTROLLED STUDY; CORTICAL BONE; ENZYME RELEASE; FATIGUE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OSTEOCYTE; PROTEIN EXPRESSION; RAT; REPRODUCIBILITY; UPREGULATION; ANIMAL; BYSTANDER EFFECT; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; BYSTANDER EFFECT; CONNEXINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OSTEOCYTES; RANK LIGAND; RATS; RECEPTORS, PURINERGIC P2X7;

EID: 84955088976     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2740     Document Type: Article

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