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Volumn 27, Issue 2, 2012, Pages 374-389

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

Author keywords

APOPTOSIS; BONE RESORPTION; CONNEXIN 43; OSTEOBLAST; OSTEOCYTE; OSTEOPROTEGERIN; PERIOSTEAL BONE FORMATION; SOST SCLEROSTIN

Indexed keywords

CONNEXIN 43; OSTEOPROTEGERIN; SCLEROSTIN;

EID: 84856160446     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.548     Document Type: Article
Times cited : (204)

References (79)
  • 1
    • 84882477144 scopus 로고    scopus 로고
    • The osteocyte
    • Bilezikian J.P. Raisz L.G. Martin T.J. editors. 3rd ed. San Diego, CA: Academic Press
    • Klein-Nulend J, Bonewald LF,. The osteocyte. In:, Bilezikian JP, Raisz LG, Martin TJ, editors. Principles of bone biology 3rd ed. San Diego, CA: Academic Press; 2008. p. 153-74.
    • (2008) Principles of Bone Biology , pp. 153-174
    • Klein-Nulend, J.1    Bonewald, L.F.2
  • 2
    • 77956863339 scopus 로고    scopus 로고
    • Sclerostin: A gem from the genome leads to bone-building antibodies
    • Paszty C, Turner CH, Robinson MK,. Sclerostin: a gem from the genome leads to bone-building antibodies. J Bone Miner Res. 2010; 25: 1897-04.
    • (2010) J Bone Miner Res. , vol.25 , pp. 1897-1894
    • Paszty, C.1    Turner, C.H.2    Robinson, M.K.3
  • 10
    • 34249657953 scopus 로고    scopus 로고
    • Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction
    • DOI 10.1016/j.cmet.2007.05.001, PII S1550413107001283
    • Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K,. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 2007; 5: 464-75. (Pubitemid 46825494)
    • (2007) Cell Metabolism , vol.5 , Issue.6 , pp. 464-475
    • Tatsumi, S.1    Ishii, K.2    Amizuka, N.3    Li, M.4    Kobayashi, T.5    Kohno, K.6    Ito, M.7    Takeshita, S.8    Ikeda, K.9
  • 11
    • 84856156566 scopus 로고    scopus 로고
    • Osteocyte apoptosis induce bone resorption and impairs the skeletal response to weightlessness
    • Bellido T,. Osteocyte apoptosis induce bone resorption and impairs the skeletal response to weightlessness. BoneKEy-osteovision. 2007; 4: 252-6.
    • (2007) BoneKEy-osteovision. , vol.4 , pp. 252-256
    • Bellido, T.1
  • 12
    • 50949132946 scopus 로고    scopus 로고
    • Cell-cell communication in the osteoblast/osteocyte lineage
    • Civitelli R,. Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys. 2008; 473: 188-92.
    • (2008) Arch Biochem Biophys. , vol.473 , pp. 188-192
    • Civitelli, R.1
  • 13
    • 0037382614 scopus 로고    scopus 로고
    • Beyond the gap: Functions of unpaired connexon channels
    • DOI 10.1038/nrm1072
    • Goodenough DA, Paul DL,. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol. 2003; 4: 285-94. (Pubitemid 36383955)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.4 , pp. 285-294
    • Goodenough, D.A.1    Paul, D.L.2
  • 14
    • 1942503184 scopus 로고    scopus 로고
    • Gap junctions and connexin-interacting proteins
    • DOI 10.1016/j.cardiores.2003.12.009, PII S0008636303007776
    • Giepmans BN,. Gap junctions and connexin-interacting proteins. Cardiovasc Res. 2004; 62: 233-45. (Pubitemid 38496537)
    • (2004) Cardiovascular Research , vol.62 , Issue.2 , pp. 233-245
    • Giepmans, B.N.G.1
  • 16
    • 0037040922 scopus 로고    scopus 로고
    • Transduction of cell survival signals by connexin-43 hemichannels
    • DOI 10.1074/jbc.M108625200
    • Plotkin LI, Manolagas SC, Bellido T,. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem. 2002; 277: 8648-57. (Pubitemid 34968331)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.10 , pp. 8648-8657
    • Plotkin, L.I.1    Manolagas, S.C.2    Bellido, T.3
  • 17
    • 80053047894 scopus 로고    scopus 로고
    • Connexin43 interacts with βarrestin: A pre-requisite for osteoblast survival induced by parathyroid hormone
    • Bivi N, Lezcano V, Romanello M, Bellido T, Plotkin LI,. Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. J Cell Biochem. 2011; 112: 2920-30.
    • (2011) J Cell Biochem. , vol.112 , pp. 2920-2930
    • Bivi, N.1    Lezcano, V.2    Romanello, M.3    Bellido, T.4    Plotkin, L.I.5
  • 18
    • 0041589372 scopus 로고    scopus 로고
    • Gap Junctional Communication Modulates Gene Transcription by Altering the Recruitment of Sp1 and Sp3 to Connexin-response Elements in Osteoblast Promoters
    • DOI 10.1074/jbc.M212554200
    • Stains JP, Lecanda F, Screen J, Towler DA, Civitelli R,. Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters. J Biol Chem. 2003; 278: 24377-87. (Pubitemid 37548589)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.27 , pp. 24377-24387
    • Stains, J.P.1    Lecanda, F.2    Screen, J.3    Towler, D.A.4    Civitelli, R.5
  • 22
    • 54249141694 scopus 로고    scopus 로고
    • Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo
    • Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T,. Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. J Bone Miner Res. 2008; 23: 1712-21.
    • (2008) J Bone Miner Res. , vol.23 , pp. 1712-1721
    • Plotkin, L.I.1    Lezcano, V.2    Thostenson, J.3    Weinstein, R.S.4    Manolagas, S.C.5    Bellido, T.6
  • 24
    • 0026764280 scopus 로고
    • Tissue- and site-specific DNA recombination in transgenic mice
    • Orban PC, Chui D, Marth JD,. Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA. 1992; 89: 6861-5.
    • (1992) Proc Natl Acad Sci USA. , vol.89 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 25
    • 0035135651 scopus 로고    scopus 로고
    • Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene
    • DOI 10.1002/1526-968X(200101)29:1<1::AID-GENE1000>3.0.CO;2-0
    • Theis M, de Wit C, Schlaeger TM, Eckardt D, Kruger O, Doring B, Risau W, Deutsch U, Pohl U, Willecke K,. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001; 29: 1-13. (Pubitemid 32110313)
    • (2001) Genesis , vol.29 , Issue.1 , pp. 1-13
    • Theis, M.1    De Wit, C.2    Schlaeger, T.M.3    Eckardt, D.4    Krger, O.5    Dring, B.6    Risau, W.7    Deutsch, U.8    Pohl, U.9    Willecke, K.10
  • 28
    • 65549126824 scopus 로고    scopus 로고
    • Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body
    • Calera MR, Wang Z, Sanchez-Olea R, Paul DL, Civan MM, Goodenough DA,. Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci. 2009; 50: 2185-93.
    • (2009) Invest Ophthalmol Vis Sci. , vol.50 , pp. 2185-2193
    • Calera, M.R.1    Wang, Z.2    Sanchez-Olea, R.3    Paul, D.L.4    Civan, M.M.5    Goodenough, D.A.6
  • 29
    • 2942750269 scopus 로고    scopus 로고
    • Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    • DOI 10.1016/j.bone.2004.03.006, PII S8756328204001097
    • Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg MS, Mina M, Harris MA, Harris SE, Rowe DW,. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone. 2004; 35: 74-82. (Pubitemid 38789150)
    • (2004) Bone , vol.35 , Issue.1 , pp. 74-82
    • Kalajzic, I.1    Braut, A.2    Guo, D.3    Jiang, X.4    Kronenberg, M.S.5    Mina, M.6    Harris, M.A.7    Harris, S.E.8    Rowe, D.W.9
  • 32
    • 45849120957 scopus 로고    scopus 로고
    • Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment
    • Allen MR, Reinwald S, Burr DB,. Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment. Calcif Tissue Int. 2008; 82: 354-60.
    • (2008) Calcif Tissue Int. , vol.82 , pp. 354-360
    • Allen, M.R.1    Reinwald, S.2    Burr, D.B.3
  • 33
    • 79958736766 scopus 로고    scopus 로고
    • A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice
    • Plotkin LI, Bivi N, Bellido T,. A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice. Bone. 2011; 49: 122-7.
    • (2011) Bone. , vol.49 , pp. 122-127
    • Plotkin, L.I.1    Bivi, N.2    Bellido, T.3
  • 34
    • 0032856213 scopus 로고    scopus 로고
    • Missing observations in bone histomorphometry on osteoporosis: Implications and suggestions for an approach
    • DOI 10.1016/S8756-3282(99)00194-5, PII S8756328299001945
    • Hauge E, Mosekilde L, Melsen F,. Missing observations in bone histomorphometry on osteoporosis: implications and suggestions for an approach. Bone. 1999; 25: 389-95. (Pubitemid 29424231)
    • (1999) Bone , vol.25 , Issue.4 , pp. 389-395
    • Hauge, E.1    Mosekilde, L.2    Melsen, F.3
  • 36
    • 80052303008 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
    • Rhee Y, Bivi N, Farrow EG, Lezcano V, Plotkin LI, White KE, Bellido T,. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone. 2011; 49: 636-43.
    • (2011) Bone. , vol.49 , pp. 636-643
    • Rhee, Y.1    Bivi, N.2    Farrow, E.G.3    Lezcano, V.4    Plotkin, L.I.5    White, K.E.6    Bellido, T.7
  • 37
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts: A putative explanation for why intermittent administration is needed for bone anabolism
    • DOI 10.1074/jbc.M307444200
    • Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL,. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003; 278: 50259-72. (Pubitemid 37548867)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6    Weinstein, R.S.7    O'Brien, C.A.8    Manolagas, S.C.9    Jilka, R.L.10
  • 38
    • 0029671373 scopus 로고    scopus 로고
    • Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
    • Erlebacher A, Derynck R,. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996; 132: 195-210.
    • (1996) J Cell Biol. , vol.132 , pp. 195-210
    • Erlebacher, A.1    Derynck, R.2
  • 41
    • 0036020416 scopus 로고    scopus 로고
    • Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone
    • DOI 10.1016/S8756-3282(02)00819-0, PII S8756328202008190
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM,. Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. Bone. 2002; 31: 313-8. (Pubitemid 34822826)
    • (2002) Bone , vol.31 , Issue.2 , pp. 313-318
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 42
    • 0034645070 scopus 로고    scopus 로고
    • Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    • Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, Civitelli R,. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol. 2000; 151: 931-44.
    • (2000) J Cell Biol. , vol.151 , pp. 931-944
    • Lecanda, F.1    Warlow, P.M.2    Sheikh, S.3    Furlan, F.4    Steinberg, T.H.5    Civitelli, R.6
  • 43
    • 58249087710 scopus 로고    scopus 로고
    • Giant osteoclast formation and long-term oral bisphosphonate therapy
    • Weinstein RS, Roberson PK, Manolagas SC,. Giant osteoclast formation and long-term oral bisphosphonate therapy. N Engl J Med. 2009; 360: 53-62.
    • (2009) N Engl J Med. , vol.360 , pp. 53-62
    • Weinstein, R.S.1    Roberson, P.K.2    Manolagas, S.C.3
  • 47
    • 44449087410 scopus 로고    scopus 로고
    • Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction
    • DOI 10.1359/jbmr.080207
    • Kogianni G, Mann V, Noble BS,. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localised bone destruction. J Bone Miner Res. 2008; 23: 915-27. (Pubitemid 351768810)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.6 , pp. 915-927
    • Kogianni, G.1    Mann, V.2    Noble, B.S.3
  • 48
    • 84856134501 scopus 로고    scopus 로고
    • Detection of apoptosis of bone cells in vitro
    • Westendorf J.J. editor. Clifton, NJ: Humana Press
    • Bellido T, Plotkin LI,. Detection of apoptosis of bone cells in vitro. In:, Westendorf JJ, editor. Osteoporosis. Clifton, NJ: Humana Press; 2007. p. 51-75.
    • (2007) Osteoporosis , pp. 51-75
    • Bellido, T.1    Plotkin, L.I.2
  • 50
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
    • DOI 10.1210/en.2005-0239
    • Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL,. Chronic elevation of PTH in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005; 146: 4577-83. (Pubitemid 41446595)
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4    Fu, Q.5    O'Brien, C.A.6    Manolagas, S.C.7    Jilka, R.L.8
  • 51
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • DOI 10.1016/j.bone.2005.03.018, PII S8756328205001171
    • Keller H, Kneissel M,. SOST is a target gene for PTH in bone. Bone. 2005; 37: 148-58. (Pubitemid 40962421)
    • (2005) Bone , vol.37 , Issue.2 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 52
    • 0030706118 scopus 로고    scopus 로고
    • Strain and other mechanical influences on bone strength and maintenance
    • Frost HM,. Strain and other mechanical influences on bone strength and maintenance. Curr Opin Orthop. 1997; 8: 60-70. (Pubitemid 27505327)
    • (1997) Current Opinion in Orthopaedics , vol.8 , Issue.5 , pp. 60-70
    • Frost, H.M.1
  • 55
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to forkhead box O-mediated transcription
    • DOI 10.1074/jbc.M702811200
    • Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC,. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007; 282: 27298-305. (Pubitemid 47501978)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.37 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    O'Brien, C.A.4    Manolagas, S.C.5
  • 56
    • 44449136981 scopus 로고    scopus 로고
    • Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)
    • DOI 10.1359/jbmr.080222
    • Grimston SK, Brodt MD, Silva MJ, Civitelli R,. Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the Connexin43 gene (Gja1). J Bone Miner Res. 2008; 23: 879-86. (Pubitemid 351768806)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.6 , pp. 879-886
    • Grimston, S.K.1    Brodt, M.D.2    Silva, M.J.3    Civitelli, R.4
  • 58
    • 84856136061 scopus 로고    scopus 로고
    • Connexin 43 and osteocyte regulation of osteoclastogenesis and bone resorption
    • Zhang Y, Paul EM, Donahue HJ,. Connexin 43 and osteocyte regulation of osteoclastogenesis and bone resorption. J Bone Miner Res. 2009; 24: S13.
    • (2009) J Bone Miner Res. , vol.24
    • Zhang, Y.1    Paul, E.M.2    Donahue, H.J.3
  • 59
    • 33845987983 scopus 로고    scopus 로고
    • Skeletal unloading induces osteoblast apoptosis and targets α5β1-PI3K-Bcl-2 signaling in rat bone
    • DOI 10.1016/j.yexcr.2006.10.021, PII S0014482706004460
    • Dufour C, Holy X, Marie PJ,. Skeletal unloading induces osteoblast apoptosis and targets alpha5beta1-PI3K-Bcl-2 signaling in rat bone. Exp Cell Res. 2007; 313: 394-403. (Pubitemid 46048823)
    • (2007) Experimental Cell Research , vol.313 , Issue.2 , pp. 394-403
    • Dufour, C.1    Holy, X.2    Marie, P.J.3
  • 60
    • 33748197707 scopus 로고    scopus 로고
    • Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes
    • DOI 10.1016/j.bone.2006.04.014, PII S8756328206004091
    • Basso N, Heersche JN,. Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes. Bone. 2006; 39: 807-14. (Pubitemid 44311707)
    • (2006) Bone , vol.39 , Issue.4 , pp. 807-814
    • Basso, N.1    Heersche, J.N.M.2
  • 61
    • 33846255349 scopus 로고    scopus 로고
    • The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone
    • Mann V, Huber C, Kogianni G, Jones D, Noble B,. The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone. J Musculoskelet Neuronal Interact. 2006; 6: 408-17. (Pubitemid 46099730)
    • (2006) Journal of Musculoskeletal Neuronal Interactions , vol.6 , Issue.4 , pp. 408-417
    • Mann, V.1    Huber, C.2    Kogianni, G.3    Jones, D.4    Noble, B.5
  • 64
    • 21844442343 scopus 로고    scopus 로고
    • Mechanical strain opens connexin 43 hemichannels in osteocytes: A novel mechanism for the release of prostaglandin
    • DOI 10.1091/mbc.E04-10-0912
    • Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, Sprague E, Jiang JX,. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell. 2005; 16: 3100-6. (Pubitemid 40962583)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.7 , pp. 3100-3106
    • Cherian, P.P.1    Siller-Jackson, A.J.2    Gu, S.3    Wang, X.4    Bonewald, L.F.5    Sprague, E.6    Jiang, J.X.7
  • 65
    • 78649542978 scopus 로고    scopus 로고
    • Mechanical induction of PGE(2) in osteocytes blocks glucocorticoid induced apoptosis through both the beta-catenin and PKA pathways
    • Kitase Y, Barragan L, Jiang JX, Johnson ML, Bonewald LF,. Mechanical induction of PGE(2) in osteocytes blocks glucocorticoid induced apoptosis through both the beta-catenin and PKA pathways. J Bone Miner Res. 2010; 25: 2381-92.
    • (2010) J Bone Miner Res. , vol.25 , pp. 2381-2392
    • Kitase, Y.1    Barragan, L.2    Jiang, J.X.3    Johnson, M.L.4    Bonewald, L.F.5
  • 66
    • 0030854867 scopus 로고    scopus 로고
    • Multiple extracellular signals promote osteoblast survival and apoptosis
    • DOI 10.1210/en.138.9.3849
    • Hill PA, Tumber A, Meikle MC,. Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology. 1997; 138: 3849-58. (Pubitemid 27351939)
    • (1997) Endocrinology , vol.138 , Issue.9 , pp. 3849-3858
    • Hill, P.A.1    Tumber, A.2    Meikle, M.C.3
  • 68
    • 66349117300 scopus 로고    scopus 로고
    • Sca-1+ stem cell survival and engraftment in the infarcted heart: Dual role for preconditioning-induced connexin-43
    • Lu G, Haider HK, Jiang S, Ashraf M,. Sca-1+ stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation. 2009; 119: 2587-96.
    • (2009) Circulation. , vol.119 , pp. 2587-2596
    • Lu, G.1    Haider, H.K.2    Jiang, S.3    Ashraf, M.4
  • 70
    • 33846560757 scopus 로고    scopus 로고
    • Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles
    • DOI 10.1002/jcb.21089
    • Ponik SM, Triplett JW, Pavalko FM,. Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles. J Cell Biochem. 2007; 100: 794-807. (Pubitemid 46180540)
    • (2007) Journal of Cellular Biochemistry , vol.100 , Issue.3 , pp. 794-807
    • Ponik, S.M.1    Triplett, J.W.2    Pavalko, F.M.3
  • 71
    • 34249871139 scopus 로고    scopus 로고
    • Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes
    • DOI 10.1002/jcp.21021
    • Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ,. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol. 2007; 212: 207-14. (Pubitemid 46867603)
    • (2007) Journal of Cellular Physiology , vol.212 , Issue.1 , pp. 207-214
    • Genetos, D.C.1    Kephart, C.J.2    Zhang, Y.3    Yellowley, C.E.4    Donahue, H.J.5
  • 72
    • 11144317306 scopus 로고    scopus 로고
    • Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription
    • DOI 10.1091/mbc.E04-04-0339
    • Stains JP, Civitelli R,. Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. Mol Biol Cell. 2005; 16: 64-72. (Pubitemid 40024291)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.1 , pp. 64-72
    • Stains, J.P.1    Civitelli, R.2
  • 74
    • 24044540751 scopus 로고    scopus 로고
    • Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption
    • DOI 10.1016/j.bbrc.2005.06.211, PII S0006291X05014348
    • Gu G, Mulari M, Peng Z, Hentunen TA, Vaananen HK,. Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption. Biochem Biophys Res Commun. 2005; 335: 1095-101. (Pubitemid 41215531)
    • (2005) Biochemical and Biophysical Research Communications , vol.335 , Issue.4 , pp. 1095-1101
    • Gu, G.1    Mulari, M.2    Peng, Z.3    Hentunen, T.A.4    Vaananen, H.K.5
  • 76
    • 60849091616 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression
    • Sato MM, Nakashima A, Nashimoto M, Yawaka Y, Tamura M,. Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression. Genes Cells. 2009; 14: 141-53.
    • (2009) Genes Cells. , vol.14 , pp. 141-153
    • Sato, M.M.1    Nakashima, A.2    Nashimoto, M.3    Yawaka, Y.4    Tamura, M.5
  • 78
    • 38949092911 scopus 로고    scopus 로고
    • Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells
    • DOI 10.1182/blood-2007-05-092031
    • Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Lasio MG, Rustighi A, Del Sal G, Zauli G,. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008; 111: 1287-94. (Pubitemid 351213412)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1287-1294
    • Secchiero, P.1    Corallini, F.2    Rimondi, E.3    Chiaruttini, C.4    Grazia Di Iasio, M.5    Rustighi, A.6    Del Sal, G.7    Zauli, G.8
  • 79
    • 33749385706 scopus 로고    scopus 로고
    • Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation
    • DOI 10.1242/dev.02506
    • Francis RJ, Lo CW,. Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation. Development. 2006; 133: 3451-60. (Pubitemid 44501847)
    • (2006) Development , vol.133 , Issue.17 , pp. 3451-3460
    • Francis, R.J.B.1    Lo, C.W.2


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