Chondrocyte apoptosis: A cause or consequence of osteoarthritis?

International Journal of Rheumatic Diseases

Volumn 14, Issue 2, 2011, Pages 159-166

  Zamli, Zaitunnatakhin ^a   Sharif, Mohammed ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Articular cartilage degradation; Chondrocyte apoptosis; Osteoarthritis

Indexed keywords

COLLAGEN; COLLAGEN TYPE 2; CYTOSKELETON PROTEIN; FIBRONECTIN; GELATINASE A; INTERLEUKIN 1BETA; LAMININ; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROSTAGLANDIN E; PROTEOGLYCAN; REACTIVE OXYGEN METABOLITE; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

AGING; ARTICULAR CARTILAGE; BONE DENSITY; BONE PLATE; CARTILAGE DEGENERATION; CELL COUNT; CELL DEATH; CELL SURVIVAL; CHONDROCYTE APOPTOSIS; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENCHONDRAL OSSIFICATION; HUMAN; HYPERPLASIA; NONHUMAN; OSTEOARTHRITIS; OTOSCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SYNOVIAL FLUID; SYNOVIUM;

ANIMALS; APOPTOSIS; CARTILAGE, ARTICULAR; CHONDROCYTES; HUMANS; OSTEOARTHRITIS; RISK FACTORS;

EID: 79955141040     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/j.1756-185X.2011.01618.x     Document Type: Review

References (62)

1. Dickson J, Hosie G (2003) Osteoarthritis: Your Questions Answered. Elsevier Science, China.
2. Goldring MB (2006) Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol 20(5), 1003-25.
3. Roach HI, Tilley S (2008) The pathogenesis of osteoarthritis. In: Bronner F, Farach-Carson MC (eds) Bone and Osteoarthritis, pp 1-18. Springer, London.
4. Glasson SS (2007) In vivo osteoarthritis target validation utilizing genetically-modified mice. Curr Drug Targets 8, 367-76.
5. Harris ED Jr (2001) The bone and joint decade: a catalyst for progress. Arthritis Rheum 44(9), 1969-70.
6. Hashimoto S, Ochs RL, Komiya S, Lotz M (1998) Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41(9), 1632-8.
7. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F (1998) Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41(2), 284-9.
8. Sharif M, Whitehouse A, Sharman P, Perry M, Adams M (2004) Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 50(2), 507-15.
9. Matsuo M, Nishida K, Yoshida A, Murakami T, Inoue H (2001) Expression of caspase-3 and -9 relevant to cartilage destruction and chondrocyte apoptosis in human osteoarthritic cartilage. Acta Med Okayama 55(6), 333-40.
10. Mistry D, Oue Y, Chambers MG, Kayser MV, Mason RM (2004) Chondrocyte death during murine osteoarthritis. Osteoarthritis Cartilage 12(2), 131-41.
11. Thomas CM, Fuller CJ, Whittles CE, Sharif M (2007) Chondrocyte death by apoptosis is associated with cartilage matrix degradation. Osteoarthritis Cartilage 15(1), 27-34.
12. Kim HA, Lee YJ, Seong SC, Choe KW, Song YW (2000) Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 27(2), 455-62.
13. Mitrovic D, Quintero M, Stankovic A, Ryckewaert A (1983) Cell density of adult human femoral condylar articular cartilage: joints with normal and fibrillated surfaces. Lab Invest 49, 309-16.
14. Wei L, Sun X-j, Wang Z, Chen Q (2006) CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Research & Therapy 8, R37. doi:.
15. Roach HI, Aigner T, Kouri JB (2004) Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis 9(3), 265-77.
16. Almonte-Becerril M, Navarro-Garcia F, Gonzalez-Robles A, Vega-Lopez M, Lavalle C, Kouri J (2010) Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model. Apoptosis 15(5), 631-8.
17. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4), 239-57.
18. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4), 495-516.
19. Aigner T, Kim HA (2002) Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration. Arthritis Rheum 46(8), 1986-96.
20. Del Carlo M, Loeser R (2008) Cell death in osteoarthritis. Curr Rheumatol Rep 10(1), 37-42.
21. Zemmyo M, Meharra EJ, Kühn K, Creighton-Achermann L, Lotz M (2003) Accelerated, aging-dependent development of osteoarthritis in α1 integrin-deficient mice. Arthritis Rheum 48(10), 2873-80.
22. Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M (2010) Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 62(3), 791-801.
23. D'Lima D, Hermida J, Hashimoto S, Colwell C, Lotz M (2006) Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54(6), 1814-21.
24. Hashimoto S, Takahashi K, Amiel D, Coutts RD, Lotz M (1998) Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41(7), 1266-74.
25. Hashimoto S, Nishiyama T, Hayashi S, et al. (2009) Role of p53 in human chondrocyte apoptosis in response to shear strain. Arthritis Rheum 60(8), 2340-9.
26. Perez HE, Luna MJ, Rojas ML, Kouri JB (2005) Chondroptosis: an immunohistochemical study of apoptosis and Golgi complex in chondrocytes from human osteoarthritic cartilage. Apoptosis 10(5), 1105-10.
27. Jimenez PA, Glasson SS, Trubetskoy OV, Haimes HB (1997) Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes. Lab Anim Sci 47(6), 598-601.
28. Todd Allen R, Robertson CM, Harwood FL, et al. (2004) Characterization of mature vs aged rabbit articular cartilage: analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis. Osteoarthritis Cartilage 12(11), 917-23.
29. Hashimoto S, Ochs RL, Rosen F, et al. (1998) Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci 95(6), 3094-9.
30. Mobasheri A (2002) Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis. Med Hypotheses 58(3), 193-7.
31. Adams CS, Horton WE Jr (1998) Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 250(4), 418-25.
32. Yatsugi N, Tsukazaki T, Osaki M, Koji T, Yamashita S, Shindo H (2000) Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc. J Orthop Sci 5(2), 150-6.
33. Loening AM, James IE, Levenston ME, et al. (2000) Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys 381(2), 205-12.
34. Bobinac D, Spanjol J, Zoricic S, Maric I (2003) Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 32(3), 284-90.
35. Aigner T, Fundel K, Saas J, et al. (2006) Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 54(11), 3533-44.
36. Thomas CM, Whittles CE, Fuller CJ, Sharif M (2010) Variations in chondrocyte apoptosis may explain the increased prevalence of osteoarthritis in some joints. Rheumatol Int (forthcoming). doi.
37. Kühn K, D'Lima DD, Hashimoto S, Lotz M (2004) Cell death in cartilage. Osteoarthritis Cartilage 12(1), 1-16.
38. Goggs R, Carter SD, Schulze-Tanzil G, Shakibaei M, Mobasheri A (2003) Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet J 166(2), 140-58.
39. Yang C, Li S-W, Helminen HJ, Khillan JS, Bao Y, Prockop DJ (1997) Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp Cell Res 235(2), 370-3.
40. Murray RC, Janicke HC, Henson FM, Goodship A (2000) Equine carpal articular cartilage fibronectin distribution associated with training, joint location and cartilage deterioration. Equine Vet J 32(1), 47-51.
41. Burton-Wurster N, Lust G, Macleod JN (1997) Cartilage fibronectin isoforms: in search of functions for a special population of matrix glycoproteins. Matrix Biol 15(7), 441-54.
42. Clements KM, Hollander AP, Sharif M, Adams MA (2004) Cyclic loading can denature type II collagen in articular cartilage. Connect Tissue Res 45(3), 174-80.
43. Summers GC, Merrill A, Sharif M, Adams MA (2008) Swelling of articular cartilage depends on the integrity of adjacent cartilage and bone. Biorheology 45(3-4), 365-74.
44. Clements KM, Bee ZC, Crossingham GV, Adams MA, Sharif M (2001) How severe must repetitive loading be to kill chondrocytes in articular cartilage? Osteoarthritis Cartilage 9(5), 499-507.
45. D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, Lotz MK (2001) Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 9(8), 712-9.
46. Kim HT, Lo MY, Pillarisetty R (2002) Chondrocyte apoptosis following intraarticular fracture in humans. Osteoarthritis Cartilage 10(9), 747-9.
47. Lo MY, Kim HT (2004) Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1. J Orthop Res 22(1), 140-4.
48. Anderson-MacKenzie JM, Quasnichka HL, Starr RL, Lewis EJ, Billingham ME, Bailey AJ (2005) Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol 37(1), 224-36.
49. Huebner JL, Johnson KA, Kraus VB, Terkeltaub RA (2009) Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage 17(8), 1056-64.
50. Tessier JJ, Bowyer J, Brownrigg NJ, et al. (2003) Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging. Osteoarthritis Cartilage 11(12), 845-53.
51. Bendele AM (2001) Animal models of osteoarthritis. J Musculoskelet Neuronal Interact 1, 363-7.
52. Muraoka T, Hagino H, Okano T, Enokida M, Teshima R (2007) Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis. Arthritis Rheum 56(10), 3366-74.
53. Johnson K, Svensson CI, Etten DV, et al. (2004) Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum 50(4), 1216-25.
54. Corvol M-T (2000) The chondrocyte: from cell aging to osteoarthritis. Joint Bone Spine 67(6), 557-60.
55. Aigner T, Sachse A, Gebhard PM, Roach HI (2006) Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev 58(2), 128-49.
56. Sutton S, Clutterbuck A, Harris P, et al. (2009) The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet J 179(1), 10-24.
57. Stoop R, Van Der Kraan PM, Buma P, et al. (1999) Type II collagen degradation in spontaneous osteoarthritis in C57BL/6 and BALB/c mice. Arthritis Rheum 42(11), 2381-9.
58. Karsdal MA, Leeming DJ, Dam EB, et al. (2008) Should subchondral bone turnover be targeted when treating osteoarthritis? Osteoarthritis Cartilage 16(6), 638-46.
59. Huebner JL, Hanes MA, Beekman B, TeKoppele JM, Kraus VB (2002) A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. Osteoarthritis Cartilage 10(10), 758-67.
60. Attur M, Samuels J, Krasnokutsky S, Abramson SB (2010) Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence? Best Pract Res Clin Rheumatol 24(1), 71-9.
61. Ostalowska A, Birkner E, Wiecha M, et al. (2006) Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint. Osteoarthritis Cartilage 14(2), 139-45.
62. Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS (2006) Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 14(2), 101-13.