Increased Apoptosis in Human Osteoarthritic Cartilage Corresponds to Reduced Cell Density and Expression of Caspase-3

Arthritis and Rheumatism

Volumn 50, Issue 2, 2004, Pages 507-515

  Sharif, Mohammed ^a   Whitehouse, Anne ^a   Sharman, Patrick ^a   Perry, Mark ^a   Adams, Mike ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; INHIBITOR OF APOPTOSIS PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DENSITY; CONTROLLED STUDY; HIP OSTEOARTHRITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE OSTEOARTHRITIS; NICK END LABELING; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; APOPTOSIS; BIOLOGICAL MARKERS; CARTILAGE, ARTICULAR; CASPASE 3; CASPASES; CELL COUNT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 1042278739     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20020     Document Type: Article

References (28)

1. Hamerman D. Aging and osteoarthritis: basic mechanisms. J Am Geriatr Soc 1993;41:760-70.
2. Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000;43:1916-26.
3. Westacott CI, Sharif M. Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin Arthritis Rheum 1996;25:254-72.
4. Kuettner KE. Biochemistry of articular cartilage in health and disease. Clin Biochem 1992;25:155-63.
5. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57.
6. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 1998;41:284-9.
7. Hashimoto S, Ochs RL, Komiya S, Lotz M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998;41:1632-8.
8. Hashimoto S, Takahashi K, Amiel D, Coutts RD, Lotz M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998;41:1266-74.
9. Aigner T, Hemmel M, Neureiter D, Gebhard PM, Zeiler G, Kirchner T, et al. Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritic human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 2001;44:1304-12.
10. Kim HA, Lee YJ, Seong SC, Choe KW, Song YW. Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 2000;27:455-62.
11. Heraud F, Heraud A, Harmand MF. Apoptosis in normal and osteoarthritic human articular cartilage. Ann Rheum Dis 2000;59:959-65.
12. Kouri JB, Jimenez SA, Quintero M, Chico A. Ultrastructural study of chondrocytes from fibrillated and non-fibrillated human osteoarthritic cartilage. Osteoarthritis Cartilage 1996;4:111-25.
13. Kouri JB, Aguilera JM, Reyes J, Lozoya KA, Gonzalez S. Apoptotic chondrocytes from osteoarthrotic human articular cartilage and abnormal calcification of subchondral bone. J Rheumatol 2000;27:1005-19.
14. Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998;273:9357-60.
15. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
16. Gorczyca W, Bruno S, Melamed MR, Darzynkiewicz Z. Cell cycle-related expression of p120 nucleolar antigen in normal human lymphocytes and in cells of HL-60 and MOLT-4 leukemic lines: effects of methotrexate, camptothecin, and teniposide. Cancer Res 1992;52:3491-4.
17. Guilak F, Ratcliffe A, Mow VC. Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study. J Orthop Res 1995;13:410-21.
18. Clements KM, Bee ZC, Crossingham GV, Adams MA, Sharif M. How severe must repetitive loading be to kill chondrocytes in articular cartilage? Osteoarthritis Cartilage 2001;9:499-507.
19. Adams CS, Horton WE Jr. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 1998;250:418-25.
20. Stockwell RA. The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. J Anat 1971;109:411-21.
21. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, et al. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci U S A 1998;95:3094-9.
22. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
23. Vignon E, Arlot M, Patricot LM, Vignon G. The cell density of human femoral head cartilage. Clin Orthop 1976;121:303-8.
24. Yatsugi N, Tsukazaki T, Osaki M, Koji T, Yamashita S, Shindo H. Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc. J Orthop Sci 2000;5:150-6.
25. Feng L, Balakir R, Precht P, Horton WE Jr. Bcl-2 regulates chondrocyte morphology and aggrecan gene expression independent of caspase activation and full apoptosis. J Cell Biochem 1999;74:576-86.
26. Kim HA, Song YW. Apoptotic chondrocyte death in rheumatoid arthritis. Arthritis Rheum 1999;42:1528-37.
27. Pfander D, Cramer T, Weseloh G, Pullig O, Schuppan D, Bauer M, et al. Hepatocyte growth factor in human osteoarthritic cartilage. Osteoarthritis Cartilage 1999;7:548-59.
28. Blanco FJ, Ochs RL, Schwarz H, Lotz M. Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 1995;146:75-85.