Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice

Annals of the Rheumatic Diseases

Volumn 63, Issue 4, 2004, Pages 453-456

  Okazaki, R ^a   Sakai, A ^a   Ootsuyama, A ^a   Sakata, T ^a   Nakamura, T ^a   Norimura, T ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CELL; BONE MASS; CONTROLLED STUDY; IMMOBILIZATION; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIBIA; TRABECULAR BONE;

ANIMALS; BODY WEIGHT; BONE MARROW CELLS; GENES, P53; IMMOBILIZATION; IN SITU NICK-END LABELING; MICE; MICE, INBRED STRAINS; OSTEOGENESIS; RNA, MESSENGER; TIBIA;

EID: 1842505620     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2003.011643     Document Type: Article

References (15)

1. Chappard D, Minaire P, Privat C, Berard E, Mendoza-Sarmiento J, Tournebise H, et al. Effects of tiludronate on bone loss in paraplegic patients. J Bone Miner Res 1995;10:112-18.
2. Sakai A, Nakamura T, Tsurukami H, Okazaki R, Nishida S, Tanaka Y, et al. Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice. Bone 1996;18:479-86.
3. Wlodarski P, Wasik M, Ratajczak MZ, Sevignani C, Hoser G, Kawiak J, et al. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 1998;91:2998-3006.
4. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 1998;102:274-82.
5. Norimura T, Nomoto S, Katsuki M, Gondo Y, Kondo S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nat Med 1996;2:577-80.
6. Okazaki R, Sakai A, Ootsuyama A, Sakata T, Nakamura T, Norimura T. Apoptosis and p53 expression in chondrocytes relate to degeneration in articular cartilage of immobilized knee joints. J Rheumatol 2003;30:559-66.
7. Sakai A, Sakata T, Tanaka S, Okazaki R, Kunugita N, Norimura T, et al. Disruption of the p53 gene results in preserved trabecular bone mass and bone formation after mechanical unloading. J Bone Miner Res 2002;17:119-27.
8. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610.
9. Will K, Warnecke G, Bergmann S, Deppert W. Species-and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53. Nucleic Acids Res 1995;23:4023-8.
10. Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DH, Thomson AW. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 1997;158:5676-84.
11. Eberhardt AW, Yeager-Jones A, Blair HC. Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocarticoid-treated rabbits. Endocrinology 2001;142:1333-40.
12. Ke HZ, Paralkar VM, Grosser WA, Crawford DT, Qi H, Simmons HA, et al. Effects of CP-336, 156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models. Endocrinology 1998;139:2068-76.
13. Okozaki R, Sakai A, Uezono Y, Ootsuyama A, Kunugita N, Nakamura T, et al. Sequential changes in transforming growth factor (TGF)-β1 concentration in synovial fluid and mRNA expression of TGF-β1 receptors in chondrocytes after immobilization of rabbit knees. J Bone Miner Metab 2001;19:228-35.
14. Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, et al. Transforming growth factor-1 mediates cellular response to DNA damage in situ. Cancer Res 2002;62:5627-31.
15. Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Am J Physiol 1997;273:E1133-9.