메뉴 건너뛰기




Volumn 32, Issue 40, 2013, Pages 4798-4805

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation

Author keywords

cartilage; chondrocytes; enchondroma; p107; pRB; Prx1 Cre

Indexed keywords

PROTEIN P107; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F3;

EID: 84885183132     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.496     Document Type: Article
Times cited : (8)

References (51)
  • 1
    • 0028946875 scopus 로고
    • Incidence of cancer in children in the United States Sex-, race-, and 1-year age-specific rates by histologic type
    • Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer 1995; 75: 2186-2195.
    • (1995) Cancer , vol.75 , pp. 2186-2195
    • Gurney, J.G.1    Severson, R.K.2    Davis, S.3    Robison, L.L.4
  • 2
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 5
    • 0026744563 scopus 로고
    • Mice de ficient for Rb are nonviable and show de fects in neurogenesis and haematopoiesis
    • Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K et al. Mice de ficient for Rb are nonviable and show de fects in neurogenesis and haematopoiesis. Nature 1992; 359: 288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6
  • 6
    • 0037468222 scopus 로고    scopus 로고
    • Extraembryonic function of Rb is essential for embryonic Development and viability
    • Wu L, de bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y et al. Extraembryonic function of Rb is essential for embryonic Development and viability. Nature 2003; 421: 942-947.
    • (2003) Nature , vol.421 , pp. 942-947
    • Wu, L.1    De Bruin, A.2    Saavedra, H.I.3    Starovic, M.4    Trimboli, A.5    Yang, Y.6
  • 7
    • 0029819994 scopus 로고    scopus 로고
    • PRb controls proliferation, differentiation, and Death of skeletal muscle cells and other lineages during embryogenesis
    • Zacksenhaus E, Jiang Z, Chung D, Marth JD, Phillips RA, Gallie BL. pRb controls proliferation, differentiation, and Death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev 1996; 10: 3051-3064.
    • (1996) Genes Dev , vol.10 , pp. 3051-3064
    • Zacksenhaus, E.1    Jiang, Z.2    Chung, D.3    Marth, J.D.4    Phillips, R.A.5    Gallie, B.L.6
  • 8
    • 0037305849 scopus 로고    scopus 로고
    • Conditional mutation of Rb causes cell cycle de fects without apoptosis in the central nervous system
    • MacPherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T. Conditional mutation of Rb causes cell cycle de fects without apoptosis in the central nervous system. Mol Cell Biol 2003; 23: 1044-1053.
    • (2003) Mol Cell Biol , vol.23 , pp. 1044-1053
    • Macpherson, D.1    Sage, J.2    Crowley, D.3    Trumpp, A.4    Bronson, R.T.5    Jacks, T.6
  • 9
    • 0035796491 scopus 로고    scopus 로고
    • Cellautonomous and non-cell-autonomous functions of the Rb tumor suppressor in Developing central nervous system
    • Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cellautonomous and non-cell-autonomous functions of the Rb tumor suppressor in Developing central nervous system. EMBO J 2001; 20: 3402-3413.
    • (2001) EMBO J , vol.20 , pp. 3402-3413
    • Lipinski, M.M.1    Macleod, K.F.2    Williams, B.O.3    Mullaney, T.L.4    Crowley, D.5    Jacks, T.6
  • 10
    • 18444389748 scopus 로고    scopus 로고
    • Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical Development
    • Ferguson KL, Vanderluit JL, Hebert JM, McIntosh WC, Tibbo E, MacLaurin JG et al. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical Development. EMBO J 2002; 21: 3337-3346.
    • (2002) EMBO J , vol.21 , pp. 3337-3346
    • Ferguson, K.L.1    Vanderluit, J.L.2    Hebert, J.M.3    McIntosh, W.C.4    Tibbo, E.5    Maclaurin, J.G.6
  • 11
    • 0037975570 scopus 로고    scopus 로고
    • Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
    • de bruin A, Wu L, Saavedra HI, Wilson P, Yang Y, Rosol TJ et al. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci USA 2003; 100: 6546-6551.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6546-6551
    • De Bruin, A.1    Wu, L.2    Saavedra, H.I.3    Wilson, P.4    Yang, Y.5    Rosol, T.J.6
  • 12
    • 37549011769 scopus 로고    scopus 로고
    • De regulated E2f-2 underlies cell cycle and maturation de fects in retinoblastoma null erythroblasts
    • Dirlam A, Spike BT, Macleod KF. de regulated E2f-2 underlies cell cycle and maturation de fects in retinoblastoma null erythroblasts. Mol Cell Biol 2007; 27: 8713-8728.
    • (2007) Mol Cell Biol , vol.27 , pp. 8713-8728
    • Dirlam, A.1    Spike, B.T.2    Macleod, K.F.3
  • 14
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rbdeficient mouse embryos
    • Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rbdeficient mouse embryos. Mol Cell 1998; 2: 293-304.
    • (1998) Mol Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 16
    • 0035118893 scopus 로고    scopus 로고
    • E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
    • Ziebold U, Reza T, Caron A, Lees JA. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 2001; 15: 386-391.
    • (2001) Genes Dev , vol.15 , pp. 386-391
    • Ziebold, U.1    Reza, T.2    Caron, A.3    Lees, J.A.4
  • 19
    • 70349269164 scopus 로고    scopus 로고
    • Mutation of p107 exacerbates the consequences of rb loss in embryonic tissues and causes cardiac and blood vessel de fects
    • Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel de fects. Proc Natl Acad Sci USA 2009; 106: 14932-14936.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14932-14936
    • Berman, S.D.1    West, J.C.2    Danielian, P.S.3    Caron, A.M.4    Stone, J.R.5    Lees, J.A.6
  • 20
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 2003; 424: 223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Perez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 21
    • 3042813439 scopus 로고    scopus 로고
    • Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
    • Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A et al. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 2004; 131: 2737-2748.
    • (2004) Development , vol.131 , pp. 2737-2748
    • Ruiz, S.1    Santos, M.2    Segrelles, C.3    Leis, H.4    Jorcano, J.L.5    Berns, A.6
  • 22
    • 9444242683 scopus 로고    scopus 로고
    • Shared role of the pRB-related p130 and p107 proteins in limb Development
    • Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N et al. Shared role of the pRB-related p130 and p107 proteins in limb Development. Genes Dev 1996; 10: 1633-1644.
    • (1996) Genes Dev , vol.10 , pp. 1633-1644
    • Cobrinik, D.1    Lee, M.H.2    Hannon, G.3    Mulligan, G.4    Bronson, R.T.5    Dyson, N.6
  • 24
    • 0038302770 scopus 로고    scopus 로고
    • Constitutive E2F1 overexpression de lays endochondral bone formation by inhibiting chondrocyte differentiation
    • Scheijen B, Bronk M, Van Der Meer T, Bernards R. Constitutive E2F1 overexpression de lays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol 2003; 23: 3656-3668.
    • (2003) Mol Cell Biol , vol.23 , pp. 3656-3668
    • Scheijen, B.1    Bronk, M.2    Van Der Meer, T.3    Bernards, R.4
  • 28
    • 53349141349 scopus 로고    scopus 로고
    • The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone Development
    • Berman SD, Yuan TL, Miller ES, Lee EY, Caron A, Lees JA. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone Development. Mol Cancer Res 2008; 6: 1440-1451.
    • (2008) Mol Cancer Res , vol.6 , pp. 1440-1451
    • Berman, S.D.1    Yuan, T.L.2    Miller, E.S.3    Lee, E.Y.4    Caron, A.5    Lees, J.A.6
  • 29
    • 57449095858 scopus 로고    scopus 로고
    • Impaired bone Development and increased mesenchymal progenitor cells in calvaria of RB1-/-mice
    • Gutierrez GM, Kong E, Sabbagh Y, Brown NE, Lee JS, de may MB et al. Impaired bone Development and increased mesenchymal progenitor cells in calvaria of RB1-/-mice. Proc Natl Acad Sci USA 2008; 105: 18402-18407.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18402-18407
    • Gutierrez, G.M.1    Kong, E.2    Sabbagh, Y.3    Brown, N.E.4    Lee, J.S.5    Demay, M.B.6
  • 30
    • 0034840594 scopus 로고    scopus 로고
    • The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
    • Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC et al. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell 2001; 8: 303-316.
    • (2001) Mol Cell , vol.8 , pp. 303-316
    • Thomas, D.M.1    Carty, S.A.2    Piscopo, D.M.3    Lee, J.S.4    Wang, W.F.5    Forrester, W.C.6
  • 31
    • 0036076389 scopus 로고    scopus 로고
    • Expression of Cre Recombinase in the Developing mouse limb bud driven by a Prxl enhancer
    • Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ. Expression of Cre Recombinase in the Developing mouse limb bud driven by a Prxl enhancer. Genesis 2002; 33: 77-80.
    • (2002) Genesis , vol.33 , pp. 77-80
    • Logan, M.1    Martin, J.F.2    Nagy, A.3    Lobe, C.4    Olson, E.N.5    Tabin, C.J.6
  • 32
    • 66349137046 scopus 로고    scopus 로고
    • Localization of the cis-enhancer element for mouse type X collagen expression in hypertrophic chondrocytes in vivo
    • Zheng Q, Keller B, Zhou G, Napierala D, Chen Y, Zabel B et al. Localization of the cis-enhancer element for mouse type X collagen expression in hypertrophic chondrocytes in vivo. J Bone Miner Res 2009; 24: 1022-1032.
    • (2009) J Bone Miner Res , vol.24 , pp. 1022-1032
    • Zheng, Q.1    Keller, B.2    Zhou, G.3    Napierala, D.4    Chen, Y.5    Zabel, B.6
  • 34
    • 84885176532 scopus 로고    scopus 로고
    • 4th edn. Saunders Philadelphia, PA
    • Miller MD. Review of Orthopaedics. 4th edn. Saunders: Philadelphia, PA, 2004, xv 704 pp.
    • (2004) Review of Orthopaedics , vol.15 , pp. 704
    • Miller, M.D.1
  • 35
    • 77954030485 scopus 로고    scopus 로고
    • Cartilage tumours and bone Development: Molecular pathology and possible therapeutic targets
    • Bovee JV, Hogendoorn PC, Wunder JS, Alman BA. Cartilage tumours and bone Development: Molecular pathology and possible therapeutic targets. Nat Rev Cancer 2010; 10: 481-488.
    • (2010) Nat Rev Cancer , vol.10 , pp. 481-488
    • Bovee, J.V.1    Hogendoorn, P.C.2    Wunder, J.S.3    Alman, B.A.4
  • 36
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM. Developmental regulation of the growth plate. Nature 2003; 423: 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 38
    • 45349086509 scopus 로고    scopus 로고
    • Conditional mouse osteosarcoma, de pendent on p53 loss and potentiated by loss of Rb, mimics the human disease
    • Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI et al. Conditional mouse osteosarcoma, de pendent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev 2008; 22: 1662-1676.
    • (2008) Genes Dev , vol.22 , pp. 1662-1676
    • Walkley, C.R.1    Qudsi, R.2    Sankaran, V.G.3    Perry, J.A.4    Gostissa, M.5    Roth, S.I.6
  • 40
    • 0035071674 scopus 로고    scopus 로고
    • Alterations in the regulatory pathway involving p16, pRb and cdk4 in human chondrosarcoma
    • Asp J, Inerot S, Block JA, Lindahl A. Alterations in the regulatory pathway involving p16, pRb and cdk4 in human chondrosarcoma. J Orthop Res 2001; 19: 149-154.
    • (2001) J Orthop Res , vol.19 , pp. 149-154
    • Asp, J.1    Inerot, S.2    Block, J.A.3    Lindahl, A.4
  • 44
    • 53149144278 scopus 로고    scopus 로고
    • A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma
    • Boeuf S, Kunz P, Hennig T, Lehner B, Hogendoorn P, Bovee J et al. A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma. J Pathol 2008; 216: 158-166.
    • (2008) J Pathol , vol.216 , pp. 158-166
    • Boeuf, S.1    Kunz, P.2    Hennig, T.3    Lehner, B.4    Hogendoorn, P.5    Bovee, J.6
  • 45
    • 30344434306 scopus 로고    scopus 로고
    • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation
    • Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC et al. Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol 2006; 168: 321-330.
    • (2006) Am J Pathol , vol.168 , pp. 321-330
    • Tiet, T.D.1    Hopyan, S.2    Nadesan, P.3    Gokgoz, N.4    Poon, R.5    Lin, A.C.6
  • 48
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21: 70-71.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 49
    • 33947216150 scopus 로고    scopus 로고
    • Selective requirements for E2f3 in the Development and tumorigenicity of Rb-deficient chimeric tissues
    • Parisi T, Yuan TL, Faust AM, Caron AM, Bronson R, Lees JA. Selective requirements for E2f3 in the Development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol 2007; 27: 2283-2293.
    • (2007) Mol Cell Biol , vol.27 , pp. 2283-2293
    • Parisi, T.1    Yuan, T.L.2    Faust, A.M.3    Caron, A.M.4    Bronson, R.5    Lees, J.A.6
  • 50
    • 34548080918 scopus 로고    scopus 로고
    • Age-related changes in trabecular architecture differ in female and male C57BL/6J mice
    • Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 2007; 22: 1197-1207.
    • (2007) J Bone Miner Res , vol.22 , pp. 1197-1207
    • Glatt, V.1    Canalis, E.2    Stadmeyer, L.3    Bouxsein, M.L.4
  • 51
    • 0028071586 scopus 로고
    • Characterization of primary cultures of chondrocytes from type II collagen/betagalactosidase transgenic mice
    • Lefebvre V, Garofalo S, Zhou G, Metsaranta M, Vuorio E, de crombrugghe B. Characterization of primary cultures of chondrocytes from type II collagen/betagalactosidase transgenic mice. Matrix Biol 1994; 14: 329-335.
    • (1994) Matrix Biol , vol.14 , pp. 329-335
    • Lefebvre, V.1    Garofalo, S.2    Zhou, G.3    Metsaranta, M.4    Vuorio, E.5    De Crombrugghe, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.