Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis

Journal of Clinical Investigation

Volumn 126, Issue 8, 2016, Pages 2893-2902

  Zhang, Minjie ^a   Mani, Sriniwasan B ^a   He, Yao ^a,b   Hall, Amber M ^a   Xu, Lin ^c   Li, Yefu ^c   Zurakowski, David ^a   Jay, Gregory D ^d   Warman, Matthew L ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b SICHUAN UNIVERSITY   (China)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d Brown University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA TOXIN A; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE INJURY; CATABOLISM; CELL DEATH; CELL KILLING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HISTOPATHOLOGY; KNEE MENISCUS; KNEE SURGERY; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; STAINING; THREE DIMENSIONAL IMAGING; ANIMAL; ARTHROPATHY; C57BL MOUSE; CARTILAGE; CHONDROCYTE; CYTOLOGY; DISEASE MODEL; INJURIES; KNEE; METABOLISM; PATHOLOGY;

AGING; ANIMALS; CARTILAGE; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; IMAGING, THREE-DIMENSIONAL; JOINT DISEASES; KNEE JOINT; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; OSTEOARTHRITIS;

EID: 84987776649     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI83676     Document Type: Article

References (43)

1. Pearle AD, Warren RF, Rodeo SA. Basic science of articular cartilage and osteoarthritis. Clin Sports Med. 2005;24(1):1-12.
2. Buckwalter JA, Mankin HJ, Grodzinsky AJ. Articular cartilage and osteoarthritis. Instr Course Lect. 2005;54:465-480.
3. Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014;28(1):5-15.
4. Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum Dis Clin North Am. 2013;39(1):1-19.
5. Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol. 2005;17(2):195-200.
6. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376(9746):1094-1108.
7. Weinstein AM, et al. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am. 2013;95(5):385-392.
8. Grogan SP, D'Lima DD. Joint aging and chondrocyte cell death. Int J Clin Rheumtol. 2010;5(2):199-214.
9. Martin JA, Buckwalter JA. Aging, articular cartilage chondrocyte senescence and osteoarthritis. Biogerontology. 2002;3(5):257-264.
10. Cao Y, et al. Proinflammatory cytokines stimulate mitochondrial superoxide flashes in articular chondrocytes in vitro and in situ. PLoS One. 2013;8(6):e66444.
11. Loeser RF. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthr Cartil. 2009;17(8):971-979.
12. Colwell CW Jr, et al. In vivo changes after mechanical injury. Clin Orthop Relat Res. 2001;(391 suppl):S116-S123.
13. Duda GN, Eilers M, Loh L, Hoffman JE, Kääb M, Schaser K. Chondrocyte death precedes structural damage in blunt impact trauma. Clin Orthop Relat Res. 2001;(393):302-309.
14. Seol D, et al. Chondrogenic progenitor cells respond to cartilage injury. Arthritis Rheum. 2012;64(11):3626-3637.
15. Poulet B, et al. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis Rheum. 2012;64(10):3256-3266.
16. Burleigh A, et al. Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo. Arthritis Rheum. 2012;64(7):2278-2288.
17. Little CB, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009;60(12):3723-3733.
18. Majumdar MK, et al. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum. 2007;56(11):3670-3674.
19. Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthr Cartil. 2010;18(suppl 3):S17-S23.
20. Kozhemyakina E, et al. Identification of a prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol. 2015;67(5):1261-1273.
21. Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol. 2008;180(7):4742-4753.
22. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthr Cartil. 2007;15(9):1061-1069.
23. Henry SP, Liang S, Akdemir KC, de Crombrugghe B. The postnatal role of Sox9 in cartilage. J Bone Miner Res. 2012;27(12):2511-2525.
24. Loty B, Courpied JP, Tomeno B, Kerboull M, Postel M, Forest M. [Massive bone allografts sterilized by irradiation: evaluation following 5 years of use]. Acta Orthop Belg. 1991;57(suppl 2):35-43.
25. Parsch D, Brümmendorf TH, Richter W, Fellenberg J. Replicative aging of human articular chondrocytes during ex vivo expansion. Arthritis Rheum. 2002;46(11):2911-2916.
26. Xu L, et al. Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. Arthritis Rheum. 2010;62(9):2736-2744.
27. Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS. Hypoxia-inducible factor-2α regulates Fasmediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 2012;19(3):440-450.
28. Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A. 2013;110(15):5852-5857.
29. Wong BL, Bae WC, Chun J, Gratz KR, Lotz M, Sah RL. Biomechanics of cartilage articulation: effects of lubrication and degeneration on shear deformation. Arthritis Rheum. 2008;58(7):2065-2074.
30. Jay GD, et al. Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum. 2007;56(11):3662-3669.
31. Karamchedu NP, Tofte JN, Waller KA, Zhang LX, Patel TK, Jay GD. Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis. Arthritis Res Ther. 2015;18(1):64.
32. Verschure PJ, Van Marle J, Van Noorden CJ, Van den Berg WB. The contribution of quantitative confocal laser scanning microscopy in cartilage research: chondrocyte insulin-like growth factor-1 receptors in health and pathology. Microsc Res Tech. 1997;37(4):285-298.
33. Zelenski NA, et al. Type VI collagen regulates pericellular matrix properties, chondrocyte swelling, and mechanotransduction in mouse articular cartilage. Arthritis Rheumatol. 2015;67(5):1286-1294.
34. Jablonski CL, Ferguson S, Pozzi A, Clark AL. Integrin α1β1 participates in chondrocyte transduction of osmotic stress. Biochem Biophys Res Commun. 2014;445(1):184-190.
35. Stok KS, Müller R. Morphometric characterization of murine articular cartilage-novel application of confocal laser scanning microscopy. Microsc Res Tech. 2009;72(9):650-658.
36. Wong M, Wuethrich P, Eggli P, Hunziker E. Zonespecific cell biosynthetic activity in mature bovine articular cartilage: a new method using confocal microscopic stereology and quantitative autoradiography. J Orthop Res. 1996;14(3):424-432.
37. Ruan MZ, Dawson B, Jiang MM, Gannon F, Heggeness M, Lee BH. Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography. Arthritis Rheum. 2013;65(2):388-396.
38. Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T, Gsell W. Imaging technologies for preclinical models of bone and joint disorders. EJNMMI Res. 2011;1(1):11.
39. Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, Koretsky AP. MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A. 2004;101(30):10901-10906.
40. Ullmann JF, Cowin G, Kurniawan ND, Collin SP. Magnetic resonance histology of the adult zebrafish brain: optimization of fixation and gadolinium contrast enhancement. NMR Biomed. 2010;23(4):341-346.
41. Xie L, Lin AS, Levenston ME, Guldberg RE. Quantitative assessment of articular cartilage morphology via EPIC-microCT. Osteoarthr Cartil. 2009;17(3):313-320.
42. Anderson DD, et al. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res. 2011;29(6):802-809.
43. Combes AN, Short KM, Lefevre J, Hamilton NA, Little MH, Smyth IM. An integrated pipeline for the multidimensional analysis of branching morphogenesis. Nat Protoc. 2014;9(12):2859-2879.