p107 and p130 coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development

Developmental Biology

Volumn 247, Issue 2, 2002, Pages 271-285

  Rossi, Ferdinand ^a   MacLean, Helen E ^b   Yuan, Wei ^a   Francis, Richard O ^a   Semenova, Ekaterina ^a   Lin, Carol S ^a   Kronenberg, Henry M ^b   Cobrinik, David ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cbfa1; Chondrocyte; Chondrogenesis; Hypertrophic differentiation; p107; p130

Indexed keywords

ALCIAN BLUE; COLLAGEN TYPE 2; ISOPROTEIN; PROTEIN P107; PROTEIN P130; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; DEREGULATION; EMBRYO; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION; HYPERTROPHY; MESENCHYME; MITOSIS INHIBITION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 0036308935     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0691     Document Type: Article

References (48)

1. Sox9 is required for cartilage formation
2. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
3. Shared role of the pRB-related p130 and p107 proteins in limb development
4. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
5. Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesis
6. Cbfa1: A molecular switch in osteoblast biology
7. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
8. Cbfa1 is a positive regulatory factor in chondrocyte maturation
9. Does adult fracture repair recapitulate embryonic skeletal formation?
10. The membranous skeleton: The role of cell condensations in vertebrate skeletogenesis
11. Cell division in the early growth and morphogenesis of the chick limb
12. Cartilage morphology
13. Maturational disturbance of chondrocytes in Cbfa1-deficient mice
14. Spondylome-taphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition
15. Changes in rate of cellular proliferation during the differentiation of cartilage and muscle in the mesenchyme of the embryonic chick wing
16. Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene
17. The retinoblastoma gene family is differentially expressed during embryogenesis
18. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
19. Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes
20. Regulation of chondrocyte differentiation by Cbfa1
21. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
22. Collagen gene expression during limb cartilage differentiation
23. Quantitation of type II procollagen mRNA levels during chick limb cartilage differentiation
24. The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate
25. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats
26. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development
27. Targeted disruption of p107: Functional overlap between p107 and Rb
28. Specific staining of sulfate groups with Alcian blue at low pH
29. The retinoblastoma gene family in differentiation and development
30. Tissue-specific and differential expression of alternatively spliced alpha 1(II) collagen mRNAs in early human embryos
31. Type IIA. procollagen: Expression in developing chicken limb cartilage and human osteoarthritic articular cartilage
32. Type II collagen mRNA containing an alternatively spliced exon predominates in the chick limb prior to chondrogenesis
33. Preferential expression of alternatively spliced mRNAs encoding type II procollagen with a cysteine-rich amino-propeptide in differentiating cartilage and nonchondrogenic tissues during early mouse development
34. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
35. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
36. BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
37. p107 is a suppressor of retinoblastoma development in pRb-deficient mice
38. In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth
39. Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: Differential expression of the amino-propeptide
40. Alternative splice form of type II procollagen mRNA (IIA) is predominant in skeletal precursors and non-cartilaginous tissues during early mouse development
41. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
42. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
43. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
44. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
45. Morphological foundations of precartilage development in mesenchyme
46. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
47. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
48. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome