Identification of a central role for complement in osteoarthritis

Nature Medicine

Volumn 17, Issue 12, 2011, Pages 1674-1679

  Wang, Qian ^a,b   Rozelle, Andrew L ^a,b   Lepus, Christin M ^a,b   Scanzello, Carla R ^c   Song, Jason J ^a,b   Larsen, D Meegan ^a,b   Crish, James F ^d   Bebek, Gurkan ^d,e   Ritter, Susan Y ^f   Lindstrom, Tamsin M ^a,b   Hwang, Inyong ^a,b   Wong, Heidi H ^a,b   Punzi, Leonardo ^g   Encarnacion, Angelo ^b   Shamloo, Mehrdad ^b   Goodman, Stuart B ^b   Wyss Coray, Tony ^a,b   Goldring, Steven R ^h   Banda, Nirmal K ^i,j   Thurman, Joshua M ^i,j   Gobezie, Reuben ^d   Crow, Mary K ^h   Holers, V Michael ^i,j   Lee, David M ^f,k   Robinson, William H ^a,b   more..

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g UNIVERSITY OF PADOVA   (Italy)

^h HOSPITAL FOR SPECIAL SURGERY   (United States)

ⁱ UNIVERSITY OF COLORADO   (United States)

^j UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^k NOVARTIS PHARMA AG   (Switzerland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; COLLAGENASE 3; COMPLEMENT; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT MEMBRANE ATTACK COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL CULTURE; COMPLEMENT SYSTEM; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; JOINT STABILITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEOMICS; SYNOVIAL FLUID; SYNOVIUM; TRANSCRIPTOMICS; WILD TYPE;

ANIMALS; ANTIGENS, CD59; CARTILAGE; CHONDROCYTES; COMPLEMENT C5; COMPLEMENT C6; COMPLEMENT MEMBRANE ATTACK COMPLEX; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; JOINTS; MATRIX METALLOPROTEINASE 13; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROTEOMICS; SYNOVIAL FLUID;

MUS;

EID: 84856100338     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2543     Document Type: Article

References (32)

1. Felson D.T. Clinical practice. Osteoarthritis of the knee. N. Engl. J. Med. 354, 841-848 (2006).
2. Goldring M.B. & Goldring S.R. Osteoarthritis. J. Cell. Physiol. 213, 626-634 (2007). (Pubitemid 350058254)
3. Pelletier J.P., Martel-Pelletier J. & Abramson S.B. Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets. Arthritis Rheum. 44, 1237-1247 (2001). (Pubitemid 32537520)
4. Hill C.L. et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann. Rheum. Dis. 66, 1599-1603 (2007). (Pubitemid 350205447)
5. Gobezie R. et al. High abundance synovial fluid proteome: Distinct profiles in health and osteoarthritis. Arthritis Res. Ther. 9, R36 (2007).
6. Kemper C. & Atkinson J.P. T-cell regulation: With complements from innate immunity. Nat. Rev. Immunol. 7, 9-18 (2007). (Pubitemid 46020823)
7. Cooke T.D., Bennett E.L. & Ohno O. The deposition of immunoglobulins and complement in osteoarthritic cartilage. Int. Orthop. 4, 211-217 (1980). (Pubitemid 11241178)
8. Corvetta A. et al. Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma. Clin. Exp. Rheumatol. 10, 433-438 (1992).
9. Cooke T.D. Significance of immune complex deposits in osteoarthritic cartilage. J. Rheumatol. 14 (Spec No), 77-79 (1987). (Pubitemid 17139528)
10. Kamekura S. et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 13, 632-641 (2005). (Pubitemid 40867863)
11. Englund M. & Lohmander L.S. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum. 50, 2811-2819 (2004). (Pubitemid 39209518)
12. Ooi Y.M. & Colten H.R. Genetic defect in secretion of complement C5 in mice. Nature 232, 207-208 (1979). (Pubitemid 10196511)
13. Huber-Lang M. et al. Generation of C5a in the absence of C3: A new complement activation pathway. Nat. Med. 12, 682-687 (2006). (Pubitemid 43865238)
14. Banda N.K. et al. Mechanisms of effects of complement inhibition in murine collagen-induced arthritis. Arthritis Rheum. 46, 3065-3075 (2002). (Pubitemid 35315902)
15. Banda N.K. et al. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J. Immunol. 183, 5928-5937 (2009).
16. Glasson S.S. In vivo osteoarthritis target validation utilizing genetically-modified mice. Curr. Drug Targets 8, 367-376 (2007).
17. Glasson S.S. et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434, 644-648 (2005). (Pubitemid 40488556)
18. Stanton H. et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434, 648-652 (2005). (Pubitemid 40488557)
19. Happonen K.E. et al. Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum. 62, 3574-3583 (2010).
20. Neidhart M. et al. Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation. Br. J. Rheumatol. 36, 1151-1160 (1997).
21. Scanzello C.R., Plaas A. & Crow M.K. Innate immune system activation in osteoarthritis: Is osteoarthritis a chronic wound? Curr. Opin. Rheumatol. 20, 565-572 (2008).
22. Sofat N. Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int. J. Exp. Pathol. 90, 463-479 (2009).
23. Sjöberg A., Onnerfjord P., Morgelin M., Heinegard D. & Blom A.M. The extracellular matrix and inflammation: Fibromodulin activates the classical pathway of complement by directly binding C1q. J. Biol. Chem. 280, 32301-32308 (2005). (Pubitemid 41361839)
24. Bohana-Kashtan O., Ziporen L., Donin N., Kraus S. & Fishelson Z. Cell signals transduced by complement. Mol. Immunol. 41, 583-597 (2004). (Pubitemid 38824616)
25. Scanzello C.R. et al. Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms. Arthritis Rheum. 63, 391-400 (2011).
26. Attur M. et al. Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: Evidence for signaling via the EP4 receptor. J. Immunol. 181, 5082-5088 (2008).
27. Badea T.D. et al. Sublytic terminal complement attack induces c-fos transcriptional activation in myotubes. J. Neuroimmunol. 142, 58-66 (2003). (Pubitemid 38368588)
28. Rus H.G., Niculescu F. & Shin M.L. Sublytic complement attack induces cell cycle in oligodendrocytes. J. Immunol. 156, 4892-4900 (1996).
29. Kraus S., Seger R. & Fishelson Z. Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysis. Clin. Exp. Immunol. 123, 366-374 (2001). (Pubitemid 32289953)
30. Litherland G.J. et al. Protein kinase C isoforms ε and τ mediate collagenase expression and cartilage destruction via STAT3-and ERK-dependent c-fos induction. J. Biol. Chem. 285, 22414-22425 (2010).
31. Daiger S.P. Genetics. Was the Human Genome Project worth the effort? Science 308, 362-364 (2005). (Pubitemid 40530062)
32. Rogers J. et al. Complement activation by β-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 89, 10016-10020 (1992).