메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages

Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and sost in Osteocytes at unloading

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN BCL 2;

EID: 84863111789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040143     Document Type: Article
Times cited : (88)

References (58)
  • 1
    • 0003527888 scopus 로고
    • Berlin: Springer-Verlag, Mit Vier Nachworten Und Historischen Dokumenten Auflage 2010
    • Wolff J, (1892) Das gesetz der transformation der knochen. Berlin: Springer-Verlag.- Reprint 300 Seiten- Mit vier Nachworten und historischen Dokumenten Auflage 2010.
    • (1892) Das gesetz der transformation der knochen
    • Wolff, J.1
  • 2
    • 0033991384 scopus 로고    scopus 로고
    • Does osteocyte formation cause the nonlinear refilling of osteons?
    • Martin RB, (2000) Does osteocyte formation cause the nonlinear refilling of osteons? Bone 26: 71-78.
    • (2000) Bone , vol.26 , pp. 71-78
    • Martin, R.B.1
  • 3
    • 0036712047 scopus 로고    scopus 로고
    • Mechanical strain and bone cell function: a review
    • Ehrlich PJ, Lanyon LE, (2002) Mechanical strain and bone cell function: a review. Osteoporos Int 13: 688-700.
    • (2002) Osteoporos Int , vol.13 , pp. 688-700
    • Ehrlich, P.J.1    Lanyon, L.E.2
  • 4
    • 0141630244 scopus 로고    scopus 로고
    • "Whither flows the fluid in bone?" An osteocyte's perspective
    • Tate MLK, (2003) "Whither flows the fluid in bone?" An osteocyte's perspective. J Biomech 36: 1409-1424.
    • (2003) J Biomech , vol.36 , pp. 1409-1424
    • Tate, M.L.K.1
  • 5
    • 0032895922 scopus 로고    scopus 로고
    • Mechanotransduction in bone-role of the lacuno-canalicular network
    • Burger EH, Klein-Nulend J, (1999) Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB Journal 13.
    • (1999) FASEB Journal , vol.13
    • Burger, E.H.1    Klein-Nulend, J.2
  • 6
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald L, Johnson M, (2008) Osteocytes, mechanosensing and Wnt signaling. Bone 42: 606-615.
    • (2008) Bone , vol.42 , pp. 606-615
    • Bonewald, L.1    Johnson, M.2
  • 7
    • 50949131016 scopus 로고    scopus 로고
    • The osteocyte lineage
    • Noble B, (2008) The osteocyte lineage. Arch biochem biophys 473: 106-111.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 106-111
    • Noble, B.1
  • 8
    • 34249657953 scopus 로고    scopus 로고
    • Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction
    • Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, et al. (2007) Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction. Cell Metabolism 5: 464-475.
    • (2007) Cell Metabolism , vol.5 , pp. 464-475
    • Tatsumi, S.1    Ishii, K.2    Amizuka, N.3    Li, M.4    Kobayashi, T.5
  • 9
    • 0029147728 scopus 로고
    • Quantitative evaluation on osteocyte canalicular density in human secondary osteons
    • Marotti G, Ferretti M, Remaggi F, Palumbo C, (1995) Quantitative evaluation on osteocyte canalicular density in human secondary osteons. Bone 16: 125-128.
    • (1995) Bone , vol.16 , pp. 125-128
    • Marotti, G.1    Ferretti, M.2    Remaggi, F.3    Palumbo, C.4
  • 10
    • 0036948178 scopus 로고    scopus 로고
    • Relationships between osteocyte density and bone formation rate in human cancellous bone
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM, (2002) Relationships between osteocyte density and bone formation rate in human cancellous bone. Bone 31: 709-711.
    • (2002) Bone , vol.31 , pp. 709-711
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 11
    • 0242708809 scopus 로고    scopus 로고
    • Histomorphometric analysis of the effects of osteocyte density on osteonal morphology and remodeling
    • Metz LN, Martin RB, Turner AS, (2003) Histomorphometric analysis of the effects of osteocyte density on osteonal morphology and remodeling. Bone 33: 753-759.
    • (2003) Bone , vol.33 , pp. 753-759
    • Metz, L.N.1    Martin, R.B.2    Turner, A.S.3
  • 12
    • 10744221383 scopus 로고    scopus 로고
    • Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
    • Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, et al. (2003) Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO Journal 22: 6267-6276.
    • (2003) EMBO Journal , vol.22 , pp. 6267-6276
    • Winkler, D.G.1    Sutherland, M.K.2    Geoghegan, J.C.3    Yu, C.4    Hayes, T.5
  • 14
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
    • Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, et al. (2005) Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146: 4577-4583.
    • (2005) Endocrinology , vol.146 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4    Fu, Q.5
  • 15
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X, Zhang Y, Kang H, Liu W, Liu P, et al. (2005) Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 280: 19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4    Liu, P.5
  • 17
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semenov M, Tamai K, He X, (2005) SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 280: 26770-26775.
    • (2005) J Biol Chem , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 18
    • 33845927993 scopus 로고    scopus 로고
    • Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
    • van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, et al. (2007) Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J Bone Miner Res 22: 19-28.
    • (2007) J Bone Miner Res , vol.22 , pp. 19-28
    • van Bezooijen, R.L.1    Svensson, J.P.2    Eefting, D.3    Visser, A.4    van der Horst, G.5
  • 19
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, et al. (2008) Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23: 860-869.
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3    Sun, N.4    Daugherty, B.5
  • 20
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • Lin C, Jiang X, Dai Z, Guo X, Weng T, et al. (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24: 1651-1661.
    • (2009) J Bone Miner Res , vol.24 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3    Guo, X.4    Weng, T.5
  • 21
    • 0033981552 scopus 로고    scopus 로고
    • Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo
    • Verborgt O, Gibson GJ, Schaffler MB, (2000) Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res 15: 60-67.
    • (2000) J Bone Miner Res , vol.15 , pp. 60-67
    • Verborgt, O.1    Gibson, G.J.2    Schaffler, M.B.3
  • 22
    • 38049068610 scopus 로고    scopus 로고
    • Perspective: Quantifying osteoblast and osteocyte apoptosis: challenges and rewards
    • Jilka RL, Weinstein RS, Parfitt AM, Manolagas SC, (2007) Perspective: Quantifying osteoblast and osteocyte apoptosis: challenges and rewards. J Bone Miner Res 22: 1492-1501.
    • (2007) J Bone Miner Res , vol.22 , pp. 1492-1501
    • Jilka, R.L.1    Weinstein, R.S.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 23
    • 18244392443 scopus 로고    scopus 로고
    • Cell death independent of caspases: a review
    • Broker LE, Kruyt FA, Giaccone G, (2005) Cell death independent of caspases: a review. Clin Cancer Res 11: 3155-3162.
    • (2005) Clin Cancer Res , vol.11 , pp. 3155-3162
    • Broker, L.E.1    Kruyt, F.A.2    Giaccone, G.3
  • 24
    • 41149115987 scopus 로고    scopus 로고
    • Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications
    • Silva MT, Vale A, Santos NMN, (2008) Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications. Apoptosis 13: 463-482.
    • (2008) Apoptosis , vol.13 , pp. 463-482
    • Silva, M.T.1    Vale, A.2    Santos, N.M.N.3
  • 25
    • 54549121675 scopus 로고    scopus 로고
    • Clearance deficiency-A potential link between infections and autoimmunity{star, open}
    • Schulze C, Munoz L, Franz S, Sarter K, Chaurio R, et al. (2008) Clearance deficiency-A potential link between infections and autoimmunity{star, open}. Autoimmunity Reviews 8: 5-8.
    • (2008) Autoimmunity Reviews , vol.8 , pp. 5-8
    • Schulze, C.1    Munoz, L.2    Franz, S.3    Sarter, K.4    Chaurio, R.5
  • 26
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong WX, (2006) Necrotic death as a cell fate. Genes dev 20: 1-15.
    • (2006) Genes Dev , vol.20 , pp. 1-15
    • Zong, W.X.1
  • 27
    • 41449099766 scopus 로고    scopus 로고
    • Osteoclasts - the innate immune cells of the bone
    • Wu Y, Humphrey MB, Nakamura MC, (2008) Osteoclasts- the innate immune cells of the bone. Autoimmunity 41: 183-194.
    • (2008) Autoimmunity , vol.41 , pp. 183-194
    • Wu, Y.1    Humphrey, M.B.2    Nakamura, M.C.3
  • 28
    • 77953407742 scopus 로고    scopus 로고
    • Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis
    • Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, et al. (2010) Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol cell biol 30: 3071-3085.
    • (2010) Mol Cell Biol , vol.30 , pp. 3071-3085
    • Kramer, I.1    Halleux, C.2    Keller, H.3    Pegurri, M.4    Gooi, J.H.5
  • 30
    • 80053938104 scopus 로고    scopus 로고
    • Evidence for osteocyte regulation of bone homeostasis through RANKL expression
    • Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, et al. (2011) Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat med 17: 1231-1234.
    • (2011) Nat Med , vol.17 , pp. 1231-1234
    • Nakashima, T.1    Hayashi, M.2    Fukunaga, T.3    Kurata, K.4    Oh-Hora, M.5
  • 31
    • 81255143269 scopus 로고    scopus 로고
    • Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis
    • doi:10.1371/journal.pone.0027487
    • Moriishi T, Maruyama Z, Fukuyama R, Ito M, Toshihiro Miyazaki, et al. (2011) Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PLoS ONE 6(11): e27487 doi:10.1371/journal.pone.0027487.
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Moriishi, T.1    Maruyama, Z.2    Fukuyama, R.3    Ito, M.4    Toshihiro, M.5
  • 32
    • 0010546273 scopus 로고    scopus 로고
    • Changes in trabecular bone turnover and bone marrow cell development in tail-suspended mice
    • Sakai A, Nakamura T, (2001) Changes in trabecular bone turnover and bone marrow cell development in tail-suspended mice. J Musculoskelet Neuronal Interact 1: 387-392.
    • (2001) J Musculoskelet Neuronal Interact , vol.1 , pp. 387-392
    • Sakai, A.1    Nakamura, T.2
  • 33
    • 84455191881 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis
    • Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, et al. (2011) Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone. 50(1): 409-19.
    • (2011) Bone , vol.50 , Issue.1 , pp. 409-419
    • Wang, Y.1    Liu, W.2    Masuyama, R.3    Fukuyama, R.4    Ito, M.5
  • 34
    • 0035494469 scopus 로고    scopus 로고
    • Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    • Liu W, Toyosawa S, Furuichi T, Kanatani N, Yoshida C, et al. (2001) Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol 155: 157-166.
    • (2001) J Cell Biol , vol.155 , pp. 157-166
    • Liu, W.1    Toyosawa, S.2    Furuichi, T.3    Kanatani, N.4    Yoshida, C.5
  • 35
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, et al. (2004) Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev 18: 952-963.
    • (2004) Genes Dev , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5
  • 37
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald LF, (2011) The amazing osteocyte. J Bone Miner Res 26: 229-238.
    • (2011) J Bone Miner Res , vol.26 , pp. 229-238
    • Bonewald, L.F.1
  • 38
    • 0034773406 scopus 로고    scopus 로고
    • Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts
    • Toyosawa S, Shintani S, Fujiwara T, Ooshima T, Sato A, et al. (2001) Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. J Bone Miner Res 16: 2017-2026.
    • (2001) J Bone Miner Res , vol.16 , pp. 2017-2026
    • Toyosawa, S.1    Shintani, S.2    Fujiwara, T.3    Ooshima, T.4    Sato, A.5
  • 39
    • 68849117424 scopus 로고    scopus 로고
    • Identification of differentially expressed genes between osteoblasts and osteocytes
    • Paic F, Igwe JC, Nori R, Kronenberg MS, Franceschetti T, et al. (2009) Identification of differentially expressed genes between osteoblasts and osteocytes. Bone 45: 682-692.
    • (2009) Bone , vol.45 , pp. 682-692
    • Paic, F.1    Igwe, J.C.2    Nori, R.3    Kronenberg, M.S.4    Franceschetti, T.5
  • 40
    • 3543006559 scopus 로고    scopus 로고
    • Immunohistological identification of receptor activator of NF-kappaB ligand (RANKL) in human, ovine and bovine bone tissues
    • Mueller RJ, Richards RG, (2004) Immunohistological identification of receptor activator of NF-kappaB ligand (RANKL) in human, ovine and bovine bone tissues. J Mater Sci Mater Med 15: 367-372.
    • (2004) J Mater Sci Mater Med , vol.15 , pp. 367-372
    • Mueller, R.J.1    Richards, R.G.2
  • 41
    • 2342529836 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    • Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, et al. (2004) The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol endocrinol 18: 1222-1237.
    • (2004) Mol Endocrinol , vol.18 , pp. 1222-1237
    • Bodine, P.V.1    Zhao, W.2    Kharode, Y.P.3    Bex, F.J.4    Lambert, A.J.5
  • 42
    • 33646856033 scopus 로고    scopus 로고
    • Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
    • Morvan F, Boulukos K, Clement-Lacroix P, Roman Roman S, Suc-Royer I, et al. (2006) Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 21: 934-945.
    • (2006) J Bone Miner Res , vol.21 , pp. 934-945
    • Morvan, F.1    Boulukos, K.2    Clement-Lacroix, P.3    Roman Roman, S.4    Suc-Royer, I.5
  • 43
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, et al. (2008) Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 283: 5866-5875.
    • (2008) J Biol Chem , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3    Condon, K.W.4    Allen, M.R.5
  • 44
    • 84861760073 scopus 로고    scopus 로고
    • Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered
    • Moustafa A, Sugiyama T, Prasad J, Zaman G, Gross TS, et al. (2011) Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int 23: 1225-1234.
    • (2011) Osteoporos Int , vol.23 , pp. 1225-1234
    • Moustafa, A.1    Sugiyama, T.2    Prasad, J.3    Zaman, G.4    Gross, T.S.5
  • 45
    • 0036197329 scopus 로고    scopus 로고
    • Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen
    • Heino TJ, Hentunen TA, Vaananen HK, (2002) Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen. J Cell Biochem 85: 185-197.
    • (2002) J Cell Biochem , vol.85 , pp. 185-197
    • Heino, T.J.1    Hentunen, T.A.2    Vaananen, H.K.3
  • 46
    • 37449027378 scopus 로고    scopus 로고
    • Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading
    • You L, Temiyasathit S, Lee P, Kim CH, Tummala P, et al. (2008) Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 42: 172-179.
    • (2008) Bone , vol.42 , pp. 172-179
    • You, L.1    Temiyasathit, S.2    Lee, P.3    Kim, C.H.4    Tummala, P.5
  • 48
    • 0025151170 scopus 로고
    • Continuing periosteal apposition. II: The significance of peak bone mass, strain equilibrium, and age-related activity differentials for mechanical compensation in human tubular bones
    • Lazenby RA, (1990) Continuing periosteal apposition. II: The significance of peak bone mass, strain equilibrium, and age-related activity differentials for mechanical compensation in human tubular bones. Am J Phys Anthropol 82: 473-484.
    • (1990) Am J Phys Anthropol , vol.82 , pp. 473-484
    • Lazenby, R.A.1
  • 50
    • 29344475700 scopus 로고    scopus 로고
    • Structural adaptations to bone loss in aging men and women
    • Russo C, Lauretani F, Seeman E, Bartali B, Bandinelli S, et al. (2006) Structural adaptations to bone loss in aging men and women. Bone 38: 112-118.
    • (2006) Bone , vol.38 , pp. 112-118
    • Russo, C.1    Lauretani, F.2    Seeman, E.3    Bartali, B.4    Bandinelli, S.5
  • 51
    • 0034768401 scopus 로고    scopus 로고
    • During aging, men lose less bone than women because they gain more periosteal bone, not because they resorb less endosteal bone
    • Seeman E, (2001) During aging, men lose less bone than women because they gain more periosteal bone, not because they resorb less endosteal bone. Calcif Tissue Int 69: 205-208.
    • (2001) Calcif Tissue Int , vol.69 , pp. 205-208
    • Seeman, E.1
  • 52
    • 33846601758 scopus 로고    scopus 로고
    • Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts
    • Hedgecock N, Hadi T, Chen A, Curtiss S, Martin R, et al. (2007) Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts. Bone 40: 627-637.
    • (2007) Bone , vol.40 , pp. 627-637
    • Hedgecock, N.1    Hadi, T.2    Chen, A.3    Curtiss, S.4    Martin, R.5
  • 53
    • 0033794197 scopus 로고    scopus 로고
    • Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen
    • Zhao W, Byrne MH, Wang Y, Krane SM, (2000) Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen. J Clin Invest 106: 941-949.
    • (2000) J Clin Invest , vol.106 , pp. 941-949
    • Zhao, W.1    Byrne, M.H.2    Wang, Y.3    Krane, S.M.4
  • 54
    • 27744461726 scopus 로고    scopus 로고
    • Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    • Poole KE, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, et al. (2005) Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 19: 1842-1844.
    • (2005) FASEB J , vol.19 , pp. 1842-1844
    • Poole, K.E.1    van Bezooijen, R.L.2    Loveridge, N.3    Hamersma, H.4    Papapoulos, S.E.5
  • 55
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
    • Li X, (2005) Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling. J Biol Chem 280: 19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1
  • 56
    • 22844445934 scopus 로고    scopus 로고
    • SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
    • Semenov M, (2005) SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor. J Biol Chem 280: 26770-26775.
    • (2005) J Biol Chem , vol.280 , pp. 26770-26775
    • Semenov, M.1
  • 57
    • 44449099165 scopus 로고    scopus 로고
    • Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
    • Li X, Ominsky MS, Niu Q-T, Sun N, Daugherty B, et al. (2008) Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength. J Bone Miner Res 23: 860-869.
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.-T.3    Sun, N.4    Daugherty, B.5
  • 58
    • 40349083697 scopus 로고    scopus 로고
    • Nonpharmacological approaches to improve bone health and reduce osteoporosis
    • Schwab P, Klein RF, (2008) Nonpharmacological approaches to improve bone health and reduce osteoporosis. Curr Opin Rheumatol 20: 213-217.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 213-217
    • Schwab, P.1    Klein, R.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.