Cell death in osteoarthritis

Current Rheumatology Reports

Volumn 10, Issue 1, 2008, Pages 37-42

  Del Carlo Jr , Marcello ^b   Loeser, Richard F ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CARBAMIC ACID DERIVATIVE; CASPASE 1 INHIBITOR; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE INHIBITOR; ENZYME INHIBITOR; FAS LIGAND; GROWTH FACTOR; HEAT SHOCK PROTEIN 70; LIPOCORTIN 5; MATRIX METALLOPROTEINASE; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDINEDIONE DERIVATIVE; QUINOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROISOQUINOLINE; TETRAHYDROQUINOLINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGY; CARTILAGE CELL; CELL DEATH; CELL FUNCTION; CELL PROTECTION; DNA DEGRADATION; DRUG MECHANISM; EXTRACELLULAR MATRIX; HUMAN; IN VIVO GENE TRANSFER; NECROSIS; NICK END LABELING; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PLASMID; REVIEW; ANIMAL; CARTILAGE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GROWTH PLATE; IMMUNOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT;

ANIMALS; APOPTOSIS; CARTILAGE; CHONDROCYTES; DISEASE MODELS, ANIMAL; GROWTH PLATE; HUMANS; NECROSIS; OSTEOARTHRITIS; RABBITS;

EID: 44949140678     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-008-0007-8     Document Type: Review

References (54)

1. Aigner T, Kim HA, Roach HI: Apoptosis in osteoarthritis. Rheum Dis Clin North Am 2004, 30:639-653.
2. Kuhn K, D'Lima DD, Hashimoto S, Lotz M: Cell death in cartilage. Osteoarthritis Cartilage 2004, 12:1-16.
3. Aigner T, Hemmel M, Neureiter D, et al.: Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 2001, 44:1304-1312.
4. Roach HI, Aigner T, Kouri JB: Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis 2004, 9:265-277.
5. Perez HE, Luna MJ, Rojas ML, Kouri JB: Chondroptosis: an immunohistochemical study of apoptosis and Golgi complex in chondrocytes from human osteoarthritic cartilage. Apoptosis 2005, 10:1105-1110.
6. Svoboda KK: Chondrocyte-matrix attachment complexes mediate survival and differentiation. Microsc Res Tech 1998, 43:111-122.
7. Kim HA, Suh DI, Song YW: Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage. J Rheumatol 2001, 28:2038-2045.
8. Thomas CM, Fuller CJ, Whittles CE, Sharif M: Chondrocyte death by apoptosis is associated with cartilage matrix degradation. Osteoarthritis Cartilage 2007, 15:27-34.
9. Loeser RF, Shanker G: Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro. Arthritis Rheum 2000, 43:1552-1559.
10. Pulai JI, Del Carlo M Jr, Loeser RF: The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro. Arthritis Rheum 2002, 46:1528-1535.
11. Zemmyo M, Meharra EJ, Kuhn K, et al.: Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice. Arthritis Rheum 2003, 48:2873-2880.
12. Park M, Yong Y, Choi SW, et al.: Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability. Nat Cell Biol 2007, 9:287-298.
13. Tew SR, Kwan AP, Hann A, et al.: The reactions of articular cartilage to experimental wounding: role of apoptosis. Arthritis Rheum 2000, 43:215-225.
14. Chen CT, Burton-Wurster N, Borden C, et al.: Chondrocyte necrosis and apoptosis in impact damaged articular cartilage. J Orthop Res 2001, 19:703-711.
15. Milentijevic D, Rubel IF, Liew AS, et al.: An in vivo rabbit model for cartilage trauma: a preliminary study of the influence of impact stress magnitude on chondrocyte death and matrix damage. J Orthop Trauma 2005, 19:466-473.
16. Kurz B, Lemke A, Kehn M, et al.: Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum 2004, 50:123-130.
17. Green DM, Noble PC, Ahuero JS, Birdsall HH: Cellular events leading to chondrocyte death after cartilage impact injury. Arthritis Rheum 2006, 54:1509-1517.
18. Healy ZR, Lee NH, Gao X, et al.: Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A 2005, 102:14010-14015.
19. Ishizaki Y, Burne JF, Raff MC: Autocrine signals enable chondrocytes to survive in culture. J Cell Biol 1994, 126:1069-1077.
20. Del Carlo M, Loeser RF: Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI. Am J Physiol Cell Physiol 2006, 290:C802-811.
21. Morita K, Miyamoto T, Fujita N, et al.: Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 2007, 204:1613-1623.
22. Sharif M, Whitehouse A, Sharman P, et al.: Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 2004, 50:507-515.
23. Emans PJ, Bulstra SK, Kuijer R: The effects of different decalcification protocols on TUNEL and general cartilage staining. Biotech Histochem 2005, 80:111-115.
24. Mistry D, Oue Y, Chambers MG, et al.: Chondrocyte death during murine osteoarthritis. Osteoarthritis Cartilage 2004, 12:131-141.
25. Pennock AT, Robertson CM, Emmerson BC, et al.: Role of apoptotic and matrix-degrading genes in articular cartilage and meniscus of mature and aged rabbits during development of osteoarthritis. Arthritis Rheum 2007, 56:1529-1536.
26. Lee SW, Lee HJ, Chung WT, et al.: TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Arthritis Rheum 2004, 50:534-542.
27. Jallali N, Ridha H, Thrasivoulou C, et al.: Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity. Osteoarthritis Cartilage 2005, 13:614-622.
28. Wei L, Sun XJ, Wang Z, Chen Q: CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase. Arthritis Res Ther 2006, 8:R37.
29. Polzer K, Schett G, Zwerina J: The lonely death: chondrocyte apoptosis in TNF-induced arthritis. Autoimmunity 2007, 40:333-336.
30. Del Carlo Jr M, Loeser RF: Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels. Arthritis Rheum 2003, 48:3419-3430.
31. Lum JJ, DeBerardinis RJ, Thompson CB: Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 2005, 6:439-448.
32. Kouri-Flores JB, Abbud-Lozoya KA, Roja-Morales L: Kinetics of the ultrastructural changes in apoptotic chondrocytes from an osteoarthrosis rat model: a window of comparison to the cellular mechanism of apoptosis in human chondrocytes. Ultrastruct Pathol 2002, 26:33-40.
33. Bohensky J, Shapiro IM, Leshinsky S, et al.: HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy 2007, 3:207-214.
34. Bohensky J, Shapiro IM, Leshinsky S, et al.: PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate. J Cell Physiol 2007, 213:246-251.
35. Hiran TS, Moulton PJ, Hancock JT: Detection of superoxide and NADPH oxidase in porcine articular chondrocytes. Free Radic Biol Med 1997, 23:736-743.
36. van Lent PL, Nabbe KC, Blom AB, et al.: NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis. Arthritis Res Ther 2005, 7:R885-895.
37. D'Lima D, Hermida J, Hashimoto S, et al.: Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 2006, 54:1814-1821.
38. Dang AC, Warren AP, Kim HT: Beneficial effects of intra-articular caspase inhibition therapy following osteochondral injury. Osteoarthritis Cartilage 2006, 14:526-532.
39. Costouros JG, Kim HT: Preventing chondrocyte programmed cell death caused by iatrogenic injury. Knee 2007, 14:107-111.
40. Huser CA, Peacock M, Davies ME: Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma. Osteoarthritis Cartilage 2006, 14:1002-1010.
41. Grossin L, Cournil-Henrionnet C, Pinzano A, et al.: Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. FASEB J 2006, 20:65-75.
42. Dollings PJ, Dietrich AJ, Havran LM, et al., assignees: Pyrimidoindolones and methods for using same. US patent 7,256,198. 2007.
43. Bebbington D, Knegtel R, Mortimore M, et al., assignees: Carbamate caspase inhibitors and uses thereof. US patent 7,074,782. 2006.
44. Golec JM, Bebbington D, Brenchley G, et al., assignees: Caspase inhibitors and uses thereof. US patent 7,053,057. 2006.
45. Golec JM, Lauffer DJ, Livingston DJ, et al., assignees: Inhibitors of interleukin 1-beta converting enzyme. US patent 6,974,809. 2005.
46. Zhou T, Ichikawa K, Kimberly RP, Koopman WJ, assignees: Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof. US patent 7,244,429. 2007.
47. Mercep M, Mesic M, Tomaskovic L, Markovic S, assignees: Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules. US patent 7,157,433. 2007.
48. Filvaroff EH, Okumu FW, assignees: Use of insulin for the treatment of cartilaginous disorders. US patent 7,268,112. 2007.
49. Wei L, Sun X, Kanbe K, et al.: Chondrocyte death induced by pathological concentration of chemokine stromal cell-derived factor-1. J Rheum 2006, 33:1818-1826.
50. Racz B, Reglodi D, Fodor B, et al.: Hyperosmotic stress-induced apoptotic signaling pathways in chondrocytes. Bone 2007, 40:1536-1543.
51. Wang G, Beier F: Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J Bone Min Research 2005, 20:1022-1031.
52. Shan Z-Z, Masuko-Hongo K, Dai S-M, et al.: A potential role of 15-deoxy-{delta}12,14-prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis. J Biol Chem 2004, 279:37939-37950.
53. Yoon HS, Kim HA, Song YW: Inhibition of NF-kappaB renders human juvenile costal chondrocyte cell lines sensitive to TNF-alpha-mediated cell death. Rheumatol Int 2006, 26:201-208.
54. Loeser RF, Forsyth CB, Samarel AM, Im HJ: Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 2003, 278:24577-24585.