Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation

Oncogene

Volumn 33, Issue 14, 2014, Pages 1862-1871

  Ito, K ^a   Maruyama, Z ^a,b   Sakai, A ^a,c   Izumi, S ^a   Moriishi, T ^a   Yoshida, C A ^a   Miyazaki, T ^a   Komori, H ^a   Takada, K ^c   Kawaguchi, H ^b   Komori, T ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cdk6; Chondrocyte; Cyclin D1; p53; Rb

Indexed keywords

BROXURIDINE; CELL CYCLE PROTEIN 6; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; CYCLIN E; DIHYDROFOLATE REDUCTASE; DNA NUCLEOTIDYLEXOTRANSFERASE; PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B MYB GENE; CARTILAGE CELL; CDC25A GENE; CELL COUNT; CELL CYCLE PROGRESSION; CELL CYCLE PROTEIN 6 GENE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; COL2A1 GENE; CONTROLLED STUDY; CYCLIN E GENE; DIHYDROFOLATE REDUCTASE GENE; DOWN REGULATION; DWARFISM; EMBRYO; ENZYME ACTIVITY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE DELETION; GENE OVEREXPRESSION; IN VIVO STUDY; MOUSE; NICK END LABELING; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SKELETON; TRANSCRIPTION INITIATION; UPREGULATION; WILD TYPE;

MUS; MUS MUSCULUS;

ANIMALS; APOPTOSIS; BROMODEOXYURIDINE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROCYTES; CYCLIN D1; CYCLIN-DEPENDENT KINASE 6; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; RETROVIRIDAE; SARCOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84897968837     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.130     Document Type: Article

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