메뉴 건너뛰기




Volumn 310, Issue 7, 2016, Pages F596-F606

TGF-β signaling in the kidney: Profibrotic and protective effects

Author keywords

Apoptosis; Autophagy; BMP; Fibrosis; Inflammation; Kidney; Smad; TGF

Indexed keywords

ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEIN;

EID: 84984656688     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00365.2015     Document Type: Review
Times cited : (207)

References (102)
  • 1
    • 80054728443 scopus 로고    scopus 로고
    • Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation andfibrosis
    • Anders HJ, Ryu M. Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney Int 80: 915-925, 2011
    • (2011) Kidney Int , vol.80 , pp. 915-925
    • Anders, H.J.1    Ryu, M.2
  • 2
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFbetaactivation
    • Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci 116: 217-224, 2003
    • (2003) J Cell Sci , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 3
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810, 2000
    • (2000) J Biol Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 5
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growthfactor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350-1358, 2000
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 7
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissuefibrosis
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 8
    • 79551599216 scopus 로고    scopus 로고
    • The protective role of Smad7 in diabetic kidney disease: Mechanismand therapeutic potential
    • Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, Chung AC, Lan HY. The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60: 590-601, 2011
    • (2011) Diabetes , vol.60 , pp. 590-601
    • Chen, H.Y.1    Huang, X.R.2    Wang, W.3    Li, J.H.4    Heuchel, R.L.5    Chung, A.C.6    Lan, H.Y.7
  • 11
    • 34548834734 scopus 로고    scopus 로고
    • Pirfenidoneslows renal function decline in patients with focal segmental glomerulosclerosis
    • Cho ME, Smith DC, Branton MH, Penzak SR, Kopp JB. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2: 906-913, 2007
    • (2007) Clin J am Soc Nephrol , vol.2 , pp. 906-913
    • Cho, M.E.1    Smith, D.C.2    Branton, M.H.3    Penzak, S.R.4    Kopp, J.B.5
  • 12
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health anddisease
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 368: 651-662, 2013
    • (2013) N Engl J Med , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 13
    • 84864120935 scopus 로고    scopus 로고
    • TGF-beta signaling via TAK1 pathway: Rolein kidney fibrosis
    • Choi ME, Ding Y, Kim SI. TGF-beta signaling via TAK1 pathway: role in kidney fibrosis. Semin Nephrol 32: 244-252, 2012
    • (2012) Semin Nephrol , vol.32 , pp. 244-252
    • Choi, M.E.1    Ding, Y.2    Kim, S.I.3
  • 14
    • 65249099522 scopus 로고    scopus 로고
    • Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
    • Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 24: 1443-1454, 2009
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1443-1454
    • Chung, A.C.1    Huang, X.R.2    Zhou, L.3    Heuchel, R.4    Lai, K.N.5    Lan, H.Y.6
  • 15
    • 84931438789 scopus 로고    scopus 로고
    • Smad7 protects againstchronic aristolochic acid nephropathy in mice
    • Dai XY, Zhou L, Huang XR, Fu P, Lan HY. Smad7 protects against chronic aristolochic acid nephropathy in mice. Oncotarget 20: 11930-11944, 2015
    • (2015) Oncotarget , vol.20 , pp. 11930-11944
    • Dai, X.Y.1    Zhou, L.2    Huang, X.R.3    Fu, P.4    Lan, H.Y.5
  • 16
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 17
    • 84893378908 scopus 로고    scopus 로고
    • Regulation of autophagy by TGF-beta: Emerging rolein kidney fibrosis
    • Ding Y, Choi ME. Regulation of autophagy by TGF-beta: emerging role in kidney fibrosis. Semin Nephrol 34: 62-71, 2014
    • (2014) Semin Nephrol , vol.34 , pp. 62-71
    • Ding, Y.1    Choi, M.E.2
  • 18
    • 78549252103 scopus 로고    scopus 로고
    • TGF-beta1 protects against mesangial cell apoptosis via induction of autophagy
    • Ding Y, Kim JK, Kim SI, Na HJ, Jun SY, Lee SJ, Choi ME. TGF-beta1 protects against mesangial cell apoptosis via induction of autophagy. J Biol Chem 285: 37909-37919, 2010
    • (2010) J Biol Chem , vol.285 , pp. 37909-37919
    • Ding, Y.1    Kim, J.K.2    Kim, S.I.3    Na, H.J.4    Jun, S.Y.5    Lee, S.J.6    Choi, M.E.7
  • 19
    • 84919676763 scopus 로고    scopus 로고
    • Autophagyregulates TGF-beta expression and suppresses kidney fibrosis induced byunilateral ureteral obstruction
    • Ding Y, Kim SL, Lee SY, Koo JK, Wang Z, Choi ME. Autophagy regulates TGF-beta expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction. J Am Soc Nephrol 25: 2835-2846, 2014
    • (2014) J am Soc Nephrol , vol.25 , pp. 2835-2846
    • Ding, Y.1    Kim, S.L.2    Lee, S.Y.3    Koo, J.K.4    Wang, Z.5    Choi, M.E.6
  • 21
    • 84888998567 scopus 로고    scopus 로고
    • Slowing progression of chronic kidneydisease
    • Drawz PE, Rosenberg ME. Slowing progression of chronic kidney disease. Kidney Int Suppl 3: 372-376, 2013
    • (2013) Kidney Int Suppl , vol.3 , pp. 372-376
    • Drawz, P.E.1    Rosenberg, M.E.2
  • 22
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-betatype I receptor through Smad7 and induces receptor degradation
    • Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 276: 12477-12480, 2001
    • (2001) J Biol Chem , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 23
    • 0036197606 scopus 로고    scopus 로고
    • Transforminggrowth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
    • Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 90-914, 2002
    • (2002) Mol Biol Cell , vol.13 , pp. 90-914
    • Edlund, S.1    Landstrom, M.2    Heldin, C.H.3    Aspenstrom, P.4
  • 25
    • 84899152739 scopus 로고    scopus 로고
    • The physical basis of renal fibrosis:Effects of altered hydrodynamic forces on kidney homeostasis
    • Grabias BM, Konstantopoulos K. The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis. Am J Physiol Renal Physiol 306: F473-F485, 2014
    • (2014) Am Jphysiol Renal Physiol , vol.306 , pp. F473-F485
    • Grabias, B.M.1    Konstantopoulos, K.2
  • 28
    • 49949092931 scopus 로고    scopus 로고
    • Mice overexpressing latent TGF1 are protected against renal fibrosis in obstructivekidney disease
    • Huang XR, Chung AC, Wang XJ, Lai KN, Lan HY. Mice overexpressing latent TGF1 are protected against renal fibrosis in obstructive kidney disease. Am J Physiol Renal Physiol 295: F118-F127, 2008
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. F118-F127
    • Huang, X.R.1    Chung, A.C.2    Wang, X.J.3    Lai, K.N.4    Lan, H.Y.5
  • 30
    • 84881636594 scopus 로고    scopus 로고
    • Macrophage-specific deletion oftransforming growth factor1 does not prevent renal fibrosis after severeischemia-reperfusion or obstructive injury
    • Huen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. Am J Physiol Renal Physiol 305: F477-F484, 2013
    • (2013) Am J Physiol Renal Physiol , vol.305 , pp. F477-F484
    • Huen, S.C.1    Moeckel, G.W.2    Cantley, L.G.3
  • 32
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin preventsfibrotic disease in rat kidney
    • Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 2: 418-423, 1996
    • (1996) Nat Med , vol.2 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3    Kaneda, Y.4    Imai, E.5    Noble, N.A.6    Border, W.A.7
  • 35
    • 84925427675 scopus 로고    scopus 로고
    • Forced vital capacity in idiopathicpulmonary fibrosis-FDA review of pirfenidone and nintedanib
    • Karimi-Shah BA, Chowdhury BA. Forced vital capacity in idiopathic pulmonary fibrosis-FDA review of pirfenidone and nintedanib. N Engl J Med 372: 1189-1191, 2015
    • (2015) N Engl Jmed , vol.372 , pp. 1189-1191
    • Karimi-Shah, B.A.1    Chowdhury, B.A.2
  • 36
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligasethat targets the TGF beta receptor for degradation
    • Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 6: 1365-1375, 2000
    • (2000) Mol Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 37
    • 69249131695 scopus 로고    scopus 로고
    • Transforminggrowth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediatedautophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells
    • Kim SI, Kwak JH, Na HJ, Kim JK, Ding Y, Choi ME. Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem 284: 22285-22296, 2009
    • (2009) J Biol Chem , vol.284 , pp. 22285-22296
    • Kim, S.I.1    Kwak, J.H.2    Na, H.J.3    Kim, J.K.4    Ding, Y.5    Choi, M.E.6
  • 38
    • 34247874465 scopus 로고    scopus 로고
    • TGF-activated kinase 1 and TAK1-binding protein 1 cooperate to mediateTGF1-induced MKK3-p38 MAPK activation and stimulation of type I collagen
    • Kim SI, Kwak JH, Zachariah M, He Y, Wang L, Choi ME. TGF-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF1-induced MKK3-p38 MAPK activation and stimulation of type I collagen. Am J Physiol Renal Physiol 292: F1471-F1478, 2007
    • (2007) Am J Physiol Renal Physiol , vol.292 , pp. F1471-F1478
    • Kim, S.I.1    Kwak, J.H.2    Zachariah, M.3    He, Y.4    Wang, L.5    Choi, M.E.6
  • 39
    • 84921673692 scopus 로고    scopus 로고
    • TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation
    • Kim SI, Lee SY, Wang Z, Ding Y, Haque N, Zhang J, Zhou J, Choi ME. TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation. J Am Soc Nephrol 25: 1966-1978, 2014
    • (2014) J am Soc Nephrol , vol.25 , pp. 1966-1978
    • Kim, S.I.1    Lee, S.Y.2    Wang, Z.3    Ding, Y.4    Haque, N.5    Zhang, J.6    Zhou, J.7    Choi, M.E.8
  • 40
    • 84859509946 scopus 로고    scopus 로고
    • Autophagypromotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1
    • Kim SI, Na HJ, Ding Y, Wang Z, Lee SJ, Choi ME. Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1. J Biol Chem 287: 11677-11688, 2012
    • (2012) J Biol Chem , vol.287 , pp. 11677-11688
    • Kim, S.I.1    Na, H.J.2    Ding, Y.3    Wang, Z.4    Lee, S.J.5    Choi, M.E.6
  • 43
    • 0025896187 scopus 로고
    • Lipoprotein (A) inhibits the generation of transforming growth factor beta: An endogenous inhibitor ofsmooth muscle cell migration
    • Kojima S, Harpel PC, Rifkin DB. Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol 113: 1439-1445, 1991
    • (1991) J Cell Biol , vol.113 , pp. 1439-1445
    • Kojima, S.1    Harpel, P.C.2    Rifkin, D.B.3
  • 46
    • 0037498439 scopus 로고    scopus 로고
    • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    • Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003
    • (2003) J am Soc Nephrol , vol.14 , pp. 1535-1548
    • Lan, H.Y.1    Mu, W.2    Tomita, N.3    Huang, X.R.4    Li, J.H.5    Zhu, H.J.6    Morishita, R.7    Johnson, R.J.8
  • 48
    • 84925147408 scopus 로고    scopus 로고
    • Therapeutic targets for treating fibrotickidney diseases
    • Lee SY, Kim SI, Choi ME. Therapeutic targets for treating fibrotic kidney diseases. Transl Res 165: 512-530, 2015
    • (2015) Transl Res , vol.165 , pp. 512-530
    • Lee, S.Y.1    Kim, S.I.2    Choi, M.E.3
  • 50
    • 69849100333 scopus 로고    scopus 로고
    • Inhibition ofintegrin-linked kinase attenuates renal interstitial fibrosis
    • Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 20: 1907-1918, 2009
    • (2009) J am Socnephrol , vol.20 , pp. 1907-1918
    • Li, Y.1    Tan, X.2    Dai, C.3    Stolz, D.B.4    Wang, D.5    Liu, Y.6
  • 51
    • 84871901528 scopus 로고    scopus 로고
    • Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NFkappaB-dependent mechanisms in mice
    • Liu GX, Li YQ, Huang XR, Wei L, Chen HY, Shi YJ, Heuchel RL, Lan HY. Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NFkappaB-dependent mechanisms in mice. PLoS One 8: e53573, 2013
    • (2013) Plos One , vol.8
    • Liu, G.X.1    Li, Y.Q.2    Huang, X.R.3    Wei, L.4    Chen, H.Y.5    Shi, Y.J.6    Heuchel, R.L.7    Lan, H.Y.8
  • 53
    • 84870671176 scopus 로고    scopus 로고
    • Association of retinoic acidreceptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease
    • Long YB, Qin YH, Zhou TB, Lei FY. Association of retinoic acid receptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease. Int J Mol Sci 13: 14073-14085, 2012
    • (2012) Int J Mol Sci , vol.13 , pp. 14073-14085
    • Long, Y.B.1    Qin, Y.H.2    Zhou, T.B.3    Lei, F.Y.4
  • 56
    • 0141537244 scopus 로고    scopus 로고
    • Transforming growth factor-beta-dependent and-independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
    • Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and-independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol 163: 1261-1273, 2003
    • (2003) Am J Pathol , vol.163 , pp. 1261-1273
    • Ma, L.J.1    Yang, H.2    Gaspert, A.3    Carlesso, G.4    Barty, M.M.5    Davidson, J.M.6    Sheppard, D.7    Fogo, A.B.8
  • 57
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol 13: 616-630, 2012
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 59
    • 84862785580 scopus 로고    scopus 로고
    • Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro
    • Meng XM, Huang XR, Xiao J, Chen HY, Zhong X, Chung AC, Lan HY. Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro. J Pathol 227: 175-188, 2012
    • (2012) J Pathol , vol.227 , pp. 175-188
    • Meng, X.M.1    Huang, X.R.2    Xiao, J.3    Chen, H.Y.4    Zhong, X.5    Chung, A.C.6    Lan, H.Y.7
  • 60
    • 84856691720 scopus 로고    scopus 로고
    • Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
    • Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY. Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81: 266-279, 2012
    • (2012) Kidney Int , vol.81 , pp. 266-279
    • Meng, X.M.1    Huang, X.R.2    Xiao, J.3    Chung, A.C.4    Qin, W.5    Chen, H.Y.6    Lan, H.Y.7
  • 64
    • 0035651361 scopus 로고    scopus 로고
    • Bonemorphogenetic protein-7 improves renal fibrosis and accelerates thereturn of renal function
    • Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13, Suppl 1: S14-S21, 2002
    • (2002) J am Soc Nephrol , vol.13 , pp. S14-S21
    • Morrissey, J.1    Hruska, K.2    Guo, G.3    Wang, S.4    Chen, Q.5    Klahr, S.6
  • 65
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophageactivation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969, 2008
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 66
    • 0029893734 scopus 로고    scopus 로고
    • Extracellular signal-regulatedkinase and the small GTP-binding protein, Rac, contribute to the effectsof transforming growth factor-beta1 on gene expression
    • Mucsi I, Skorecki KL, Goldberg HJ. Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression. J Biol Chem 271: 16567-16572, 1996
    • (1996) J Biol Chem , vol.271 , pp. 16567-16572
    • Mucsi, I.1    Skorecki, K.L.2    Goldberg, H.J.3
  • 68
    • 0034602959 scopus 로고    scopus 로고
    • Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
    • Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275: 3577-3582, 2000
    • (2000) J Biol Chem , vol.275 , pp. 3577-3582
    • Ohashi, K.1    Nagata, K.2    Maekawa, M.3    Ishizaki, T.4    Narumiya, S.5    Mizuno, K.6
  • 69
    • 0038351964 scopus 로고    scopus 로고
    • A dominantnegative TAK1 inhibits cellular fibrotic responses induced by TGF-beta
    • Ono K, Ohtomo T, Ninomiya-Tsuji J, Tsuchiya M. A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta. Biochem Biophys Res Commun 307: 332-337, 2003
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 332-337
    • Ono, K.1    Ohtomo, T.2    Ninomiya-Tsuji, J.3    Tsuchiya, M.4
  • 71
    • 27844595882 scopus 로고    scopus 로고
    • BMP7 signaling in renal development anddisease
    • Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med 11: 512-518, 2005
    • (2005) Trends Mol Med , vol.11 , pp. 512-518
    • Patel, S.R.1    Dressler, G.R.2
  • 72
    • 20744455828 scopus 로고    scopus 로고
    • Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis
    • Prelog M, Scheidegger P, Peter S, Gershwin ME, Wick G, Sgonc R. Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis. Arthritis Rheum 52: 1804-1811, 2005
    • (2005) Arthritis Rheum , vol.52 , pp. 1804-1811
    • Prelog, M.1    Scheidegger, P.2    Peter, S.3    Gershwin, M.E.4    Wick, G.5    Sgonc, R.6
  • 75
    • 70349659502 scopus 로고    scopus 로고
    • Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression
    • Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstadt H, Schaefer L, Pfeilschifter J, Huwiler A. Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney Int 76: 857-867, 2009
    • (2009) Kidney Int , vol.76 , pp. 857-867
    • Ren, S.1    Babelova, A.2    Moreth, K.3    Xin, C.4    Eberhardt, W.5    Doller, A.6    Pavenstadt, H.7    Schaefer, L.8    Pfeilschifter, J.9    Huwiler, A.10
  • 76
    • 84883820451 scopus 로고    scopus 로고
    • Unchaining the beast; insights from structuraland evolutionary studies on TGFbeta secretion, sequestration, and activation
    • Robertson IB, Rifkin DB. Unchaining the beast; insights from structural and evolutionary studies on TGFbeta secretion, sequestration, and activation. Cytokine Growth Factor Rev 24: 355-372, 2013
    • (2013) Cytokine Growth Factor Rev , vol.24 , pp. 355-372
    • Robertson, I.B.1    Rifkin, D.B.2
  • 77
    • 0346727324 scopus 로고    scopus 로고
    • Targeteddisruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112: 1486-1494, 2003
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 80
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta byanti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45: 522-530, 1996
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 84
    • 34347375050 scopus 로고    scopus 로고
    • Renal fibrosis andglomerulosclerosis in a new mouse model of diabetic nephropathy and itsregression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    • Sugimoto H, Grahovac G, Zeisberg M, Kalluri R. Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 56: 1825-1833, 2007
    • (2007) Diabetes , vol.56 , pp. 1825-1833
    • Sugimoto, H.1    Grahovac, G.2    Zeisberg, M.3    Kalluri, R.4
  • 85
    • 84891679916 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction inlung diseases: Emphasis on mitophagy
    • Sureshbabu A, Bhandari V. Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy. Front Physiol 4: 384, 2013
    • (2013) Front Physiol , vol.4
    • Sureshbabu, A.1    Bhandari, V.2
  • 86
    • 84921725981 scopus 로고    scopus 로고
    • Oxidative stress and autophagy:Crucial modulators of kidney injury
    • Sureshbabu A, Ryter SW, Choi ME. Oxidative stress and autophagy: crucial modulators of kidney injury. Redox Biol 4: 208-214, 2015
    • (2015) Redox Biol , vol.4 , pp. 208-214
    • Sureshbabu, A.1    Ryter, S.W.2    Choi, M.E.3
  • 87
    • 80052977584 scopus 로고    scopus 로고
    • Relative roles ofTGF-beta and IGFBP-5 in idiopathic pulmonary fibrosis
    • Sureshbabu A, Tonner E, Allan GJ, Flint DJ. Relative roles of TGF-beta and IGFBP-5 in idiopathic pulmonary fibrosis. Pulm Med 2011: 517687, 2011
    • (2011) Pulm Med , vol.2011
    • Sureshbabu, A.1    Tonner, E.2    Allan, G.J.3    Flint, D.J.4
  • 88
    • 77955393793 scopus 로고    scopus 로고
    • Regulation of autophagy bytransforming growth factor-beta (TGF-beta) signaling
    • Suzuki HI, Kiyono K, Miyazono K. Regulation of autophagy by transforming growth factor-beta (TGF-beta) signaling. Autophagy 6: 645-647, 2010
    • (2010) Autophagy , vol.6 , pp. 645-647
    • Suzuki, H.I.1    Kiyono, K.2    Miyazono, K.3
  • 90
    • 84903648153 scopus 로고    scopus 로고
    • Cellular mechanisms of tissuefibrosis. 8 Current and future drug targets in fibrosis: Focus on Rho GTPase-regulated gene transcription
    • Tsou PS, Haak AJ, Khanna D, Neubig RR. Cellular mechanisms of tissue fibrosis. 8 Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription. Am J Physiol Cell Physiol 307: C2-C13, 2014
    • (2014) Am J Physiol Cell Physiol , vol.307 , pp. CC2-C13
    • Tsou, P.S.1    Haak, A.J.2    Khanna, D.3    Neubig, R.R.4
  • 93
    • 2542441495 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 signals opposingtransforming growth factor beta in mesangial cells
    • Wang S, Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J Biol Chem 279: 23200-23206, 2004
    • (2004) J Biol Chem , vol.279 , pp. 23200-23206
    • Wang, S.1    Hirschberg, R.2
  • 95
    • 28544450380 scopus 로고    scopus 로고
    • Transforming growth factor-betaactivation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2
    • Wilkes MC, Mitchell H, Penheiter SG, Dore JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB. Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 65: 10431-10440, 2005
    • (2005) Cancer Res , vol.65 , pp. 10431-10440
    • Wilkes, M.C.1    Mitchell, H.2    Penheiter, S.G.3    Dore, J.J.4    Suzuki, K.5    Edens, M.6    Sharma, D.K.7    Pagano, R.E.8    Leof, E.B.9
  • 96
    • 84908321410 scopus 로고    scopus 로고
    • Transforming growth factor beta3 attenuates the development ofradiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance
    • Xu L, Xiong S, Guo R, Yang Z, Wang Q, Xiao F, Wang H, Pan X, Zhu M. Transforming growth factor beta3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance. Immunol Lett 162: 27-33, 2014
    • (2014) Immunol Lett , vol.162 , pp. 27-33
    • Xu, L.1    Xiong, S.2    Guo, R.3    Yang, Z.4    Wang, Q.5    Xiao, F.6    Wang, H.7    Pan, X.8    Zhu, M.9
  • 97
    • 84863255432 scopus 로고    scopus 로고
    • Tgf-beta1 inducesautophagy and promotes apoptosis in renal tubular epithelial cells
    • Xu Y, Yang S, Huang J, Ruan S, Zheng Z, Lin J. Tgf-beta1 induces autophagy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med 29: 781-790, 2012
    • (2012) Int Jmol Med , vol.29 , pp. 781-790
    • Xu, Y.1    Yang, S.2    Huang, J.3    Ruan, S.4    Zheng, Z.5    Lin, J.6
  • 98
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor betareceptor binds to and activates phosphatidylinositol 3-kinase
    • Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280: 10870-10876, 2005
    • (2005) J Biolchem , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 100
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 101
    • 84872197845 scopus 로고    scopus 로고
    • The controversial role of retinoicacid in fibrotic diseases: Analysis of involved signaling pathways
    • Zhou TB, Drummen GP, Qin YH. The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways. Int J Mol Sci 14: 226-243, 2012
    • (2012) Int Jmol Sci , vol.14 , pp. 226-243
    • Zhou, T.B.1    Drummen, G.P.2    Qin, Y.H.3
  • 102
    • 0034608948 scopus 로고    scopus 로고
    • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    • Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 97: 8015-8020, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8015-8020
    • Ziyadeh, F.N.1    Hoffman, B.B.2    Han, D.C.3    Iglesias-De La Cruz, M.C.4    Hong, S.W.5    Isono, M.6    Chen, S.7    McGowan, T.A.8    Sharma, K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.