-
1
-
-
80054728443
-
Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation andfibrosis
-
Anders HJ, Ryu M. Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney Int 80: 915-925, 2011
-
(2011)
Kidney Int
, vol.80
, pp. 915-925
-
-
Anders, H.J.1
Ryu, M.2
-
3
-
-
0034711307
-
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
-
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
4
-
-
84939486401
-
Klotho, stem cells, aging
-
Bian A, Neyra JA, Zhan M, Hu MC. Klotho, stem cells, aging. Clin Interv Aging 10: 1233-1243, 2015
-
(2015)
Clininterv Aging
, vol.10
, pp. 1233-1243
-
-
Bian, A.1
Neyra, J.A.2
Zhan, M.3
Hu, M.C.4
-
5
-
-
0034604110
-
Role of transforming growthfactor beta in human disease
-
Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350-1358, 2000
-
(2000)
N Engl J Med
, vol.342
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
6
-
-
81155149867
-
Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency
-
Boon MR, van der Horst G, van der Pluijm G, Tamsma JT, Smit JW, Rensen PC. Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency. Cytokine Growth Factor Rev 22: 221-229, 2011
-
(2011)
Cytokine Growth Factor Rev
, vol.22
, pp. 221-229
-
-
Boon, M.R.1
Van Der Horst, G.2
Van Der Pluijm, G.3
Tamsma, J.T.4
Smit, J.W.5
Rensen, P.C.6
-
7
-
-
0028109801
-
Transforming growth factor beta in tissuefibrosis
-
Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994
-
(1994)
N Engl J Med
, vol.331
, pp. 1286-1292
-
-
Border, W.A.1
Noble, N.A.2
-
8
-
-
79551599216
-
The protective role of Smad7 in diabetic kidney disease: Mechanismand therapeutic potential
-
Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, Chung AC, Lan HY. The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60: 590-601, 2011
-
(2011)
Diabetes
, vol.60
, pp. 590-601
-
-
Chen, H.Y.1
Huang, X.R.2
Wang, W.3
Li, J.H.4
Heuchel, R.L.5
Chung, A.C.6
Lan, H.Y.7
-
9
-
-
84877929064
-
Pirfenidone inhibits macrophage infiltration in 5⁄6 nephrectomized rats
-
Chen JF, Ni HF, Pan MM, Liu H, Xu M, Zhang MH, Liu BC. Pirfenidone inhibits macrophage infiltration in 5⁄6 nephrectomized rats. Am J Physiol Renal Physiol 304: F676-F685, 2013
-
(2013)
Am J Physiol Renal Physiol
, vol.304
, pp. F676-F685
-
-
Chen, J.F.1
Ni, H.F.2
Pan, M.M.3
Liu, H.4
Xu, M.5
Zhang, M.H.6
Liu, B.C.7
-
10
-
-
0037229517
-
Reversibility of established diabetic glomerulopathy by anti-TGFbeta antibodies in db/db mice
-
Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Reversibility of established diabetic glomerulopathy by anti-TGFbeta antibodies in db/db mice. Biochem Biophys Res Commun 300: 16-22, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 16-22
-
-
Chen, S.1
Iglesias-De La Cruz, M.C.2
Jim, B.3
Hong, S.W.4
Isono, M.5
Ziyadeh, F.N.6
-
11
-
-
34548834734
-
Pirfenidoneslows renal function decline in patients with focal segmental glomerulosclerosis
-
Cho ME, Smith DC, Branton MH, Penzak SR, Kopp JB. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 2: 906-913, 2007
-
(2007)
Clin J am Soc Nephrol
, vol.2
, pp. 906-913
-
-
Cho, M.E.1
Smith, D.C.2
Branton, M.H.3
Penzak, S.R.4
Kopp, J.B.5
-
13
-
-
84864120935
-
TGF-beta signaling via TAK1 pathway: Rolein kidney fibrosis
-
Choi ME, Ding Y, Kim SI. TGF-beta signaling via TAK1 pathway: role in kidney fibrosis. Semin Nephrol 32: 244-252, 2012
-
(2012)
Semin Nephrol
, vol.32
, pp. 244-252
-
-
Choi, M.E.1
Ding, Y.2
Kim, S.I.3
-
14
-
-
65249099522
-
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
-
Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 24: 1443-1454, 2009
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 1443-1454
-
-
Chung, A.C.1
Huang, X.R.2
Zhou, L.3
Heuchel, R.4
Lai, K.N.5
Lan, H.Y.6
-
15
-
-
84931438789
-
Smad7 protects againstchronic aristolochic acid nephropathy in mice
-
Dai XY, Zhou L, Huang XR, Fu P, Lan HY. Smad7 protects against chronic aristolochic acid nephropathy in mice. Oncotarget 20: 11930-11944, 2015
-
(2015)
Oncotarget
, vol.20
, pp. 11930-11944
-
-
Dai, X.Y.1
Zhou, L.2
Huang, X.R.3
Fu, P.4
Lan, H.Y.5
-
16
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
17
-
-
84893378908
-
Regulation of autophagy by TGF-beta: Emerging rolein kidney fibrosis
-
Ding Y, Choi ME. Regulation of autophagy by TGF-beta: emerging role in kidney fibrosis. Semin Nephrol 34: 62-71, 2014
-
(2014)
Semin Nephrol
, vol.34
, pp. 62-71
-
-
Ding, Y.1
Choi, M.E.2
-
18
-
-
78549252103
-
TGF-beta1 protects against mesangial cell apoptosis via induction of autophagy
-
Ding Y, Kim JK, Kim SI, Na HJ, Jun SY, Lee SJ, Choi ME. TGF-beta1 protects against mesangial cell apoptosis via induction of autophagy. J Biol Chem 285: 37909-37919, 2010
-
(2010)
J Biol Chem
, vol.285
, pp. 37909-37919
-
-
Ding, Y.1
Kim, J.K.2
Kim, S.I.3
Na, H.J.4
Jun, S.Y.5
Lee, S.J.6
Choi, M.E.7
-
19
-
-
84919676763
-
Autophagyregulates TGF-beta expression and suppresses kidney fibrosis induced byunilateral ureteral obstruction
-
Ding Y, Kim SL, Lee SY, Koo JK, Wang Z, Choi ME. Autophagy regulates TGF-beta expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction. J Am Soc Nephrol 25: 2835-2846, 2014
-
(2014)
J am Soc Nephrol
, vol.25
, pp. 2835-2846
-
-
Ding, Y.1
Kim, S.L.2
Lee, S.Y.3
Koo, J.K.4
Wang, Z.5
Choi, M.E.6
-
20
-
-
79953138206
-
Klotho inhibits transforming growth factor-beta1 (TGFbeta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
-
Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M. Klotho inhibits transforming growth factor-beta1 (TGFbeta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665, 2011
-
(2011)
J Biol Chem
, vol.286
, pp. 8655-8665
-
-
Doi, S.1
Zou, Y.2
Togao, O.3
Pastor, J.V.4
John, G.B.5
Wang, L.6
Shiizaki, K.7
Gotschall, R.8
Schiavi, S.9
Yorioka, N.10
Takahashi, M.11
Boothman, D.A.12
Kuro-O, M.13
-
21
-
-
84888998567
-
Slowing progression of chronic kidneydisease
-
Drawz PE, Rosenberg ME. Slowing progression of chronic kidney disease. Kidney Int Suppl 3: 372-376, 2013
-
(2013)
Kidney Int Suppl
, vol.3
, pp. 372-376
-
-
Drawz, P.E.1
Rosenberg, M.E.2
-
22
-
-
0035918274
-
Smurf1 interacts with transforming growth factor-betatype I receptor through Smad7 and induces receptor degradation
-
Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 276: 12477-12480, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
Chiba, T.4
Tanaka, K.5
Imamura, T.6
Miyazono, K.7
-
23
-
-
0036197606
-
Transforminggrowth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
-
Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 90-914, 2002
-
(2002)
Mol Biol Cell
, vol.13
, pp. 90-914
-
-
Edlund, S.1
Landstrom, M.2
Heldin, C.H.3
Aspenstrom, P.4
-
24
-
-
0036899231
-
Transforming growth factor-beta(1)in the kidney and urine of patients with glomerular disease and proteinuria
-
Goumenos DS, Tsakas S, El Nahas AM, Alexandri S, Oldroyd S, Kalliakmani P, Vlachojannis JG. Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria. Nephrol Dial Transplant 17: 2145-2152, 2002
-
(2002)
Nephrol Dial Transplant
, vol.17
, pp. 2145-2152
-
-
Goumenos, D.S.1
Tsakas, S.2
El Nahas, A.M.3
Alexandri, S.4
Oldroyd, S.5
Kalliakmani, P.6
Vlachojannis, J.G.7
-
25
-
-
84899152739
-
The physical basis of renal fibrosis:Effects of altered hydrodynamic forces on kidney homeostasis
-
Grabias BM, Konstantopoulos K. The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis. Am J Physiol Renal Physiol 306: F473-F485, 2014
-
(2014)
Am Jphysiol Renal Physiol
, vol.306
, pp. F473-F485
-
-
Grabias, B.M.1
Konstantopoulos, K.2
-
26
-
-
0027220011
-
Proliferation of human smooth muscle cells promoted bylipoprotein(a)
-
Grainger DJ, Kirschenlohr HL, Metcalfe JC, Weissberg PL, Wade DP, Lawn RM. Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science 260: 1655-1658, 1993
-
(1993)
Science
, vol.260
, pp. 1655-1658
-
-
Grainger, D.J.1
Kirschenlohr, H.L.2
Metcalfe, J.C.3
Weissberg, P.L.4
Wade, D.P.5
Lawn, R.M.6
-
27
-
-
77951169411
-
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
-
Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120: 1084-1096, 2010
-
(2010)
J Clin Invest
, vol.120
, pp. 1084-1096
-
-
Hartleben, B.1
Godel, M.2
Meyer-Schwesinger, C.3
Liu, S.4
Ulrich, T.5
Kobler, S.6
Wiech, T.7
Grahammer, F.8
Arnold, S.J.9
Lindenmeyer, M.T.10
Cohen, C.D.11
Pavenstadt, H.12
Kerjaschki, D.13
Mizushima, N.14
Shaw, A.S.15
Walz, G.16
Huber, T.B.17
-
28
-
-
49949092931
-
Mice overexpressing latent TGF1 are protected against renal fibrosis in obstructivekidney disease
-
Huang XR, Chung AC, Wang XJ, Lai KN, Lan HY. Mice overexpressing latent TGF1 are protected against renal fibrosis in obstructive kidney disease. Am J Physiol Renal Physiol 295: F118-F127, 2008
-
(2008)
Am J Physiol Renal Physiol
, vol.295
, pp. F118-F127
-
-
Huang, X.R.1
Chung, A.C.2
Wang, X.J.3
Lai, K.N.4
Lan, H.Y.5
-
29
-
-
39049125285
-
Latent TGF-beta1protects against crescentic glomerulonephritis
-
Huang XR, Chung AC, Zhou L, Wang XJ, Lan HY. Latent TGF-beta1 protects against crescentic glomerulonephritis. J Am Soc Nephrol 19: 233-242, 2008
-
(2008)
J am Soc Nephrol
, vol.19
, pp. 233-242
-
-
Huang, X.R.1
Chung, A.C.2
Zhou, L.3
Wang, X.J.4
Lan, H.Y.5
-
30
-
-
84881636594
-
Macrophage-specific deletion oftransforming growth factor1 does not prevent renal fibrosis after severeischemia-reperfusion or obstructive injury
-
Huen SC, Moeckel GW, Cantley LG. Macrophage-specific deletion of transforming growth factor1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. Am J Physiol Renal Physiol 305: F477-F484, 2013
-
(2013)
Am J Physiol Renal Physiol
, vol.305
, pp. F477-F484
-
-
Huen, S.C.1
Moeckel, G.W.2
Cantley, L.G.3
-
31
-
-
3242797424
-
Smad3 deficiencyattenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
-
Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 66: 597-604, 2004
-
(2004)
Kidney Int
, vol.66
, pp. 597-604
-
-
Inazaki, K.1
Kanamaru, Y.2
Kojima, Y.3
Sueyoshi, N.4
Okumura, K.5
Kaneko, K.6
Yamashiro, Y.7
Ogawa, H.8
Nakao, A.9
-
32
-
-
0029905441
-
Gene therapy by skeletal muscle expression of decorin preventsfibrotic disease in rat kidney
-
Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 2: 418-423, 1996
-
(1996)
Nat Med
, vol.2
, pp. 418-423
-
-
Isaka, Y.1
Brees, D.K.2
Ikegaya, K.3
Kaneda, Y.4
Imai, E.5
Noble, N.A.6
Border, W.A.7
-
33
-
-
77956476201
-
Expression patterns of connective tissue growth factor and of TGFisoforms during glomerular injury recapitulate glomerulogenesis
-
Ito Y, Goldschmeding R, Kasuga H, Claessen N, Nakayama M, Yuzawa Y, Sawai A, Matsuo S, Weening JJ, Aten J. Expression patterns of connective tissue growth factor and of TGFisoforms during glomerular injury recapitulate glomerulogenesis. Am J Physiol Renal Physiol 299: F545-F558, 2010
-
(2010)
Am J Physiol Renal Physiol
, vol.299
, pp. F545-F558
-
-
Ito, Y.1
Goldschmeding, R.2
Kasuga, H.3
Claessen, N.4
Nakayama, M.5
Yuzawa, Y.6
Sawai, A.7
Matsuo, S.8
Weening, J.J.9
Aten, J.10
-
34
-
-
36749085479
-
All-trans-retinoic acid aggravatescryoglobulin-associated membranoproliferative glomerulonephritis in mice
-
Iyoda M, Hudkins KL, Wietecha TA, Banas MC, Guo S, Liu G, Wang L, Kowalewska J, Alpers CE. All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. Nephrol Dial Transplant 22: 3451-3461, 2007
-
(2007)
Nephrol Dial Transplant
, vol.22
, pp. 3451-3461
-
-
Iyoda, M.1
Hudkins, K.L.2
Wietecha, T.A.3
Banas, M.C.4
Guo, S.5
Liu, G.6
Wang, L.7
Kowalewska, J.8
Alpers, C.E.9
-
35
-
-
84925427675
-
Forced vital capacity in idiopathicpulmonary fibrosis-FDA review of pirfenidone and nintedanib
-
Karimi-Shah BA, Chowdhury BA. Forced vital capacity in idiopathic pulmonary fibrosis-FDA review of pirfenidone and nintedanib. N Engl J Med 372: 1189-1191, 2015
-
(2015)
N Engl Jmed
, vol.372
, pp. 1189-1191
-
-
Karimi-Shah, B.A.1
Chowdhury, B.A.2
-
36
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligasethat targets the TGF beta receptor for degradation
-
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 6: 1365-1375, 2000
-
(2000)
Mol Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
37
-
-
69249131695
-
Transforminggrowth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediatedautophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells
-
Kim SI, Kwak JH, Na HJ, Kim JK, Ding Y, Choi ME. Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem 284: 22285-22296, 2009
-
(2009)
J Biol Chem
, vol.284
, pp. 22285-22296
-
-
Kim, S.I.1
Kwak, J.H.2
Na, H.J.3
Kim, J.K.4
Ding, Y.5
Choi, M.E.6
-
38
-
-
34247874465
-
TGF-activated kinase 1 and TAK1-binding protein 1 cooperate to mediateTGF1-induced MKK3-p38 MAPK activation and stimulation of type I collagen
-
Kim SI, Kwak JH, Zachariah M, He Y, Wang L, Choi ME. TGF-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF1-induced MKK3-p38 MAPK activation and stimulation of type I collagen. Am J Physiol Renal Physiol 292: F1471-F1478, 2007
-
(2007)
Am J Physiol Renal Physiol
, vol.292
, pp. F1471-F1478
-
-
Kim, S.I.1
Kwak, J.H.2
Zachariah, M.3
He, Y.4
Wang, L.5
Choi, M.E.6
-
39
-
-
84921673692
-
TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation
-
Kim SI, Lee SY, Wang Z, Ding Y, Haque N, Zhang J, Zhou J, Choi ME. TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation. J Am Soc Nephrol 25: 1966-1978, 2014
-
(2014)
J am Soc Nephrol
, vol.25
, pp. 1966-1978
-
-
Kim, S.I.1
Lee, S.Y.2
Wang, Z.3
Ding, Y.4
Haque, N.5
Zhang, J.6
Zhou, J.7
Choi, M.E.8
-
40
-
-
84859509946
-
Autophagypromotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1
-
Kim SI, Na HJ, Ding Y, Wang Z, Lee SJ, Choi ME. Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1. J Biol Chem 287: 11677-11688, 2012
-
(2012)
J Biol Chem
, vol.287
, pp. 11677-11688
-
-
Kim, S.I.1
Na, H.J.2
Ding, Y.3
Wang, Z.4
Lee, S.J.5
Choi, M.E.6
-
41
-
-
84862952042
-
The role of autophagy in unilateral ureteralobstruction rat model
-
Kim WY, Nam SA, Song HC, Ko JS, Park SH, Kim HL, Choi EJ, Kim YS, Kim J, Kim YK. The role of autophagy in unilateral ureteral obstruction rat model. Nephrology (Carlton) 17: 148-159, 2012
-
(2012)
Nephrology (Carlton)
, vol.17
, pp. 148-159
-
-
Kim, W.Y.1
Nam, S.A.2
Song, H.C.3
Ko, J.S.4
Park, S.H.5
Kim, H.L.6
Choi, E.J.7
Kim, Y.S.8
Kim, J.9
Kim, Y.K.10
-
42
-
-
77957252460
-
Tubular overexpression of transforming growth factor-beta1 induces autophagy and
-
Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hahnel B, Hosser H, Grone HJ, Kriz W. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 177: 632-643, 2010
-
(2010)
Am J Pathol
, vol.177
, pp. 632-643
-
-
Koesters, R.1
Kaissling, B.2
Lehir, M.3
Picard, N.4
Theilig, F.5
Gebhardt, R.6
Glick, A.B.7
Hahnel, B.8
Hosser, H.9
Grone, H.J.10
Kriz, W.11
-
43
-
-
0025896187
-
Lipoprotein (A) inhibits the generation of transforming growth factor beta: An endogenous inhibitor ofsmooth muscle cell migration
-
Kojima S, Harpel PC, Rifkin DB. Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol 113: 1439-1445, 1991
-
(1991)
J Cell Biol
, vol.113
, pp. 1439-1445
-
-
Kojima, S.1
Harpel, P.C.2
Rifkin, D.B.3
-
44
-
-
0029953788
-
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease
-
Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Bottinger EP, Klotman PE, Thorgeirsson SS. Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 74: 991-1003, 1996
-
(1996)
Lab Invest
, vol.74
, pp. 991-1003
-
-
Kopp, J.B.1
Factor, V.M.2
Mozes, M.3
Nagy, P.4
Sanderson, N.5
Bottinger, E.P.6
Klotman, P.E.7
Thorgeirsson, S.S.8
-
45
-
-
0027531528
-
Transforming growthfactor beta 1 null mutation in mice causes excessive inflammatory response and early death
-
Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90: 770-774, 1993
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.G.2
Becker, D.3
Geiser, A.4
Lyght, M.5
Flanders, K.C.6
Roberts, A.B.7
Sporn, M.B.8
Ward, J.M.9
Karlsson, S.10
-
46
-
-
0037498439
-
Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
-
Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003
-
(2003)
J am Soc Nephrol
, vol.14
, pp. 1535-1548
-
-
Lan, H.Y.1
Mu, W.2
Tomita, N.3
Huang, X.R.4
Li, J.H.5
Zhu, H.J.6
Morishita, R.7
Johnson, R.J.8
-
47
-
-
79551654684
-
Distinct macrophage phenotypes contribute to kidneyinjury and repair
-
Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG. Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22: 317-326, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 317-326
-
-
Lee, S.1
Huen, S.2
Nishio, H.3
Nishio, S.4
Lee, H.K.5
Choi, B.S.6
Ruhrberg, C.7
Cantley, L.G.8
-
48
-
-
84925147408
-
Therapeutic targets for treating fibrotickidney diseases
-
Lee SY, Kim SI, Choi ME. Therapeutic targets for treating fibrotic kidney diseases. Transl Res 165: 512-530, 2015
-
(2015)
Transl Res
, vol.165
, pp. 512-530
-
-
Lee, S.Y.1
Kim, S.I.2
Choi, M.E.3
-
49
-
-
33646164362
-
Transforminggrowth factor-beta regulation of immune responses
-
Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24: 99-146, 2006
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
Robertson, A.K.4
Flavell, R.A.5
-
50
-
-
69849100333
-
Inhibition ofintegrin-linked kinase attenuates renal interstitial fibrosis
-
Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 20: 1907-1918, 2009
-
(2009)
J am Socnephrol
, vol.20
, pp. 1907-1918
-
-
Li, Y.1
Tan, X.2
Dai, C.3
Stolz, D.B.4
Wang, D.5
Liu, Y.6
-
51
-
-
84871901528
-
Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NFkappaB-dependent mechanisms in mice
-
Liu GX, Li YQ, Huang XR, Wei L, Chen HY, Shi YJ, Heuchel RL, Lan HY. Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NFkappaB-dependent mechanisms in mice. PLoS One 8: e53573, 2013
-
(2013)
Plos One
, vol.8
-
-
Liu, G.X.1
Li, Y.Q.2
Huang, X.R.3
Wei, L.4
Chen, H.Y.5
Shi, Y.J.6
Heuchel, R.L.7
Lan, H.Y.8
-
52
-
-
84898772136
-
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension
-
Liu GX, Li YQ, Huang XR, Wei LH, Zhang Y, Feng M, Meng XM, Chen HY, Shi YJ, Lan HY. Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. Clin Sci (Lond) 127: 195-208, 2014
-
(2014)
Clin Sci (Lond)
, vol.127
, pp. 195-208
-
-
Liu, G.X.1
Li, Y.Q.2
Huang, X.R.3
Wei, L.H.4
Zhang, Y.5
Feng, M.6
Meng, X.M.7
Chen, H.Y.8
Shi, Y.J.9
Lan, H.Y.10
-
53
-
-
84870671176
-
Association of retinoic acidreceptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease
-
Long YB, Qin YH, Zhou TB, Lei FY. Association of retinoic acid receptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease. Int J Mol Sci 13: 14073-14085, 2012
-
(2012)
Int J Mol Sci
, vol.13
, pp. 14073-14085
-
-
Long, Y.B.1
Qin, Y.H.2
Zhou, T.B.3
Lei, F.Y.4
-
54
-
-
84885300451
-
Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease
-
Lu J, Cao Q, Zheng D, Sun Y, Wang C, Yu X, Wang Y, Lee VW, Zheng G, Tan TK, Wang X, Alexander SI, Harris DC, Wang Y. Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney Int 84: 745-755, 2013
-
(2013)
Kidney Int
, vol.84
, pp. 745-755
-
-
Lu, J.1
Cao, Q.2
Zheng, D.3
Sun, Y.4
Wang, C.5
Yu, X.6
Wang, Y.7
Lee, V.W.8
Zheng, G.9
Tan, T.K.10
Wang, X.11
Alexander, S.I.12
Harris, D.C.13
Wang, Y.14
-
55
-
-
79958133285
-
TGF1-activated kinase-1 regulates inflammation and fibrosis in theobstructed kidney
-
Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ. TGF1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney. Am J Physiol Renal Physiol 300: F1410-F1421, 2011
-
(2011)
Am J Physiol Renal Physiol
, vol.300
, pp. F1410-F1421
-
-
Ma, F.Y.1
Tesch, G.H.2
Ozols, E.3
Xie, M.4
Schneider, M.D.5
Nikolic-Paterson, D.J.6
-
56
-
-
0141537244
-
Transforming growth factor-beta-dependent and-independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
-
Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and-independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol 163: 1261-1273, 2003
-
(2003)
Am J Pathol
, vol.163
, pp. 1261-1273
-
-
Ma, L.J.1
Yang, H.2
Gaspert, A.3
Carlesso, G.4
Barty, M.M.5
Davidson, J.M.6
Sheppard, D.7
Fogo, A.B.8
-
57
-
-
84866742560
-
TGFbeta signalling in context
-
Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol 13: 616-630, 2012
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 616-630
-
-
Massague, J.1
-
58
-
-
77956548300
-
Smad2 protects against TGF-beta/Smad3mediated renal fibrosis
-
Meng XM, Huang XR, Chung AC, Qin W, Shao X, Igarashi P, Ju W, Bottinger EP, Lan HY. Smad2 protects against TGF-beta/Smad3mediated renal fibrosis. J Am Soc Nephrol 21: 1477-1487, 2010
-
(2010)
J am Soc Nephrol
, vol.21
, pp. 1477-1487
-
-
Meng, X.M.1
Huang, X.R.2
Chung, A.C.3
Qin, W.4
Shao, X.5
Igarashi, P.6
Ju, W.7
Bottinger, E.P.8
Lan, H.Y.9
-
59
-
-
84862785580
-
Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro
-
Meng XM, Huang XR, Xiao J, Chen HY, Zhong X, Chung AC, Lan HY. Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro. J Pathol 227: 175-188, 2012
-
(2012)
J Pathol
, vol.227
, pp. 175-188
-
-
Meng, X.M.1
Huang, X.R.2
Xiao, J.3
Chen, H.Y.4
Zhong, X.5
Chung, A.C.6
Lan, H.Y.7
-
60
-
-
84856691720
-
Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
-
Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY. Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81: 266-279, 2012
-
(2012)
Kidney Int
, vol.81
, pp. 266-279
-
-
Meng, X.M.1
Huang, X.R.2
Xiao, J.3
Chung, A.C.4
Qin, W.5
Chen, H.Y.6
Lan, H.Y.7
-
62
-
-
0033667371
-
Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction
-
Miyajima A, Chen J, Lawrence C, Ledbetter S, Soslow RA, Stern J, Jha S, Pigato J, Lemer ML, Poppas DP, Vaughan ED, Felsen D. Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int 58: 2301-2313, 2000
-
(2000)
Kidney Int
, vol.58
, pp. 2301-2313
-
-
Miyajima, A.1
Chen, J.2
Lawrence, C.3
Ledbetter, S.4
Soslow, R.A.5
Stern, J.6
Jha, S.7
Pigato, J.8
Lemer, M.L.9
Poppas, D.P.10
Vaughan, E.D.11
Felsen, D.12
-
63
-
-
0034758667
-
Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis
-
Morath C, Dechow C, Lehrke I, Haxsen V, Waldherr R, Floege J, Ritz E, Wagner J. Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis. J Am Soc Nephrol 12: 2300-2309, 2001
-
(2001)
J am Soc Nephrol
, vol.12
, pp. 2300-2309
-
-
Morath, C.1
Dechow, C.2
Lehrke, I.3
Haxsen, V.4
Waldherr, R.5
Floege, J.6
Ritz, E.7
Wagner, J.8
-
64
-
-
0035651361
-
Bonemorphogenetic protein-7 improves renal fibrosis and accelerates thereturn of renal function
-
Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13, Suppl 1: S14-S21, 2002
-
(2002)
J am Soc Nephrol
, vol.13
, pp. S14-S21
-
-
Morrissey, J.1
Hruska, K.2
Guo, G.3
Wang, S.4
Chen, Q.5
Klahr, S.6
-
65
-
-
56749174940
-
Exploring the full spectrum of macrophageactivation
-
Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969, 2008
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
-
66
-
-
0029893734
-
Extracellular signal-regulatedkinase and the small GTP-binding protein, Rac, contribute to the effectsof transforming growth factor-beta1 on gene expression
-
Mucsi I, Skorecki KL, Goldberg HJ. Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression. J Biol Chem 271: 16567-16572, 1996
-
(1996)
J Biol Chem
, vol.271
, pp. 16567-16572
-
-
Mucsi, I.1
Skorecki, K.L.2
Goldberg, H.J.3
-
67
-
-
84940787634
-
Renalfibrosis is not reduced by blocking transforming growth factor-beta signaling in matrix-producing interstitial cells
-
Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L. Renal fibrosis is not reduced by blocking transforming growth factor-beta signaling in matrix-producing interstitial cells. Kidney Int 88: 503-514, 2015
-
(2015)
Kidney Int
, vol.88
, pp. 503-514
-
-
Neelisetty, S.1
Alford, C.2
Reynolds, K.3
Woodbury, L.4
Nlandu-Khodo, S.5
Yang, H.6
Fogo, A.B.7
Hao, C.M.8
Harris, R.C.9
Zent, R.10
Gewin, L.11
-
68
-
-
0034602959
-
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
-
Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275: 3577-3582, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 3577-3582
-
-
Ohashi, K.1
Nagata, K.2
Maekawa, M.3
Ishizaki, T.4
Narumiya, S.5
Mizuno, K.6
-
69
-
-
0038351964
-
A dominantnegative TAK1 inhibits cellular fibrotic responses induced by TGF-beta
-
Ono K, Ohtomo T, Ninomiya-Tsuji J, Tsuchiya M. A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta. Biochem Biophys Res Commun 307: 332-337, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.307
, pp. 332-337
-
-
Ono, K.1
Ohtomo, T.2
Ninomiya-Tsuji, J.3
Tsuchiya, M.4
-
70
-
-
50249112541
-
Autophagy protects renal tubular cells againstcyclosporine toxicity
-
Pallet N, Bouvier N, Legendre C, Gilleron J, Codogno P, Beaune P, Thervet E, Anglicheau D. Autophagy protects renal tubular cells against cyclosporine toxicity. Autophagy 4: 783-791, 2008
-
(2008)
Autophagy
, vol.4
, pp. 783-791
-
-
Pallet, N.1
Bouvier, N.2
Legendre, C.3
Gilleron, J.4
Codogno, P.5
Beaune, P.6
Thervet, E.7
Anglicheau, D.8
-
71
-
-
27844595882
-
BMP7 signaling in renal development anddisease
-
Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med 11: 512-518, 2005
-
(2005)
Trends Mol Med
, vol.11
, pp. 512-518
-
-
Patel, S.R.1
Dressler, G.R.2
-
72
-
-
20744455828
-
Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis
-
Prelog M, Scheidegger P, Peter S, Gershwin ME, Wick G, Sgonc R. Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis. Arthritis Rheum 52: 1804-1811, 2005
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1804-1811
-
-
Prelog, M.1
Scheidegger, P.2
Peter, S.3
Gershwin, M.E.4
Wick, G.5
Sgonc, R.6
-
73
-
-
79960946532
-
TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29
-
Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY. TGF-beta/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol 22: 1462-1474, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 1462-1474
-
-
Qin, W.1
Chung, A.C.2
Huang, X.R.3
Meng, X.M.4
Hui, D.S.5
Yu, C.M.6
Sung, J.J.7
Lan, H.Y.8
-
74
-
-
68149178848
-
Pirfenidone is renoprotective indiabetic kidney disease
-
RamachandraRao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S, Shaw MA, Sharma K. Pirfenidone is renoprotective in diabetic kidney disease. J Am Soc Nephrol 20: 1765-1775, 2009
-
(2009)
J am Soc Nephrol
, vol.20
, pp. 1765-1775
-
-
Ramachandrarao, S.P.1
Zhu, Y.2
Ravasi, T.3
McGowan, T.A.4
Toh, I.5
Dunn, S.R.6
Okada, S.7
Shaw, M.A.8
Sharma, K.9
-
75
-
-
70349659502
-
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression
-
Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstadt H, Schaefer L, Pfeilschifter J, Huwiler A. Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney Int 76: 857-867, 2009
-
(2009)
Kidney Int
, vol.76
, pp. 857-867
-
-
Ren, S.1
Babelova, A.2
Moreth, K.3
Xin, C.4
Eberhardt, W.5
Doller, A.6
Pavenstadt, H.7
Schaefer, L.8
Pfeilschifter, J.9
Huwiler, A.10
-
76
-
-
84883820451
-
Unchaining the beast; insights from structuraland evolutionary studies on TGFbeta secretion, sequestration, and activation
-
Robertson IB, Rifkin DB. Unchaining the beast; insights from structural and evolutionary studies on TGFbeta secretion, sequestration, and activation. Cytokine Growth Factor Rev 24: 355-372, 2013
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, pp. 355-372
-
-
Robertson, I.B.1
Rifkin, D.B.2
-
77
-
-
0346727324
-
Targeteddisruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
-
Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112: 1486-1494, 2003
-
(2003)
J Clin Invest
, vol.112
, pp. 1486-1494
-
-
Sato, M.1
Muragaki, Y.2
Saika, S.3
Roberts, A.B.4
Ooshima, A.5
-
78
-
-
79958297487
-
Antifibrotic activities of pirfenidone in animal models
-
Schaefer CJ, Ruhrmund DW, Pan L, Seiwert SD, Kossen K. Antifibrotic activities of pirfenidone in animal models. Eur Respir Rev 20: 85-97, 2011
-
(2011)
Eur Respir Rev
, vol.20
, pp. 85-97
-
-
Schaefer, C.J.1
Ruhrmund, D.W.2
Pan, L.3
Seiwert, S.D.4
Kossen, K.5
-
79
-
-
79957670746
-
Pirfenidone for diabetic nephropathy
-
Sharma K, Ix JH, Mathew AV, Cho M, Pflueger A, Dunn SR, Francos B, Sharma S, Falkner B, McGowan TA, Donohue M, Ramachandrarao S, Xu R, Fervenza FC, Kopp JB. Pirfenidone for diabetic nephropathy. J Am Soc Nephrol 22: 1144-1151, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 1144-1151
-
-
Sharma, K.1
Ix, J.H.2
Mathew, A.V.3
Cho, M.4
Pflueger, A.5
Dunn, S.R.6
Francos, B.7
Sharma, S.8
Falkner, B.9
McGowan, T.A.10
Donohue, M.11
Ramachandrarao, S.12
Xu, R.13
Fervenza, F.C.14
Kopp, J.B.15
-
80
-
-
0029924637
-
Neutralization of TGF-beta byanti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
-
Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45: 522-530, 1996
-
(1996)
Diabetes
, vol.45
, pp. 522-530
-
-
Sharma, K.1
Jin, Y.2
Guo, J.3
Ziyadeh, F.N.4
-
81
-
-
79959250326
-
LatentTGF-beta structure and activation
-
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. Latent TGF-beta structure and activation. Nature 474: 343-349, 2011
-
(2011)
Nature
, vol.474
, pp. 343-349
-
-
Shi, M.1
Zhu, J.2
Wang, R.3
Chen, X.4
Mi, L.5
Walz, T.6
Springer, T.A.7
-
82
-
-
0031834709
-
Pirfenidone improves renal function and fibrosis in the postobstructed kidney
-
Shimizu T, Kuroda T, Hata S, Fukagawa M, Margolin SB, Kurokawa K. Pirfenidone improves renal function and fibrosis in the postobstructed kidney. Kidney Int 54: 99-109, 1998
-
(1998)
Kidney Int
, vol.54
, pp. 99-109
-
-
Shimizu, T.1
Kuroda, T.2
Hata, S.3
Fukagawa, M.4
Margolin, S.B.5
Kurokawa, K.6
-
83
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
-
Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-699, 1992
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
Ormsby, I.2
Kier, A.B.3
Pawlowski, S.4
Diebold, R.J.5
Yin, M.6
Allen, R.7
Sidman, C.8
Proetzel, G.9
Calvin, D.10
Annunziata, N.11
Doetschman, T.12
-
84
-
-
34347375050
-
Renal fibrosis andglomerulosclerosis in a new mouse model of diabetic nephropathy and itsregression by bone morphogenic protein-7 and advanced glycation end product inhibitors
-
Sugimoto H, Grahovac G, Zeisberg M, Kalluri R. Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 56: 1825-1833, 2007
-
(2007)
Diabetes
, vol.56
, pp. 1825-1833
-
-
Sugimoto, H.1
Grahovac, G.2
Zeisberg, M.3
Kalluri, R.4
-
85
-
-
84891679916
-
Targeting mitochondrial dysfunction inlung diseases: Emphasis on mitophagy
-
Sureshbabu A, Bhandari V. Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy. Front Physiol 4: 384, 2013
-
(2013)
Front Physiol
, vol.4
-
-
Sureshbabu, A.1
Bhandari, V.2
-
86
-
-
84921725981
-
Oxidative stress and autophagy:Crucial modulators of kidney injury
-
Sureshbabu A, Ryter SW, Choi ME. Oxidative stress and autophagy: crucial modulators of kidney injury. Redox Biol 4: 208-214, 2015
-
(2015)
Redox Biol
, vol.4
, pp. 208-214
-
-
Sureshbabu, A.1
Ryter, S.W.2
Choi, M.E.3
-
87
-
-
80052977584
-
Relative roles ofTGF-beta and IGFBP-5 in idiopathic pulmonary fibrosis
-
Sureshbabu A, Tonner E, Allan GJ, Flint DJ. Relative roles of TGF-beta and IGFBP-5 in idiopathic pulmonary fibrosis. Pulm Med 2011: 517687, 2011
-
(2011)
Pulm Med
, vol.2011
-
-
Sureshbabu, A.1
Tonner, E.2
Allan, G.J.3
Flint, D.J.4
-
88
-
-
77955393793
-
Regulation of autophagy bytransforming growth factor-beta (TGF-beta) signaling
-
Suzuki HI, Kiyono K, Miyazono K. Regulation of autophagy by transforming growth factor-beta (TGF-beta) signaling. Autophagy 6: 645-647, 2010
-
(2010)
Autophagy
, vol.6
, pp. 645-647
-
-
Suzuki, H.I.1
Kiyono, K.2
Miyazono, K.3
-
89
-
-
79956011495
-
A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis
-
Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, Rota S, Remuzzi G, Rump LC, Sellin LK, Heaton JP, Streisand JB, Hard ML, Ledbetter SR, Vincenti F. A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int 79: 1236-1243, 2011
-
(2011)
Kidney Int
, vol.79
, pp. 1236-1243
-
-
Trachtman, H.1
Fervenza, F.C.2
Gipson, D.S.3
Heering, P.4
Jayne, D.R.5
Peters, H.6
Rota, S.7
Remuzzi, G.8
Rump, L.C.9
Sellin, L.K.10
Heaton, J.P.11
Streisand, J.B.12
Hard, M.L.13
Ledbetter, S.R.14
Vincenti, F.15
-
90
-
-
84903648153
-
Cellular mechanisms of tissuefibrosis. 8 Current and future drug targets in fibrosis: Focus on Rho GTPase-regulated gene transcription
-
Tsou PS, Haak AJ, Khanna D, Neubig RR. Cellular mechanisms of tissue fibrosis. 8 Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription. Am J Physiol Cell Physiol 307: C2-C13, 2014
-
(2014)
Am J Physiol Cell Physiol
, vol.307
, pp. CC2-C13
-
-
Tsou, P.S.1
Haak, A.J.2
Khanna, D.3
Neubig, R.R.4
-
91
-
-
78751516162
-
MiR-200a Prevents renal fibrogenesis through repression of TGF-beta2 expression
-
Wang B, Koh P, Winbanks C, Coughlan MT, McClelland A, Watson A, Jandeleit-Dahm K, Burns WC, Thomas MC, Cooper ME, Kantharidis P. miR-200a Prevents renal fibrogenesis through repression of TGF-beta2 expression. Diabetes 60: 280-287, 2011
-
(2011)
Diabetes
, vol.60
, pp. 280-287
-
-
Wang, B.1
Koh, P.2
Winbanks, C.3
Coughlan, M.T.4
McClelland, A.5
Watson, A.6
Jandeleit-Dahm, K.7
Burns, W.C.8
Thomas, M.C.9
Cooper, M.E.10
Kantharidis, P.11
-
92
-
-
0037648482
-
Bone morphogenic protein-7 (BMP-7), anovel therapy for diabetic nephropathy
-
Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 63: 2037-2049, 2003
-
(2003)
Kidney Int
, vol.63
, pp. 2037-2049
-
-
Wang, S.1
Chen, Q.2
Simon, T.C.3
Strebeck, F.4
Chaudhary, L.5
Morrissey, J.6
Liapis, H.7
Klahr, S.8
Hruska, K.A.9
-
93
-
-
2542441495
-
Bone morphogenetic protein-7 signals opposingtransforming growth factor beta in mesangial cells
-
Wang S, Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J Biol Chem 279: 23200-23206, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 23200-23206
-
-
Wang, S.1
Hirschberg, R.2
-
94
-
-
23944486004
-
Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7
-
Wang W, Huang XR, Li AG, Liu F, Li JH, Truong LD, Wang XJ, Lan HY. Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol 16: 1371-1383, 2005
-
(2005)
J am Soc Nephrol
, vol.16
, pp. 1371-1383
-
-
Wang, W.1
Huang, X.R.2
Li, A.G.3
Liu, F.4
Li, J.H.5
Truong, L.D.6
Wang, X.J.7
Lan, H.Y.8
-
95
-
-
28544450380
-
Transforming growth factor-betaactivation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2
-
Wilkes MC, Mitchell H, Penheiter SG, Dore JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB. Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 65: 10431-10440, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 10431-10440
-
-
Wilkes, M.C.1
Mitchell, H.2
Penheiter, S.G.3
Dore, J.J.4
Suzuki, K.5
Edens, M.6
Sharma, D.K.7
Pagano, R.E.8
Leof, E.B.9
-
96
-
-
84908321410
-
Transforming growth factor beta3 attenuates the development ofradiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance
-
Xu L, Xiong S, Guo R, Yang Z, Wang Q, Xiao F, Wang H, Pan X, Zhu M. Transforming growth factor beta3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-gamma/IL-4 balance. Immunol Lett 162: 27-33, 2014
-
(2014)
Immunol Lett
, vol.162
, pp. 27-33
-
-
Xu, L.1
Xiong, S.2
Guo, R.3
Yang, Z.4
Wang, Q.5
Xiao, F.6
Wang, H.7
Pan, X.8
Zhu, M.9
-
97
-
-
84863255432
-
Tgf-beta1 inducesautophagy and promotes apoptosis in renal tubular epithelial cells
-
Xu Y, Yang S, Huang J, Ruan S, Zheng Z, Lin J. Tgf-beta1 induces autophagy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med 29: 781-790, 2012
-
(2012)
Int Jmol Med
, vol.29
, pp. 781-790
-
-
Xu, Y.1
Yang, S.2
Huang, J.3
Ruan, S.4
Zheng, Z.5
Lin, J.6
-
98
-
-
15444372825
-
Type I transforming growth factor betareceptor binds to and activates phosphatidylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280: 10870-10876, 2005
-
(2005)
J Biolchem
, vol.280
, pp. 10870-10876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
99
-
-
0042932781
-
TGF-beta isoforms in renalfibrogenesis
-
Yu L, Border WA, Huang Y, Noble NA. TGF-beta isoforms in renal fibrogenesis. Kidney Int 64: 844-856, 2003
-
(2003)
Kidney Int
, vol.64
, pp. 844-856
-
-
Yu, L.1
Border, W.A.2
Huang, Y.3
Noble, N.A.4
-
100
-
-
0038717407
-
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
-
Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003
-
(2003)
Nat Med
, vol.9
, pp. 964-968
-
-
Zeisberg, M.1
Hanai, J.2
Sugimoto, H.3
Mammoto, T.4
Charytan, D.5
Strutz, F.6
Kalluri, R.7
-
101
-
-
84872197845
-
The controversial role of retinoicacid in fibrotic diseases: Analysis of involved signaling pathways
-
Zhou TB, Drummen GP, Qin YH. The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways. Int J Mol Sci 14: 226-243, 2012
-
(2012)
Int Jmol Sci
, vol.14
, pp. 226-243
-
-
Zhou, T.B.1
Drummen, G.P.2
Qin, Y.H.3
-
102
-
-
0034608948
-
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
-
Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 97: 8015-8020, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8015-8020
-
-
Ziyadeh, F.N.1
Hoffman, B.B.2
Han, D.C.3
Iglesias-De La Cruz, M.C.4
Hong, S.W.5
Isono, M.6
Chen, S.7
McGowan, T.A.8
Sharma, K.9
|