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Volumn 10, Issue , 2015, Pages 1233-1243

Klotho, stem cells, and aging

Author keywords

Aging; Cell senescence; Klotho; Stem cells; Wnt

Indexed keywords

KLOTHO PROTEIN; SOMATOMEDIN; WNT PROTEIN; BETA GLUCURONIDASE;

EID: 84939486401     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S84978     Document Type: Review
Times cited : (101)

References (145)
  • 1
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390(6655):45–51.
    • (1997) Nature , vol.390 , Issue.6655 , pp. 45-51
    • Kuro-O, M.1    Matsumura, Y.2    Aizawa, H.3
  • 2
    • 24944481544 scopus 로고    scopus 로고
    • Suppression of aging in mice by the hormone klotho
    • Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone klotho. Science. 2005;309(5742):1829–1833.
    • (2005) Science , vol.309 , Issue.5742 , pp. 1829-1833
    • Kurosu, H.1    Yamamoto, M.2    Clark, J.D.3
  • 3
    • 27644564931 scopus 로고    scopus 로고
    • Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice
    • Masuda H, Chikuda H, Suga T, Kawaguchi H, Kuro-o M. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev. 2005;126(12):1274–1283.
    • (2005) Mech Ageing Dev , vol.126 , Issue.12 , pp. 1274-1283
    • Masuda, H.1    Chikuda, H.2    Suga, T.3    Kawaguchi, H.4    Kuro-O, M.5
  • 4
    • 0032489424 scopus 로고    scopus 로고
    • Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein
    • Shiraki-Iida T, Aizawa H, Matsumura Y, et al. Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 1998;424(1–2):6–10.
    • (1998) FEBS Lett , vol.424 , Issue.12 , pp. 6-10
    • Shiraki-Iida, T.1    Aizawa, H.2    Matsumura, Y.3
  • 5
    • 0032578906 scopus 로고    scopus 로고
    • Molecular cloning of rat klotho cDNA: Markedly decreased expression of klotho by acute inflammatory stress
    • Ohyama Y, Kurabayashi M, Masuda H, et al. Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochem Biophys Res Commun. 1998;251(3):920–925.
    • (1998) Biochem Biophys Res Commun , vol.251 , Issue.3 , pp. 920-925
    • Ohyama, Y.1    Kurabayashi, M.2    Masuda, H.3
  • 6
    • 0032567647 scopus 로고    scopus 로고
    • Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
    • Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun. 1998;242(3):626–630.
    • (1998) Biochem Biophys Res Commun , vol.242 , Issue.3 , pp. 626-630
    • Matsumura, Y.1    Aizawa, H.2    Shiraki-Iida, T.3    Nagai, R.4    Kuro-O, M.5    Nabeshima, Y.6
  • 7
    • 0034685014 scopus 로고    scopus 로고
    • Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys
    • Kato Y, Arakawa E, Kinoshita S, et al. Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys. Biochem Biophys Res Commun. 2000;267(2):597–602.
    • (2000) Biochem Biophys Res Commun , vol.267 , Issue.2 , pp. 597-602
    • Kato, Y.1    Arakawa, E.2    Kinoshita, S.3
  • 8
    • 84906877850 scopus 로고    scopus 로고
    • Identification of cleavage sites leading to the shed form of the anti-aging protein klotho
    • Chen CD, Tung TY, Liang J, et al. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014;53(34):5579–5587.
    • (2014) Biochemistry , vol.53 , Issue.34 , pp. 5579-5587
    • Chen, C.D.1    Tung, T.Y.2    Liang, J.3
  • 9
    • 38049144010 scopus 로고    scopus 로고
    • Insulin stimulates the cleavage and release of the extracellular domain of klotho by ADAM10 and ADAM17
    • Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007;104(50):19796–19801.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.50 , pp. 19796-19801
    • Chen, C.D.1    Podvin, S.2    Gillespie, E.3    Leeman, S.E.4    Abraham, C.R.5
  • 10
    • 70349437179 scopus 로고    scopus 로고
    • Klotho is a substrate for α-, β- and γ-secretase
    • Bloch L, Sineshchekova O, Reichenbach D, et al. Klotho is a substrate for α-, β- and γ-secretase. FEBS Lett. 2009;583(19):3221–3224.
    • (2009) FEBS Lett , vol.583 , Issue.19 , pp. 3221-3224
    • Bloch, L.1    Sineshchekova, O.2    Reichenbach, D.3
  • 11
    • 78649642147 scopus 로고    scopus 로고
    • Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    • Hu MC, Shi M, Zhang J, Quinones H, Kuro-o M, Moe OW. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int. 2010;78(12):1240–1251.
    • (2010) Kidney Int , vol.78 , Issue.12 , pp. 1240-1251
    • Hu, M.C.1    Shi, M.2    Zhang, J.3    Quinones, H.4    Kuro-O, M.5    Moe, O.W.6
  • 12
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu MC, Shi M, Zhang J, et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010;24(9):3438–3450.
    • (2010) FASEB J , vol.24 , Issue.9 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 13
    • 2342610541 scopus 로고    scopus 로고
    • Secreted klotho protein in sera and CSF: Implication for post-translational cleavage in release of klotho protein from cell membrane
    • Imura A, Iwano A, Tohyama O, et al. Secreted klotho protein in sera and CSF: implication for post-translational cleavage in release of klotho protein from cell membrane. FEBS Lett. 2004;565(1–3):143–147.
    • (2004) FEBS Lett , vol.565 , Issue.13 , pp. 143-147
    • Imura, A.1    Iwano, A.2    Tohyama, O.3
  • 14
    • 84888403692 scopus 로고    scopus 로고
    • Klotho in the cerebrospinal fluid of adults with and without Alzheimer’s disease
    • Semba RD, Moghekar AR, Hu J, et al. Klotho in the cerebrospinal fluid of adults with and without Alzheimer’s disease. Neurosci Lett. 2014;558:37–40.
    • (2014) Neurosci Lett , vol.558 , pp. 37-40
    • Semba, R.D.1    Moghekar, A.R.2    Hu, J.3
  • 15
    • 78651408919 scopus 로고    scopus 로고
    • Klotho deficiency causes vascular calcification in chronic kidney disease
    • Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22(1):124–136.
    • (2011) J am Soc Nephrol , vol.22 , Issue.1 , pp. 124-136
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 16
    • 84922484086 scopus 로고    scopus 로고
    • The demonstration of αklotho deficiency in human chronic kidney disease with a novel synthetic antibody
    • Barker SL, Pastor J, Carranza D, et al. The demonstration of αklotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant. 2015;30(2):223–233.
    • (2015) Nephrol Dial Transplant , vol.30 , Issue.2 , pp. 223-233
    • Barker, S.L.1    Pastor, J.2    Carranza, D.3
  • 17
    • 77951871631 scopus 로고    scopus 로고
    • Regulation of ion channels by secreted klotho: Mechanisms and implications
    • Huang CL. Regulation of ion channels by secreted klotho: mechanisms and implications. Kidney Int. 2010;77(10):855–860.
    • (2010) Kidney Int , vol.77 , Issue.10 , pp. 855-860
    • Huang, C.L.1
  • 18
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • Liu H, Fergusson MM, Castilho RM, et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007;317(5839):803–806.
    • (2007) Science , vol.317 , Issue.5839 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3
  • 19
    • 76249084836 scopus 로고    scopus 로고
    • Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-klotho complex formation
    • Goetz R, Nakada Y, Hu MC, et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-klotho complex formation. Proc Natl Acad Sci U S A. 2010;107(1):407–412.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.1 , pp. 407-412
    • Goetz, R.1    Nakada, Y.2    Hu, M.C.3
  • 20
    • 78049511826 scopus 로고    scopus 로고
    • Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: Circadian variance, effects of treatment, and relationship to parathyroid status
    • Carpenter TO, Insogna KL, Zhang JH, et al. Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status. J Clin Endocrinol Metab. 2010;95(11):E352–E357.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.11 , pp. E352-E357
    • Carpenter, T.O.1    Insogna, K.L.2    Zhang, J.H.3
  • 22
    • 1642352496 scopus 로고    scopus 로고
    • Klotho is a novel β-glucuronidase capable of hydrolyzing steroid beta-glucuronides
    • Tohyama O, Imura A, Iwano A, et al. Klotho is a novel β-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem. 2004;279(11):9777–9784.
    • (2004) J Biol Chem , vol.279 , Issue.11 , pp. 9777-9784
    • Tohyama, O.1    Imura, A.2    Iwano, A.3
  • 23
    • 54149087686 scopus 로고    scopus 로고
    • The β-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6
    • Lu P, Boros S, Chang Q, Bindels RJ, Hoenderop JG. The β-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrol Dial Transplant. 2008;23(11):3397–3402.
    • (2008) Nephrol Dial Transplant , vol.23 , Issue.11 , pp. 3397-3402
    • Lu, P.1    Boros, S.2    Chang, Q.3    Bindels, R.J.4    Hoenderop, J.G.5
  • 24
    • 84919782510 scopus 로고    scopus 로고
    • Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms
    • Wolf MT, An SW, Nie M, Bal MS, Huang CL. Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms. J Biol Chem. 2014;289(52):35849–35857.
    • (2014) J Biol Chem , vol.289 , Issue.52 , pp. 35849-35857
    • Wolf, M.T.1    An, S.W.2    Nie, M.3    Bal, M.S.4    Huang, C.L.5
  • 25
    • 47749148805 scopus 로고    scopus 로고
    • Removal of sialic acid involving klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    • Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro OM, Huang CL. Removal of sialic acid involving klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A. 2008;105(28):9805–9810.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.28 , pp. 9805-9810
    • Cha, S.K.1    Ortega, B.2    Kurosu, H.3    Rosenblatt, K.P.4    Kuro, O.M.5    Huang, C.L.6
  • 26
    • 67649834455 scopus 로고    scopus 로고
    • Regulation of renal outer medullary potassium channel and renal K(+) excretion by klotho
    • Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL. Regulation of renal outer medullary potassium channel and renal K(+) excretion by klotho. Mol Pharmacol. 2009;76(1):38–46.
    • (2009) Mol Pharmacol , vol.76 , Issue.1 , pp. 38-46
    • Cha, S.K.1    Hu, M.C.2    Kurosu, H.3    Kuro-O, M.4    Moe, O.5    Huang, C.L.6
  • 30
    • 84920019035 scopus 로고    scopus 로고
    • Upregulation of the creatine transporter Slc6A8 by klotho
    • Almilaji A, Sopjani M, Elvira B, et al. Upregulation of the creatine transporter Slc6A8 by klotho. Kidney Blood Press Res. 2014;39(6):516–525.
    • (2014) Kidney Blood Press Res , vol.39 , Issue.6 , pp. 516-525
    • Almilaji, A.1    Sopjani, M.2    Elvira, B.3
  • 32
    • 84920837819 scopus 로고    scopus 로고
    • Regulation of the voltage gated k channel kv1.3 by recombinant human klotho protein
    • Almilaji A, Honisch S, Liu G, et al. Regulation of the voltage gated k channel kv1.3 by recombinant human klotho protein. Kidney Blood Press Res. 2014;39(6):609–622.
    • (2014) Kidney Blood Press Res , vol.39 , Issue.6 , pp. 609-622
    • Almilaji, A.1    Honisch, S.2    Liu, G.3
  • 33
    • 84878226726 scopus 로고    scopus 로고
    • Klotho sensitivity of the hERG channel
    • Munoz C, Pakladok T, Almilaji A, et al. Klotho sensitivity of the hERG channel. FEBS Lett. 2013;587(11):1663–1668.
    • (2013) FEBS Lett , vol.587 , Issue.11 , pp. 1663-1668
    • Munoz, C.1    Pakladok, T.2    Almilaji, A.3
  • 34
    • 84866679694 scopus 로고    scopus 로고
    • Hill AP. HERG K(+) channels: Structure, function, and clinical significance
    • Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP. hERG K(+) channels: structure, function, and clinical significance. Physiol Rev. 2012;92(3):1393–1478.
    • (2012) Physiol Rev , vol.92 , Issue.3 , pp. 1393-1478
    • Vandenberg, J.I.1    Perry, M.D.2    Perrin, M.J.3    Mann, S.A.4    Ke, Y.5
  • 36
    • 84907479053 scopus 로고    scopus 로고
    • Zhang J, et al. α-Klotho protects against oxidative damage in pulmonary epithelia
    • Ravikumar P, Ye J, Zhang J, et al. α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol. 2014;307(7):L566–L575.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.307 , Issue.7 , pp. L566-L575
    • Ravikumar, P.1    Ye, J.2
  • 37
    • 84897954107 scopus 로고    scopus 로고
    • Klotho has dual protective effects on cisplatin-induced acute kidney injury
    • Panesso MC, Shi M, Cho HJ, et al. Klotho has dual protective effects on cisplatin-induced acute kidney injury. Kidney Int. 2014;85(4):855–870.
    • (2014) Kidney Int , vol.85 , Issue.4 , pp. 855-870
    • Panesso, M.C.1    Shi, M.2    Cho, H.J.3
  • 38
    • 77956637592 scopus 로고    scopus 로고
    • Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
    • Ohnishi M, Razzaque MS. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J. 2010;24(9):3562–3571.
    • (2010) FASEB J , vol.24 , Issue.9 , pp. 3562-3571
    • Ohnishi, M.1    Razzaque, M.S.2
  • 39
    • 0035208924 scopus 로고    scopus 로고
    • The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc
    • Morishita K, Shirai A, Kubota M, et al. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr. 2001;131(12):3182–3188.
    • (2001) J Nutr , vol.131 , Issue.12 , pp. 3182-3188
    • Morishita, K.1    Shirai, A.2    Kubota, M.3
  • 40
    • 67349229781 scopus 로고    scopus 로고
    • Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase
    • Ohnishi M, Nakatani T, Lanske B, Razzaque MS. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase. Kidney Int. 2009;75(11):1166–1172.
    • (2009) Kidney Int , vol.75 , Issue.11 , pp. 1166-1172
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 41
    • 33746341155 scopus 로고    scopus 로고
    • Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice
    • Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 2006;12(7):298–305.
    • (2006) Trends Mol Med , vol.12 , Issue.7 , pp. 298-305
    • Razzaque, M.S.1    Lanske, B.2
  • 42
    • 84915782238 scopus 로고    scopus 로고
    • The kidney is the principal organ mediating klotho effects
    • Lindberg K, Amin R, Moe OW, et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol. 2014;25(10):2169–2175.
    • (2014) J am Soc Nephrol , vol.25 , Issue.10 , pp. 2169-2175
    • Lindberg, K.1    Amin, R.2    Moe, O.W.3
  • 43
    • 2342599742 scopus 로고    scopus 로고
    • Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression
    • Takeshita K, Fujimori T, Kurotaki Y, et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation. 2004;109(14):1776–1782.
    • (2004) Circulation , vol.109 , Issue.14 , pp. 1776-1782
    • Takeshita, K.1    Fujimori, T.2    Kurotaki, Y.3
  • 44
    • 84873658813 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and klotho: Physiology and pathophysiology of an endocrine network of mineral metabolism
    • Hu MC, Shiizaki K, Kuro-o M, Moe OW. Fibroblast growth factor 23 and klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol. 2013;75:503–533.
    • (2013) Annu Rev Physiol , vol.75 , pp. 503-533
    • Hu, M.C.1    Shiizaki, K.2    Kuro-O, M.3    Moe, O.W.4
  • 45
    • 84859522038 scopus 로고    scopus 로고
    • Secreted klotho and chronic kidney disease
    • Hu MC, Kuro-o M, Moe OW. Secreted klotho and chronic kidney disease. Adv Exp Med Biol. 2012;728:126–157.
    • (2012) Adv Exp Med Biol , vol.728 , pp. 126-157
    • Hu, M.C.1    Kuro-O, M.2    Moe, O.W.3
  • 46
    • 84925735151 scopus 로고    scopus 로고
    • Klotho and chronic kidney disease
    • Hu MC, Kuro-o M, Moe OW. Klotho and chronic kidney disease. Contrib Nephrol. 2013;180:47–63.
    • (2013) Contrib Nephrol , vol.180 , pp. 47-63
    • Hu, M.C.1    Kuro-O, M.2    Moe, O.W.3
  • 47
    • 84880579414 scopus 로고    scopus 로고
    • Chronic kidney disease: A clinical model of premature aging
    • Stenvinkel P, Larsson TE. Chronic kidney disease: a clinical model of premature aging. Am J Kidney Dis. 2013;62(2):339–351.
    • (2013) Am J Kidney Dis , vol.62 , Issue.2 , pp. 339-351
    • Stenvinkel, P.1    Larsson, T.E.2
  • 49
    • 84878862873 scopus 로고    scopus 로고
    • Senescence regulation by the p53 protein family
    • Qian Y, Chen X. Senescence regulation by the p53 protein family. Methods Mol Biol. 2013;965:37–61.
    • (2013) Methods Mol Biol , vol.965 , pp. 37-61
    • Qian, Y.1    Chen, X.2
  • 50
    • 84892731189 scopus 로고    scopus 로고
    • Cellular senescence and its effector programs
    • Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev. 2014;28(2):99–114.
    • (2014) Genes Dev , vol.28 , Issue.2 , pp. 99-114
    • Salama, R.1    Sadaie, M.2    Hoare, M.3    Narita, M.4
  • 52
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: From physiology to pathology
    • Muñoz-Espín D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15(7):482–496.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , Issue.7 , pp. 482-496
    • Muñoz-Espín, D.1    Serrano, M.2
  • 53
    • 80855128461 scopus 로고    scopus 로고
    • Cellular senescence: A link between cancer and age-related degenerative disease?
    • Campisi J, Andersen JK, Kapahi P, Melov S. Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol. 2011;21(6):354–359.
    • (2011) Semin Cancer Biol , vol.21 , Issue.6 , pp. 354-359
    • Campisi, J.1    Ersen, J.K.2    Kapahi, P.3    Melov, S.4
  • 54
    • 84876707441 scopus 로고    scopus 로고
    • Cellular senescence in cardiovascular diseases: Potential age-related mechanisms and implications for treatment
    • Olivieri F, Recchioni R, Marcheselli F, et al. Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment. Curr Pharm Des. 2013;19(9):1710–1719.
    • (2013) Curr Pharm Des , vol.19 , Issue.9 , pp. 1710-1719
    • Olivieri, F.1    Recchioni, R.2    Marcheselli, F.3
  • 55
    • 84904626614 scopus 로고    scopus 로고
    • Cell senescence: Role in aging and age-related diseases
    • Campisi J, Robert L. Cell senescence: role in aging and age-related diseases. Interdiscip Top Gerontol. 2014;39:45–61.
    • (2014) Interdiscip Top Gerontol , vol.39 , pp. 45-61
    • Campisi, J.1    Robert, L.2
  • 56
    • 84908450979 scopus 로고    scopus 로고
    • Endothelial cell senescence and age-related vascular diseases
    • Tian XL, Li Y. Endothelial cell senescence and age-related vascular diseases. J Genet Genomics. 2014;41(9):485–495.
    • (2014) J Genet Genomics , vol.41 , Issue.9 , pp. 485-495
    • Tian, X.L.1    Li, Y.2
  • 57
    • 84902297367 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
    • Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care. 2014;17(4):324–328.
    • (2014) Curr Opin Clin Nutr Metab Care , vol.17 , Issue.4 , pp. 324-328
    • Zhu, Y.1    Armstrong, J.L.2    Tchkonia, T.3    Kirkland, J.L.4
  • 58
    • 84875453097 scopus 로고    scopus 로고
    • FOXA1 mediates p16(INK4a) activation during cellular senescence
    • Li Q, Zhang Y, Fu J, et al. FOXA1 mediates p16(INK4a) activation during cellular senescence. EMBO J. 2013;32(6):858–873.
    • (2013) EMBO J , vol.32 , Issue.6 , pp. 858-873
    • Li, Q.1    Zhang, Y.2    Fu, J.3
  • 59
    • 80053391506 scopus 로고    scopus 로고
    • Lemaitre JM. P53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression
    • Prieur A, Besnard E, Babled A, Lemaitre JM. p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression. Nat Commun. 2011;2:473.
    • (2011) Nat Commun , vol.2 , pp. 473
    • Prieur, A.1    Besnard, E.2    Babled, A.3
  • 60
    • 84884887531 scopus 로고    scopus 로고
    • CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion
    • Leontieva OV, Blagosklonny MV. CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion. Cell Cycle. 2013;12(18):3063–3069.
    • (2013) Cell Cycle , vol.12 , Issue.18 , pp. 3063-3069
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 61
    • 33749342012 scopus 로고    scopus 로고
    • Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
    • de Oliveira RM. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett. 2006;580(24):5753–5758.
    • (2006) FEBS Lett , vol.580 , Issue.24 , pp. 5753-5758
    • De Oliveira, R.M.1
  • 62
    • 28844474827 scopus 로고    scopus 로고
    • Anti-apoptotic and anti-senescence effects of klotho on vascular endothelial cells
    • Ikushima M, Rakugi H, Ishikawa K, et al. Anti-apoptotic and anti-senescence effects of klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339(3):827–832.
    • (2006) Biochem Biophys Res Commun , vol.339 , Issue.3 , pp. 827-832
    • Ikushima, M.1    Rakugi, H.2    Ishikawa, K.3
  • 63
    • 80053274845 scopus 로고    scopus 로고
    • Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway
    • Maekawa Y, Ohishi M, Ikushima M, et al. Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway. Geriatr Gerontol Int. 2011;11(4):510–516.
    • (2011) Geriatr Gerontol Int , vol.11 , Issue.4 , pp. 510-516
    • Maekawa, Y.1    Ohishi, M.2    Ikushima, M.3
  • 64
    • 84895930872 scopus 로고    scopus 로고
    • Liver autophagy: Much more than just taking out the trash
    • Schneider JL, Cuervo AM. Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol. 2014;11(3):187–200.
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , Issue.3 , pp. 187-200
    • Schneider, J.L.1    Cuervo, A.M.2
  • 65
    • 84891741302 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: Roles in disease and aging
    • Cuervo AM, Wong E. Chaperone-mediated autophagy: roles in disease and aging. Cell Res. 2014;24(1):92–104.
    • (2014) Cell Res , vol.24 , Issue.1 , pp. 92-104
    • Cuervo, A.M.1    Wong, E.2
  • 66
    • 84873660610 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651–662.
    • (2013) N Engl J Med , vol.368 , Issue.7 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 67
    • 78651300628 scopus 로고    scopus 로고
    • Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging
    • Iida RH, Kanko S, Suga T, Morito M, Yamane A. Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging. Mol Cell Biochem. 2011;348(1–2):89–98.
    • (2011) Mol Cell Biochem , vol.348 , Issue.12 , pp. 89-98
    • Iida, R.H.1    Kanko, S.2    Suga, T.3    Morito, M.4    Yamane, A.5
  • 68
    • 41549156809 scopus 로고    scopus 로고
    • Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
    • Shiozaki M, Yoshimura K, Shibata M, et al. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience. 2008;152(4):924–941.
    • (2008) Neuroscience , vol.152 , Issue.4 , pp. 924-941
    • Shiozaki, M.1    Yoshimura, K.2    Shibata, M.3
  • 69
    • 84876461971 scopus 로고    scopus 로고
    • Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells
    • Shu G, Xie B, Ren F, et al. Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. Cell Oncol (Dordr). 2013;36(2):121–129.
    • (2013) Cell Oncol (Dordr) , vol.36 , Issue.2 , pp. 121-129
    • Shu, G.1    Xie, B.2    Ren, F.3
  • 70
    • 84874016733 scopus 로고    scopus 로고
    • Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: Tumor suppressive role of klotho in gastric cancer
    • Xie B, Zhou J, Shu G, et al. Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int. 2013;13(1):18.
    • (2013) Cancer Cell Int , vol.13 , Issue.1 , pp. 18
    • Xie, B.1    Zhou, J.2    Shu, G.3
  • 71
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science. 2010;327(5965):542–545.
    • (2010) Science , vol.327 , Issue.5965 , pp. 542-545
    • Li, L.1    Clevers, H.2
  • 72
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: Units of development, units of regeneration, and units in evolution
    • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell. 2000;100(1):157–168.
    • (2000) Cell , vol.100 , Issue.1 , pp. 157-168
    • Weissman, I.L.1
  • 73
    • 79955511101 scopus 로고    scopus 로고
    • Emerging models and paradigms for stem cell ageing
    • Jones DL, Rando TA. Emerging models and paradigms for stem cell ageing. Nat Cell Biol. 2011;13(5):506–512.
    • (2011) Nat Cell Biol , vol.13 , Issue.5 , pp. 506-512
    • Jones, D.L.1    Rando, T.A.2
  • 74
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: Is it ever too old to become young again?
    • Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009;9(1):57–62.
    • (2009) Nat Rev Immunol , vol.9 , Issue.1 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.3
  • 75
    • 5444271778 scopus 로고    scopus 로고
    • Stem cells, aging, and cancer: Inevitabilities and outcomes
    • Bell DR, Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene. 2004;23(43):7290–7296.
    • (2004) Oncogene , vol.23 , Issue.43 , pp. 7290-7296
    • Bell, D.R.1    Van Zant, G.2
  • 76
    • 34249885603 scopus 로고    scopus 로고
    • Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
    • Ruzankina Y, Pinzon-Guzman C, Asare A, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007;1(1):113–126.
    • (2007) Cell Stem Cell , vol.1 , Issue.1 , pp. 113-126
    • Ruzankina, Y.1    Pinzon-Guzman, C.2    Asare, A.3
  • 77
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol. 2009;71:241–260.
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 78
    • 74049092761 scopus 로고    scopus 로고
    • Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin
    • Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. Aging Cell. 2009;8(6):738–751.
    • (2009) Aging Cell , vol.8 , Issue.6 , pp. 738-751
    • Rittié, L.1    Stoll, S.W.2    Kang, S.3    Voorhees, J.J.4    Fisher, G.J.5
  • 79
    • 37549039009 scopus 로고    scopus 로고
    • A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis
    • Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell. 2008;2(1):50–59.
    • (2008) Cell Stem Cell , vol.2 , Issue.1 , pp. 50-59
    • Brack, A.S.1    Conboy, I.M.2    Conboy, M.J.3    Shen, J.4    Rando, T.A.5
  • 80
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447(7143):407–412.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 407-412
    • Berger, S.L.1
  • 81
    • 68049097008 scopus 로고    scopus 로고
    • Epigenetic dynamics of stem cells and cell lineage commitment: Digging Waddington’s canal
    • Hemberger M, Dean W, Reik W. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington’s canal. Nat Rev Mol Cell Biol. 2009;10(8):526–537.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.8 , pp. 526-537
    • Hemberger, M.1    Dean, W.2    Reik, W.3
  • 82
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • Mikkelsen TS, Ku M, Jaffe DB, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature. 2007;448(7153):553–560.
    • (2007) Nature , vol.448 , Issue.7153 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3
  • 83
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125(2):315–326.
    • (2006) Cell , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 84
    • 78349235475 scopus 로고    scopus 로고
    • Tendon-derived stem/progenitor cell aging: Defective self-renewal and altered fate
    • Zhou Z, Akinbiyi T, Xu L, et al. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Aging Cell. 2010;9(5):911–915.
    • (2010) Aging Cell , vol.9 , Issue.5 , pp. 911-915
    • Zhou, Z.1    Akinbiyi, T.2    Xu, L.3
  • 85
    • 34547924424 scopus 로고    scopus 로고
    • Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    • Brack AS, Conboy MJ, Roy S, et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007;317(5839):807–810.
    • (2007) Science , vol.317 , Issue.5839 , pp. 807-810
    • Brack, A.S.1    Conboy, M.J.2    Roy, S.3
  • 87
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo K, Ema H, Morita Y, Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med. 2000;192(9):1273–1280.
    • (2000) J Exp Med , vol.192 , Issue.9 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 88
    • 77953121698 scopus 로고    scopus 로고
    • Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    • Sotiropoulou PA, Candi A, Mascré G, et al. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol. 2010;12(6):572–582.
    • (2010) Nat Cell Biol , vol.12 , Issue.6 , pp. 572-582
    • Sotiropoulou, P.A.1    Candi, A.2    Mascré, G.3
  • 89
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007;447(7145):725–729.
    • (2007) Nature , vol.447 , Issue.7145 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 90
    • 1242341960 scopus 로고    scopus 로고
    • Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
    • Maslov AY, Barone TA, Plunkett RJ, Pruitt SC. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci. 2004;24(7):1726–1733.
    • (2004) J Neurosci , vol.24 , Issue.7 , pp. 1726-1733
    • Maslov, A.Y.1    Barone, T.A.2    Plunkett, R.J.3    Pruitt, S.C.4
  • 91
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
    • Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16(6):2027–2033.
    • (1996) J Neurosci , vol.16 , Issue.6 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 92
    • 66449086247 scopus 로고    scopus 로고
    • Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
    • Inomata K, Aoto T, Binh NT, et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell. 2009;137(6):1088–1099.
    • (2009) Cell , vol.137 , Issue.6 , pp. 1088-1099
    • Inomata, K.1    Aoto, T.2    Binh, N.T.3
  • 93
    • 13244287677 scopus 로고    scopus 로고
    • Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche
    • Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science. 2005;307(5710):720–724.
    • (2005) Science , vol.307 , Issue.5710 , pp. 720-724
    • Nishimura, E.K.1    Granter, S.R.2    Fisher, D.E.3
  • 94
    • 70350506802 scopus 로고    scopus 로고
    • FoxO3 regulates neural stem cell homeostasis
    • Renault VM, Rafalski VA, Morgan AA, et al. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009;5(5):527–539.
    • (2009) Cell Stem Cell , vol.5 , Issue.5 , pp. 527-539
    • Renault, V.M.1    Rafalski, V.A.2    Morgan, A.A.3
  • 95
    • 53749098061 scopus 로고    scopus 로고
    • Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression
    • Nishino J, Kim I, Chada K, Morrison SJ. Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell. 2008;135(2):227–239.
    • (2008) Cell , vol.135 , Issue.2 , pp. 227-239
    • Nishino, J.1    Kim, I.2    Chada, K.3    Morrison, S.J.4
  • 96
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsky AV, Slutsky SG, Joseph NM, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006;443(7110):448–452.
    • (2006) Nature , vol.443 , Issue.7110 , pp. 448-452
    • Molofsky, A.V.1    Slutsky, S.G.2    Joseph, N.M.3
  • 97
    • 40549103466 scopus 로고    scopus 로고
    • Epidermal stem cells are retained in vivo throughout skin aging
    • Giangreco A, Qin M, Pintar JE, Watt FM. Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell. 2008;7(2):250–259.
    • (2008) Aging Cell , vol.7 , Issue.2 , pp. 250-259
    • Giangreco, A.1    Qin, M.2    Pintar, J.E.3    Watt, F.M.4
  • 98
    • 36248973631 scopus 로고    scopus 로고
    • Intrinsic changes and extrinsic influences of myogenic stem cell function during aging
    • Brack AS, Rando TA. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 2007;3(3):226–237.
    • (2007) Stem Cell Rev , vol.3 , Issue.3 , pp. 226-237
    • Brack, A.S.1    Rando, T.A.2
  • 99
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007;8(9):703–713.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.9 , pp. 703-713
    • Sharpless, N.E.1    Depinho, R.A.2
  • 100
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • Rando TA. Stem cells, ageing and the quest for immortality. Nature. 2006;441(7097):1080–1086.
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1080-1086
    • Rando, T.A.1
  • 101
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37(5):961–976.
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.5 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 102
    • 34548186667 scopus 로고    scopus 로고
    • D’Adda di Fagagna F. Cellular senescence: When bad things happen to good cells
    • Campisi J, d’Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8(9):729–740.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1
  • 104
    • 40349085766 scopus 로고    scopus 로고
    • The longest telomeres: A general signature of adult stem cell compartments
    • Flores I, Canela A, Vera E, Tejera A, Cotsarelis G, Blasco MA. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 2008;22(5):654–667.
    • (2008) Genes Dev , vol.22 , Issue.5 , pp. 654-667
    • Flores, I.1    Canela, A.2    Vera, E.3    Tejera, A.4    Cotsarelis, G.5    Blasco, M.A.6
  • 105
    • 84918496767 scopus 로고    scopus 로고
    • Characterization of bone marrow-derived mesenchymal stem cells in aging
    • Baker N, Boyette LB, Tuan RS. Characterization of bone marrow-derived mesenchymal stem cells in aging. Bone. 2015;70:37–47.
    • (2015) Bone , vol.70 , pp. 37-47
    • Baker, N.1    Boyette, L.B.2    Tuan, R.S.3
  • 106
    • 84911910450 scopus 로고    scopus 로고
    • Stem cells and aberrant signaling of molecular systems in skin aging
    • Peng Y, Xuan M, Leung VY, Cheng B. Stem cells and aberrant signaling of molecular systems in skin aging. Ageing Res Rev. 2015;19:8–21.
    • (2015) Ageing Res Rev , vol.19 , pp. 8-21
    • Peng, Y.1    Xuan, M.2    Leung, V.Y.3    Cheng, B.4
  • 107
    • 84923595419 scopus 로고    scopus 로고
    • Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia
    • Fry CS, Lee JD, Mula J, et al. Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015;21(1):76–80.
    • (2015) Nat Med , vol.21 , Issue.1 , pp. 76-80
    • Fry, C.S.1    Lee, J.D.2    Mula, J.3
  • 108
    • 84887925653 scopus 로고    scopus 로고
    • Stem cells in plastic surgery: A review of current clinical and translational applications
    • Salibian AA, Widgerow AD, Abrouk M, Evans GR. Stem cells in plastic surgery: a review of current clinical and translational applications. Arch Plast Surg. 2013;40(6):666–675.
    • (2013) Arch Plast Surg , vol.40 , Issue.6 , pp. 666-675
    • Salibian, A.A.1    Widgerow, A.D.2    Abrouk, M.3    Evans, G.R.4
  • 109
    • 50949122123 scopus 로고    scopus 로고
    • Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells
    • Florian C, Langmann T, Weber BH, Morsczeck C. Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells. Biochem Biophys Res Commun. 2008;374(2):187–191.
    • (2008) Biochem Biophys Res Commun , vol.374 , Issue.2 , pp. 187-191
    • Florian, C.1    Langmann, T.2    Weber, B.H.3    Morsczeck, C.4
  • 110
    • 47349116339 scopus 로고    scopus 로고
    • Stem cell review series: Aging of the skeletal muscle stem cell niche
    • Gopinath SD, Rando TA. Stem cell review series: aging of the skeletal muscle stem cell niche. Aging Cell. 2008;7(4):590–598.
    • (2008) Aging Cell , vol.7 , Issue.4 , pp. 590-598
    • Gopinath, S.D.1    Rando, T.A.2
  • 112
    • 84925830213 scopus 로고    scopus 로고
    • FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6
    • Uchihashi K, Nakatani T, Goetz R, Mohammadi M, He X, Razzaque MS. FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6. Contrib Nephrol. 2013;180:124–137.
    • (2013) Contrib Nephrol , vol.180 , pp. 124-137
    • Uchihashi, K.1    Nakatani, T.2    Goetz, R.3    Mohammadi, M.4    He, X.5    Razzaque, M.S.6
  • 113
    • 84893475629 scopus 로고    scopus 로고
    • Future treatment approaches to multiple sclerosis
    • Derwenskus J, Lublin FD. Future treatment approaches to multiple sclerosis. Handb Clin Neurol. 2014;122:563–577.
    • (2014) Handb Clin Neurol , vol.122 , pp. 563-577
    • Derwenskus, J.1    Lublin, F.D.2
  • 114
    • 16544382863 scopus 로고    scopus 로고
    • Stem-cell repair of infarcted myocardium: Ready for clinical application?
    • Lee S, Bick-Forrester J, Makkar RR, Forrester JS. Stem-cell repair of infarcted myocardium: ready for clinical application? Am Heart Hosp J. 2004;2(2):100–106.
    • (2004) Am Heart Hosp J , vol.2 , Issue.2 , pp. 100-106
    • Lee, S.1    Bick-Forrester, J.2    Makkar, R.R.3    Forrester, J.S.4
  • 115
    • 84939494398 scopus 로고    scopus 로고
    • A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients
    • Qiao LY, Huang FJ, Zhao M, et al. A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. Cell Transplant. 2014;23 Suppl 1:S65–S72.
    • (2014) Cell Transplant , vol.23 , pp. S65-S72
    • Qiao, L.Y.1    Huang, F.J.2    Zhao, M.3
  • 116
    • 84867044027 scopus 로고    scopus 로고
    • The future of glioma treatment: Stem cells, nanotechnology and personalized medicine
    • Rahman M, Hoh B, Kohler N, Dunbar EM, Murad GJ. The future of glioma treatment: stem cells, nanotechnology and personalized medicine. Future Oncol. 2012;8(9):1149–1156.
    • (2012) Future Oncol , vol.8 , Issue.9 , pp. 1149-1156
    • Rahman, M.1    Hoh, B.2    Kohler, N.3    Dunbar, E.M.4    Murad, G.J.5
  • 117
    • 0034220058 scopus 로고    scopus 로고
    • Improvement of multiple pathophysiological phenotypes of klotho (Kl/kl) mice by adenovirus-mediated expression of the klotho gene
    • Shiraki-Iida T, Iida A, Nabeshima Y, et al. Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. J Gene Med. 2000;2(4):233–242.
    • (2000) J Gene Med , vol.2 , Issue.4 , pp. 233-242
    • Shiraki-Iida, T.1    Iida, A.2    Nabeshima, Y.3
  • 118
    • 84904057558 scopus 로고    scopus 로고
    • Antiaging gene klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats
    • Wang Y, Sun Z. Antiaging gene klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J Hypertens. 2014;32(8):1629–1636.
    • (2014) J Hypertens , vol.32 , Issue.8 , pp. 1629-1636
    • Wang, Y.1    Sun, Z.2
  • 119
    • 70349659193 scopus 로고    scopus 로고
    • Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage
    • Wang Y, Sun Z. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension. 2009;54(4):810–817.
    • (2009) Hypertension , vol.54 , Issue.4 , pp. 810-817
    • Wang, Y.1    Sun, Z.2
  • 120
    • 0036235099 scopus 로고    scopus 로고
    • In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
    • Mitani H, Ishizaka N, Aizawa T, et al. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension. 2002;39(4):838–843.
    • (2002) Hypertension , vol.39 , Issue.4 , pp. 838-843
    • Mitani, H.1    Ishizaka, N.2    Aizawa, T.3
  • 121
    • 0034710838 scopus 로고    scopus 로고
    • In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
    • Saito Y, Nakamura T, Ohyama Y, et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun. 2000;276(2):767–772.
    • (2000) Biochem Biophys Res Commun , vol.276 , Issue.2 , pp. 767-772
    • Saito, Y.1    Nakamura, T.2    Ohyama, Y.3
  • 122
    • 84929353472 scopus 로고    scopus 로고
    • Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate
    • Xie J, Yoon J, An SW, Kuro-o OM, Huang CL. Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol. 2015;26(5):1150–1160.
    • (2015) J am Soc Nephrol , vol.26 , Issue.5 , pp. 1150-1160
    • Xie, J.1    Yoon, J.2    An, S.W.3    Kuro-O, O.M.4    Huang, C.L.5
  • 123
    • 84995608786 scopus 로고    scopus 로고
    • Curing genetic disease with gene therapy
    • Williams DA. Curing genetic disease with gene therapy. Trans Am Clin Climatol Assoc. 2014;125:122–128.
    • (2014) Trans am Clin Climatol Assoc , vol.125 , pp. 122-128
    • Williams, D.A.1
  • 124
    • 84921459183 scopus 로고    scopus 로고
    • Gene electrotransfer clinical trials
    • Heller R, Heller LC. Gene electrotransfer clinical trials. Adv Genet. 2015;89:235–262.
    • (2015) Adv Genet , vol.89 , pp. 235-262
    • Heller, R.1    Heller, L.C.2
  • 125
    • 79953138206 scopus 로고    scopus 로고
    • Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    • Doi S, Zou Y, Togao O, et al. Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem. 2011;286(10):8655–8665.
    • (2011) J Biol Chem , vol.286 , Issue.10 , pp. 8655-8665
    • Doi, S.1    Zou, Y.2    Togao, O.3
  • 126
    • 84871924970 scopus 로고    scopus 로고
    • The secreted klotho protein restores phosphate retention and suppresses accelerated aging in klotho mutant mice
    • Chen TH, Kuro OM, Chen CH, et al. The secreted klotho protein restores phosphate retention and suppresses accelerated aging in klotho mutant mice. Eur J Pharmacol. 2013;698(1–3):67–73.
    • (2013) Eur J Pharmacol , vol.698 , Issue.1-3 , pp. 67-73
    • Chen, T.H.1    Kuro, O.M.2    Chen, C.H.3
  • 127
    • 72049124334 scopus 로고    scopus 로고
    • The PPARγ agonist pioglitazone ameliorates aging-related progressive renal injury
    • Yang HC, Deleuze S, Zuo Y, Potthoff SA, Ma LJ, Fogo AB. The PPARγ agonist pioglitazone ameliorates aging-related progressive renal injury. J Am Soc Nephrol. 2009;20(11):2380–2388.
    • (2009) J am Soc Nephrol , vol.20 , Issue.11 , pp. 2380-2388
    • Yang, H.C.1    Deleuze, S.2    Zuo, Y.3    Potthoff, S.A.4    Ma, L.J.5    Fogo, A.B.6
  • 128
    • 50849091263 scopus 로고    scopus 로고
    • Klotho is a target gene of PPAR-γ
    • Zhang H, Li Y, Fan Y, et al. Klotho is a target gene of PPAR-γ. Kidney Int. 2008;74(6):732–739.
    • (2008) Kidney Int , vol.74 , Issue.6 , pp. 732-739
    • Zhang, H.1    Li, Y.2    Fan, Y.3
  • 129
    • 50849105720 scopus 로고    scopus 로고
    • PPAR-γ and aging: One link through klotho?
    • Zhang R, Zheng F. PPAR-γ and aging: one link through klotho? Kidney Int. 2008;74(6):702–704.
    • (2008) Kidney Int , vol.74 , Issue.6 , pp. 702-704
    • Zhang, R.1    Zheng, F.2
  • 130
    • 84896120214 scopus 로고    scopus 로고
    • Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats
    • Chen LJ, Cheng MF, Ku PM, Lin JW. Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats. Biomed Res Int. 2014;2014:309151.
    • (2014) Biomed Res Int , vol.2014 , pp. 2014
    • Chen, L.J.1    Cheng, M.F.2    Ku, P.M.3    Lin, J.W.4
  • 131
    • 77953670159 scopus 로고    scopus 로고
    • Role of fosinopril and valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells
    • Zhou Q, Lin S, Tang R, Veeraragoo P, Peng W, Wu R. Role of fosinopril and valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells. Kidney Blood Press Res. 2010;33(3):186–192.
    • (2010) Kidney Blood Press Res , vol.33 , Issue.3 , pp. 186-192
    • Zhou, Q.1    Lin, S.2    Tang, R.3    Veeraragoo, P.4    Peng, W.5    Wu, R.6
  • 132
    • 79952167540 scopus 로고    scopus 로고
    • Angiotensin II blockade upregulates the expression of klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
    • Yoon HE, Ghee JY, Piao S, et al. Angiotensin II blockade upregulates the expression of klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant. 2011;26(3):800–813.
    • (2011) Nephrol Dial Transplant , vol.26 , Issue.3 , pp. 800-813
    • Yoon, H.E.1    Ghee, J.Y.2    Piao, S.3
  • 133
    • 84887302965 scopus 로고    scopus 로고
    • Effect of renin-angiotensin system blockade on soluble klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria
    • Karalliedde J, Maltese G, Hill B, Viberti G, Gnudi L. Effect of renin-angiotensin system blockade on soluble klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria. Clin J Am Soc Nephrol. 2013;8(11):1899–1905.
    • (2013) Clin J am Soc Nephrol , vol.8 , Issue.11 , pp. 1899-1905
    • Karalliedde, J.1    Maltese, G.2    Hill, B.3    Viberti, G.4    Gnudi, L.5
  • 134
    • 5444269240 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells
    • Narumiya H, Sasaki S, Kuwahara N, et al. HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. Cardiovasc Res. 2004;64(2):331–336.
    • (2004) Cardiovasc Res , vol.64 , Issue.2 , pp. 331-336
    • Narumiya, H.1    Sasaki, S.2    Kuwahara, N.3
  • 135
    • 84860778116 scopus 로고    scopus 로고
    • Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    • Lim K, Lu TS, Molostvov G, et al. Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012;125(18):2243–2255.
    • (2012) Circulation , vol.125 , Issue.18 , pp. 2243-2255
    • Lim, K.1    Lu, T.S.2    Molostvov, G.3
  • 136
    • 84870624437 scopus 로고    scopus 로고
    • Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet
    • Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82(12):1261–1270.
    • (2012) Kidney Int , vol.82 , Issue.12 , pp. 1261-1270
    • Lau, W.L.1    Leaf, E.M.2    Hu, M.C.3
  • 137
    • 80054945714 scopus 로고    scopus 로고
    • Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
    • Forster RE, Jurutka PW, Hsieh JC, et al. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem Biophys Res Commun. 2011;414(3):557–562.
    • (2011) Biochem Biophys Res Commun , vol.414 , Issue.3 , pp. 557-562
    • Forster, R.E.1    Jurutka, P.W.2    Hsieh, J.C.3
  • 138
    • 80052318645 scopus 로고    scopus 로고
    • Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
    • de Borst MH, Vervloet MG, ter Wee PM, Navis G. Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol. 2011;22(9):1603–1609.
    • (2011) J am Soc Nephrol , vol.22 , Issue.9 , pp. 1603-1609
    • De Borst, M.H.1    Vervloet, M.G.2    Ter Wee, P.M.3    Navis, G.4
  • 140
    • 84928476747 scopus 로고    scopus 로고
    • Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation
    • Oh HJ, Nam BY, Lee MJ, et al. Decreased circulating klotho levels in patients undergoing dialysis and relationship to oxidative stress and inflammation. Perit Dial Int. 2015;35(1):43–51.
    • (2015) Perit Dial Int , vol.35 , Issue.1 , pp. 43-51
    • Oh, H.J.1    Nam, B.Y.2    Lee, M.J.3
  • 141
    • 27844561111 scopus 로고    scopus 로고
    • Regulation of oxidative stress by the anti-aging hormone klotho
    • Yamamoto M, Clark JD, Pastor JV, et al. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem. 2005;280(45):38029–38034.
    • (2005) J Biol Chem , vol.280 , Issue.45 , pp. 38029-38034
    • Yamamoto, M.1    Clark, J.D.2    Pastor, J.V.3
  • 142
    • 40149102029 scopus 로고    scopus 로고
    • Klotho as a regulator of oxidative stress and senescence
    • Kuro-o M. Klotho as a regulator of oxidative stress and senescence. Biol Chem. 389(3):233–241.
    • Biol Chem , vol.389 , Issue.3 , pp. 233-241
    • Kuro-O, M.1
  • 143
    • 84899980351 scopus 로고    scopus 로고
    • Soluble α-klotho and its relation to kidney function and fibroblast growth factor-23
    • Scholze A, Liu Y, Pedersen L, et al. Soluble α-klotho and its relation to kidney function and fibroblast growth factor-23. J Clin Endocrinol Metab. 2014;99(5):E855–E861.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.5 , pp. E855-E861
    • Scholze, A.1    Liu, Y.2    Pedersen, L.3
  • 144
    • 84880702133 scopus 로고    scopus 로고
    • Soluble serum klotho levels in healthy subjects. Comparison of two different immunoassays
    • Pedersen L, Pedersen SM, Brasen CL, Rasmussen LM. Soluble serum klotho levels in healthy subjects. Comparison of two different immunoassays. Clin Biochem. 2013;46(12):1079–1083.
    • (2013) Clin Biochem , vol.46 , Issue.12 , pp. 1079-1083
    • Pedersen, L.1    Pedersen, S.M.2    Brasen, C.L.3    Rasmussen, L.M.4
  • 145
    • 77955272026 scopus 로고    scopus 로고
    • Establishment of sandwich ELISA for soluble α-klotho measurement: Age-dependent change of soluble α-klotho levels in healthy subjects
    • Yamazaki Y, Imura A, Urakawa I, et al. Establishment of sandwich ELISA for soluble α-klotho measurement: age-dependent change of soluble α-klotho levels in healthy subjects. Biochem Biophys Res Commun. 2010;398(3):513–518.
    • (2010) Biochem Biophys Res Commun , vol.398 , Issue.3 , pp. 513-518
    • Yamazaki, Y.1    Imura, A.2    Urakawa, I.3


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