Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

Nephrology Dialysis Transplantation

Volumn 24, Issue 5, 2009, Pages 1443-1454

  Chung, Arthur C K ^a   Huang, Xiao R ^a   Zhou, Li ^a   Heuchel, Rainer ^b   Lai, Kar Neng ^a   Lan, Hui Y ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Renal fibrosis; Renal inflammation; Smad7; TGF signalling; UUO

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPROTEGERIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE SEVERITY; EXON; EXTRACELLULAR MATRIX; GENE DISRUPTION; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MACROPHAGE; MALE; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; URETER OBSTRUCTION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; DISEASE MODELS, ANIMAL; EIF-2 KINASE; FIBROSIS; INFLAMMATION; KIDNEY; MICE; MICE, KNOCKOUT; NF-KAPPA B; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION;

EID: 65249099522     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn699     Document Type: Article

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