Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 8655-8665

  Doi, Shigehiro ^a   Zou, Yonglong ^a   Togao, Osamu ^b   Pastor, Johanne V ^a   John, George B ^a   Wang, Lei ^a   Shiizaki, Kazuhiro ^a   Gotschall, Russell ^c   Schiavi, Susan ^c   Yorioka, Noriaki ^d   Takahashi, Masaya ^b   Boothman, David A ^a   Kuro o, Makoto ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c GENZYME CORPORATION   (United States)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CYTOLOGY; DISEASES; MAMMALS; PATHOLOGY; PROTEINS; SIGNALING;

CELL SURFACE RECEPTORS; ECTODOMAIN SHEDDING; EPITHELIAL TO MESENCHYMAL TRANSITIONS; EXTRACELLULAR DOMAINS; PATHOLOGICAL PROCESS; TRANS-MEMBRANE PROTEINS; TRANSFORMING GROWTH FACTORS; UNILATERAL URETERAL OBSTRUCTIONS;

CELL SIGNALING;

KLOTHO PROTEIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; GENE REPLACEMENT THERAPY; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MALE; MESENCHYME CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; URETER OBSTRUCTION;

MUS;

EID: 79953138206     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.174037     Document Type: Article

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