메뉴 건너뛰기




Volumn 127, Issue 3, 2014, Pages 195-208

Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension

Author keywords

Hypertensive nephropathy; MiR 29; Nuclear factor B (NF B); Smad3; Smad7; Sp1

Indexed keywords

ANGIOTENSIN II; CREATININE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 29B; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE E3;

EID: 84898772136     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20130706     Document Type: Article
Times cited : (46)

References (36)
  • 1
    • 33748316445 scopus 로고    scopus 로고
    • The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease
    • Remuzzi, G., Perico, N., Macia, M. and Ruggenenti, P. (2005) The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease. Kidney Int. 68, S57-S65.
    • (2005) Kidney Int. , vol.68
    • Remuzzi, G.1    Perico, N.2    Macia, M.3    Ruggenenti, P.4
  • 2
    • 33750741932 scopus 로고    scopus 로고
    • Renin-angiotensin-aldosterone system and progression of renal disease
    • Ruster, C. and Wolf, G. (2006) Renin-angiotensin-aldosterone system and progression of renal disease. J. Am. Soc. Nephrol. 17, 2985-2991.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 2985-2991
    • Ruster, C.1    Wolf, G.2
  • 3
    • 78650521920 scopus 로고    scopus 로고
    • Epidemiology of hypertensive kidney disease
    • Udani, S., Lazich, I. and Bakris, G. L. (2011) Epidemiology of hypertensive kidney disease. Nat. Rev. Nephrol. 7, 11-21.
    • (2011) Nat. Rev. Nephrol. , vol.7 , pp. 11-21
    • Udani, S.1    Lazich, I.2    Bakris, G.L.3
  • 5
    • 33846362954 scopus 로고    scopus 로고
    • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
    • Mehta, P. K. and Griendling, K. K. (2007) Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am. J. Physiol. Cell Physiol. 292, C82-C97.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292
    • Mehta, P.K.1    Griendling, K.K.2
  • 6
    • 79960112806 scopus 로고    scopus 로고
    • Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis
    • Ruster, C. and Wolf, G. (2011) Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis. J. Am. Soc. Nephrol. 22, 1189-1199.
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1189-1199
    • Ruster, C.1    Wolf, G.2
  • 7
    • 18844387660 scopus 로고    scopus 로고
    • Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-β-independent mechanism
    • Rodriguez-Vita, J., Sanchez-Lopez, E., Esteban, V., Ruperez, M., Egido, J. and Ruiz-Ortega, M. (2005) Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-β-independent mechanism. Circulation 111, 2509-2517.
    • (2005) Circulation , vol.111 , pp. 2509-2517
    • Rodriguez-Vita, J.1    Sanchez-Lopez, E.2    Esteban, V.3    Ruperez, M.4    Egido, J.5    Ruiz-Ortega, M.6
  • 10
    • 70349659185 scopus 로고    scopus 로고
    • Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-β-dependent and -independent Smad pathways: the role of Smad3
    • Yang, F., Chung, A. C., Huang, X. R. and Lan, H. Y. (2009) Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-β-dependent and -independent Smad pathways: the role of Smad3. Hypertension 54, 877-884.
    • (2009) Hypertension , vol.54 , pp. 877-884
    • Yang, F.1    Chung, A.C.2    Huang, X.R.3    Lan, H.Y.4
  • 11
    • 77955489258 scopus 로고    scopus 로고
    • Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition
    • Yang, F., Huang, X. R., Chung, A. C., Hou, C. C., Lai, K. N. and Lan, H. Y. (2010) Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition. J. Pathol. 221, 390-401.
    • (2010) J. Pathol. , vol.221 , pp. 390-401
    • Yang, F.1    Huang, X.R.2    Chung, A.C.3    Hou, C.C.4    Lai, K.N.5    Lan, H.Y.6
  • 13
    • 77951499390 scopus 로고    scopus 로고
    • Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling
    • Huang, X. R., Chung, A. C., Yang, F., Yue, W., Deng, C., Lau, C. P., Tse, H. F. and Lan, H. Y. (2010) Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling. Hypertension 55, 1165-1171.
    • (2010) Hypertension , vol.55 , pp. 1165-1171
    • Huang, X.R.1    Chung, A.C.2    Yang, F.3    Yue, W.4    Deng, C.5    Lau, C.P.6    Tse, H.F.7    Lan, H.Y.8
  • 14
    • 84859754188 scopus 로고    scopus 로고
    • Smad3 mediates ANG II-induced hypertensive kidney disease in mice
    • Liu, Z., Huang, X. R. and Lan, H. Y. (2012) Smad3 mediates ANG II-induced hypertensive kidney disease in mice. Am. J. Physiol. Renal Physiol. 302, F986-F997.
    • (2012) Am. J. Physiol. Renal Physiol. , vol.302
    • Liu, Z.1    Huang, X.R.2    Lan, H.Y.3
  • 15
    • 42649120148 scopus 로고    scopus 로고
    • Smad7 as a therapeutic agent for chronic kidney diseases
    • Lan, H. Y. (2008) Smad7 as a therapeutic agent for chronic kidney diseases. Front. Biosci. 13, 4984-4992.
    • (2008) Front. Biosci. , vol.13 , pp. 4984-4992
    • Lan, H.Y.1
  • 16
    • 65249099522 scopus 로고    scopus 로고
    • Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
    • Chung, A. C., Huang, X. R., Zhou, L., Heuchel, R., Lai, K. N. and Lan, H. Y. (2009) Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol. Dial. Transplant. 24, 1443-1454.
    • (2009) Nephrol. Dial. Transplant. , vol.24 , pp. 1443-1454
    • Chung, A.C.1    Huang, X.R.2    Zhou, L.3    Heuchel, R.4    Lai, K.N.5    Lan, H.Y.6
  • 17
    • 79551599216 scopus 로고    scopus 로고
    • The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential
    • Chen, H. Y., Huang, X. R., Wang, W., Li, J. H., Heuchel, R. L., Chung, A. C. and Lan, H. Y. (2011) The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60, 590-601.
    • (2011) Diabetes , vol.60 , pp. 590-601
    • Chen, H.Y.1    Huang, X.R.2    Wang, W.3    Li, J.H.4    Heuchel, R.L.5    Chung, A.C.6    Lan, H.Y.7
  • 18
    • 84871901528 scopus 로고    scopus 로고
    • Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGFβ/Smad3-NF-κB-dependent mechanisms in mice
    • Liu, G. X., Li, Y. Q., Huang, X. R., Wei, L., Chen, H. Y., Shi, Y. J., Heuchel, R. L. and Lan, H. Y. (2013) Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGFβ/Smad3-NF-κB-dependent mechanisms in mice. PLoS ONE 8, e53573.
    • (2013) PLoS ONE , vol.8
    • Liu, G.X.1    Li, Y.Q.2    Huang, X.R.3    Wei, L.4    Chen, H.Y.5    Shi, Y.J.6    Heuchel, R.L.7    Lan, H.Y.8
  • 19
    • 0037498439 scopus 로고    scopus 로고
    • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    • Lan, H. Y., Mu, W., Tomita, N., Huang, X. R., Li, J. H., Zhu, H. J., Morishita, R. and Johnson, R. J. (2003) Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J. Am. Soc. Nephrol. 14, 1535-1548.
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 1535-1548
    • Lan, H.Y.1    Mu, W.2    Tomita, N.3    Huang, X.R.4    Li, J.H.5    Zhu, H.J.6    Morishita, R.7    Johnson, R.J.8
  • 20
    • 0028889864 scopus 로고
    • A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens
    • Lan, H. Y., Mu, W., Nikolic-Paterson, D. J. and Atkins, R. C. (1995) A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J. Histochem. Cytochem. 43, 97-102.
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 97-102
    • Lan, H.Y.1    Mu, W.2    Nikolic-Paterson, D.J.3    Atkins, R.C.4
  • 24
    • 0034671506 scopus 로고    scopus 로고
    • Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2(I)-collagen (COL1A2) transcription
    • Zhang, W., Ou, J., Inagaki, Y., Greenwel, P. and Ramirez, F. (2000) Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2(I)-collagen (COL1A2) transcription. J. Biol. Chem. 275, 39237-39245.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39237-39245
    • Zhang, W.1    Ou, J.2    Inagaki, Y.3    Greenwel, P.4    Ramirez, F.5
  • 25
    • 0034661835 scopus 로고    scopus 로고
    • Sp1-like activity mediates angiotensin-II-induced plasminogen-activator inhibitor type-1 (PAI-1) gene expression in mesangial cells
    • Motojima, M., Ando, T. and Yoshioka, T. (2000) Sp1-like activity mediates angiotensin-II-induced plasminogen-activator inhibitor type-1 (PAI-1) gene expression in mesangial cells. Biochem. J. 349, 435-441.
    • (2000) Biochem. J. , vol.349 , pp. 435-441
    • Motojima, M.1    Ando, T.2    Yoshioka, T.3
  • 26
    • 0035831503 scopus 로고    scopus 로고
    • Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2(I)-collagen expression in human glomerular mesangial cells
    • Poncelet, A. C. and Schnaper, H. W. (2001) Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2(I)-collagen expression in human glomerular mesangial cells. J. Biol. Chem. 276, 6983-6992.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6983-6992
    • Poncelet, A.C.1    Schnaper, H.W.2
  • 28
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation
    • Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H. and Wrana, J. L. (2000) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFβ receptor for degradation. Mol. Cell 6, 1365-1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 29
    • 45149101298 scopus 로고    scopus 로고
    • Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication
    • Tan, R., He, W., Lin, X., Kiss, L. P. and Liu, Y. (2008) Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication. Am. J. Physiol. Renal Physiol. 294, F1076-F1083.
    • (2008) Am. J. Physiol. Renal Physiol. , vol.294
    • Tan, R.1    He, W.2    Lin, X.3    Kiss, L.P.4    Liu, Y.5
  • 32
    • 15944368868 scopus 로고    scopus 로고
    • Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney
    • Ng, Y. Y., Hou, C. C., Wang, W., Huang, X. R. and Lan, H. Y. (2005) Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int. 67, S83-S91.
    • (2005) Kidney Int. , vol.67
    • Ng, Y.Y.1    Hou, C.C.2    Wang, W.3    Huang, X.R.4    Lan, H.Y.5
  • 33
    • 34249895264 scopus 로고    scopus 로고
    • Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice
    • Ka, S. M., Huang, X. R., Lan, H. Y., Tsai, P. Y., Yang, S. M., Shui, H. A. and Chen, A. (2007) Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice. J. Am. Soc. Nephrol. 18, 1777-1788.
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1777-1788
    • Ka, S.M.1    Huang, X.R.2    Lan, H.Y.3    Tsai, P.Y.4    Yang, S.M.5    Shui, H.A.6    Chen, A.7
  • 35
    • 84873406358 scopus 로고    scopus 로고
    • Smad7 suppresses renal fibrosis via altering expression of TGFβ/Smad3-regulated microRNAs
    • Chung, A. C., Dong, Y., Yang, W., Zhong, X., Li, R. and Lan, H. Y. (2013) Smad7 suppresses renal fibrosis via altering expression of TGFβ/Smad3-regulated microRNAs. Mol. Ther. 21, 388-398.
    • (2013) Mol. Ther. , vol.21 , pp. 388-398
    • Chung, A.C.1    Dong, Y.2    Yang, W.3    Zhong, X.4    Li, R.5    Lan, H.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.