Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

Journal of the American Society of Nephrology

Volumn 14, Issue 6, 2003, Pages 1535-1548

  Lan, Hui Y ^a   Mu, Wei ^a   Tomita, Naruya ^b   Huang, Xiao R ^a   Li, Jin H ^a   Zhu, Hong Jian ^c   Morishita, Ryuichi ^b   Johnson, Richard J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SAFETY; SIGNAL TRANSDUCTION; ULTRASOUND; ULTRASOUND MICROBUBBLE SYSTEM; WESTERN BLOTTING;

EID: 0037498439     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000067632.04658.B8     Document Type: Article

References (52)

1. Eddy AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 7: 2495-2508, 1996
2. Border WA, Noble NA: Mechanisms of disease: Transforming growth factor (β) in tissue fibrosis. N Eng J Med 331: 1286-1292, 1994
3. Border WA, Noble NA: TGF-β in kidney fibrosis: A target for gene therapy. Kidney Int 51: 1388-1396, 1997
4. Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney. J Clin Invest 92: 2597-2601, 1993
5. Creely JJ, Dimari SJ, Howe AM, Haralson MA: Effects of transforming growth factor-β on collagen synthesis by normal rat kidney epithelial cells. Am J Pathol 140: 45-55, 1992
6. Fan JM, Ng YY, Hill P, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: TGF-β regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 56: 1455-1467, 1999
7. Jinde K, Nikolic-Paterson DJ, Huang XR, Sakai H, Kurokawa K, Atkins RC, Lan HY: Tubular phenotypic changes in tubulointerstitial fibrosis in human glomerulonephritis. Am J Kid Dis 38: 761-769, 2001
8. Kretzschmar M, Massague J: Smads: Mediators and regulators of TGF-β signaling. Curr Opin Genet Dev 8: 103-111, 1998
9. Massague J, Chen YG: Controlling TGF-β signaling. Genes Dev 14: 627-644, 2000
10. Miyazono K: Positive and negative regulation of TGF-β signaling. J Cell Sci 113: 1101-1109, 2000
11. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol Cell 6: 1365-1375, 2000
12. Poncelet AC, de Caestecker MP, Schnaper HW: The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int 56: 1354-1365, 1999
13. Poncelet AC, Schnaper HW: Sp1 and Smad Proteins Cooperate to Mediate transforming growth factor-β 1-induced α 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 276: 6983-6992, 2001
14. Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten Dijke P, Mundel P, Bottinger EP: Apoptosis in podocytes induced by TGF-β and Smad7. J Clin Invest 108: 807-816, 2001
15. Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, Iwamoto I: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 104: 5-11, 1999
16. Terada Y, Hanada S, Nakao A, Kuwahara M, Sasaki S, Marumo F: Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int 61[Suppl 1]: S94-S98, 2002
17. Hill-Kapturczak N, Truong L, Thamilselvan V, Visner GA, Nick HS, Agarwal A: Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-β in human renal epithelial cells. J Biol Chem 275: 40904-40909, 2000
18. Chen R, Huang C, Morinelli TA, Trojanowska M, Paul RV: Blockade of the effects of TGF-β1 on mesangial cells by overexpression of Smad7. J Am Soc Nephrol 13: 887-893, 2002
19. Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY: Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13: 1464-1472, 2002
20. Zhu HJ, Iaria J, Sizeland AM: Smad7 differentially regulates transforming growth factor β-mediated signaling pathways. J Biol Chem 274: 32258-32264, 1999
21. Watsuji T, Okamoto Y, Emi N, Katsuoka Y, Hagiwara M: Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system. Biochem Biophys Res Commun 234: 769-773, 1997
22. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC: A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 43: 97-102, 1995
23. 2+ dependent protein phosphatase β. Biochem Biophys Res Commun 207: 708-714, 1995
24. Imai E, Isaka Y: Strategies of gene transfer to the kidney. Kidney Int 53: 264-272, 1998
25. Fine LG: Gene transfer into the kidney: Promise for unravelling disease mechanisms, limitations for human gene therapy [Editorial]. Kidney Int 49: 612-619, 1996
26. Tomita N, Morishita R, Lan HY, Yamamoto K, Hashizume M, Notake M, Toyosawa K, Fujitani B, Mu W, Nikolic-Paterson DJ, Atkins RC, Kaneda Y, Higaki J, Ogihara T: In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis. J Am Soc Nephrol 11: 1244-1252, 2000
27. Lai L-W, Moeckel GW, Lien Y-HH: Kidney targeted liposome- mediated gene transfer in mice. Gene Ther 4: 426-431, 1997
28. Tsujie M, Isaka Y, Nakamura H, Akagi Y, Kaneda Y, Ueda N, Imai E, Hori M: Prolonged transgene expression in glomeruli using an EB virus replicon vector system combined with AVE type HVJ liposomes. Kidney Int 59: 1390-1396, 2001
29. Tsujie M, Isaka Y, Nakamura H, Imai E, Hori M: Electroporation-mediated gene transfer that targets glomeruli. J Am Soc Nephrol 12: 949-954, 2002
30. Maruyama H, Higuchi N, Nishikawa Y, Hirahara H, Iino N, Kameda S, Kawachi H, Yaoita E, Gejyo F, Miyazaki J: Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats. Hum Gene Ther 13: 455-468, 2002
31. Newman CM, Lawrie A, Brisken AF, Cumberland DC: Ultrasound gene therapy: On the road from concept to reality. Echocardiography 18: 339-347, 2001
32. Blomley MJK, Cooke JC, Unger EC, Monaghan MJ, Cosgrove DO: Science, medicine, and the future: Microbubble contrast agents: a new era in ultrasound. BMJ 322: 1222-1225, 2001
33. Harvey CJ, Blomley MJ, Eckersley RJ, Cosgrove DO: Developments in ultrasound contrast media. Eur Radiol 11: 675-689, 2001
34. Lawrie A, Brisken AF, Francis SE, Tayler DI, Chamberlain J, Crossman DC, Cumberland DC, Newman CM: Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro. Circulation 99: 2617-2620, 1999
35. Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC, Newman CM: Microbubble-enhanced ultrasound for vascular gene delivery. Gene Ther 7: 2023-2027, 2000
36. Unger EC, Hersh E, Vannan M, McCreery T: Gene delivery using ultrasound contrast agents. Echocardiography 18: 355-361, 2001
37. Huber S: Doppler ultrasound in the diagnosis of breast lesions. Anticancer Res 18: 2147-2150, 1998
38. Manome Y, Nakamura M, Ohno T, Furuhata H: Ultrasound facilitates transduction of naked plasmid DNA into colon carcinoma cells in vitro and in vivo. Hum Gene Ther 11: 1521-1528, 2000
39. Miller MW: Gene transfection and drug delivery. Ultrasound Med Biol 26 Suppl 1: S59-S62, 2000
40. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, Aoki M, Ogihara T, Yasufumi K, Morishita R: Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 105: 1233-1239, 2002
41. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R: Development of safe and efficient novel nonviral gene transfer using ultrasound: Enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 9: 372-380, 2002
42. Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, Grayburn PA: Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 101: 2554-2556, 2000
43. Akagi Y, Isaka Y, Arai M, Kaneko T, Takenaka M, Moriyama T, Kaneda Y, Ando A, Orita Y, Kamada T, Ueda N, Imai E: Inhibition of TGF-β 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 50: 148-155, 1996
44. Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 2: 418-423, 1996
45. Coroneos E, Assouad M, Krishnan B, Truong LD: Urinary obstruction causes irreversible renal failure by inducing chronic tubulointerstitial nephritis. Clin Nephrol 48: 125-128, 1997
46. Isono M, Chen S, Won Hong S, Iglesias-de la Cruz MC, Ziyadeh FN: Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296: 1356-1365, 2002
47. Hong SW, Isono M, Chen S, Iglesias-De La Cruz MC, Han DC, Ziyadeh FN: Increased glomerular and tubular expression of transforming growth factor-β1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158: 1653-1663, 2001
48. Schiffer M, Schiffer LE, Gupta A, Shaw AS, Roberts IS, Mundel P, Bottinger EP: Inhibitory smads and tgf-β signaling in glomerular cells. J Am Soc Nephrol 13: 2657-2666, 2002
49. Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S: Smad7 mediates transforming growth factor-β-induced apoptosis in mesangial cells. Kidney Int 62: 1178-1186, 2002
50. Lallemand F, Mazars A, Prunier C, Bertrand F, Kornprost M, Gallea S, Roman-Roman S, Cherqui G, Atfi A: Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells. Oncogene 20: 879-884, 2002
51. Nagarajan RP, Chen F, Li W, Vig E, Harrington MA, Nakshatri H, Chen Y: Repression of transforming-growth-factor-β-mediated transcription by nuclear factor κB. Biochem J 348: 591-596, 2000
52. Mazars A, Lallemand F, Prunier C, Marais J, Ferrand N, Pessah M, Cherqui G, Atfi A: Evidence for a role of the JNK cascade in Smad7-mediated apoptosis. J Biol Chem 276: 36797-36803, 2002