Signaling mechanism of TGF-β1 in prevention of renal inflammation: Role of Smad7

Journal of the American Society of Nephrology

Volumn 16, Issue 5, 2005, Pages 1371-1383

  Wang, Wansheng ^a   Huang, Xiao R ^a   Li, Allen G ^b   Liu, Fang ^a   Li, Jin Hua ^a   Truong, Luan D ^a,c   Wang, Xiao J ^b   Lan, Hui Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; DNA BINDING PROTEIN; INTERLEUKIN 1; SMAD7 PROTEIN, HUMAN; SMAD7 PROTEIN, MOUSE; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY TUBULE CELL; MACROPHAGE; MOUSE; NEPHRITIS; NONHUMAN; OBSTRUCTIVE NEPHROPATHY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; BLOOD; DISEASE MODEL; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; KIDNEY; LEUKOCYTE; METABOLISM; PHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; KIDNEY; KIDNEY DISEASES; LEUKOCYTES; MICE; MICE, TRANSGENIC; NF-KAPPA B; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 23944486004     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2004121070     Document Type: Article

References (47)

1. Letterio JJ, Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol 16: 137-161, 1998
2. Border WA, Noble NA: TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int 51: 1388-1396, 1997
3. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson N, Bottinger EP, Klotman PE, Thorgeirsson SS: Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 74: 991-1003, 1996
4. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci U S A 97: 8015-8020, 2000
5. Ma LJ, Jha S, Ling H, Pozzi A, Ledbetter S, Fogo AB: Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int 65: 106-115, 2004
6. Roberts AB: Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 24: 111-119, 1998
7. Yaswen L, Kulkarni AB, Fredrickson T, Mittleman B, Schiffman R, Payne S, Longenecker G, Mozes E, Karlsson S: Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood 87: 1439-1445, 1996
8. Chen W, Jin W, Cook M, Weiner HL, Wahl SM: Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J Immunol 161: 6297-6304, 1998
9. Jin YX, Xu LY, Guo H, Ishikawa M, Link H, Xiao BG: TGF-β1 inhibits protracted-relapsing experimental autoimmune encephalomyelitis by activating dendritic cells. J Autoimmun 14: 213-220, 2000
10. Piccirillo CA, Chang Y, Prud'homme GJ: TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol 161: 3950-3956, 1998
11. Raz E, Dudler J, Lotz M, Baird SM, Berry CC, Eisenberg RA, Carson DA: Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 4: 286-292, 1995
12. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MB, Thorgeirsson SS: Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A 92: 2572-2576, 1995
13. He W, Li AG, Wang D, Han S, Zheng B, Goumans MJ, Ten Dijke P, Wang XJ: Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues. EMBO J 21: 2580-2590, 2002
14. Li AG, Wang D, Feng XH, Wang XJ: Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 23: 1770-1781, 2004
15. Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ: Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003
16. Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY: Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13: 1464-1472, 2002
17. Wang W, Tzanidis A, Divjak M, Thomson NM, Stein-Oakley AN: Altered signaling and regulatory mechanisms of apoptosis in focal and segmental glomerulosclerosis. J Am Soc Nephrol 12: 1422-1433, 2001
18. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB: Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunol 163: 6800-6809, 1999
19. Timchenko NA, Wilde M, Iakova P, Albrecht JH, Darlington GJ: E2F/p107 and E2F/p130 complexes are regulated by C/EBPα in 3T3-L1 adipocytes. Nucleic Acids Res 27: 3621-3630, 1999
20. Lan HY, Bacher M, Yang N, Mu W, Nikolic-Paterson DJ, Metz C, Meinhardt A, Bucala R, Atkins RC: The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat. J Exp Med 185: 1455-1465, 1997
21. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC: A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 43: 97-102, 1995
22. Timoshanko JR, Kitching AR, Iwakura Y, Holdsworth SR, Tipping PG: Leukocyte-derived interleukin-1β interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol 164: 1967-1977, 2004
23. Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H: Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes 52: 2586-2593, 2003
24. Barnes PJ, Karin M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071, 1997
25. Lallemand F, Mazars A, Prunier C, Bertrand F, Kornprost M, Gallea S, Roman-Roman S, Cherqui G, Atfi A: Smad7 inhibits the survival nuclear factor kappaB and potentiates apoptosis in epithelial cells. Oncogene 20: 879-884, 2001
26. Zhao J, Shi W, Chen H, Warburton D: Smad7 and Smad6 differentially modulate transforming growth factor beta-induced inhibition of embryonic lung morphogenesis. J Biol Chem 275: 23992-23997, 2000
27. Afrakhte M, Moren A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin CH, Heldin NE, ten Dijke P: Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. Biochem Biophys Res Commun 249: 505-511, 1998
28. Lyons RM, Gentry LE, Purchio AF, Moses HL: Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol 110: 1361-1367, 1990
29. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D: The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 96: 319-328, 1999
30. Werner F, Jain MK, Feinberg MW, Sibinga NE, Pellacani A, Wiesel P, Chin MT, Topper JN, Perrella MA, Lee ME: Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem 275: 36653-36658, 2000
31. Cottrez F, Groux H: Regulation of TGF-beta response during T cell activation is modulated by IL-10. J Immunol 167: 773-778, 2001
32. Chernajovsky Y, Adams G, Triantaphyllopoulos K, Ledda MF, Podhajcer OL: Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model. Gene Ther 4: 553-559, 1997
33. Cautain B, Damoiseaux J, Bernard I, van Straaten H, van Breda Vriesman P, Boneu B, Druet P, Saoudi A: Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. Eur J Immunol 31: 1132-1140, 2001
34. Fuss IJ, Boirivant M, Lacy B, Strober W: The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J Immunol 168: 900-908, 2002
35. Hansen G, McIntire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, DeKruyff RH, Umetsu DT: CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest 105: 61-70, 2000
36. Thorbecke GJ, Umetsu DT, deKruyff RH, Hansen G, Chen LZ, Hochwald GM: When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes. Cytokine Growth Factor Rev 11: 89-96, 2000
37. Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL: CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RB high-induced colitis by a TGF-beta-dependent mechanism. J Immunol 170: 2516-2522, 2003
38. Kanamaru Y, Nakao A, Mamura M, Suzuki Y, Shirato I, Okumura K, Tomino Y, Ra C: Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol 166: 2818-2823, 2001
39. Ng YY, Hou CC, Wang W, Huang XR, Lan HY: Blockade of NF-kappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int Suppl 94: S83-S91, 2005
40. Guijarro C, Egido J: Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 59: 415-424, 2001
41. Lee FT, Cao Z, Long DM, Panagiotopoulos S, Jerums G, Cooper ME, Forbes JM: Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. J Am Soc Nephrol 15: 2139-2151, 2004
42. Nagarajan RP, Chen F, Li W, Vig E, Harrington MA, Nakshatri H, Chen Y: Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. Biochem J 348: 591-596, 2000
43. Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten Dijke P, Mundel P, Bottinger EP: Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 108: 807-816, 2001
44. Azuma M, Motegi K, Aota K, Yamashita T, Yoshida H, Sato M: TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells: A possible mechanism of growth suppression by TGF-beta1. Exp Cell Res 250: 213-222, 1999
45. Miller DM, Ogawa Y, Iwata KK, ten Dijke P, Purchio AF, Soloff MS, Gentry LE: Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide. Mol Endocrinol 6: 694-702, 1992
46. Bottinger EP, Factor VM, Tsang ML, Weatherbee JA, Kopp JB, Qian SW, Wakefield LM, Roberts AB, Thorgeirsson SS, Sporn MB: The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice. Proc Natl Acad Sci U S A 93: 5877-5882, 1996
47. Zhang Y, McCormick LL, Gilliam AC: Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol 121: 713-719, 2003