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Volumn 227, Issue 2, 2012, Pages 175-188

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

Author keywords

renal fibrosis; renal inflammation; Smad; TGF receptor II

Indexed keywords

COLLAGEN TYPE 1; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 84862785580     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3976     Document Type: Article
Times cited : (137)

References (39)
  • 1
    • 0036786834 scopus 로고    scopus 로고
    • TGF-beta signaling in renal disease
    • Bottinger EP, Bitzer M,. TGF-beta signaling in renal disease. J Am Soc Nephrol 2002; 13: 2600-2610.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2600-2610
    • Bottinger, E.P.1    Bitzer, M.2
  • 2
    • 0036203790 scopus 로고    scopus 로고
    • It's a Smad world: Regulation of TGF-beta signaling in the kidney
    • Schnaper HW, Hayashida T, Poncelet AC,. It's a Smad world: regulation of TGF-beta signaling in the kidney. J Am Soc Nephrol 2002; 13: 1126-1128.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1126-1128
    • Schnaper, H.W.1    Hayashida, T.2    Poncelet, A.C.3
  • 3
    • 14844337071 scopus 로고    scopus 로고
    • Transforming growth factor-beta and Smad signalling in kidney diseases
    • Wang W, Koka V, Lan HY,. Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) 2005; 10: 48-56.
    • (2005) Nephrology (Carlton) , vol.10 , pp. 48-56
    • Wang, W.1    Koka, V.2    Lan, H.Y.3
  • 4
    • 0029953788 scopus 로고    scopus 로고
    • Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease
    • Kopp JB, Factor VM, Mozes M, et al., Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 1996; 74: 991-1003.
    • (1996) Lab Invest , vol.74 , pp. 991-1003
    • Kopp, J.B.1    Factor, V.M.2    Mozes, M.3
  • 5
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB,. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998; 16: 137-161.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 6
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, Huh CG, Becker D, et al., Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 1993; 90: 770-774.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3
  • 7
    • 49949092931 scopus 로고    scopus 로고
    • Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease
    • Huang XR, Chung AC, Wang XJ, et al., Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease. Am J Physiol Renal Physiol 2008; 295: F118-F127.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Huang, X.R.1    Chung, A.C.2    Wang, X.J.3
  • 8
    • 23944486004 scopus 로고    scopus 로고
    • Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7
    • Wang W, Huang XR, Li AG, et al., Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol 2005; 16: 1371-1383.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1371-1383
    • Wang, W.1    Huang, X.R.2    Li, A.G.3
  • 9
    • 39049125285 scopus 로고    scopus 로고
    • Latent TGF-beta1 protects against crescentic glomerulonephritis
    • Huang XR, Chung AC, Zhou L, et al., Latent TGF-beta1 protects against crescentic glomerulonephritis. J Am Soc Nephrol 2008; 19: 233-242.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 233-242
    • Huang, X.R.1    Chung, A.C.2    Zhou, L.3
  • 10
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE,. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003; 425: 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 11
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J, Wotton D,. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 2000; 19: 1745-1754.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 12
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M, Muragaki Y, Saika S, et al., Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 112: 1486-1494.
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3
  • 13
    • 77956548300 scopus 로고    scopus 로고
    • Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
    • Meng XM, Huang XR, Chung AC, et al., Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol 2010; 21: 1477-1487.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1477-1487
    • Meng, X.M.1    Huang, X.R.2    Chung, A.C.3
  • 14
    • 65249099522 scopus 로고    scopus 로고
    • Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
    • Chung AC, Huang XR, Zhou L, et al., Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 2009; 24: 1443-1454.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1443-1454
    • Chung, A.C.1    Huang, X.R.2    Zhou, L.3
  • 15
    • 3242797424 scopus 로고    scopus 로고
    • Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
    • Inazaki K, Kanamaru Y, Kojima Y, et al., Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 2004; 66: 597-604.
    • (2004) Kidney Int , vol.66 , pp. 597-604
    • Inazaki, K.1    Kanamaru, Y.2    Kojima, Y.3
  • 16
    • 77951499390 scopus 로고    scopus 로고
    • Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling
    • Huang XR, Chung AC, Yang F, et al., Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling. Hypertension 2010; 55: 1165-1171.
    • (2010) Hypertension , vol.55 , pp. 1165-1171
    • Huang, X.R.1    Chung, A.C.2    Yang, F.3
  • 17
    • 14644431025 scopus 로고    scopus 로고
    • Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney
    • Hou CC, Wang W, Huang XR, et al., Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol 2005; 166: 761-771.
    • (2005) Am J Pathol , vol.166 , pp. 761-771
    • Hou, C.C.1    Wang, W.2    Huang, X.R.3
  • 18
    • 0037498439 scopus 로고    scopus 로고
    • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    • Lan HY, Mu W, Tomita N, et al., Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 2003; 14: 1535-1548.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1535-1548
    • Lan, H.Y.1    Mu, W.2    Tomita, N.3
  • 19
    • 15944368868 scopus 로고    scopus 로고
    • Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney
    • Ng YY, Hou CC, Wang W, et al., Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int Suppl 2005; S83-S91.
    • (2005) Kidney Int Suppl
    • Ng, Y.Y.1    Hou, C.C.2    Wang, W.3
  • 20
    • 34249895264 scopus 로고    scopus 로고
    • Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice
    • Ka SM, Huang XR, Lan HY, et al., Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice. J Am Soc Nephrol 2007; 18: 1777-1788.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1777-1788
    • Ka, S.M.1    Huang, X.R.2    Lan, H.Y.3
  • 21
    • 79551599216 scopus 로고    scopus 로고
    • The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential
    • Chen HY, Huang XR, Wang W, et al., The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 2011; 60: 590-601.
    • (2011) Diabetes , vol.60 , pp. 590-601
    • Chen, H.Y.1    Huang, X.R.2    Wang, W.3
  • 22
    • 0030579203 scopus 로고    scopus 로고
    • TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima M, Oshima H, Taketo MM,. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol 1996; 179: 297-302.
    • (1996) Dev Biol , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 23
    • 0036291255 scopus 로고    scopus 로고
    • Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract
    • Shao X, Somlo S, Igarashi P,. Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol 2002; 13: 1837-1846.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1837-1846
    • Shao, X.1    Somlo, S.2    Igarashi, P.3
  • 24
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • Leveen P, Larsson J, Ehinger M, et al., Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood 2002; 100: 560-568.
    • (2002) Blood , vol.100 , pp. 560-568
    • Leveen, P.1    Larsson, J.2    Ehinger, M.3
  • 25
    • 33750693942 scopus 로고    scopus 로고
    • Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
    • Fu P, Liu F, Su S, et al., Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol 2006; 17: 3105-3114.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3105-3114
    • Fu, P.1    Liu, F.2    Su, S.3
  • 26
    • 33646794060 scopus 로고    scopus 로고
    • Essential role of Smad3 in angiotensin II-induced vascular fibrosis
    • Wang W, Huang XR, Canlas E, et al., Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 2006; 98: 1032-1039.
    • (2006) Circ Res , vol.98 , pp. 1032-1039
    • Wang, W.1    Huang, X.R.2    Canlas, E.3
  • 27
    • 77949395650 scopus 로고    scopus 로고
    • Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling
    • Chung AC, Zhang H, Kong YZ, et al., Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. J Am Soc Nephrol 2010; 21: 249-260.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 249-260
    • Chung, A.C.1    Zhang, H.2    Kong, Y.Z.3
  • 28
    • 0028889864 scopus 로고
    • A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens
    • Lan HY, Mu W, Nikolic-Paterson DJ, et al., A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 1995; 43: 97-102.
    • (1995) J Histochem Cytochem , vol.43 , pp. 97-102
    • Lan, H.Y.1    Mu, W.2    Nikolic-Paterson, D.J.3
  • 29
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S, Itoh S, Vivien D, et al., Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 1998; 17: 3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3
  • 30
    • 79959993387 scopus 로고    scopus 로고
    • Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis
    • Medina C, Santos-Martinez MJ, Santana A, et al., Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis. J Pathol 2011; 224: 461-472.
    • (2011) J Pathol , vol.224 , pp. 461-472
    • Medina, C.1    Santos-Martinez, M.J.2    Santana, A.3
  • 31
    • 78650925648 scopus 로고    scopus 로고
    • Epithelium-specific deletion of TGF-beta receptor type II protects mice from bleomycin-induced pulmonary fibrosis
    • Li M, Krishnaveni MS, Li C, et al., Epithelium-specific deletion of TGF-beta receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest 2011; 121: 277-287.
    • (2011) J Clin Invest , vol.121 , pp. 277-287
    • Li, M.1    Krishnaveni, M.S.2    Li, C.3
  • 32
    • 70350512321 scopus 로고    scopus 로고
    • Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction
    • Anumanthan G, Tanaka ST, Adams CM, et al., Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol 2009; 182: 1775-1780.
    • (2009) J Urol , vol.182 , pp. 1775-1780
    • Anumanthan, G.1    Tanaka, S.T.2    Adams, C.M.3
  • 33
    • 0042090396 scopus 로고    scopus 로고
    • Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice
    • Denton CP, Zheng B, Evans LA, et al., Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem 2003; 278: 25109-25119.
    • (2003) J Biol Chem , vol.278 , pp. 25109-25119
    • Denton, C.P.1    Zheng, B.2    Evans, L.A.3
  • 34
    • 34247478597 scopus 로고    scopus 로고
    • TGF-beta type II receptor deficiency prevents renal injury via decrease in ERK activity in crescentic glomerulonephritis
    • Song CY, Kim BC, Hong HK, et al., TGF-beta type II receptor deficiency prevents renal injury via decrease in ERK activity in crescentic glomerulonephritis. Kidney Int 2007; 71: 882-888.
    • (2007) Kidney Int , vol.71 , pp. 882-888
    • Song, C.Y.1    Kim, B.C.2    Hong, H.K.3
  • 35
    • 77955602214 scopus 로고    scopus 로고
    • TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis
    • Gewin L, Bulus N, Mernaugh G, et al., TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol 2010; 21: 1334-1343.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1334-1343
    • Gewin, L.1    Bulus, N.2    Mernaugh, G.3
  • 36
    • 20844454775 scopus 로고    scopus 로고
    • Activation of ERK in renal fibrosis after unilateral ureteral obstruction: Modulation by antioxidants
    • Pat B, Yang T, Kong C, et al., Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. Kidney Int 2005; 67: 931-943.
    • (2005) Kidney Int , vol.67 , pp. 931-943
    • Pat, B.1    Yang, T.2    Kong, C.3
  • 37
    • 78349289577 scopus 로고    scopus 로고
    • A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren
    • Wu WP, Chang CH, Chiu YT, et al., A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. Am J Physiol Renal Physiol 2010; 299: F929-F941.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Wu, W.P.1    Chang, C.H.2    Chiu, Y.T.3
  • 38
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li MO, Sanjabi S, Flavell RA,. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006; 25: 455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 39
    • 67650538040 scopus 로고    scopus 로고
    • Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells
    • Zhang F, Tsai S, Kato K, et al., Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem 2009; 284: 17564-17574.
    • (2009) J Biol Chem , vol.284 , pp. 17564-17574
    • Zhang, F.1    Tsai, S.2    Kato, K.3


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