Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy

Kidney International

Volumn 63, Issue 6, 2003, Pages 2037-2049

  Wang, Song ^a   Chen, Qing ^a   Simon, Theodore C ^a   Strebeck, Frank ^a   Chaudhary, Lala ^a   Morrissey, Jeremiah ^a   Liapis, Helen ^a   Klahr, Saulo ^a   Hruska, Keith A ^a  

^a NONE

Author keywords

BMP 7; Chronic kidney disease; Diabetic nephropathy

Indexed keywords

ALBUMIN; ENALAPRIL; INSULIN; OSTEOGENIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFICACY; FEMALE; GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS FILTRATION RATE; HYPERTROPHY; KIDNEY MASS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; URINARY EXCRETION;

EID: 0037648482     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00035.x     Document Type: Article

References (36)

1. HRUSKA KA, Guo G, WOZNIAK M, et al: Osteogenic protein-1 (OP-1) prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol 279:F130-F143, 2000
2. GROBSTEIN C: Morphogenetic interactions between embryonic mouse tissues separated by a membrane filter. Nature 172:869-871, 1953
3. SAXEN L: Organogenesis of the Kidney, Cambridge, UK, Cambridge University Press, 1987
4. LUO G, HOFMANN C, BRONCKERS AL, et al: BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9:2808-2820, 1995
5. DUDLEY AT, LYONS KM, ROBERTSON EJ: A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9:2795-2807, 1995
6. VUKICEVIC S, KOPP JB, LUYTEN FP, el al: Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci USA 93:9021-9026, 1996
7. KISPERT A, VAINIO S, MCMAHON AP: Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 125:4225-4234, 1998
8. DORAI H, VUKICEVIC S, SAMPATH TK: Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol 184:37-45, 2000
9. SIMON M, MARESH JG, HARRIS SE, et al: Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. Am J Physiol 276:F382-F389, 1999
10. WANG S-N, LAPAGE J, HIRSCHBERG R: Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. J Am Soc Nephrol 12:2392-2399, 2001
11. VUKICEVIC S, BASIC V, ROGIC D, et al: Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest 102:202-214, 1998
12. LAL MA, KÖRNER A, MATSUO Y, et al: Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats. Diabetes 49:1381-1389, 2000
13. ISHIDOYA S, MORRISSEY J, MCCRACKEN R, et al: Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral ligation. Kidney Int 47:1285-1294, 1995
14. SURENDRAN K, MCCAUL SP, SIMON TC: A role for Wnt-4 in renal fibrosis. Am J Physiol Renal Physiol 282:F431-F441, 2002
15. SASSY-PRIGENT C, HEUDES D, JOUQUEY S, et al: Morphometric detection of incipient glomerular lesions in diabetic nephropathy in rats. Lab Invest 73:64-71, 1995
16. REMUZZI A, PERICO N, AMUCHASTEGUI CS, et al: Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J Am Soc Nephrol 4:40-49, 1993
17. ZATZ R, DUNN BR, MEYER TW, et al: Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 77:1925-1930, 1986
18. ANDERSON S, RENNKE HG, GARCIA DL, et al: Short and long-term effects of antihypertensive therapy in the diabetic rat. Kidney Int 36:526-536, 1989
19. KATOH M, OHMACHI Y, KUROSAWA Y, et al: Effects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice. Eur J Pharmacol 398:381-387, 2000
20. LEWIS EJ, HUNSICKER LG, BAIN RP, et al: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 329:1456-1462, 1993
21. GOULD SE, DAY M, JONES S, et al: BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. Kidney Int 61:51-60, 2002
22. SHARMA K, YULIN J, GUO J, et al: Neutralization of TGF-B by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in streptozotocin-diabetic mice. Diabetes 45:522-530, 1996
23. WILSON GL, LETTER EH: Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes. Curr Top Microbiol Immunol 156:27-54, 1990
24. YAMAMOTO T, NAKAMURA T, NOBLE NA, et al: Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90:1814-1818, 1993
25. NAKAMURA T, FUKUI M, EBIHARA I, et al: mRNA expression of growth factors in glomeruli from diabetic rats. Diabetes 42:450-456, 1993
26. SHANKLAND SJ, SCHOLEY JW: Expression of transforming growth factor B1 during diabetic renal hypertrophy. Kidney Int 46:430-442, 1994
27. MATHIESEN ER, HOMMEL E, GIESE J, et al: Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. Br Med J 303:81-87, 1991
28. WIEGMANN TB, HERRON KG, CHONKO AM, et al: Effect of angiotensin-converting enzyme inhibition on renal function and albuminuria in normotensive type I diabetic patients. Diabetes 41:62-67, 1992
29. DAVIES MR, LUND RJ, HRUSKA KA: BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol, in press
30. MORRISSEY J, HRUSKA K, GUO G, et al: Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13:814-821, 2002
31. LYONS KM, HOGAN BL, ROBERTSON EJ: Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech Dev 50:71-83, 1995
32. STARK K, VAINIO S, VASSILEVA G, et al: Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372:679-683, 1994
33. HILL-KAPTURCZAK N, TRUONG L, THAMILSELVAN V, et al: Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-β in human renal epithelial cells. J Biol Chem 275:40904-40909, 2000
34. HILL C, FLYVBJERG A, GRØNBÆK H, et al: The renal expression of transforming growth factor-β isoforms and their receptors in acute and chronic experimental diabetes in rats. Endocrinology 141: 1196-1208, 2000
35. SHARMA VK, BOLOGA RM, XU G-P, et al: Intragraft TGF-[beta]1 mRNA: A correlate of interstitial fibrosis and chronic allograft nephropathy. Kidney Int 49:1297-1303, 1996
36. SHARMA K, ZIYADEH FN: Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 44:1139-1146, 1995