-
1
-
-
76149093866
-
Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease?
-
COI: 1:CAS:528:DC%2BC3cXitV2jtb0%3D, PID: 20130173
-
Adlard PA et al. (2010) Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer’s disease? J Neurosci 30(5):1631–1636
-
(2010)
J Neurosci
, vol.30
, Issue.5
, pp. 1631-1636
-
-
Adlard, P.A.1
-
2
-
-
66249101637
-
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+
-
COI: 1:CAS:528:DC%2BD1MXmsl2nsrg%3D, PID: 19416844
-
Andersson DA et al. (2009) Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A 106(20):8374–8379
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.20
, pp. 8374-8379
-
-
Andersson, D.A.1
-
3
-
-
0035923750
-
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
-
COI: 1:CAS:528:DC%2BD3MXovFOis74%3D, PID: 11719200
-
Annaert WG et al. (2001) Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron 32(4):579–589
-
(2001)
Neuron
, vol.32
, Issue.4
, pp. 579-589
-
-
Annaert, W.G.1
-
4
-
-
84872351818
-
Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies
-
COI: 1:CAS:528:DC%2BC3sXos1WisA%3D%3D, PID: 23155049
-
Avrahami L et al. (2013) Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem 288(2):1295–1306
-
(2013)
J Biol Chem
, vol.288
, Issue.2
, pp. 1295-1306
-
-
Avrahami, L.1
-
5
-
-
5444235015
-
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
-
COI: 1:CAS:528:DC%2BD2cXovVOmtbY%3D, PID: 15447675
-
Bellingham SA et al. (2004) Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts. J Neurochem 91(2):423–428
-
(2004)
J Neurochem
, vol.91
, Issue.2
, pp. 423-428
-
-
Bellingham, S.A.1
-
6
-
-
0037064026
-
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells
-
COI: 1:CAS:528:DC%2BD38Xns1Cnu7w%3D, PID: 12163492
-
Beranger F et al. (2002) Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells. J Biol Chem 277(41):38972–38977
-
(2002)
J Biol Chem
, vol.277
, Issue.41
, pp. 38972-38977
-
-
Beranger, F.1
-
7
-
-
60949111784
-
Wnt signaling in Alzheimer’s disease: up or down, that is the question
-
COI: 1:CAS:528:DC%2BD1MXkvVSit7s%3D, PID: 19101658
-
Boonen RA, van Tijn P, Zivkovic D (2009) Wnt signaling in Alzheimer’s disease: up or down, that is the question. Ageing Res Rev 8(2):71–82
-
(2009)
Ageing Res Rev
, vol.8
, Issue.2
, pp. 71-82
-
-
Boonen, R.A.1
van Tijn, P.2
Zivkovic, D.3
-
8
-
-
84990875119
-
-
Bush AI The Metal Theory of Alzheimer’s Disease
-
Bush AI The Metal Theory of Alzheimer’s Disease. J Alzheimers Dis, 2012
-
(2012)
J Alzheimers Dis
-
-
-
9
-
-
0037474287
-
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein
-
COI: 1:CAS:528:DC%2BD3sXmt1KitQ%3D%3D, PID: 12435726
-
Cai D et al. (2003) Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem 278(5):3446–3454
-
(2003)
J Biol Chem
, vol.278
, Issue.5
, pp. 3446-3454
-
-
Cai, D.1
-
10
-
-
32444439640
-
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons
-
COI: 1:CAS:528:DC%2BD28Xhslehtb0%3D, PID: 16449385
-
Cai D et al. (2006) Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A 103(6):1936–1940
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.6
, pp. 1936-1940
-
-
Cai, D.1
-
11
-
-
0036878788
-
Calcium leak from intracellular stores--the enigma of calcium signalling
-
COI: 1:CAS:528:DC%2BD3sXhtFKntbc%3D, PID: 12543095
-
Camello C et al. (2002) Calcium leak from intracellular stores--the enigma of calcium signalling. Cell Calcium 32(5–6):355–361
-
(2002)
Cell Calcium
, vol.32
, Issue.5-6
, pp. 355-361
-
-
Camello, C.1
-
12
-
-
0029888368
-
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer’s disease and Down’s syndrome
-
COI: 1:STN:280:DyaK283jvFGltA%3D%3D, PID: 8642396
-
Cataldo AM et al. (1996) Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer’s disease and Down’s syndrome. J Neuropathol Exp Neurol 55(6):704–715
-
(1996)
J Neuropathol Exp Neurol
, vol.55
, Issue.6
, pp. 704-715
-
-
Cataldo, A.M.1
-
13
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
-
COI: 1:CAS:528:DC%2BD3cXlsVGmtLw%3D, PID: 10880397
-
Cataldo AM et al. (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157(1):277–286
-
(2000)
Am J Pathol
, vol.157
, Issue.1
, pp. 277-286
-
-
Cataldo, A.M.1
-
14
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
COI: 1:CAS:528:DC%2BD2cXntlWitbo%3D, PID: 15330337
-
Cataldo AM et al. (2004) Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 63(8):821–830
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, Issue.8
, pp. 821-830
-
-
Cataldo, A.M.1
-
15
-
-
1542438695
-
Presenilin-interacting proteins
-
PID: 14585160
-
Chen Q, Schubert D (2002) Presenilin-interacting proteins. Expert Rev Mol Med 4(19):1–18
-
(2002)
Expert Rev Mol Med
, vol.4
, Issue.19
, pp. 1-18
-
-
Chen, Q.1
Schubert, D.2
-
16
-
-
0034711207
-
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
-
COI: 1:CAS:528:DC%2BD3cXoslWlsrk%3D, PID: 10962005
-
Chen F et al. (2000) Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem 275(47):36794–36802
-
(2000)
J Biol Chem
, vol.275
, Issue.47
, pp. 36794-36802
-
-
Chen, F.1
-
17
-
-
41549155927
-
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
-
COI: 1:CAS:528:DC%2BD1cXltVOisrc%3D, PID: 18400162
-
Cirrito JR et al. (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58(1):42–51
-
(2008)
Neuron
, vol.58
, Issue.1
, pp. 42-51
-
-
Cirrito, J.R.1
-
18
-
-
78649731881
-
Presenilins: how much more than gamma-secretase?!
-
Coen, K., W. Annaert, Presenilins: how much more than gamma-secretase?! Biochem Soc Trans, 2010. 38(6): 1474–1478.
-
(2010)
Biochem Soc Trans
, vol.38
, Issue.6
, pp. 1474-1478
-
-
Coen, K.1
Annaert, W.2
-
19
-
-
84865086929
-
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
-
COI: 1:CAS:528:DC%2BC38XhtVOhtLnK, PID: 22753898
-
Coen K et al. (2012) Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J Cell Biol 198(1):23–35
-
(2012)
J Cell Biol
, vol.198
, Issue.1
, pp. 23-35
-
-
Coen, K.1
-
20
-
-
84870407757
-
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment
-
COI: 1:CAS:528:DC%2BC38XhvVWns77P, PID: 23122960
-
Dobrowolski R et al. (2012) Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Rep 2(5):1316–1328
-
(2012)
Cell Rep
, vol.2
, Issue.5
, pp. 1316-1328
-
-
Dobrowolski, R.1
-
21
-
-
77956647381
-
Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3cXhtFyitb%2FJ, PID: 20817278
-
Duce JA et al. (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer’s disease. Cell 142(6):857–867
-
(2010)
Cell
, vol.142
, Issue.6
, pp. 857-867
-
-
Duce, J.A.1
-
22
-
-
4644257963
-
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
-
COI: 1:CAS:528:DC%2BD2cXotVehtLk%3D, PID: 15452145
-
Esselens C et al. (2004) Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol 166(7):1041–1054
-
(2004)
J Cell Biol
, vol.166
, Issue.7
, pp. 1041-1054
-
-
Esselens, C.1
-
23
-
-
20144377557
-
The neurobiology of zinc in health and disease
-
COI: 1:CAS:528:DC%2BD2MXks1OitLg%3D, PID: 15891778
-
Frederickson CJ, Koh JY, Bush AI (2005) The neurobiology of zinc in health and disease. Nat Rev Neurosci 6(6):449–462
-
(2005)
Nat Rev Neurosci
, vol.6
, Issue.6
, pp. 449-462
-
-
Frederickson, C.J.1
Koh, J.Y.2
Bush, A.I.3
-
24
-
-
34447315525
-
Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
-
COI: 1:CAS:528:DC%2BD2sXovVyjurc%3D, PID: 17630980
-
Gandy S et al. (2007) Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem 102(3):619–626
-
(2007)
J Neurochem
, vol.102
, Issue.3
, pp. 619-626
-
-
Gandy, S.1
-
25
-
-
4944225803
-
Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD
-
COI: 1:CAS:528:DC%2BD2cXotlGrtrg%3D, PID: 15280425
-
Gowrishankar K, Zeidler MG, Vincenz C (2004) Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. J Cell Sci 117(Pt 18):4099–4111
-
(2004)
J Cell Sci
, vol.117
, pp. 4099-4111
-
-
Gowrishankar, K.1
Zeidler, M.G.2
Vincenz, C.3
-
26
-
-
84875697145
-
Metal dyshomeostasis and oxidative stress in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC38XhsVyhtrnO, PID: 22982299
-
Greenough MA, Camakaris J, Bush AI (2013) Metal dyshomeostasis and oxidative stress in Alzheimer’s disease. Neurochem Int 62(5):540–555
-
(2013)
Neurochem Int
, vol.62
, Issue.5
, pp. 540-555
-
-
Greenough, M.A.1
Camakaris, J.2
Bush, A.I.3
-
27
-
-
79953167471
-
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity
-
COI: 1:CAS:528:DC%2BC3MXjtFOitb0%3D, PID: 21239495
-
Greenough MA et al. (2011) Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity. J Biol Chem 286(11):9776–9786
-
(2011)
J Biol Chem
, vol.286
, Issue.11
, pp. 9776-9786
-
-
Greenough, M.A.1
-
28
-
-
77950583465
-
Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1
-
COI: 1:CAS:528:DC%2BC3cXls1WmsLc%3D
-
Gu Q, Lin RL (2010a) Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol (1985) 108(4):891–897
-
(2010)
J Appl Physiol (1985)
, vol.108
, Issue.4
, pp. 891-897
-
-
Gu, Q.1
Lin, R.L.2
-
29
-
-
77950583465
-
Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1
-
COI: 1:CAS:528:DC%2BC3cXls1WmsLc%3D, PID: 20133428
-
Gu Q, Lin RL (2010b) Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol 108(4):891–897
-
(2010)
J Appl Physiol
, vol.108
, Issue.4
, pp. 891-897
-
-
Gu, Q.1
Lin, R.L.2
-
30
-
-
69249084030
-
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease
-
COI: 1:CAS:528:DC%2BD1MXpsFymtrs%3D, PID: 19542222
-
Hung YH et al. (2009) Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. J Biol Chem 284(33):21899–21907
-
(2009)
J Biol Chem
, vol.284
, Issue.33
, pp. 21899-21907
-
-
Hung, Y.H.1
-
31
-
-
1242316263
-
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities
-
COI: 1:CAS:528:DC%2BD2cXitl2jt7s%3D, PID: 14982851
-
Jin LW et al. (2004) Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol 164(3):975–985
-
(2004)
Am J Pathol
, vol.164
, Issue.3
, pp. 975-985
-
-
Jin, L.W.1
-
32
-
-
0036327098
-
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
-
COI: 1:CAS:528:DC%2BD38XmtVeksLw%3D, PID: 12147673
-
Kaether C et al. (2002) Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 158(3):551–561
-
(2002)
J Cell Biol
, vol.158
, Issue.3
, pp. 551-561
-
-
Kaether, C.1
-
33
-
-
0344873113
-
Mutant presenilin (A260V) affects Rab8 in PC12D cell
-
COI: 1:CAS:528:DC%2BD3sXpt1Squr8%3D, PID: 14643748
-
Kametani F et al. (2004) Mutant presenilin (A260V) affects Rab8 in PC12D cell. Neurochem Int 44(5):313–320
-
(2004)
Neurochem Int
, vol.44
, Issue.5
, pp. 313-320
-
-
Kametani, F.1
-
34
-
-
24744459453
-
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling
-
COI: 1:CAS:528:DC%2BD2MXpslaqu7o%3D, PID: 16014629
-
Kang DE et al. (2005) Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem 280(36):31537–31547
-
(2005)
J Biol Chem
, vol.280
, Issue.36
, pp. 31537-31547
-
-
Kang, D.E.1
-
35
-
-
84978413985
-
-
Kepp KP Alzheimer’s disease due to loss of function: a new synthesis of the data
-
Kepp KP Alzheimer’s disease due to loss of function: a new synthesis of the available data. Prog Neurobiol, 2016
-
(2016)
Prog Neurobiol
-
-
-
36
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
COI: 1:CAS:528:DyaK2cXkvVSiu7g%3D, PID: 8021238
-
Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269(26):17386–17389
-
(1994)
J Biol Chem
, vol.269
, Issue.26
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
37
-
-
0029950149
-
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
-
COI: 1:CAS:528:DyaK28XjtlylsLY%3D, PID: 8743946
-
Koo EH et al. (1996) Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 109(Pt 5):991–998
-
(1996)
J Cell Sci
, vol.109
, pp. 991-998
-
-
Koo, E.H.1
-
38
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD38Xotleqtr8%3D, PID: 12415294
-
LaFerla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer’s disease. Nat Rev Neurosci 3(11):862–872
-
(2002)
Nat Rev Neurosci
, vol.3
, Issue.11
, pp. 862-872
-
-
LaFerla, F.M.1
-
39
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
COI: 1:CAS:528:DC%2BC3cXovFartbs%3D, PID: 20541250
-
Lee JH et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141(7):1146–1158
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1146-1158
-
-
Lee, J.H.1
-
40
-
-
84940796652
-
Presenilin 1 maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification
-
COI: 1:CAS:528:DC%2BC2MXhtlOmtbvJ, PID: 26299959
-
Lee JH et al. (2015) Presenilin 1 maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification. Cell Rep 12(9):1430–1444
-
(2015)
Cell Rep
, vol.12
, Issue.9
, pp. 1430-1444
-
-
Lee, J.H.1
-
41
-
-
0036453087
-
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface
-
COI: 1:CAS:528:DC%2BD38XovVyht7o%3D, PID: 12460547
-
Leem JY et al. (2002) A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 11(1):64–82
-
(2002)
Neurobiol Dis
, vol.11
, Issue.1
, pp. 64-82
-
-
Leem, J.Y.1
-
42
-
-
0035887735
-
Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+
-
COI: 1:CAS:528:DC%2BD3MXoslCqur8%3D, PID: 11588174
-
Li Y et al. (2001) Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+. J Neurosci 21(20):8015–8025
-
(2001)
J Neurosci
, vol.21
, Issue.20
, pp. 8015-8025
-
-
Li, Y.1
-
43
-
-
33845217332
-
Mutations of presenilin genes in dilated cardiomyopathy and heart failure
-
COI: 1:CAS:528:DC%2BD28Xht1yksr7L, PID: 17186461
-
Li D et al. (2006) Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet 79(6):1030–1039
-
(2006)
Am J Hum Genet
, vol.79
, Issue.6
, pp. 1030-1039
-
-
Li, D.1
-
44
-
-
84879792609
-
Polymorphisms of presenilin-1 gene associate with dilated cardiomyopathy susceptibility
-
COI: 1:CAS:528:DC%2BC3MXhtlOntrzF, PID: 21656036
-
Li H et al. (2011a) Polymorphisms of presenilin-1 gene associate with dilated cardiomyopathy susceptibility. Mol Cell Biochem 358(1–2):31–36
-
(2011)
Mol Cell Biochem
, vol.358
, Issue.1-2
, pp. 31-36
-
-
Li, H.1
-
45
-
-
79956310601
-
Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction
-
PID: 21524270
-
Li A et al. (2011b) Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res 8(3):313–322
-
(2011)
Curr Alzheimer Res
, vol.8
, Issue.3
, pp. 313-322
-
-
Li, A.1
-
46
-
-
74849118341
-
Lipid rafts as a membrane-organizing principle
-
COI: 1:CAS:528:DC%2BD1MXhs1WksrfJ, PID: 20044567
-
Lingwood D, Simons K (2010) Lipid rafts as a membrane-organizing principle. Science 327(5961):46–50
-
(2010)
Science
, vol.327
, Issue.5961
, pp. 46-50
-
-
Lingwood, D.1
Simons, K.2
-
47
-
-
55549134611
-
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
-
COI: 1:CAS:528:DC%2BD1cXhtlCjtLrL, PID: 18953351
-
Lloyd-Evans E et al. (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14(11):1247–1255
-
(2008)
Nat Med
, vol.14
, Issue.11
, pp. 1247-1255
-
-
Lloyd-Evans, E.1
-
48
-
-
84883516027
-
Metalloproteomics: principles, challenges and applications to neurodegeneration
-
PID: 23882215
-
Lothian A et al. (2013) Metalloproteomics: principles, challenges and applications to neurodegeneration. Front Aging Neurosci 5:35
-
(2013)
Front Aging Neurosci
, vol.5
, pp. 35
-
-
Lothian, A.1
-
49
-
-
0033779649
-
Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses
-
COI: 1:CAS:528:DC%2BD3cXnsFyjsLs%3D, PID: 11018793
-
Lu YM et al. (2000) Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses. Synapse 38(2):187–197
-
(2000)
Synapse
, vol.38
, Issue.2
, pp. 187-197
-
-
Lu, Y.M.1
-
50
-
-
77951022798
-
Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2
-
COI: 1:CAS:528:DC%2BC3cXhslegsL0%3D, PID: 19821015
-
Matias CM et al. (2010) Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2. J Fluoresc 20(1):377–380
-
(2010)
J Fluoresc
, vol.20
, Issue.1
, pp. 377-380
-
-
Matias, C.M.1
-
51
-
-
23844529915
-
Involvement of presenilins in cell-survival signalling pathways
-
COI: 1:CAS:528:DC%2BD2MXmvFSntLk%3D, PID: 16042546
-
McCarthy JV (2005) Involvement of presenilins in cell-survival signalling pathways. Biochem Soc Trans 33(Pt 4):568–572
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 568-572
-
-
McCarthy, J.V.1
-
52
-
-
0030064136
-
Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer’s beta-amyloid precursor protein
-
COI: 1:CAS:528:DyaK28XlsVyjtA%3D%3D, PID: 8576122
-
McConlogue L et al. (1996) Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer’s beta-amyloid precursor protein. J Biol Chem 271(3):1343–1348
-
(1996)
J Biol Chem
, vol.271
, Issue.3
, pp. 1343-1348
-
-
McConlogue, L.1
-
53
-
-
0023065242
-
Intracellular protein catabolism and its control during nutrient deprivation and supply
-
COI: 1:CAS:528:DyaL2sXkvFGksrc%3D, PID: 3300746
-
Mortimore GE, Poso AR (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 7:539–564
-
(1987)
Annu Rev Nutr
, vol.7
, pp. 539-564
-
-
Mortimore, G.E.1
Poso, A.R.2
-
54
-
-
80053044013
-
Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells
-
COI: 1:CAS:528:DC%2BC3MXhtFyqsbvP, PID: 21848366
-
Mukhopadhyay I et al. (2011) Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. J Recept Signal Transduct Res 31(5):350–358
-
(2011)
J Recept Signal Transduct Res
, vol.31
, Issue.5
, pp. 350-358
-
-
Mukhopadhyay, I.1
-
55
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
COI: 1:CAS:528:DyaK1cXltlemsbo%3D, PID: 9738936
-
Murayama M et al. (1998) Direct association of presenilin-1 with beta-catenin. FEBS Lett 433(1–2):73–77
-
(1998)
FEBS Lett
, vol.433
, Issue.1-2
, pp. 73-77
-
-
Murayama, M.1
-
56
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
COI: 1:CAS:528:DyaK1cXotVWis78%3D, PID: 9856475
-
Naruse S et al. (1998) Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21(5):1213–1221
-
(1998)
Neuron
, vol.21
, Issue.5
, pp. 1213-1221
-
-
Naruse, S.1
-
57
-
-
79951985639
-
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner
-
COI: 1:CAS:528:DC%2BC3MXislGisb0%3D, PID: 21414900
-
Neely KM, Green KN, LaFerla FM (2011) Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner. J Neurosci 31(8):2781–2791
-
(2011)
J Neurosci
, vol.31
, Issue.8
, pp. 2781-2791
-
-
Neely, K.M.1
Green, K.N.2
LaFerla, F.M.3
-
58
-
-
34248185927
-
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
-
COI: 1:CAS:528:DC%2BD2sXlt1Omt7g%3D, PID: 17431506
-
Nelson O et al. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest 117(5):1230–1239
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1230-1239
-
-
Nelson, O.1
-
59
-
-
79959329917
-
Mutagenesis mapping of the presenilin 1 calcium leak conductance pore
-
COI: 1:CAS:528:DC%2BC3MXns1Kksb0%3D, PID: 21531718
-
Nelson O et al. (2011) Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. J Biol Chem 286(25):22339–22347
-
(2011)
J Biol Chem
, vol.286
, Issue.25
, pp. 22339-22347
-
-
Nelson, O.1
-
60
-
-
30044445876
-
Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7
-
COI: 1:CAS:528:DC%2BD28Xjslakug%3D%3D, PID: 16251357
-
Norgate M et al. (2006) Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Mol Biol Cell 17(1):475–484
-
(2006)
Mol Biol Cell
, vol.17
, Issue.1
, pp. 475-484
-
-
Norgate, M.1
-
61
-
-
78650862568
-
Syntaxin 5 is required for copper homeostasis in Drosophila and mammals
-
COI: 1:CAS:528:DC%2BC3MXntlOh, PID: 21188142
-
Norgate M et al. (2010) Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. PLoS One 5(12):e14303
-
(2010)
PLoS One
, vol.5
, Issue.12
-
-
Norgate, M.1
-
62
-
-
38349133632
-
Interference with splicing of presenilin transcripts has potent dominant negative effects on presenilin activity
-
COI: 1:CAS:528:DC%2BD1cXoslWktg%3D%3D, PID: 17981814
-
Nornes S et al. (2008) Interference with splicing of presenilin transcripts has potent dominant negative effects on presenilin activity. Hum Mol Genet 17(3):402–412
-
(2008)
Hum Mol Genet
, vol.17
, Issue.3
, pp. 402-412
-
-
Nornes, S.1
-
63
-
-
77953726485
-
Autophagy impairment stimulates PS1 expression and gamma-secretase activity
-
COI: 1:CAS:528:DC%2BC3cXpt1WjtLg%3D, PID: 20168091
-
Ohta K et al. (2010) Autophagy impairment stimulates PS1 expression and gamma-secretase activity. Autophagy 6(3):345–352
-
(2010)
Autophagy
, vol.6
, Issue.3
, pp. 345-352
-
-
Ohta, K.1
-
64
-
-
80053111747
-
Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse
-
COI: 1:CAS:528:DC%2BC3MXht1ehs73M, PID: 21943607
-
Pan E et al. (2011) Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. Neuron 71(6):1116–1126
-
(2011)
Neuron
, vol.71
, Issue.6
, pp. 1116-1126
-
-
Pan, E.1
-
65
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
COI: 1:CAS:528:DyaK1MXksVWmu70%3D, PID: 10383380
-
Perez RG et al. (1999) Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem 274(27):18851–18856
-
(1999)
J Biol Chem
, vol.274
, Issue.27
, pp. 18851-18856
-
-
Perez, R.G.1
-
66
-
-
0035116513
-
Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation
-
COI: 1:CAS:528:DC%2BD3MXhtF2qu7s%3D, PID: 11157069
-
Pigino G et al. (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21(3):834–842
-
(2001)
J Neurosci
, vol.21
, Issue.3
, pp. 834-842
-
-
Pigino, G.1
-
67
-
-
33644652433
-
Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments
-
COI: 1:CAS:528:DC%2BD28Xjt1Siu7w%3D, PID: 16497228
-
Rechards M et al. (2006) Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic 7(3):354–364
-
(2006)
Traffic
, vol.7
, Issue.3
, pp. 354-364
-
-
Rechards, M.1
-
68
-
-
35748940970
-
Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway
-
COI: 1:CAS:528:DC%2BD2sXhtFykurbN, PID: 17716970
-
Repetto E et al. (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem 282(43):31504–31516
-
(2007)
J Biol Chem
, vol.282
, Issue.43
, pp. 31504-31516
-
-
Repetto, E.1
-
69
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
COI: 1:CAS:528:DC%2BD2sXos1Crt7w%3D, PID: 17634375
-
Ring S et al. (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27(29):7817–7826
-
(2007)
J Neurosci
, vol.27
, Issue.29
, pp. 7817-7826
-
-
Ring, S.1
-
70
-
-
0025260882
-
Assessment of Fura-2 for measurements of cytosolic free calcium
-
COI: 1:CAS:528:DyaK3cXitFehsrs%3D, PID: 2191782
-
Roe MW, Lemasters JJ, Herman B (1990) Assessment of Fura-2 for measurements of cytosolic free calcium. Cell Calcium 11(2–3):63–73
-
(1990)
Cell Calcium
, vol.11
, Issue.2-3
, pp. 63-73
-
-
Roe, M.W.1
Lemasters, J.J.2
Herman, B.3
-
71
-
-
69249227502
-
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
-
COI: 1:CAS:528:DC%2BD1MXpsleqsrc%3D, PID: 19672277
-
Saftig P, Klumperman J (2009) Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol 10(9):623–635
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, Issue.9
, pp. 623-635
-
-
Saftig, P.1
Klumperman, J.2
-
72
-
-
0014225180
-
Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs
-
COI: 1:CAS:528:DyaF1MXhvVehug%3D%3D, PID: 5688464
-
Sandhoff K, Andreae U, Jatzkewitz H (1968) Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs. Pathol Eur 3(2):278–285
-
(1968)
Pathol Eur
, vol.3
, Issue.2
, pp. 278-285
-
-
Sandhoff, K.1
Andreae, U.2
Jatzkewitz, H.3
-
73
-
-
33751087756
-
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines
-
COI: 1:CAS:528:DC%2BD28Xht1yksr7N, PID: 17108181
-
Sato C et al. (2006) Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. J Neurosci 26(46):12081–12088
-
(2006)
J Neurosci
, vol.26
, Issue.46
, pp. 12081-12088
-
-
Sato, C.1
-
74
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
COI: 1:CAS:528:DC%2BD2cXjs1ygtL8%3D, PID: 15066262
-
Saura CA et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42(1):23–36
-
(2004)
Neuron
, vol.42
, Issue.1
, pp. 23-36
-
-
Saura, C.A.1
-
75
-
-
0033958665
-
Alzheimer’s presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor
-
COI: 1:CAS:528:DC%2BD3cXhtVaksLc%3D, PID: 10607841
-
Scheper W et al. (2000) Alzheimer’s presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor. Hum Mol Genet 9(2):303–310
-
(2000)
Hum Mol Genet
, vol.9
, Issue.2
, pp. 303-310
-
-
Scheper, W.1
-
76
-
-
1342306722
-
Rab6 membrane association is dependent of presenilin 1 and cellular phosphorylation events
-
COI: 1:CAS:528:DC%2BD2cXhs12ms74%3D, PID: 14992812
-
Scheper W, Zwart R, Baas F (2004) Rab6 membrane association is dependent of presenilin 1 and cellular phosphorylation events. Brain Res Mol Brain Res 122(1):17–23
-
(2004)
Brain Res Mol Brain Res
, vol.122
, Issue.1
, pp. 17-23
-
-
Scheper, W.1
Zwart, R.2
Baas, F.3
-
77
-
-
33846282302
-
The presenilin hypothesis of Alzheimer’s disease: evidence for a loss-of-function pathogenic mechanism
-
COI: 1:CAS:528:DC%2BD2sXptVCgsg%3D%3D, PID: 17197420
-
Shen J, Kelleher RJ III (2007) The presenilin hypothesis of Alzheimer’s disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A 104(2):403–409
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.2
, pp. 403-409
-
-
Shen, J.1
Kelleher, R.J.2
-
78
-
-
1642456618
-
Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
-
COI: 1:CAS:528:DC%2BD2cXntVOhtw%3D%3D, PID: 14751776
-
Shepherd CE et al. (2004) Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques. Neurobiol Dis 15(1):115–119
-
(2004)
Neurobiol Dis
, vol.15
, Issue.1
, pp. 115-119
-
-
Shepherd, C.E.1
-
79
-
-
84859483029
-
Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels
-
COI: 1:CAS:528:DC%2BC38XkvVWlsrc%3D, PID: 22311977
-
Shilling D et al. (2012) Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. J Biol Chem 287(14):10933–10944
-
(2012)
J Biol Chem
, vol.287
, Issue.14
, pp. 10933-10944
-
-
Shilling, D.1
-
80
-
-
33749042749
-
Sorting through the cell biology of Alzheimer’s disease: intracellular pathways to pathogenesis
-
COI: 1:CAS:528:DC%2BD28XhtFensbfM, PID: 17015224
-
Small SA, Gandy S (2006) Sorting through the cell biology of Alzheimer’s disease: intracellular pathways to pathogenesis. Neuron 52(1):15–31
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 15-31
-
-
Small, S.A.1
Gandy, S.2
-
81
-
-
24644456470
-
Calcium dysregulation in Alzheimer’s disease: recent advances gained from genetically modified animals
-
COI: 1:CAS:528:DC%2BD2MXpvV2lsLg%3D, PID: 16125228
-
Smith IF, Green KN, LaFerla FM (2005) Calcium dysregulation in Alzheimer’s disease: recent advances gained from genetically modified animals. Cell Calcium 38(3–4):427–437
-
(2005)
Cell Calcium
, vol.38
, Issue.3-4
, pp. 427-437
-
-
Smith, I.F.1
Green, K.N.2
LaFerla, F.M.3
-
82
-
-
0029738342
-
Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals
-
COI: 1:CAS:528:DyaK28Xkslyjsrs%3D, PID: 8842241
-
Snitsarev VA, McNulty TJ, Taylor CW (1996) Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals. Biophys J 71(2):1048–1056
-
(1996)
Biophys J
, vol.71
, Issue.2
, pp. 1048-1056
-
-
Snitsarev, V.A.1
McNulty, T.J.2
Taylor, C.W.3
-
83
-
-
84877135946
-
Presenilin promotes dietary copper uptake
-
COI: 1:CAS:528:DC%2BC3sXnslGisLw%3D, PID: 23667524
-
Southon A et al. (2013) Presenilin promotes dietary copper uptake. PLoS One 8(5):e62811
-
(2013)
PLoS One
, vol.8
, Issue.5
-
-
Southon, A.1
-
84
-
-
15244352734
-
Calcium dysregulation, IP3 signaling, and Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2MXjtFyjs7o%3D, PID: 15746379
-
Stutzmann GE (2005) Calcium dysregulation, IP3 signaling, and Alzheimer’s disease. Neuroscientist 11(2):110–115
-
(2005)
Neuroscientist
, vol.11
, Issue.2
, pp. 110-115
-
-
Stutzmann, G.E.1
-
85
-
-
4344594413
-
Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production
-
COI: 1:CAS:528:DC%2BD2cXlvFGqurw%3D, PID: 15109302
-
Suga K et al. (2004) Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production. Biochem J 381(Pt 3):619–628
-
(2004)
Biochem J
, vol.381
, pp. 619-628
-
-
Suga, K.1
-
86
-
-
22244454702
-
Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells
-
COI: 1:CAS:528:DC%2BD2MXmsVarsbo%3D, PID: 15998293
-
Suga K et al. (2005) Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells. J Neurochem 94(2):425–439
-
(2005)
J Neurochem
, vol.94
, Issue.2
, pp. 425-439
-
-
Suga, K.1
-
87
-
-
71949111722
-
The Syntaxin 5 isoforms Syx5 and Syx5L have distinct effects on the processing of {beta}-amyloid precursor protein
-
COI: 1:CAS:528:DC%2BD1MXhsFaktLfN, PID: 19720618
-
Suga K et al. (2009) The Syntaxin 5 isoforms Syx5 and Syx5L have distinct effects on the processing of {beta}-amyloid precursor protein. J Biochem 146(6):905–915
-
(2009)
J Biochem
, vol.146
, Issue.6
, pp. 905-915
-
-
Suga, K.1
-
88
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
COI: 1:CAS:528:DC%2BD1cXht1ynt7rO, PID: 18650430
-
Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283(44):29615–29619
-
(2008)
J Biol Chem
, vol.283
, Issue.44
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
89
-
-
33748743559
-
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex
-
COI: 1:CAS:528:DC%2BD28XptlKmtbc%3D, PID: 16844686
-
Tolia A, Chavez-Gutierrez L, De Strooper B (2006) Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex. J Biol Chem 281(37):27633–27642
-
(2006)
J Biol Chem
, vol.281
, Issue.37
, pp. 27633-27642
-
-
Tolia, A.1
Chavez-Gutierrez, L.2
De Strooper, B.3
-
90
-
-
33748140720
-
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations
-
COI: 1:CAS:528:DC%2BD28XpvVKiuro%3D, PID: 16959576
-
Tu H et al. (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations. Cell 126(5):981–993
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 981-993
-
-
Tu, H.1
-
91
-
-
0141816599
-
Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane
-
COI: 1:CAS:528:DC%2BD3sXotVWgtrc%3D, PID: 14515347
-
Uemura K et al. (2003) Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane. J Neurosci Res 74(2):184–191
-
(2003)
J Neurosci Res
, vol.74
, Issue.2
, pp. 184-191
-
-
Uemura, K.1
-
92
-
-
34347269184
-
Amyloid precursor protein and presenilin involvement in cell signaling
-
COI: 1:CAS:528:DC%2BD2sXntVSlsbw%3D, PID: 17596704
-
Venezia V et al. (2007) Amyloid precursor protein and presenilin involvement in cell signaling. Neurodegener Dis 4(2–3):101–111
-
(2007)
Neurodegener Dis
, vol.4
, Issue.2-3
, pp. 101-111
-
-
Venezia, V.1
-
93
-
-
4644367903
-
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
-
COI: 1:CAS:528:DC%2BD2cXnslWnsbY%3D, PID: 15247291
-
Wang H et al. (2004) Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. J Biol Chem 279(39):40560–40566
-
(2004)
J Biol Chem
, vol.279
, Issue.39
, pp. 40560-40566
-
-
Wang, H.1
-
94
-
-
25844499702
-
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
-
COI: 1:CAS:528:DC%2BD2MXmvV2htbg%3D, PID: 15905180
-
Wang HQ et al. (2005) Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum Mol Genet 14(13):1889–1902
-
(2005)
Hum Mol Genet
, vol.14
, Issue.13
, pp. 1889-1902
-
-
Wang, H.Q.1
-
95
-
-
31044438340
-
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer’s disease mutation
-
COI: 1:CAS:528:DC%2BD28XpsVSmsQ%3D%3D, PID: 16384915
-
Wang R et al. (2006) Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer’s disease mutation. Proc Natl Acad Sci U S A 103(2):353–358
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.2
, pp. 353-358
-
-
Wang, R.1
-
96
-
-
2442421944
-
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons
-
COI: 1:CAS:528:DC%2BD2cXjvFKjsrc%3D, PID: 15123735
-
Wilson CA et al. (2004) Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol 165(3):335–346
-
(2004)
J Cell Biol
, vol.165
, Issue.3
, pp. 335-346
-
-
Wilson, C.A.1
-
97
-
-
84879232282
-
Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification
-
PID: 23773064
-
Wolfe DM et al. (2013) Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification. Eur J Neurosci 37(12):1949–1961
-
(2013)
Eur J Neurosci
, vol.37
, Issue.12
, pp. 1949-1961
-
-
Wolfe, D.M.1
-
98
-
-
84914693430
-
beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin
-
PID: 25464026
-
Wong BX et al. (2014) beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin. PLoS One 9(12):e114174
-
(2014)
PLoS One
, vol.9
, Issue.12
-
-
Wong, B.X.1
-
99
-
-
16844367458
-
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
-
COI: 1:CAS:528:DC%2BD2MXislyhur8%3D, PID: 15613471
-
Wrigley JD et al. (2005) Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity. J Biol Chem 280(13):12523–12535
-
(2005)
J Biol Chem
, vol.280
, Issue.13
, pp. 12523-12535
-
-
Wrigley, J.D.1
-
100
-
-
0029934134
-
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization
-
COI: 1:CAS:528:DyaK28XjtlylsLc%3D, PID: 8743947
-
Yamazaki T, Koo EH, Selkoe DJ (1996) Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. J Cell Sci 109(Pt 5):999–1008
-
(1996)
J Cell Sci
, vol.109
, pp. 999-1008
-
-
Yamazaki, T.1
Koo, E.H.2
Selkoe, D.J.3
-
101
-
-
70350304571
-
Calcium dysregulation in Alzheimer’s disease: from mechanisms to therapeutic opportunities
-
COI: 1:CAS:528:DC%2BD1MXhtlCmsLzI, PID: 19664678
-
Yu JT, Chang RC, Tan L (2009) Calcium dysregulation in Alzheimer’s disease: from mechanisms to therapeutic opportunities. Prog Neurobiol 89(3):240–255
-
(2009)
Prog Neurobiol
, vol.89
, Issue.3
, pp. 240-255
-
-
Yu, J.T.1
Chang, R.C.2
Tan, L.3
-
102
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
COI: 1:CAS:528:DyaK1cXms1Ojsb4%3D, PID: 9790190
-
Zhang Z et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395(6703):698–702
-
(1998)
Nature
, vol.395
, Issue.6703
, pp. 698-702
-
-
Zhang, Z.1
-
103
-
-
33845655221
-
Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment
-
COI: 1:CAS:528:DC%2BD28XlvFWlsLs%3D, PID: 16645046
-
Zhang M et al. (2006) Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB J 20(8):1176–1178
-
(2006)
FASEB J
, vol.20
, Issue.8
, pp. 1176-1178
-
-
Zhang, M.1
-
104
-
-
84862883617
-
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
-
COI: 1:CAS:528:DC%2BC38XpsV2hsr0%3D, PID: 22723704
-
Zhang X et al. (2012) A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci 32(25):8633–8648
-
(2012)
J Neurosci
, vol.32
, Issue.25
, pp. 8633-8648
-
-
Zhang, X.1
-
105
-
-
40849126725
-
Novel role of presenilins in maturation and transport of integrin beta 1
-
COI: 1:CAS:528:DC%2BD1cXitlOmt78%3D, PID: 18293935
-
Zou K et al. (2008) Novel role of presenilins in maturation and transport of integrin beta 1. Biochemistry 47(11):3370–3378
-
(2008)
Biochemistry
, vol.47
, Issue.11
, pp. 3370-3378
-
-
Zou, K.1
|