Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Cell Reports

Volumn 12, Issue 9, 2015, Pages 1430-1444

  Lee, Ju Hyun ^a,b   McBrayer, Mary Kate ^a   Wolfe, Devin M ^a   Haslett, Luke J ^c   Kumar, Asok ^a,b   Sato, Yutaka ^a   Lie, Pearl P Y ^a   Mohan, Panaiyur ^a,b   Coffey, Erin E ^d   Kompella, Uday ^e   Mitchell, Claire H ^d   Lloyd Evans, Emyr ^c   Nixon, Ralph A ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; PRESENILIN 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL L1; UNCLASSIFIED DRUG; VATPASE; VATPASE V0A1 SUBUNIT; CALCIUM; MCOLN1 PROTEIN, MOUSE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL PH; CONTROLLED STUDY; CYTOSOL; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; ANIMAL; CELL LINE; GENETICS; HOMEOSTASIS; METABOLISM; MOUSE; PH;

ANIMALS; AUTOPHAGY; CALCIUM; CELL LINE; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MICE; PRESENILIN-1; PROTEOLYSIS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84940796652     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.07.050     Document Type: Article

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