Interference with splicing of presenilin transcripts has potent dominant negative effects on presenilin activity

Human Molecular Genetics

Volumn 17, Issue 3, 2008, Pages 402-412

  Nornes, Svanhild ^a   Newman, Morgan ^a   Verdile, Giuseppe ^b,c,d   Wells, Simon ^a   Stoick Cooper, Cristi L ^e,f   Tucker, Ben ^a   Frederich Sleptsova, Inna ^b,c   Martins, Ralph ^b,c,d   Lardelli, Michael ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b EDITH COWAN UNIVERSITY   (Australia)

^c HOLLYWOOD PRIVATE HOSPITAL   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GAMMA SECRETASE; MESSENGER RNA; MORPHOLINE DERIVATIVE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXON; GENETIC CODE; GENETIC TRANSCRIPTION; HYDROCEPHALUS; MISSENSE MUTATION; MODEL; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA SPLICING; SIGNAL TRANSDUCTION; ZEBRA FISH;

ALZHEIMER DISEASE; ANIMALS; BASE SEQUENCE; CELL LINE; CODON, NONSENSE; DISEASE MODELS, ANIMAL; DNA PRIMERS; EXONS; HUMANS; HYDROCEPHALUS; MUTATION; MUTATION, MISSENSE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHENOTYPE; PICK DISEASE OF THE BRAIN; PRESENILIN-1; PRESENILIN-2; PROTEIN BIOSYNTHESIS; RNA SPLICING; TRANSCRIPTION, GENETIC; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 38349133632     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm317     Document Type: Article

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