Mutagenesis mapping of the presenilin 1 calcium leak conductance pore

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22339-22347

  Nelson, Omar ^a   Supnet, Charlene ^a   Tolia, Alexandra ^b,c   Horre, Katrien ^b,c   De Strooper, Bart ^b,c   Bezprozvanny, Ilya ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CATALYTIC CAVITIES; CATALYTIC SUBUNITS; CYSTEINE-SCANNING MUTAGENESIS; ENDOPLASMIC RETICULUM; INTRAMEMBRANE PROTEOLYSIS; LEAK CONDUCTANCE; NMR ANALYSIS; NMR STUDIES; PRESENILINS; SECRETASE COMPLEX; SECRETASES; TRANS-MEMBRANE PROTEINS; TRANSMEMBRANE DOMAIN; WATER-FILLED CAVITIES;

AMINO ACIDS; CALCIUM; MAMMALS; MUTAGENESIS; NEURODEGENERATIVE DISEASES;

PROTEINS;

CALCIUM ION; CYSTEINE; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1; PROTEIN TM6; PROTEIN TM7; PROTEIN TM9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ION CONDUCTANCE; MOUSE; MUTAGENESIS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANIMALS; CALCIUM; CELL LINE; CELL MEMBRANE; CYSTEINE; ELECTRIC CONDUCTIVITY; ENDOPLASMIC RETICULUM; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MUTAGENESIS; MUTATION; POROSITY; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY;

EID: 79959329917     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.243063     Document Type: Article

References (43)

1. Urban, S., Schlieper, D., and Freeman, M. (2002) Curr. Biol. 12, 1507-1512
2. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
3. Hass, M. R., Sato, C., Kopan, R., and Zhao, G. (2009) Semin. Cell Dev. Biol. 20, 201-210
4. Laudon, H., Hansson, E. M., Melén, K., Bergman, A., Farmery, M. R., Winblad, B., Lendahl, U., von Heijne, G., and Näslund, J. (2005) J. Biol. Chem. 280, 35352-35360
5. Spasic, D., Tolia, A., Dillen, K., Baert, V., De Strooper, B., Vrijens, S., and Annaert, W. (2006) J. Biol. Chem. 281, 26569-26577
6. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., George-Hyslop, P. S., Cordell, B., Fraser, P., and De Strooper, B. (1999) J. Cell Biol. 147, 277-294
7. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
8. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
9. De Strooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., George-Hyslop, P. S., and Van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598
10. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St George-Hyslop, P. H., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
11. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6382-6387
12. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488
13. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-441
14. Lazarov, V. K., Fraering, P. C., Ye, W., Wolfe, M. S., Selkoe, D. J., and Li, H. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 6889-6894
15. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
16. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Diehl, T. S., Moore, C. L., Tsai, J. Y., Rahmati, T., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2000) Nat. Cell Biol. 2, 428-434
17. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
18. Tolia, A., and De Strooper, B. (2009) Semin. Cell Dev. Biol. 20, 211-218
19. Khandelwal, A., Chandu, D., Roe, C. M., Kopan, R., and Quatrano, R. S. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 13337-13342
20. Bezprozvanny, I., and Mattson, M. P. (2008) Trends Neurosci. 31, 454-463
21. Ito, E., Oka, K., Etcheberrigaray, R., Nelson, T. J., McPhie, D. L., Tofel-Grehl, B., Gibson, G. E., and Alkon, D. L. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 534-538
22. Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S. F., Hao, Y. H., Serneels, L., De Strooper, B., Yu, G., and Bezprozvanny, I. (2006) Cell 126, 981-993
23. Nelson, O., Tu, H., Lei, T., Bentahir, M., de Strooper, B., and Bezprozvanny, I. (2007) J. Clin. Invest. 117, 1230-1239
24. Nelson, O., Supnet, C., Liu, H., and Bezprozvanny, I. (2010) J. Alzheimer's Dis. 21, 781-793
25. Supnet, C., and Bezprozvanny, I. (2010) Cell Calcium 47, 183-189
26. Supnet, C., and Bezprozvanny, I. (2010) J. Alzheimer's Dis. 20, S487-S498
27. Cheung, K. H., Mei, L., Mak, D. O., Hayashi, I., Iwatsubo, T., Kang, D. E., and Foskett, J. K. (2010) Sci. Signal. 3, ra22
28. Cheung, K. H., Shineman, D., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M., and Foskett, J. K. (2008) Neuron 58, 871-883
29. Tolia, A., Chávez-Gutiérrez, L., and De Strooper, B. (2006) J. Biol. Chem. 281, 27633-27642
30. Tolia, A., Horré, K., and De Strooper, B. (2008) J. Biol. Chem. 283, 19793-19803
31. Sato, C., Takagi, S., Tomita, T., and Iwatsubo, T. (2008) J. Neurosci. 28, 6264-6271
32. Sato, C., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2006) J. Neurosci. 26, 12081-12088
33. Sobhanifar, S., Schneider, B., Löhr, F., Gottstein, D., Ikeya, T., Mlynarczyk, K., Pulawski, W., Ghoshdastider, U., Kolinski, M., Filipek, S., Güntert, P., Bernhard, F., and Dötsch, V. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 9644-9649
34. Grynkiewicz, G., Poenie, M., and Tsien, R. Y. (1985) J. Biol. Chem. 260, 3440-3450
35. Hofer, A. M. (1999) Methods Mol. Biol. 114, 249-265
36. Zhang, H., Sun, S., Herreman, A., De Strooper, B., and Bezprozvanny, I. (2010) J. Neurosci. 30, 8566-8580
37. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) J. Biol. Chem. 281, 14670-14676
38. MacKinnon, R. (1995) Neuron 14, 889-892
39. Takagi, S., Tominaga, A., Sato, C., Tomita, T., and Iwatsubo, T. (2010) J. Neurosci. 30, 15943-15950
40. Herl, L., Lleo, A., Thomas, A. V., Nyborg, A. C., Jansen, K., Golde, T. E., Hyman, B. T., and Berezovska, O. (2006) Biochem. Biophys. Res. Commun. 340, 668-674
41. Cervantes, S., Gonzàlez-Duarte, R., and Marfany, G. (2001) FEBS Lett. 505, 81-86
42. Hébert, S. S., Godin, C., Tomiyama, T., Mori, H., and Lévesque, G. (2003) Biochem. Biophys. Res. Commun. 301, 119-126
43. Cervantes, S., Saura, C. A., Pomares, E., Gonzàlez-Duarte, R., and Marfany, G. (2004) J. Biol. Chem. 279, 36519-36529