Changes in the expression of the Alzheimer's disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction

Current Alzheimer Research

Volumn 8, Issue 3, 2011, Pages 313-322

  Li, A ^a   Zhou, C ^b   Moore, J ^a   Zhang, P ^a   Tsai, T H ^b   Lee, H C ^b   Romano, D M ^a   McKee, M L ^a   Schoenfeld, D A ^c   Serra, M J ^a   Raygor, K ^a   Cantiello, H F ^a   Fujimoto, J G ^b   Tanzi, R E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b USA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Alzheimer's disease; Calcium channel; Cardiomyopathy; Drosophila; Heart; Presenilin

Indexed keywords

COMPLEMENTARY DNA; DROSOPHILA PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MESSENGER RNA; PRESENILIN; PROTEIN PATCHED; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; WNT1 PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DPSN GENE; DROSOPHILA; FORELIMB; GENE; GENE OVEREXPRESSION; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART RATE; LIMB DEVELOPMENT; MALE; MITOCHONDRIAL TOXICITY; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CALCIUM CHANNELS; CARDIOMYOPATHIES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; PRESENILINS; REAL-TIME POLYMERASE CHAIN REACTION; TOMOGRAPHY, OPTICAL COHERENCE; WNT SIGNALING PATHWAY;

EID: 79956310601     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720511795563746     Document Type: Article

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