Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events

Molecular Brain Research

Volumn 122, Issue 1, 2004, Pages 17-23

  Scheper, Wiep ^a   Zwart, Rob ^a   Baas, Frank ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer's disease; Degenerative disease: Alzheimer's miscellaneous; Disorders of the nervous system; Phosphorylation; Presenilin 1; Protein trafficking; Rab6

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALCINEURIN; PRESENILIN 1; PROTEIN KINASE C; PROTEIN RAB6; RAB PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; FIBROBLAST; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; REGULATORY MECHANISM;

EID: 1342306722     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2003.11.013     Document Type: Article

References (24)

1. Beranger F., Mange A., Goud B., Lehmann S. Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells. J. Biol. Chem. 277:2002;38972-38977.
2. Bordier C. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256:1981;1604-1607.
3. Caputi A., Barindelli S., Pastorino L., Cimino M., Buxbaum J.D., Cattabeni F., Di Luca M. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C. J. Neurochem. 68:1997;2523-2529.
4. Cook D.G., Forman M.S., Sung J.C., Leight S., Kolson D.L., Iwatsubo T., Lee V.M., Doms R.W. Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat. Med. 3:1997;1021-1023.
5. Desdouits F., Buxbaum J.D., Desdouits-Magnen J., Nairn A.C., Greengard P. Amyloid alpha peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. J. Biol. Chem. 271:1996;24670-24674.
6. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1998;387-390.
7. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522.
8. Doan A., Thinakaran G., Borchelt D.R., Slunt H.H., Ratovitsky T., Podlisny M., Selkoe D.J., Seeger M., Gandy S.E., Price D.L., Sisodia S.S. Protein topology of presenilin 1. Neuron. 17:1996;1023-1030.
9. Fitzgerald M.L., Reed G.L. Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochem. J. 342(Pt 2):1999;353-360.
10. Girod A., Storrie B., Simpson J.C., Johannes L., Goud B., Roberts L.M., Lord J.M., Nilsson T., Pepperkok R. Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum. Nat. Cell Biol. 1:1999;423-430.
11. Hartmann T., Bieger S.C., Bruhl B., Tienari P.J., Ida N., Allsop D., Roberts G.W., Masters C.L., Dotti C.G., Unsicker K., Beyreuther K. Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat. Med. 3:1997;1016-1020.
12. Hartmann D., Tournoy J., Saftig P., Annaert W., DeStrooper B. Implication of APP secretases in notch signaling. J. Mol. Neurosci. 17:2001;171-181.
13. Hata R., Masumura M., Akatsu H., Li F., Fujita H., Nagai Y., Yamamoto T., Okada H., Kosaka K., Sakanaka M., Sawada T. Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray. Biochem. Biophys. Res. Commun. 284:2001;310-316.
14. Kouchi Z., Kinouchi T., Sorimachi H., Ishiura S., Suzuki K. The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis. Eur. J. Biochem. 258:1998;291-300.
15. McConlogue L., Castellano F., deWit C., Schenk D., Maltese W.A. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J. Biol. Chem. 271:1996;1343-1348.
16. Novick P., Zerial M. The diversity of Rab proteins in vesicle transport. Curr. Opin. Cell Biol. 9:1997;496-504.
17. Palacino J.J., Berechid B.E., Alexander P., Eckman C., Younkin S., Nye J.S., Wolozin B. Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. J. Biol. Chem. 275:2000;215-222.
18. Purcell K., Artavanis-Tsakonas S. The developmental role of warthog, the notch modifier encoding Drab6. J. Cell Biol. 146:1999;731-740.
19. Scheper W., Zwart R., Sluijs P., Annaert W., Gool W.A., Baas F. Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor. Hum. Mol. Genet. 9:2000;303-310.
20. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
21. Selkoe D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8:1998;447-453.
22. Thinakaran G., Teplow D.B., Siman R., Greenberg B., Sisodia S.S. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J. Biol. Chem. 271:1996;9390-9397.
23. Weggen S., Eriksen J.L., Das P., Sagi S.A., Wang R., Pietrzik C.U., Findlay K.A., Smith T.E., Murphy M.P., Bulter T., Kang D.E., Marquez-Sterling N., Golde T.E., Koo E.H. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414:2001;212-216.
24. White J., Johannes L., Mallard F., Girod A., Grill S., Reinsch S., Keller P., Tzschaschel B., Echard A., Goud B., Stelzer E.H. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J. Cell Biol. 147:1999;743-760.