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Volumn 1861, Issue 11, 2016, Pages 1719-1726

Stearoyl-CoA desaturase-1 and adaptive stress signaling

Author keywords

Endoplasmic reticulum; Lipidomics; Lipotoxicity; Monounsaturated fatty acid; Stearoyl CoA desaturase; Stress adaption

Indexed keywords

ACYL COENZYME A DESATURASE 1; INSULIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; ACYL COENZYME A DESATURASE;

EID: 84983364801     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2016.08.009     Document Type: Review
Times cited : (34)

References (116)
  • 2
    • 84859051382 scopus 로고    scopus 로고
    • Hormetic signaling patterns
    • [2] Wetzker, R., Rubio, I., Hormetic signaling patterns. Dose-Response 10 (2012), 83–90.
    • (2012) Dose-Response , vol.10 , pp. 83-90
    • Wetzker, R.1    Rubio, I.2
  • 3
    • 84867235842 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase: rogue or innocent bystander?
    • [3] Hodson, L., Fielding, B.A., Stearoyl-CoA desaturase: rogue or innocent bystander?. Prog. Lipid Res. 52 (2013), 15–42.
    • (2013) Prog. Lipid Res. , vol.52 , pp. 15-42
    • Hodson, L.1    Fielding, B.A.2
  • 4
    • 81555209601 scopus 로고    scopus 로고
    • Stearoyl CoA desaturase 1: role in cellular inflammation and stress
    • [4] Liu, X., Strable, M.S., Ntambi, J.M., Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv. Nutr. 2 (2011), 15–22.
    • (2011) Adv. Nutr. , vol.2 , pp. 15-22
    • Liu, X.1    Strable, M.S.2    Ntambi, J.M.3
  • 5
    • 77956290719 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
    • [5] Igal, R.A., Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31 (2010), 1509–1515.
    • (2010) Carcinogenesis , vol.31 , pp. 1509-1515
    • Igal, R.A.1
  • 6
    • 84920279688 scopus 로고    scopus 로고
    • Metabolic reprogramming of the heart through stearoyl-CoA desaturase
    • [6] Dobrzyn, P., Bednarski, T., Dobrzyn, A., Metabolic reprogramming of the heart through stearoyl-CoA desaturase. Prog. Lipid Res. 57 (2015), 1–12.
    • (2015) Prog. Lipid Res. , vol.57 , pp. 1-12
    • Dobrzyn, P.1    Bednarski, T.2    Dobrzyn, A.3
  • 7
    • 84893441702 scopus 로고    scopus 로고
    • Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
    • [7] Sampath, H., Ntambi, J.M., Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J. Biol. Chem. 289 (2014), 2482–2488.
    • (2014) J. Biol. Chem. , vol.289 , pp. 2482-2488
    • Sampath, H.1    Ntambi, J.M.2
  • 8
    • 84255163040 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation
    • [8] Sampath, H., Ntambi, J.M., The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann. N. Y. Acad. Sci. 1243 (2011), 47–53.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1243 , pp. 47-53
    • Sampath, H.1    Ntambi, J.M.2
  • 9
    • 84884934739 scopus 로고    scopus 로고
    • Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
    • [9] Stamatikos, A.D., Paton, C.M., Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am. J. Phys. 305 (2013), E767–E775.
    • (2013) Am. J. Phys. , vol.305 , pp. E767-E775
    • Stamatikos, A.D.1    Paton, C.M.2
  • 10
    • 84903553831 scopus 로고    scopus 로고
    • Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease
    • [10] Zhang, Z., Dales, N.A., Winther, M.D., Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. J. Med. Chem. 57 (2014), 5039–5056.
    • (2014) J. Med. Chem. , vol.57 , pp. 5039-5056
    • Zhang, Z.1    Dales, N.A.2    Winther, M.D.3
  • 11
    • 84960802555 scopus 로고    scopus 로고
    • Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors
    • [11] Uto, Y., Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors. Chem. Phys. Lipids 197 (2016), 3–12.
    • (2016) Chem. Phys. Lipids , vol.197 , pp. 3-12
    • Uto, Y.1
  • 13
    • 79953114569 scopus 로고    scopus 로고
    • Mechanisms of glycerophospholipid homeostasis in mammalian cells
    • [13] Hermansson, M., Hokynar, K., Somerharju, P., Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog. Lipid Res. 50 (2011), 240–257.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 240-257
    • Hermansson, M.1    Hokynar, K.2    Somerharju, P.3
  • 14
    • 84899551393 scopus 로고    scopus 로고
    • Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
    • [14] Hishikawa, D., Hashidate, T., Shimizu, T., Shindou, H., Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells. J. Lipid Res. 55 (2014), 799–807.
    • (2014) J. Lipid Res. , vol.55 , pp. 799-807
    • Hishikawa, D.1    Hashidate, T.2    Shimizu, T.3    Shindou, H.4
  • 15
    • 0025676462 scopus 로고
    • Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene
    • [15] Mihara, K., Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. J. Biochem. 108 (1990), 1022–1029.
    • (1990) J. Biochem. , vol.108 , pp. 1022-1029
    • Mihara, K.1
  • 16
    • 0024297268 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
    • [16] Ntambi, J.M., Buhrow, S.A., Kaestner, K.H., Christy, R.J., Sibley, E., Kelly, T.J. Jr., Lane, M.D., Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 263 (1988), 17291–17300.
    • (1988) J. Biol. Chem. , vol.263 , pp. 17291-17300
    • Ntambi, J.M.1    Buhrow, S.A.2    Kaestner, K.H.3    Christy, R.J.4    Sibley, E.5    Kelly, T.J.6    Lane, M.D.7
  • 18
    • 77954579285 scopus 로고    scopus 로고
    • Decrease in membrane phospholipid unsaturation induces unfolded protein response
    • [18] Ariyama, H., Kono, N., Matsuda, S., Inoue, T., Arai, H., Decrease in membrane phospholipid unsaturation induces unfolded protein response. J. Biol. Chem. 285 (2010), 22027–22035.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22027-22035
    • Ariyama, H.1    Kono, N.2    Matsuda, S.3    Inoue, T.4    Arai, H.5
  • 19
    • 19744379323 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    • [19] Dobrzyn, A., Dobrzyn, P., Miyazaki, M., Sampath, H., Chu, K., Ntambi, J.M., Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J. Biol. Chem. 280 (2005), 23356–23362.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23356-23362
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3    Sampath, H.4    Chu, K.5    Ntambi, J.M.6
  • 20
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • [20] Miyazaki, M., Kim, Y.C., Gray-Keller, M.P., Attie, A.D., Ntambi, J.M., The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 275 (2000), 30132–30138.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 21
    • 84933496688 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis
    • [21] Koeberle, A., Pergola, C., Shindou, H., Koeberle, S.C., Shimizu, T., Laufer, S.A., Werz, O., Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. FASEB J. 29 (2015), 2439–2449.
    • (2015) FASEB J. , vol.29 , pp. 2439-2449
    • Koeberle, A.1    Pergola, C.2    Shindou, H.3    Koeberle, S.C.4    Shimizu, T.5    Laufer, S.A.6    Werz, O.7
  • 22
    • 78650510481 scopus 로고    scopus 로고
    • Hormonal and nutritional regulation of SCD1 gene expression
    • [22] Mauvoisin, D., Mounier, C., Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 93 (2011), 78–86.
    • (2011) Biochimie , vol.93 , pp. 78-86
    • Mauvoisin, D.1    Mounier, C.2
  • 23
    • 0034847971 scopus 로고    scopus 로고
    • Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    • [23] Miyazaki, M., Man, W.C., Ntambi, J.M., Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J. Nutr. 131 (2001), 2260–2268.
    • (2001) J. Nutr. , vol.131 , pp. 2260-2268
    • Miyazaki, M.1    Man, W.C.2    Ntambi, J.M.3
  • 25
    • 0032871502 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • [25] Ntambi, J.M., Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40 (1999), 1549–1558.
    • (1999) J. Lipid Res. , vol.40 , pp. 1549-1558
    • Ntambi, J.M.1
  • 26
    • 79957896666 scopus 로고    scopus 로고
    • Sixteen years and counting: an update on leptin in energy balance
    • [26] Gautron, L., Elmquist, J.K., Sixteen years and counting: an update on leptin in energy balance. J. Clin. Invest. 121 (2011), 2087–2093.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2087-2093
    • Gautron, L.1    Elmquist, J.K.2
  • 27
    • 78449298919 scopus 로고    scopus 로고
    • Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding
    • [27] Turyn, J., Stojek, M., Swierczynski, J., Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding. Mol. Cell. Biochem. 345 (2010), 181–188.
    • (2010) Mol. Cell. Biochem. , vol.345 , pp. 181-188
    • Turyn, J.1    Stojek, M.2    Swierczynski, J.3
  • 28
    • 0030598353 scopus 로고    scopus 로고
    • Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice
    • [28] Lee, K.N., Pariza, M.W., Ntambi, J.M., Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice. Biochim. Biophys. Acta 1304 (1996), 85–88.
    • (1996) Biochim. Biophys. Acta , vol.1304 , pp. 85-88
    • Lee, K.N.1    Pariza, M.W.2    Ntambi, J.M.3
  • 29
    • 84898600202 scopus 로고    scopus 로고
    • Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRalpha-SREBP1c-dependent mechanism
    • [29] Zhang, X., Liu, J., Su, W., Wu, J., Wang, C., Kong, X., Gustafsson, J.A., Ding, J., Ma, X., Guan, Y., Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRalpha-SREBP1c-dependent mechanism. J Diabetes 6 (2014), 212–220.
    • (2014) J Diabetes , vol.6 , pp. 212-220
    • Zhang, X.1    Liu, J.2    Su, W.3    Wu, J.4    Wang, C.5    Kong, X.6    Gustafsson, J.A.7    Ding, J.8    Ma, X.9    Guan, Y.10
  • 30
    • 84876343990 scopus 로고    scopus 로고
    • cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells
    • e59763
    • [30] Antony, N., Weir, J.R., McDougall, A.R., Mantamadiotis, T., Meikle, P.J., Cole, T.J., Bird, A.D., cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One, 8, 2013, e59763.
    • (2013) PLoS One , vol.8
    • Antony, N.1    Weir, J.R.2    McDougall, A.R.3    Mantamadiotis, T.4    Meikle, P.J.5    Cole, T.J.6    Bird, A.D.7
  • 31
    • 0034254990 scopus 로고    scopus 로고
    • The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation
    • [31] Mziaut, H., Korza, G., Ozols, J., The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 8883–8888.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 8883-8888
    • Mziaut, H.1    Korza, G.2    Ozols, J.3
  • 32
    • 33745496962 scopus 로고    scopus 로고
    • Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase
    • [32] Kato, H., Sakaki, K., Mihara, K., Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J. Cell Sci. 119 (2006), 2342–2353.
    • (2006) J. Cell Sci. , vol.119 , pp. 2342-2353
    • Kato, H.1    Sakaki, K.2    Mihara, K.3
  • 33
    • 0031773193 scopus 로고    scopus 로고
    • Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease
    • [33] Heinemann, F.S., Ozols, J., Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Mol. Biol. Cell 9 (1998), 3445–3453.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3445-3453
    • Heinemann, F.S.1    Ozols, J.2
  • 34
    • 84885953389 scopus 로고    scopus 로고
    • Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation
    • [34] Schwenk, R.W., Jonas, W., Ernst, S.B., Kammel, A., Jahnert, M., Schurmann, A., Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation. Horm. Metab. Res. 45 (2013), 786–794.
    • (2013) Horm. Metab. Res. , vol.45 , pp. 786-794
    • Schwenk, R.W.1    Jonas, W.2    Ernst, S.B.3    Kammel, A.4    Jahnert, M.5    Schurmann, A.6
  • 36
    • 4644340815 scopus 로고    scopus 로고
    • Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    • [36] Lee, S.H., Dobrzyn, A., Dobrzyn, P., Rahman, S.M., Miyazaki, M., Ntambi, J.M., Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J. Lipid Res. 45 (2004), 1674–1682.
    • (2004) J. Lipid Res. , vol.45 , pp. 1674-1682
    • Lee, S.H.1    Dobrzyn, A.2    Dobrzyn, P.3    Rahman, S.M.4    Miyazaki, M.5    Ntambi, J.M.6
  • 37
    • 67749111842 scopus 로고    scopus 로고
    • Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    • [37] Sampath, H., Flowers, M.T., Liu, X., Paton, C.M., Sullivan, R., Chu, K., Zhao, M., Ntambi, J.M., Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284 (2009), 19961–19973.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19961-19973
    • Sampath, H.1    Flowers, M.T.2    Liu, X.3    Paton, C.M.4    Sullivan, R.5    Chu, K.6    Zhao, M.7    Ntambi, J.M.8
  • 38
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    • [38] Gutierrez-Juarez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B.P., Rossetti, L., Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. 116 (2006), 1686–1695.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3    Ono, H.4    Bhanot, S.5    Monia, B.P.6    Rossetti, L.7
  • 39
    • 84870472400 scopus 로고    scopus 로고
    • Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases
    • [39] Narce, M., Bellenger, J., Rialland, M., Bellenger, S., Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases. Curr. Drug Metab. 13 (2012), 1454–1463.
    • (2012) Curr. Drug Metab. , vol.13 , pp. 1454-1463
    • Narce, M.1    Bellenger, J.2    Rialland, M.3    Bellenger, S.4
  • 42
    • 84955615968 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis
    • [42] Chen, L., Ren, J., Yang, L., Li, Y., Fu, J., Li, Y., Tian, Y., Qiu, F., Liu, Z., Qiu, Y., Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis. Sci. Rep., 6, 2016, 19665.
    • (2016) Sci. Rep. , vol.6 , pp. 19665
    • Chen, L.1    Ren, J.2    Yang, L.3    Li, Y.4    Fu, J.5    Li, Y.6    Tian, Y.7    Qiu, F.8    Liu, Z.9    Qiu, Y.10
  • 44
    • 84869215008 scopus 로고    scopus 로고
    • FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
    • [44] Du, X., Wang, Q.R., Chan, E., Merchant, M., Liu, J., French, D., Ashkenazi, A., Qing, J., FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 72 (2012), 5843–5855.
    • (2012) Cancer Res. , vol.72 , pp. 5843-5855
    • Du, X.1    Wang, Q.R.2    Chan, E.3    Merchant, M.4    Liu, J.5    French, D.6    Ashkenazi, A.7    Qing, J.8
  • 45
    • 54049084951 scopus 로고    scopus 로고
    • Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis
    • [45] Scaglia, N., Igal, R.A., Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int. J. Oncol. 33 (2008), 839–850.
    • (2008) Int. J. Oncol. , vol.33 , pp. 839-850
    • Scaglia, N.1    Igal, R.A.2
  • 47
    • 84983333937 scopus 로고    scopus 로고
    • XEN801 for the treatment of acne
    • [47] Pharma, X., XEN801 for the treatment of acne. http://www.xenon-pharma.com/product-candidates/dermatologic/, 2015.
    • (2015)
    • Pharma, X.1
  • 50
    • 45449126566 scopus 로고    scopus 로고
    • Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    • [50] Flowers, M.T., Keller, M.P., Choi, Y., Lan, H., Kendziorski, C., Ntambi, J.M., Attie, A.D., Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol. Genomics 33 (2008), 361–372.
    • (2008) Physiol. Genomics , vol.33 , pp. 361-372
    • Flowers, M.T.1    Keller, M.P.2    Choi, Y.3    Lan, H.4    Kendziorski, C.5    Ntambi, J.M.6    Attie, A.D.7
  • 51
    • 0031052912 scopus 로고    scopus 로고
    • The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane
    • [51] Clamp, A.G., Ladha, S., Clark, D.C., Grimble, R.F., Lund, E.K., The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane. Lipids 32 (1997), 179–184.
    • (1997) Lipids , vol.32 , pp. 179-184
    • Clamp, A.G.1    Ladha, S.2    Clark, D.C.3    Grimble, R.F.4    Lund, E.K.5
  • 52
    • 0018171346 scopus 로고
    • Membrane lipid modification of chinese hamster ovary cells. Thermal properties of membrane phospholipids
    • [52] Rintoul, D.A., Sklar, L.A., Simoni, R.D., Membrane lipid modification of chinese hamster ovary cells. Thermal properties of membrane phospholipids. J. Biol. Chem. 253 (1978), 7447–7452.
    • (1978) J. Biol. Chem. , vol.253 , pp. 7447-7452
    • Rintoul, D.A.1    Sklar, L.A.2    Simoni, R.D.3
  • 55
    • 84894468653 scopus 로고    scopus 로고
    • Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway
    • [55] Tan, S.H., Shui, G., Zhou, J., Shi, Y., Huang, J., Xia, D., Wenk, M.R., Shen, H.M., Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy 10 (2014), 226–242.
    • (2014) Autophagy , vol.10 , pp. 226-242
    • Tan, S.H.1    Shui, G.2    Zhou, J.3    Shi, Y.4    Huang, J.5    Xia, D.6    Wenk, M.R.7    Shen, H.M.8
  • 57
    • 84929707757 scopus 로고    scopus 로고
    • SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition
    • [57] Ralston, J.C., Mutch, D.M., SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition. Prostaglandins Leukot. Essent. Fatty Acids 98 (2015), 29–37.
    • (2015) Prostaglandins Leukot. Essent. Fatty Acids , vol.98 , pp. 29-37
    • Ralston, J.C.1    Mutch, D.M.2
  • 58
    • 65249119361 scopus 로고    scopus 로고
    • Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    • [58] Shimizu, T., Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49 (2009), 123–150.
    • (2009) Annu. Rev. Pharmacol. Toxicol. , vol.49 , pp. 123-150
    • Shimizu, T.1
  • 59
    • 84873733953 scopus 로고    scopus 로고
    • Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding
    • [59] Koeberle, A., Shindou, H., Koeberle, S.C., Laufer, S.A., Shimizu, T., Werz, O., Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 2546–2551.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 2546-2551
    • Koeberle, A.1    Shindou, H.2    Koeberle, S.C.3    Laufer, S.A.4    Shimizu, T.5    Werz, O.6
  • 60
    • 84864556250 scopus 로고    scopus 로고
    • Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol
    • [60] Koeberle, A., Shindou, H., Harayama, T., Shimizu, T., Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J. Biol. Chem. 287 (2012), 27244–27254.
    • (2012) J. Biol. Chem. , vol.287 , pp. 27244-27254
    • Koeberle, A.1    Shindou, H.2    Harayama, T.3    Shimizu, T.4
  • 61
    • 77953807871 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase and insulin signaling—what is the molecular switch?
    • [61] Dobrzyn, P., Jazurek, M., Dobrzyn, A., Stearoyl-CoA desaturase and insulin signaling—what is the molecular switch?. Biochim. Biophys. Acta 1797 (2010), 1189–1194.
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 1189-1194
    • Dobrzyn, P.1    Jazurek, M.2    Dobrzyn, A.3
  • 62
    • 84942609928 scopus 로고    scopus 로고
    • Metabolic, anabolic, and mitogenic insulin responses: a tissue-specific perspective for insulin receptor activators
    • [62] Bedinger, D.H., Adams, S.H., Metabolic, anabolic, and mitogenic insulin responses: a tissue-specific perspective for insulin receptor activators. Mol. Cell. Endocrinol. 415 (2015), 143–156.
    • (2015) Mol. Cell. Endocrinol. , vol.415 , pp. 143-156
    • Bedinger, D.H.1    Adams, S.H.2
  • 63
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • [63] Hers, I., Vincent, E.E., Tavare, J.M., Akt signalling in health and disease. Cell. Signal. 23 (2011), 1515–1527.
    • (2011) Cell. Signal. , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 64
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    • [64] Rahman, S.M., Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Ntambi, J.M., Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 11110–11115.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.M.6
  • 65
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • [65] McGarry, J.D., Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 (2002), 7–18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 67
    • 84940738579 scopus 로고    scopus 로고
    • Molecular pathways: is AMPK a friend or a foe in cancer?
    • [67] Hardie, D.G., Molecular pathways: is AMPK a friend or a foe in cancer?. Clin. Cancer Res. 21 (2015), 3836–3840.
    • (2015) Clin. Cancer Res. , vol.21 , pp. 3836-3840
    • Hardie, D.G.1
  • 70
    • 13844250258 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    • [70] Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M., Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288 (2005), E599–E607.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288 , pp. E599-E607
    • Dobrzyn, A.1    Dobrzyn, P.2    Lee, S.H.3    Miyazaki, M.4    Cohen, P.5    Asilmaz, E.6    Hardie, D.G.7    Friedman, J.M.8    Ntambi, J.M.9
  • 71
    • 2942588527 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    • [71] Miyazaki, M., Dobrzyn, A., Man, W.C., Chu, K., Sampath, H., Kim, H.J., Ntambi, J.M., Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J. Biol. Chem. 279 (2004), 25164–25171.
    • (2004) J. Biol. Chem. , vol.279 , pp. 25164-25171
    • Miyazaki, M.1    Dobrzyn, A.2    Man, W.C.3    Chu, K.4    Sampath, H.5    Kim, H.J.6    Ntambi, J.M.7
  • 72
    • 84934275896 scopus 로고    scopus 로고
    • Proteostasis control by the unfolded protein response
    • [72] Hetz, C., Chevet, E., Oakes, S.A., Proteostasis control by the unfolded protein response. Nat. Cell Biol. 17 (2015), 829–838.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 829-838
    • Hetz, C.1    Chevet, E.2    Oakes, S.A.3
  • 73
    • 77957121400 scopus 로고    scopus 로고
    • Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells
    • [73] Thorn, K., Hovsepyan, M., Bergsten, P., Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells. Lipids Health Dis., 9, 2010, 108.
    • (2010) Lipids Health Dis. , vol.9 , pp. 108
    • Thorn, K.1    Hovsepyan, M.2    Bergsten, P.3
  • 74
    • 84936804235 scopus 로고    scopus 로고
    • PPARgamma agonists attenuate palmitate-induced ER stress through up-regulation of SCD-1 in macrophages
    • [74] Ikeda, J., Ichiki, T., Takahara, Y., Kojima, H., Sankoda, C., Kitamoto, S., Tokunou, T., Sunagawa, K., PPARgamma agonists attenuate palmitate-induced ER stress through up-regulation of SCD-1 in macrophages. PLoS One, 10, 2015, e0128546.
    • (2015) PLoS One , vol.10 , pp. e0128546
    • Ikeda, J.1    Ichiki, T.2    Takahara, Y.3    Kojima, H.4    Sankoda, C.5    Kitamoto, S.6    Tokunou, T.7    Sunagawa, K.8
  • 75
    • 34248198871 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    • [75] Flowers, J.B., Rabaglia, M.E., Schueler, K.L., Flowers, M.T., Lan, H., Keller, M.P., Ntambi, J.M., Attie, A.D., Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56 (2007), 1228–1239.
    • (2007) Diabetes , vol.56 , pp. 1228-1239
    • Flowers, J.B.1    Rabaglia, M.E.2    Schueler, K.L.3    Flowers, M.T.4    Lan, H.5    Keller, M.P.6    Ntambi, J.M.7    Attie, A.D.8
  • 76
    • 84898007635 scopus 로고    scopus 로고
    • De novo fatty acid synthesis at the mitotic exit is required to complete cellular division
    • [76] Scaglia, N., Tyekucheva, S., Zadra, G., Photopoulos, C., Loda, M., De novo fatty acid synthesis at the mitotic exit is required to complete cellular division. Cell Cycle 13 (2014), 859–868.
    • (2014) Cell Cycle , vol.13 , pp. 859-868
    • Scaglia, N.1    Tyekucheva, S.2    Zadra, G.3    Photopoulos, C.4    Loda, M.5
  • 77
    • 34247894035 scopus 로고    scopus 로고
    • Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
    • [77] Qin, X., Tian, J., Zhang, P., Fan, Y., Chen, L., Guan, Y., Fu, Y., Zhu, Y., Chien, S., Wang, N., Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc. Res. 74 (2007), 506–514.
    • (2007) Cardiovasc. Res. , vol.74 , pp. 506-514
    • Qin, X.1    Tian, J.2    Zhang, P.3    Fan, Y.4    Chen, L.5    Guan, Y.6    Fu, Y.7    Zhu, Y.8    Chien, S.9    Wang, N.10
  • 78
    • 84952802286 scopus 로고    scopus 로고
    • SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: effects on cellular stress, inflammatory markers and fatty acid elongation
    • [78] Ralston, J.C., Metherel, A.H., Stark, K.D., Mutch, D.M., SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: effects on cellular stress, inflammatory markers and fatty acid elongation. J. Nutr. Biochem. 27 (2016), 241–248.
    • (2016) J. Nutr. Biochem. , vol.27 , pp. 241-248
    • Ralston, J.C.1    Metherel, A.H.2    Stark, K.D.3    Mutch, D.M.4
  • 79
    • 68049142428 scopus 로고    scopus 로고
    • Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    • [79] Peter, A., Weigert, C., Staiger, H., Machicao, F., Schick, F., Machann, J., Stefan, N., Thamer, C., Haring, H.U., Schleicher, E., Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58 (2009), 1757–1765.
    • (2009) Diabetes , vol.58 , pp. 1757-1765
    • Peter, A.1    Weigert, C.2    Staiger, H.3    Machicao, F.4    Schick, F.5    Machann, J.6    Stefan, N.7    Thamer, C.8    Haring, H.U.9    Schleicher, E.10
  • 80
    • 25844454854 scopus 로고    scopus 로고
    • Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
    • [80] Busch, A.K., Gurisik, E., Cordery, D.V., Sudlow, M., Denyer, G.S., Laybutt, D.R., Hughes, W.E., Biden, T.J., Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes 54 (2005), 2917–2924.
    • (2005) Diabetes , vol.54 , pp. 2917-2924
    • Busch, A.K.1    Gurisik, E.2    Cordery, D.V.3    Sudlow, M.4    Denyer, G.S.5    Laybutt, D.R.6    Hughes, W.E.7    Biden, T.J.8
  • 82
    • 84920463916 scopus 로고    scopus 로고
    • Autophagy in cellular metabolism and cancer
    • [82] Jiang, X., Overholtzer, M., Thompson, C.B., Autophagy in cellular metabolism and cancer. J. Clin. Invest. 125 (2015), 47–54.
    • (2015) J. Clin. Invest. , vol.125 , pp. 47-54
    • Jiang, X.1    Overholtzer, M.2    Thompson, C.B.3
  • 83
    • 84964260843 scopus 로고    scopus 로고
    • ER stress: autophagy induction, inhibition and selection
    • [83] Rashid, H.O., Yadav, R.K., Kim, H.R., Chae, H.J., ER stress: autophagy induction, inhibition and selection. Autophagy 11 (2015), 1956–1977.
    • (2015) Autophagy , vol.11 , pp. 1956-1977
    • Rashid, H.O.1    Yadav, R.K.2    Kim, H.R.3    Chae, H.J.4
  • 85
    • 0022376408 scopus 로고
    • Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes
    • [85] Reunanen, H., Punnonen, E.L., Hirsimaki, P., Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes. Histochemistry 83 (1985), 513–517.
    • (1985) Histochemistry , vol.83 , pp. 513-517
    • Reunanen, H.1    Punnonen, E.L.2    Hirsimaki, P.3
  • 86
    • 84921605764 scopus 로고    scopus 로고
    • SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
    • [86] Huang, G.M., Jiang, Q.H., Cai, C., Qu, M., Shen, W., SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. Cancer Lett. 358 (2015), 180–190.
    • (2015) Cancer Lett. , vol.358 , pp. 180-190
    • Huang, G.M.1    Jiang, Q.H.2    Cai, C.3    Qu, M.4    Shen, W.5
  • 88
    • 84946554147 scopus 로고    scopus 로고
    • Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells
    • [88] Janikiewicz, J., Hanzelka, K., Dziewulska, A., Kozinski, K., Dobrzyn, P., Bernas, T., Dobrzyn, A., Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells. J. Lipid Res. 56 (2015), 1901–1911.
    • (2015) J. Lipid Res. , vol.56 , pp. 1901-1911
    • Janikiewicz, J.1    Hanzelka, K.2    Dziewulska, A.3    Kozinski, K.4    Dobrzyn, P.5    Bernas, T.6    Dobrzyn, A.7
  • 89
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • [89] Wagner, E.F., Nebreda, A.R., Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9 (2009), 537–549.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 90
    • 57049117856 scopus 로고    scopus 로고
    • Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
    • [90] Kim, I., Xu, W., Reed, J.C., Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov. 7 (2008), 1013–1030.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 1013-1030
    • Kim, I.1    Xu, W.2    Reed, J.C.3
  • 91
    • 32944478891 scopus 로고    scopus 로고
    • Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    • [91] Ranganathan, A.C., Zhang, L., Adam, A.P., Aguirre-Ghiso, J.A., Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66 (2006), 1702–1711.
    • (2006) Cancer Res. , vol.66 , pp. 1702-1711
    • Ranganathan, A.C.1    Zhang, L.2    Adam, A.P.3    Aguirre-Ghiso, J.A.4
  • 92
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
    • [92] Wang, X.Z., Ron, D., Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272 (1996), 1347–1349.
    • (1996) Science , vol.272 , pp. 1347-1349
    • Wang, X.Z.1    Ron, D.2
  • 93
    • 84872262047 scopus 로고    scopus 로고
    • Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells
    • [93] Mauvoisin, D., Charfi, C., Lounis, A.M., Rassart, E., Mounier, C., Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells. Cancer Sci. 104 (2013), 36–42.
    • (2013) Cancer Sci. , vol.104 , pp. 36-42
    • Mauvoisin, D.1    Charfi, C.2    Lounis, A.M.3    Rassart, E.4    Mounier, C.5
  • 94
    • 84884558970 scopus 로고    scopus 로고
    • Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins
    • [94] Rios-Esteves, J., Resh, M.D., Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep. 4 (2013), 1072–1081.
    • (2013) Cell Rep. , vol.4 , pp. 1072-1081
    • Rios-Esteves, J.1    Resh, M.D.2
  • 95
    • 84955490041 scopus 로고    scopus 로고
    • Fatty acylation of Wnt proteins
    • [95] Nile, A.H., Hannoush, R.N., Fatty acylation of Wnt proteins. Nat. Chem. Biol. 12 (2016), 60–69.
    • (2016) Nat. Chem. Biol. , vol.12 , pp. 60-69
    • Nile, A.H.1    Hannoush, R.N.2
  • 96
  • 98
    • 84888091333 scopus 로고    scopus 로고
    • Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
    • [98] Liu, J., Cinar, R., Xiong, K., Godlewski, G., Jourdan, T., Lin, Y., Ntambi, J.M., Kunos, G., Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 18832–18837.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 18832-18837
    • Liu, J.1    Cinar, R.2    Xiong, K.3    Godlewski, G.4    Jourdan, T.5    Lin, Y.6    Ntambi, J.M.7    Kunos, G.8
  • 102
    • 84906518583 scopus 로고    scopus 로고
    • Lipid regulation of BK channel function
    • [102] Dopico, A.M., Bukiya, A.N., Lipid regulation of BK channel function. Front. Physiol., 5, 2014, 312.
    • (2014) Front. Physiol. , vol.5 , pp. 312
    • Dopico, A.M.1    Bukiya, A.N.2
  • 103
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • [103] Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., Flier, J.S., TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116 (2006), 3015–3025.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 104
    • 80053554640 scopus 로고    scopus 로고
    • Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
    • [104] Holzer, R.G., Park, E.J., Li, N., Tran, H., Chen, M., Choi, C., Solinas, G., Karin, M., Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147 (2011), 173–184.
    • (2011) Cell , vol.147 , pp. 173-184
    • Holzer, R.G.1    Park, E.J.2    Li, N.3    Tran, H.4    Chen, M.5    Choi, C.6    Solinas, G.7    Karin, M.8
  • 105
    • 84875242776 scopus 로고    scopus 로고
    • Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
    • [105] Volmer, R., van der Ploeg, K., Ron, D., Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 4628–4633.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 4628-4633
    • Volmer, R.1    van der Ploeg, K.2    Ron, D.3
  • 106
    • 84943587206 scopus 로고    scopus 로고
    • Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders
    • [106] Koeberle, A., Werz, O., Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders. Biochem. Pharmacol. 98 (2015), 1–15.
    • (2015) Biochem. Pharmacol. , vol.98 , pp. 1-15
    • Koeberle, A.1    Werz, O.2
  • 107
    • 0030422424 scopus 로고    scopus 로고
    • Short-term regulation of acetyl CoA carboxylase in tissues of higher animals
    • [107] Allred, J.B., Reilly, K.E., Short-term regulation of acetyl CoA carboxylase in tissues of higher animals. Prog. Lipid Res. 35 (1996), 371–385.
    • (1996) Prog. Lipid Res. , vol.35 , pp. 371-385
    • Allred, J.B.1    Reilly, K.E.2
  • 108
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • [108] Cao, H., Gerhold, K., Mayers, J.R., Wiest, M.M., Watkins, S.M., Hotamisligil, G.S., Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134 (2008), 933–944.
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5    Hotamisligil, G.S.6
  • 109
    • 20444484914 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in the control of metabolism
    • [109] Dobrzyn, A., Ntambi, J.M., The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot. Essent. Fat. Acids 73 (2005), 35–41.
    • (2005) Prostaglandins Leukot. Essent. Fat. Acids , vol.73 , pp. 35-41
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 110
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • [110] Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., Lin, X., Watkins, S.M., Ivanov, A.R., Hotamisligil, G.S., Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473 (2011), 528–531.
    • (2011) Nature , vol.473 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3    Hofmann, O.4    Dicker, L.5    Hide, W.6    Lin, X.7    Watkins, S.M.8    Ivanov, A.R.9    Hotamisligil, G.S.10
  • 111
    • 84883163223 scopus 로고    scopus 로고
    • Membrane lipid saturation activates IRE1alpha without inducing clustering
    • [111] Kitai, Y., Ariyama, H., Kono, N., Oikawa, D., Iwawaki, T., Arai, H., Membrane lipid saturation activates IRE1alpha without inducing clustering. Genes Cells 18 (2013), 798–809.
    • (2013) Genes Cells , vol.18 , pp. 798-809
    • Kitai, Y.1    Ariyama, H.2    Kono, N.3    Oikawa, D.4    Iwawaki, T.5    Arai, H.6
  • 112
    • 33750906573 scopus 로고    scopus 로고
    • Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
    • [112] Pinnamaneni, S.K., Southgate, R.J., Febbraio, M.A., Watt, M.J., Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 49 (2006), 3027–3037.
    • (2006) Diabetologia , vol.49 , pp. 3027-3037
    • Pinnamaneni, S.K.1    Southgate, R.J.2    Febbraio, M.A.3    Watt, M.J.4
  • 114
    • 84954286761 scopus 로고    scopus 로고
    • Lipid droplets, lipophagy, and beyond
    • [114] Wang, C.W., Lipid droplets, lipophagy, and beyond. Biochim. Biophys. Acta 1861 (2016), 793–805.
    • (2016) Biochim. Biophys. Acta , vol.1861 , pp. 793-805
    • Wang, C.W.1
  • 115
    • 84877580262 scopus 로고    scopus 로고
    • Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
    • [115] Csermely, P., Korcsmaros, T., Kiss, H.J., London, G., Nussinov, R., Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. Pharmacol. Ther. 138 (2013), 333–408.
    • (2013) Pharmacol. Ther. , vol.138 , pp. 333-408
    • Csermely, P.1    Korcsmaros, T.2    Kiss, H.J.3    London, G.4    Nussinov, R.5
  • 116
    • 84919352979 scopus 로고    scopus 로고
    • Multi-target approach for natural products in inflammation
    • [116] Koeberle, A., Werz, O., Multi-target approach for natural products in inflammation. Drug Discov. Today 19 (2014), 1871–1882.
    • (2014) Drug Discov. Today , vol.19 , pp. 1871-1882
    • Koeberle, A.1    Werz, O.2


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