-
1
-
-
84962652590
-
Regulated cell death and adaptive stress responses
-
[1] Galluzzi, L., Bravo-San Pedro, J.M., Kepp, O., Kroemer, G., Regulated cell death and adaptive stress responses. Cell. Mol. Life Sci. 73 (2016), 2405–2410.
-
(2016)
Cell. Mol. Life Sci.
, vol.73
, pp. 2405-2410
-
-
Galluzzi, L.1
Bravo-San Pedro, J.M.2
Kepp, O.3
Kroemer, G.4
-
2
-
-
84859051382
-
Hormetic signaling patterns
-
[2] Wetzker, R., Rubio, I., Hormetic signaling patterns. Dose-Response 10 (2012), 83–90.
-
(2012)
Dose-Response
, vol.10
, pp. 83-90
-
-
Wetzker, R.1
Rubio, I.2
-
3
-
-
84867235842
-
Stearoyl-CoA desaturase: rogue or innocent bystander?
-
[3] Hodson, L., Fielding, B.A., Stearoyl-CoA desaturase: rogue or innocent bystander?. Prog. Lipid Res. 52 (2013), 15–42.
-
(2013)
Prog. Lipid Res.
, vol.52
, pp. 15-42
-
-
Hodson, L.1
Fielding, B.A.2
-
4
-
-
81555209601
-
Stearoyl CoA desaturase 1: role in cellular inflammation and stress
-
[4] Liu, X., Strable, M.S., Ntambi, J.M., Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv. Nutr. 2 (2011), 15–22.
-
(2011)
Adv. Nutr.
, vol.2
, pp. 15-22
-
-
Liu, X.1
Strable, M.S.2
Ntambi, J.M.3
-
5
-
-
77956290719
-
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
-
[5] Igal, R.A., Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31 (2010), 1509–1515.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1509-1515
-
-
Igal, R.A.1
-
6
-
-
84920279688
-
Metabolic reprogramming of the heart through stearoyl-CoA desaturase
-
[6] Dobrzyn, P., Bednarski, T., Dobrzyn, A., Metabolic reprogramming of the heart through stearoyl-CoA desaturase. Prog. Lipid Res. 57 (2015), 1–12.
-
(2015)
Prog. Lipid Res.
, vol.57
, pp. 1-12
-
-
Dobrzyn, P.1
Bednarski, T.2
Dobrzyn, A.3
-
7
-
-
84893441702
-
Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
-
[7] Sampath, H., Ntambi, J.M., Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J. Biol. Chem. 289 (2014), 2482–2488.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 2482-2488
-
-
Sampath, H.1
Ntambi, J.M.2
-
8
-
-
84255163040
-
The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation
-
[8] Sampath, H., Ntambi, J.M., The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann. N. Y. Acad. Sci. 1243 (2011), 47–53.
-
(2011)
Ann. N. Y. Acad. Sci.
, vol.1243
, pp. 47-53
-
-
Sampath, H.1
Ntambi, J.M.2
-
9
-
-
84884934739
-
Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
-
[9] Stamatikos, A.D., Paton, C.M., Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am. J. Phys. 305 (2013), E767–E775.
-
(2013)
Am. J. Phys.
, vol.305
, pp. E767-E775
-
-
Stamatikos, A.D.1
Paton, C.M.2
-
10
-
-
84903553831
-
Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease
-
[10] Zhang, Z., Dales, N.A., Winther, M.D., Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. J. Med. Chem. 57 (2014), 5039–5056.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5039-5056
-
-
Zhang, Z.1
Dales, N.A.2
Winther, M.D.3
-
11
-
-
84960802555
-
Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors
-
[11] Uto, Y., Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors. Chem. Phys. Lipids 197 (2016), 3–12.
-
(2016)
Chem. Phys. Lipids
, vol.197
, pp. 3-12
-
-
Uto, Y.1
-
12
-
-
0017181438
-
-
[12] Enoch, H.G., Catala, A., Strittmatter, P., et al. J. Biol. Chem. 251 (1976), 5095–5103.
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 5095-5103
-
-
Enoch, H.G.1
Catala, A.2
Strittmatter, P.3
-
13
-
-
79953114569
-
Mechanisms of glycerophospholipid homeostasis in mammalian cells
-
[13] Hermansson, M., Hokynar, K., Somerharju, P., Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog. Lipid Res. 50 (2011), 240–257.
-
(2011)
Prog. Lipid Res.
, vol.50
, pp. 240-257
-
-
Hermansson, M.1
Hokynar, K.2
Somerharju, P.3
-
14
-
-
84899551393
-
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
-
[14] Hishikawa, D., Hashidate, T., Shimizu, T., Shindou, H., Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells. J. Lipid Res. 55 (2014), 799–807.
-
(2014)
J. Lipid Res.
, vol.55
, pp. 799-807
-
-
Hishikawa, D.1
Hashidate, T.2
Shimizu, T.3
Shindou, H.4
-
15
-
-
0025676462
-
Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene
-
[15] Mihara, K., Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene. J. Biochem. 108 (1990), 1022–1029.
-
(1990)
J. Biochem.
, vol.108
, pp. 1022-1029
-
-
Mihara, K.1
-
16
-
-
0024297268
-
Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
-
[16] Ntambi, J.M., Buhrow, S.A., Kaestner, K.H., Christy, R.J., Sibley, E., Kelly, T.J. Jr., Lane, M.D., Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 263 (1988), 17291–17300.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 17291-17300
-
-
Ntambi, J.M.1
Buhrow, S.A.2
Kaestner, K.H.3
Christy, R.J.4
Sibley, E.5
Kelly, T.J.6
Lane, M.D.7
-
17
-
-
0032726605
-
Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
-
[17] Zheng, Y., Eilertsen, K.J., Ge, L., Zhang, L., Sundberg, J.P., Prouty, S.M., Stenn, K.S., Parimoo, S., Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse. Nat. Genet. 23 (1999), 268–270.
-
(1999)
Nat. Genet.
, vol.23
, pp. 268-270
-
-
Zheng, Y.1
Eilertsen, K.J.2
Ge, L.3
Zhang, L.4
Sundberg, J.P.5
Prouty, S.M.6
Stenn, K.S.7
Parimoo, S.8
-
18
-
-
77954579285
-
Decrease in membrane phospholipid unsaturation induces unfolded protein response
-
[18] Ariyama, H., Kono, N., Matsuda, S., Inoue, T., Arai, H., Decrease in membrane phospholipid unsaturation induces unfolded protein response. J. Biol. Chem. 285 (2010), 22027–22035.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22027-22035
-
-
Ariyama, H.1
Kono, N.2
Matsuda, S.3
Inoue, T.4
Arai, H.5
-
19
-
-
19744379323
-
Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
-
[19] Dobrzyn, A., Dobrzyn, P., Miyazaki, M., Sampath, H., Chu, K., Ntambi, J.M., Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J. Biol. Chem. 280 (2005), 23356–23362.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23356-23362
-
-
Dobrzyn, A.1
Dobrzyn, P.2
Miyazaki, M.3
Sampath, H.4
Chu, K.5
Ntambi, J.M.6
-
20
-
-
0034730532
-
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
-
[20] Miyazaki, M., Kim, Y.C., Gray-Keller, M.P., Attie, A.D., Ntambi, J.M., The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 275 (2000), 30132–30138.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30132-30138
-
-
Miyazaki, M.1
Kim, Y.C.2
Gray-Keller, M.P.3
Attie, A.D.4
Ntambi, J.M.5
-
21
-
-
84933496688
-
Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis
-
[21] Koeberle, A., Pergola, C., Shindou, H., Koeberle, S.C., Shimizu, T., Laufer, S.A., Werz, O., Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. FASEB J. 29 (2015), 2439–2449.
-
(2015)
FASEB J.
, vol.29
, pp. 2439-2449
-
-
Koeberle, A.1
Pergola, C.2
Shindou, H.3
Koeberle, S.C.4
Shimizu, T.5
Laufer, S.A.6
Werz, O.7
-
22
-
-
78650510481
-
Hormonal and nutritional regulation of SCD1 gene expression
-
[22] Mauvoisin, D., Mounier, C., Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 93 (2011), 78–86.
-
(2011)
Biochimie
, vol.93
, pp. 78-86
-
-
Mauvoisin, D.1
Mounier, C.2
-
23
-
-
0034847971
-
Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
-
[23] Miyazaki, M., Man, W.C., Ntambi, J.M., Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J. Nutr. 131 (2001), 2260–2268.
-
(2001)
J. Nutr.
, vol.131
, pp. 2260-2268
-
-
Miyazaki, M.1
Man, W.C.2
Ntambi, J.M.3
-
24
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
[24] Ntambi, J.M., Miyazaki, M., Stoehr, J.P., Lan, H., Kendziorski, C.M., Yandell, B.S., Song, Y., Cohen, P., Friedman, J.M., Attie, A.D., Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 11482–11486.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
Lan, H.4
Kendziorski, C.M.5
Yandell, B.S.6
Song, Y.7
Cohen, P.8
Friedman, J.M.9
Attie, A.D.10
-
25
-
-
0032871502
-
Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
-
[25] Ntambi, J.M., Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40 (1999), 1549–1558.
-
(1999)
J. Lipid Res.
, vol.40
, pp. 1549-1558
-
-
Ntambi, J.M.1
-
26
-
-
79957896666
-
Sixteen years and counting: an update on leptin in energy balance
-
[26] Gautron, L., Elmquist, J.K., Sixteen years and counting: an update on leptin in energy balance. J. Clin. Invest. 121 (2011), 2087–2093.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2087-2093
-
-
Gautron, L.1
Elmquist, J.K.2
-
27
-
-
78449298919
-
Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding
-
[27] Turyn, J., Stojek, M., Swierczynski, J., Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding. Mol. Cell. Biochem. 345 (2010), 181–188.
-
(2010)
Mol. Cell. Biochem.
, vol.345
, pp. 181-188
-
-
Turyn, J.1
Stojek, M.2
Swierczynski, J.3
-
28
-
-
0030598353
-
Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice
-
[28] Lee, K.N., Pariza, M.W., Ntambi, J.M., Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice. Biochim. Biophys. Acta 1304 (1996), 85–88.
-
(1996)
Biochim. Biophys. Acta
, vol.1304
, pp. 85-88
-
-
Lee, K.N.1
Pariza, M.W.2
Ntambi, J.M.3
-
29
-
-
84898600202
-
Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRalpha-SREBP1c-dependent mechanism
-
[29] Zhang, X., Liu, J., Su, W., Wu, J., Wang, C., Kong, X., Gustafsson, J.A., Ding, J., Ma, X., Guan, Y., Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRalpha-SREBP1c-dependent mechanism. J Diabetes 6 (2014), 212–220.
-
(2014)
J Diabetes
, vol.6
, pp. 212-220
-
-
Zhang, X.1
Liu, J.2
Su, W.3
Wu, J.4
Wang, C.5
Kong, X.6
Gustafsson, J.A.7
Ding, J.8
Ma, X.9
Guan, Y.10
-
30
-
-
84876343990
-
cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells
-
e59763
-
[30] Antony, N., Weir, J.R., McDougall, A.R., Mantamadiotis, T., Meikle, P.J., Cole, T.J., Bird, A.D., cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One, 8, 2013, e59763.
-
(2013)
PLoS One
, vol.8
-
-
Antony, N.1
Weir, J.R.2
McDougall, A.R.3
Mantamadiotis, T.4
Meikle, P.J.5
Cole, T.J.6
Bird, A.D.7
-
31
-
-
0034254990
-
The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation
-
[31] Mziaut, H., Korza, G., Ozols, J., The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 8883–8888.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 8883-8888
-
-
Mziaut, H.1
Korza, G.2
Ozols, J.3
-
32
-
-
33745496962
-
Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase
-
[32] Kato, H., Sakaki, K., Mihara, K., Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J. Cell Sci. 119 (2006), 2342–2353.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 2342-2353
-
-
Kato, H.1
Sakaki, K.2
Mihara, K.3
-
33
-
-
0031773193
-
Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease
-
[33] Heinemann, F.S., Ozols, J., Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Mol. Biol. Cell 9 (1998), 3445–3453.
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 3445-3453
-
-
Heinemann, F.S.1
Ozols, J.2
-
34
-
-
84885953389
-
Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation
-
[34] Schwenk, R.W., Jonas, W., Ernst, S.B., Kammel, A., Jahnert, M., Schurmann, A., Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation. Horm. Metab. Res. 45 (2013), 786–794.
-
(2013)
Horm. Metab. Res.
, vol.45
, pp. 786-794
-
-
Schwenk, R.W.1
Jonas, W.2
Ernst, S.B.3
Kammel, A.4
Jahnert, M.5
Schurmann, A.6
-
35
-
-
84903519779
-
Methylation levels of the SCD1 gene promoter and LINE-1 repeat region are associated with weight change: an intervention study
-
[35] Martin-Nunez, G.M., Cabrera-Mulero, R., Rubio-Martin, E., Rojo-Martinez, G., Olveira, G., Valdes, S., Soriguer, F., Castano, L., Morcillo, S., Methylation levels of the SCD1 gene promoter and LINE-1 repeat region are associated with weight change: an intervention study. Mol. Nutr. Food Res. 58 (2014), 1528–1536.
-
(2014)
Mol. Nutr. Food Res.
, vol.58
, pp. 1528-1536
-
-
Martin-Nunez, G.M.1
Cabrera-Mulero, R.2
Rubio-Martin, E.3
Rojo-Martinez, G.4
Olveira, G.5
Valdes, S.6
Soriguer, F.7
Castano, L.8
Morcillo, S.9
-
36
-
-
4644340815
-
Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
-
[36] Lee, S.H., Dobrzyn, A., Dobrzyn, P., Rahman, S.M., Miyazaki, M., Ntambi, J.M., Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J. Lipid Res. 45 (2004), 1674–1682.
-
(2004)
J. Lipid Res.
, vol.45
, pp. 1674-1682
-
-
Lee, S.H.1
Dobrzyn, A.2
Dobrzyn, P.3
Rahman, S.M.4
Miyazaki, M.5
Ntambi, J.M.6
-
37
-
-
67749111842
-
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
-
[37] Sampath, H., Flowers, M.T., Liu, X., Paton, C.M., Sullivan, R., Chu, K., Zhao, M., Ntambi, J.M., Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284 (2009), 19961–19973.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 19961-19973
-
-
Sampath, H.1
Flowers, M.T.2
Liu, X.3
Paton, C.M.4
Sullivan, R.5
Chu, K.6
Zhao, M.7
Ntambi, J.M.8
-
38
-
-
33745212925
-
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
-
[38] Gutierrez-Juarez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B.P., Rossetti, L., Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. 116 (2006), 1686–1695.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1686-1695
-
-
Gutierrez-Juarez, R.1
Pocai, A.2
Mulas, C.3
Ono, H.4
Bhanot, S.5
Monia, B.P.6
Rossetti, L.7
-
39
-
-
84870472400
-
Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases
-
[39] Narce, M., Bellenger, J., Rialland, M., Bellenger, S., Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases. Curr. Drug Metab. 13 (2012), 1454–1463.
-
(2012)
Curr. Drug Metab.
, vol.13
, pp. 1454-1463
-
-
Narce, M.1
Bellenger, J.2
Rialland, M.3
Bellenger, S.4
-
40
-
-
81755173915
-
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
-
[40] Roongta, U.V., Pabalan, J.G., Wang, X., Ryseck, R.P., Fargnoli, J., Henley, B.J., Yang, W.P., Zhu, J., Madireddi, M.T., Lawrence, R.M., Wong, T.W., Rupnow, B.A., Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol. Cancer Res. 9 (2011), 1551–1561.
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 1551-1561
-
-
Roongta, U.V.1
Pabalan, J.G.2
Wang, X.3
Ryseck, R.P.4
Fargnoli, J.5
Henley, B.J.6
Yang, W.P.7
Zhu, J.8
Madireddi, M.T.9
Lawrence, R.M.10
Wong, T.W.11
Rupnow, B.A.12
-
41
-
-
84863388391
-
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
-
[41] Mason, P., Liang, B., Li, L., Fremgen, T., Murphy, E., Quinn, A., Madden, S.L., Biemann, H.P., Wang, B., Cohen, A., Komarnitsky, S., Jancsics, K., Hirth, B., Cooper, C.G., Lee, E., Wilson, S., Krumbholz, R., Schmid, S., Xiang, Y., Booker, M., Lillie, J., Carter, K., SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One, 7, 2012, e33823.
-
(2012)
PLoS One
, vol.7
, pp. e33823
-
-
Mason, P.1
Liang, B.2
Li, L.3
Fremgen, T.4
Murphy, E.5
Quinn, A.6
Madden, S.L.7
Biemann, H.P.8
Wang, B.9
Cohen, A.10
Komarnitsky, S.11
Jancsics, K.12
Hirth, B.13
Cooper, C.G.14
Lee, E.15
Wilson, S.16
Krumbholz, R.17
Schmid, S.18
Xiang, Y.19
Booker, M.20
Lillie, J.21
Carter, K.22
more..
-
42
-
-
84955615968
-
Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis
-
[42] Chen, L., Ren, J., Yang, L., Li, Y., Fu, J., Li, Y., Tian, Y., Qiu, F., Liu, Z., Qiu, Y., Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis. Sci. Rep., 6, 2016, 19665.
-
(2016)
Sci. Rep.
, vol.6
, pp. 19665
-
-
Chen, L.1
Ren, J.2
Yang, L.3
Li, Y.4
Fu, J.5
Li, Y.6
Tian, Y.7
Qiu, F.8
Liu, Z.9
Qiu, Y.10
-
43
-
-
77953471622
-
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice
-
[43] Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avances, C., Allory, Y., de la Taille, A., Culine, S., Blancou, H., Cristol, J.P., Michel, F., Sardet, C., Fajas, L., Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol. Cancer Ther. 9 (2010), 1740–1754.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 1740-1754
-
-
Fritz, V.1
Benfodda, Z.2
Rodier, G.3
Henriquet, C.4
Iborra, F.5
Avances, C.6
Allory, Y.7
de la Taille, A.8
Culine, S.9
Blancou, H.10
Cristol, J.P.11
Michel, F.12
Sardet, C.13
Fajas, L.14
-
44
-
-
84869215008
-
FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
-
[44] Du, X., Wang, Q.R., Chan, E., Merchant, M., Liu, J., French, D., Ashkenazi, A., Qing, J., FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 72 (2012), 5843–5855.
-
(2012)
Cancer Res.
, vol.72
, pp. 5843-5855
-
-
Du, X.1
Wang, Q.R.2
Chan, E.3
Merchant, M.4
Liu, J.5
French, D.6
Ashkenazi, A.7
Qing, J.8
-
45
-
-
54049084951
-
Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis
-
[45] Scaglia, N., Igal, R.A., Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int. J. Oncol. 33 (2008), 839–850.
-
(2008)
Int. J. Oncol.
, vol.33
, pp. 839-850
-
-
Scaglia, N.1
Igal, R.A.2
-
46
-
-
84961411904
-
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase
-
[46] Theodoropoulos, P.C., Gonzales, S.S., Winterton, S.E., Rodriguez-Navas, C., McKnight, J.S., Morlock, L.K., Hanson, J.M., Cross, B., Owen, A.E., Duan, Y., Moreno, J.R., Lemoff, A., Mirzaei, H., Posner, B.A., Williams, N.S., Ready, J.M., Nijhawan, D., Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat. Chem. Biol. 12 (2016), 218–225.
-
(2016)
Nat. Chem. Biol.
, vol.12
, pp. 218-225
-
-
Theodoropoulos, P.C.1
Gonzales, S.S.2
Winterton, S.E.3
Rodriguez-Navas, C.4
McKnight, J.S.5
Morlock, L.K.6
Hanson, J.M.7
Cross, B.8
Owen, A.E.9
Duan, Y.10
Moreno, J.R.11
Lemoff, A.12
Mirzaei, H.13
Posner, B.A.14
Williams, N.S.15
Ready, J.M.16
Nijhawan, D.17
-
47
-
-
84983333937
-
XEN801 for the treatment of acne
-
[47] Pharma, X., XEN801 for the treatment of acne. http://www.xenon-pharma.com/product-candidates/dermatologic/, 2015.
-
(2015)
-
-
Pharma, X.1
-
48
-
-
84936846476
-
Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate
-
[48] Wang, H., Klein, M.G., Zou, H., Lane, W., Snell, G., Levin, I., Li, K., Sang, B.C., Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate. Nat. Struct. Mol. Biol. 22 (2015), 581–585.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 581-585
-
-
Wang, H.1
Klein, M.G.2
Zou, H.3
Lane, W.4
Snell, G.5
Levin, I.6
Li, K.7
Sang, B.C.8
-
49
-
-
84939498569
-
X-ray structure of a mammalian stearoyl-CoA desaturase
-
[49] Bai, Y., McCoy, J.G., Levin, E.J., Sobrado, P., Rajashankar, K.R., Fox, B.G., Zhou, M., X-ray structure of a mammalian stearoyl-CoA desaturase. Nature 524 (2015), 252–256.
-
(2015)
Nature
, vol.524
, pp. 252-256
-
-
Bai, Y.1
McCoy, J.G.2
Levin, E.J.3
Sobrado, P.4
Rajashankar, K.R.5
Fox, B.G.6
Zhou, M.7
-
50
-
-
45449126566
-
Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
-
[50] Flowers, M.T., Keller, M.P., Choi, Y., Lan, H., Kendziorski, C., Ntambi, J.M., Attie, A.D., Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol. Genomics 33 (2008), 361–372.
-
(2008)
Physiol. Genomics
, vol.33
, pp. 361-372
-
-
Flowers, M.T.1
Keller, M.P.2
Choi, Y.3
Lan, H.4
Kendziorski, C.5
Ntambi, J.M.6
Attie, A.D.7
-
51
-
-
0031052912
-
The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane
-
[51] Clamp, A.G., Ladha, S., Clark, D.C., Grimble, R.F., Lund, E.K., The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane. Lipids 32 (1997), 179–184.
-
(1997)
Lipids
, vol.32
, pp. 179-184
-
-
Clamp, A.G.1
Ladha, S.2
Clark, D.C.3
Grimble, R.F.4
Lund, E.K.5
-
52
-
-
0018171346
-
Membrane lipid modification of chinese hamster ovary cells. Thermal properties of membrane phospholipids
-
[52] Rintoul, D.A., Sklar, L.A., Simoni, R.D., Membrane lipid modification of chinese hamster ovary cells. Thermal properties of membrane phospholipids. J. Biol. Chem. 253 (1978), 7447–7452.
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 7447-7452
-
-
Rintoul, D.A.1
Sklar, L.A.2
Simoni, R.D.3
-
53
-
-
84941584955
-
Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion
-
[53] Braig, S., Schmidt, S., Stoiber, K., Händel, C., Möhn, T., Werz, O., Müller, R., Zahler, S., Koeberle, A., Käs, J.A., Vollmar, A.M., Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion. New J. Phys., 17, 2015, 083007.
-
(2015)
New J. Phys.
, vol.17
, pp. 083007
-
-
Braig, S.1
Schmidt, S.2
Stoiber, K.3
Händel, C.4
Möhn, T.5
Werz, O.6
Müller, R.7
Zahler, S.8
Koeberle, A.9
Käs, J.A.10
Vollmar, A.M.11
-
54
-
-
84897376553
-
Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes
-
[54] Lyn, R.K., Singaravelu, R., Kargman, S., O'Hara, S., Chan, H., Oballa, R., Huang, Z., Jones, D.M., Ridsdale, A., Russell, R.S., Partridge, A.W., Pezacki, J.P., Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes. Sci. Rep., 4, 2014, 4549.
-
(2014)
Sci. Rep.
, vol.4
, pp. 4549
-
-
Lyn, R.K.1
Singaravelu, R.2
Kargman, S.3
O'Hara, S.4
Chan, H.5
Oballa, R.6
Huang, Z.7
Jones, D.M.8
Ridsdale, A.9
Russell, R.S.10
Partridge, A.W.11
Pezacki, J.P.12
-
55
-
-
84894468653
-
Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway
-
[55] Tan, S.H., Shui, G., Zhou, J., Shi, Y., Huang, J., Xia, D., Wenk, M.R., Shen, H.M., Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy 10 (2014), 226–242.
-
(2014)
Autophagy
, vol.10
, pp. 226-242
-
-
Tan, S.H.1
Shui, G.2
Zhou, J.3
Shi, Y.4
Huang, J.5
Xia, D.6
Wenk, M.R.7
Shen, H.M.8
-
56
-
-
84884908920
-
Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat
-
[56] Vinknes, K.J., Elshorbagy, A.K., Drevon, C.A., Nurk, E., Tell, G.S., Nygard, O., Vollset, S.E., Refsum, H., Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat. Obesity (Silver Spring) 21 (2013), E512–E519.
-
(2013)
Obesity (Silver Spring)
, vol.21
, pp. E512-E519
-
-
Vinknes, K.J.1
Elshorbagy, A.K.2
Drevon, C.A.3
Nurk, E.4
Tell, G.S.5
Nygard, O.6
Vollset, S.E.7
Refsum, H.8
-
57
-
-
84929707757
-
SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition
-
[57] Ralston, J.C., Mutch, D.M., SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition. Prostaglandins Leukot. Essent. Fatty Acids 98 (2015), 29–37.
-
(2015)
Prostaglandins Leukot. Essent. Fatty Acids
, vol.98
, pp. 29-37
-
-
Ralston, J.C.1
Mutch, D.M.2
-
58
-
-
65249119361
-
Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
-
[58] Shimizu, T., Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49 (2009), 123–150.
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 123-150
-
-
Shimizu, T.1
-
59
-
-
84873733953
-
Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding
-
[59] Koeberle, A., Shindou, H., Koeberle, S.C., Laufer, S.A., Shimizu, T., Werz, O., Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 2546–2551.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 2546-2551
-
-
Koeberle, A.1
Shindou, H.2
Koeberle, S.C.3
Laufer, S.A.4
Shimizu, T.5
Werz, O.6
-
60
-
-
84864556250
-
Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol
-
[60] Koeberle, A., Shindou, H., Harayama, T., Shimizu, T., Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J. Biol. Chem. 287 (2012), 27244–27254.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27244-27254
-
-
Koeberle, A.1
Shindou, H.2
Harayama, T.3
Shimizu, T.4
-
61
-
-
77953807871
-
Stearoyl-CoA desaturase and insulin signaling—what is the molecular switch?
-
[61] Dobrzyn, P., Jazurek, M., Dobrzyn, A., Stearoyl-CoA desaturase and insulin signaling—what is the molecular switch?. Biochim. Biophys. Acta 1797 (2010), 1189–1194.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1189-1194
-
-
Dobrzyn, P.1
Jazurek, M.2
Dobrzyn, A.3
-
62
-
-
84942609928
-
Metabolic, anabolic, and mitogenic insulin responses: a tissue-specific perspective for insulin receptor activators
-
[62] Bedinger, D.H., Adams, S.H., Metabolic, anabolic, and mitogenic insulin responses: a tissue-specific perspective for insulin receptor activators. Mol. Cell. Endocrinol. 415 (2015), 143–156.
-
(2015)
Mol. Cell. Endocrinol.
, vol.415
, pp. 143-156
-
-
Bedinger, D.H.1
Adams, S.H.2
-
63
-
-
79960716001
-
Akt signalling in health and disease
-
[63] Hers, I., Vincent, E.E., Tavare, J.M., Akt signalling in health and disease. Cell. Signal. 23 (2011), 1515–1527.
-
(2011)
Cell. Signal.
, vol.23
, pp. 1515-1527
-
-
Hers, I.1
Vincent, E.E.2
Tavare, J.M.3
-
64
-
-
0141813781
-
Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
-
[64] Rahman, S.M., Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Ntambi, J.M., Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 11110–11115.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11110-11115
-
-
Rahman, S.M.1
Dobrzyn, A.2
Dobrzyn, P.3
Lee, S.H.4
Miyazaki, M.5
Ntambi, J.M.6
-
65
-
-
0036092239
-
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
[65] McGarry, J.D., Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 (2002), 7–18.
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
66
-
-
79952312698
-
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma
-
[66] Calvisi, D.F., Wang, C., Ho, C., Ladu, S., Lee, S.A., Mattu, S., Destefanis, G., Delogu, S., Zimmermann, A., Ericsson, J., Brozzetti, S., Staniscia, T., Chen, X., Dombrowski, F., Evert, M., Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology 140 (2011), 1071–1083.
-
(2011)
Gastroenterology
, vol.140
, pp. 1071-1083
-
-
Calvisi, D.F.1
Wang, C.2
Ho, C.3
Ladu, S.4
Lee, S.A.5
Mattu, S.6
Destefanis, G.7
Delogu, S.8
Zimmermann, A.9
Ericsson, J.10
Brozzetti, S.11
Staniscia, T.12
Chen, X.13
Dombrowski, F.14
Evert, M.15
-
67
-
-
84940738579
-
Molecular pathways: is AMPK a friend or a foe in cancer?
-
[67] Hardie, D.G., Molecular pathways: is AMPK a friend or a foe in cancer?. Clin. Cancer Res. 21 (2015), 3836–3840.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 3836-3840
-
-
Hardie, D.G.1
-
68
-
-
84879621442
-
AMPK, insulin resistance, and the metabolic syndrome
-
[68] Ruderman, N.B., Carling, D., Prentki, M., Cacicedo, J.M., AMPK, insulin resistance, and the metabolic syndrome. J. Clin. Invest. 123 (2013), 2764–2772.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 2764-2772
-
-
Ruderman, N.B.1
Carling, D.2
Prentki, M.3
Cacicedo, J.M.4
-
69
-
-
2342652187
-
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
-
[69] Dobrzyn, P., Dobrzyn, A., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M., Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 6409–6414.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 6409-6414
-
-
Dobrzyn, P.1
Dobrzyn, A.2
Miyazaki, M.3
Cohen, P.4
Asilmaz, E.5
Hardie, D.G.6
Friedman, J.M.7
Ntambi, J.M.8
-
70
-
-
13844250258
-
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
-
[70] Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., Cohen, P., Asilmaz, E., Hardie, D.G., Friedman, J.M., Ntambi, J.M., Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288 (2005), E599–E607.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
, pp. E599-E607
-
-
Dobrzyn, A.1
Dobrzyn, P.2
Lee, S.H.3
Miyazaki, M.4
Cohen, P.5
Asilmaz, E.6
Hardie, D.G.7
Friedman, J.M.8
Ntambi, J.M.9
-
71
-
-
2942588527
-
Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
-
[71] Miyazaki, M., Dobrzyn, A., Man, W.C., Chu, K., Sampath, H., Kim, H.J., Ntambi, J.M., Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J. Biol. Chem. 279 (2004), 25164–25171.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 25164-25171
-
-
Miyazaki, M.1
Dobrzyn, A.2
Man, W.C.3
Chu, K.4
Sampath, H.5
Kim, H.J.6
Ntambi, J.M.7
-
72
-
-
84934275896
-
Proteostasis control by the unfolded protein response
-
[72] Hetz, C., Chevet, E., Oakes, S.A., Proteostasis control by the unfolded protein response. Nat. Cell Biol. 17 (2015), 829–838.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 829-838
-
-
Hetz, C.1
Chevet, E.2
Oakes, S.A.3
-
73
-
-
77957121400
-
Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells
-
[73] Thorn, K., Hovsepyan, M., Bergsten, P., Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells. Lipids Health Dis., 9, 2010, 108.
-
(2010)
Lipids Health Dis.
, vol.9
, pp. 108
-
-
Thorn, K.1
Hovsepyan, M.2
Bergsten, P.3
-
74
-
-
84936804235
-
PPARgamma agonists attenuate palmitate-induced ER stress through up-regulation of SCD-1 in macrophages
-
[74] Ikeda, J., Ichiki, T., Takahara, Y., Kojima, H., Sankoda, C., Kitamoto, S., Tokunou, T., Sunagawa, K., PPARgamma agonists attenuate palmitate-induced ER stress through up-regulation of SCD-1 in macrophages. PLoS One, 10, 2015, e0128546.
-
(2015)
PLoS One
, vol.10
, pp. e0128546
-
-
Ikeda, J.1
Ichiki, T.2
Takahara, Y.3
Kojima, H.4
Sankoda, C.5
Kitamoto, S.6
Tokunou, T.7
Sunagawa, K.8
-
75
-
-
34248198871
-
Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
-
[75] Flowers, J.B., Rabaglia, M.E., Schueler, K.L., Flowers, M.T., Lan, H., Keller, M.P., Ntambi, J.M., Attie, A.D., Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56 (2007), 1228–1239.
-
(2007)
Diabetes
, vol.56
, pp. 1228-1239
-
-
Flowers, J.B.1
Rabaglia, M.E.2
Schueler, K.L.3
Flowers, M.T.4
Lan, H.5
Keller, M.P.6
Ntambi, J.M.7
Attie, A.D.8
-
76
-
-
84898007635
-
De novo fatty acid synthesis at the mitotic exit is required to complete cellular division
-
[76] Scaglia, N., Tyekucheva, S., Zadra, G., Photopoulos, C., Loda, M., De novo fatty acid synthesis at the mitotic exit is required to complete cellular division. Cell Cycle 13 (2014), 859–868.
-
(2014)
Cell Cycle
, vol.13
, pp. 859-868
-
-
Scaglia, N.1
Tyekucheva, S.2
Zadra, G.3
Photopoulos, C.4
Loda, M.5
-
77
-
-
34247894035
-
Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
-
[77] Qin, X., Tian, J., Zhang, P., Fan, Y., Chen, L., Guan, Y., Fu, Y., Zhu, Y., Chien, S., Wang, N., Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc. Res. 74 (2007), 506–514.
-
(2007)
Cardiovasc. Res.
, vol.74
, pp. 506-514
-
-
Qin, X.1
Tian, J.2
Zhang, P.3
Fan, Y.4
Chen, L.5
Guan, Y.6
Fu, Y.7
Zhu, Y.8
Chien, S.9
Wang, N.10
-
78
-
-
84952802286
-
SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: effects on cellular stress, inflammatory markers and fatty acid elongation
-
[78] Ralston, J.C., Metherel, A.H., Stark, K.D., Mutch, D.M., SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: effects on cellular stress, inflammatory markers and fatty acid elongation. J. Nutr. Biochem. 27 (2016), 241–248.
-
(2016)
J. Nutr. Biochem.
, vol.27
, pp. 241-248
-
-
Ralston, J.C.1
Metherel, A.H.2
Stark, K.D.3
Mutch, D.M.4
-
79
-
-
68049142428
-
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
-
[79] Peter, A., Weigert, C., Staiger, H., Machicao, F., Schick, F., Machann, J., Stefan, N., Thamer, C., Haring, H.U., Schleicher, E., Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58 (2009), 1757–1765.
-
(2009)
Diabetes
, vol.58
, pp. 1757-1765
-
-
Peter, A.1
Weigert, C.2
Staiger, H.3
Machicao, F.4
Schick, F.5
Machann, J.6
Stefan, N.7
Thamer, C.8
Haring, H.U.9
Schleicher, E.10
-
80
-
-
25844454854
-
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis
-
[80] Busch, A.K., Gurisik, E., Cordery, D.V., Sudlow, M., Denyer, G.S., Laybutt, D.R., Hughes, W.E., Biden, T.J., Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes 54 (2005), 2917–2924.
-
(2005)
Diabetes
, vol.54
, pp. 2917-2924
-
-
Busch, A.K.1
Gurisik, E.2
Cordery, D.V.3
Sudlow, M.4
Denyer, G.S.5
Laybutt, D.R.6
Hughes, W.E.7
Biden, T.J.8
-
81
-
-
52649151321
-
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
-
[81] Peter, A., Weigert, C., Staiger, H., Rittig, K., Cegan, A., Lutz, P., Machicao, F., Haring, H.U., Schleicher, E., Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. Am. J. Physiol. Endocrinol. Metab. 295 (2008), E339–E349.
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
, pp. E339-E349
-
-
Peter, A.1
Weigert, C.2
Staiger, H.3
Rittig, K.4
Cegan, A.5
Lutz, P.6
Machicao, F.7
Haring, H.U.8
Schleicher, E.9
-
82
-
-
84920463916
-
Autophagy in cellular metabolism and cancer
-
[82] Jiang, X., Overholtzer, M., Thompson, C.B., Autophagy in cellular metabolism and cancer. J. Clin. Invest. 125 (2015), 47–54.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 47-54
-
-
Jiang, X.1
Overholtzer, M.2
Thompson, C.B.3
-
83
-
-
84964260843
-
ER stress: autophagy induction, inhibition and selection
-
[83] Rashid, H.O., Yadav, R.K., Kim, H.R., Chae, H.J., ER stress: autophagy induction, inhibition and selection. Autophagy 11 (2015), 1956–1977.
-
(2015)
Autophagy
, vol.11
, pp. 1956-1977
-
-
Rashid, H.O.1
Yadav, R.K.2
Kim, H.R.3
Chae, H.J.4
-
84
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
[84] Hamasaki, M., Furuta, N., Matsuda, A., Nezu, A., Yamamoto, A., Fujita, N., Oomori, H., Noda, T., Haraguchi, T., Hiraoka, Y., Amano, A., Yoshimori, T., Autophagosomes form at ER-mitochondria contact sites. Nature 495 (2013), 389–393.
-
(2013)
Nature
, vol.495
, pp. 389-393
-
-
Hamasaki, M.1
Furuta, N.2
Matsuda, A.3
Nezu, A.4
Yamamoto, A.5
Fujita, N.6
Oomori, H.7
Noda, T.8
Haraguchi, T.9
Hiraoka, Y.10
Amano, A.11
Yoshimori, T.12
-
85
-
-
0022376408
-
Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes
-
[85] Reunanen, H., Punnonen, E.L., Hirsimaki, P., Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes. Histochemistry 83 (1985), 513–517.
-
(1985)
Histochemistry
, vol.83
, pp. 513-517
-
-
Reunanen, H.1
Punnonen, E.L.2
Hirsimaki, P.3
-
86
-
-
84921605764
-
SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
-
[86] Huang, G.M., Jiang, Q.H., Cai, C., Qu, M., Shen, W., SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. Cancer Lett. 358 (2015), 180–190.
-
(2015)
Cancer Lett.
, vol.358
, pp. 180-190
-
-
Huang, G.M.1
Jiang, Q.H.2
Cai, C.3
Qu, M.4
Shen, W.5
-
87
-
-
84906545326
-
Stearoyl-CoA desaturase 1 activity is required for autophagosome formation
-
[87] Ogasawara, Y., Itakura, E., Kono, N., Mizushima, N., Arai, H., Nara, A., Mizukami, T., Yamamoto, A., Stearoyl-CoA desaturase 1 activity is required for autophagosome formation. J. Biol. Chem. 289 (2014), 23938–23950.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 23938-23950
-
-
Ogasawara, Y.1
Itakura, E.2
Kono, N.3
Mizushima, N.4
Arai, H.5
Nara, A.6
Mizukami, T.7
Yamamoto, A.8
-
88
-
-
84946554147
-
Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells
-
[88] Janikiewicz, J., Hanzelka, K., Dziewulska, A., Kozinski, K., Dobrzyn, P., Bernas, T., Dobrzyn, A., Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic beta-cells. J. Lipid Res. 56 (2015), 1901–1911.
-
(2015)
J. Lipid Res.
, vol.56
, pp. 1901-1911
-
-
Janikiewicz, J.1
Hanzelka, K.2
Dziewulska, A.3
Kozinski, K.4
Dobrzyn, P.5
Bernas, T.6
Dobrzyn, A.7
-
89
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
[89] Wagner, E.F., Nebreda, A.R., Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9 (2009), 537–549.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
90
-
-
57049117856
-
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
-
[90] Kim, I., Xu, W., Reed, J.C., Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov. 7 (2008), 1013–1030.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 1013-1030
-
-
Kim, I.1
Xu, W.2
Reed, J.C.3
-
91
-
-
32944478891
-
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
-
[91] Ranganathan, A.C., Zhang, L., Adam, A.P., Aguirre-Ghiso, J.A., Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 66 (2006), 1702–1711.
-
(2006)
Cancer Res.
, vol.66
, pp. 1702-1711
-
-
Ranganathan, A.C.1
Zhang, L.2
Adam, A.P.3
Aguirre-Ghiso, J.A.4
-
92
-
-
0029938805
-
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
-
[92] Wang, X.Z., Ron, D., Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272 (1996), 1347–1349.
-
(1996)
Science
, vol.272
, pp. 1347-1349
-
-
Wang, X.Z.1
Ron, D.2
-
93
-
-
84872262047
-
Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells
-
[93] Mauvoisin, D., Charfi, C., Lounis, A.M., Rassart, E., Mounier, C., Decreasing stearoyl-CoA desaturase-1 expression inhibits beta-catenin signaling in breast cancer cells. Cancer Sci. 104 (2013), 36–42.
-
(2013)
Cancer Sci.
, vol.104
, pp. 36-42
-
-
Mauvoisin, D.1
Charfi, C.2
Lounis, A.M.3
Rassart, E.4
Mounier, C.5
-
94
-
-
84884558970
-
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins
-
[94] Rios-Esteves, J., Resh, M.D., Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep. 4 (2013), 1072–1081.
-
(2013)
Cell Rep.
, vol.4
, pp. 1072-1081
-
-
Rios-Esteves, J.1
Resh, M.D.2
-
95
-
-
84955490041
-
Fatty acylation of Wnt proteins
-
[95] Nile, A.H., Hannoush, R.N., Fatty acylation of Wnt proteins. Nat. Chem. Biol. 12 (2016), 60–69.
-
(2016)
Nat. Chem. Biol.
, vol.12
, pp. 60-69
-
-
Nile, A.H.1
Hannoush, R.N.2
-
96
-
-
33751318469
-
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
-
[96] Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., Takada, S., Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell 11 (2006), 791–801.
-
(2006)
Dev. Cell
, vol.11
, pp. 791-801
-
-
Takada, R.1
Satomi, Y.2
Kurata, T.3
Ueno, N.4
Norioka, S.5
Kondoh, H.6
Takao, T.7
Takada, S.8
-
97
-
-
84863543371
-
Structural basis of Wnt recognition by Frizzled
-
[97] Janda, C.Y., Waghray, D., Levin, A.M., Thomas, C., Garcia, K.C., Structural basis of Wnt recognition by Frizzled. Science 337 (2012), 59–64.
-
(2012)
Science
, vol.337
, pp. 59-64
-
-
Janda, C.Y.1
Waghray, D.2
Levin, A.M.3
Thomas, C.4
Garcia, K.C.5
-
98
-
-
84888091333
-
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase
-
[98] Liu, J., Cinar, R., Xiong, K., Godlewski, G., Jourdan, T., Lin, Y., Ntambi, J.M., Kunos, G., Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 18832–18837.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 18832-18837
-
-
Liu, J.1
Cinar, R.2
Xiong, K.3
Godlewski, G.4
Jourdan, T.5
Lin, Y.6
Ntambi, J.M.7
Kunos, G.8
-
99
-
-
84866296565
-
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
-
[99] Brown, W.H., Gillum, M.P., Lee, H.Y., Camporez, J.P., Zhang, X.M., Jeong, J.K., Alves, T.C., Erion, D.M., Guigni, B.A., Kahn, M., Samuel, V.T., Cravatt, B.F., Diano, S., Shulman, G.I., Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 14966–14971.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 14966-14971
-
-
Brown, W.H.1
Gillum, M.P.2
Lee, H.Y.3
Camporez, J.P.4
Zhang, X.M.5
Jeong, J.K.6
Alves, T.C.7
Erion, D.M.8
Guigni, B.A.9
Kahn, M.10
Samuel, V.T.11
Cravatt, B.F.12
Diano, S.13
Shulman, G.I.14
-
100
-
-
84903512937
-
Role of free fatty acid receptors in the regulation of energy metabolism
-
[100] Hara, T., Kashihara, D., Ichimura, A., Kimura, I., Tsujimoto, G., Hirasawa, A., Role of free fatty acid receptors in the regulation of energy metabolism. Biochim. Biophys. Acta 1841 (2014), 1292–1300.
-
(2014)
Biochim. Biophys. Acta
, vol.1841
, pp. 1292-1300
-
-
Hara, T.1
Kashihara, D.2
Ichimura, A.3
Kimura, I.4
Tsujimoto, G.5
Hirasawa, A.6
-
101
-
-
33644644599
-
PPAR gamma and human metabolic disease
-
[101] Semple, R.K., Chatterjee, V.K., O'Rahilly, S., PPAR gamma and human metabolic disease. J. Clin. Invest. 116 (2006), 581–589.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 581-589
-
-
Semple, R.K.1
Chatterjee, V.K.2
O'Rahilly, S.3
-
102
-
-
84906518583
-
Lipid regulation of BK channel function
-
[102] Dopico, A.M., Bukiya, A.N., Lipid regulation of BK channel function. Front. Physiol., 5, 2014, 312.
-
(2014)
Front. Physiol.
, vol.5
, pp. 312
-
-
Dopico, A.M.1
Bukiya, A.N.2
-
103
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
[103] Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., Flier, J.S., TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116 (2006), 3015–3025.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
104
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
[104] Holzer, R.G., Park, E.J., Li, N., Tran, H., Chen, M., Choi, C., Solinas, G., Karin, M., Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147 (2011), 173–184.
-
(2011)
Cell
, vol.147
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
Solinas, G.7
Karin, M.8
-
105
-
-
84875242776
-
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
-
[105] Volmer, R., van der Ploeg, K., Ron, D., Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 4628–4633.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 4628-4633
-
-
Volmer, R.1
van der Ploeg, K.2
Ron, D.3
-
106
-
-
84943587206
-
Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders
-
[106] Koeberle, A., Werz, O., Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders. Biochem. Pharmacol. 98 (2015), 1–15.
-
(2015)
Biochem. Pharmacol.
, vol.98
, pp. 1-15
-
-
Koeberle, A.1
Werz, O.2
-
107
-
-
0030422424
-
Short-term regulation of acetyl CoA carboxylase in tissues of higher animals
-
[107] Allred, J.B., Reilly, K.E., Short-term regulation of acetyl CoA carboxylase in tissues of higher animals. Prog. Lipid Res. 35 (1996), 371–385.
-
(1996)
Prog. Lipid Res.
, vol.35
, pp. 371-385
-
-
Allred, J.B.1
Reilly, K.E.2
-
108
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
[108] Cao, H., Gerhold, K., Mayers, J.R., Wiest, M.M., Watkins, S.M., Hotamisligil, G.S., Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134 (2008), 933–944.
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
109
-
-
20444484914
-
The role of stearoyl-CoA desaturase in the control of metabolism
-
[109] Dobrzyn, A., Ntambi, J.M., The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot. Essent. Fat. Acids 73 (2005), 35–41.
-
(2005)
Prostaglandins Leukot. Essent. Fat. Acids
, vol.73
, pp. 35-41
-
-
Dobrzyn, A.1
Ntambi, J.M.2
-
110
-
-
79957605136
-
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
-
[110] Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., Lin, X., Watkins, S.M., Ivanov, A.R., Hotamisligil, G.S., Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473 (2011), 528–531.
-
(2011)
Nature
, vol.473
, pp. 528-531
-
-
Fu, S.1
Yang, L.2
Li, P.3
Hofmann, O.4
Dicker, L.5
Hide, W.6
Lin, X.7
Watkins, S.M.8
Ivanov, A.R.9
Hotamisligil, G.S.10
-
111
-
-
84883163223
-
Membrane lipid saturation activates IRE1alpha without inducing clustering
-
[111] Kitai, Y., Ariyama, H., Kono, N., Oikawa, D., Iwawaki, T., Arai, H., Membrane lipid saturation activates IRE1alpha without inducing clustering. Genes Cells 18 (2013), 798–809.
-
(2013)
Genes Cells
, vol.18
, pp. 798-809
-
-
Kitai, Y.1
Ariyama, H.2
Kono, N.3
Oikawa, D.4
Iwawaki, T.5
Arai, H.6
-
112
-
-
33750906573
-
Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro
-
[112] Pinnamaneni, S.K., Southgate, R.J., Febbraio, M.A., Watt, M.J., Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 49 (2006), 3027–3037.
-
(2006)
Diabetologia
, vol.49
, pp. 3027-3037
-
-
Pinnamaneni, S.K.1
Southgate, R.J.2
Febbraio, M.A.3
Watt, M.J.4
-
113
-
-
84948844003
-
Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity
-
[113] Masuda, M., Miyazaki-Anzai, S., Keenan, A.L., Okamura, K., Kendrick, J., Chonchol, M., Offermanns, S., Ntambi, J.M., Kuro, O.M., Miyazaki, M., Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. J. Clin. Invest. 125 (2015), 4544–4558.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 4544-4558
-
-
Masuda, M.1
Miyazaki-Anzai, S.2
Keenan, A.L.3
Okamura, K.4
Kendrick, J.5
Chonchol, M.6
Offermanns, S.7
Ntambi, J.M.8
Kuro, O.M.9
Miyazaki, M.10
-
114
-
-
84954286761
-
Lipid droplets, lipophagy, and beyond
-
[114] Wang, C.W., Lipid droplets, lipophagy, and beyond. Biochim. Biophys. Acta 1861 (2016), 793–805.
-
(2016)
Biochim. Biophys. Acta
, vol.1861
, pp. 793-805
-
-
Wang, C.W.1
-
115
-
-
84877580262
-
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
-
[115] Csermely, P., Korcsmaros, T., Kiss, H.J., London, G., Nussinov, R., Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. Pharmacol. Ther. 138 (2013), 333–408.
-
(2013)
Pharmacol. Ther.
, vol.138
, pp. 333-408
-
-
Csermely, P.1
Korcsmaros, T.2
Kiss, H.J.3
London, G.4
Nussinov, R.5
-
116
-
-
84919352979
-
Multi-target approach for natural products in inflammation
-
[116] Koeberle, A., Werz, O., Multi-target approach for natural products in inflammation. Drug Discov. Today 19 (2014), 1871–1882.
-
(2014)
Drug Discov. Today
, vol.19
, pp. 1871-1882
-
-
Koeberle, A.1
Werz, O.2
|