메뉴 건너뛰기




Volumn 197, Issue , 2016, Pages 3-12

Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors

Author keywords

Acne; Cancer; Nonalcoholic steatohepatitis (NASH); Skin disorders; Stearoyl CoA desaturase 1 (SCD1)

Indexed keywords

A 939572; ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE INHIBITOR; ENZYME INHIBITOR; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; XEN 103;

EID: 84960802555     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2015.08.018     Document Type: Article
Times cited : (55)

References (86)
  • 1
    • 79954522888 scopus 로고    scopus 로고
    • Hepatitis C virus and host cell lipids: An intimate connection
    • G. Alvisi, V. Madan, and R. Bartenschlager Hepatitis C virus and host cell lipids: an intimate connection RNA Biol. 8 2011 258 269
    • (2011) RNA Biol. , vol.8 , pp. 258-269
    • Alvisi, G.1    Madan, V.2    Bartenschlager, R.3
  • 2
    • 79959284653 scopus 로고    scopus 로고
    • Update on fatty liver disease and steatohepatitis
    • F.Z. Aly, and D.E. Kleiner Update on fatty liver disease and steatohepatitis Adv. Anat. Pathol. 18 2011 294 300
    • (2011) Adv. Anat. Pathol. , vol.18 , pp. 294-300
    • Aly, F.Z.1    Kleiner, D.E.2
  • 3
    • 33846078041 scopus 로고    scopus 로고
    • Isotretinoin, pregnancies, abortions and birth defects: A population-based perspective
    • B. Anick, A. Laurent, K. Gideon, B. Lucie, P. Sylvie, and O. Driss Isotretinoin, pregnancies, abortions and birth defects: a population-based perspective Brit J. Clin. Pharmacol. 63 2007 196 205
    • (2007) Brit J. Clin. Pharmacol. , vol.63 , pp. 196-205
    • Anick, B.1    Laurent, A.2    Gideon, K.3    Lucie, B.4    Sylvie, P.5    Driss, O.6
  • 6
    • 84890120706 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma
    • S. Bansal, M. Berk, N. Alkhouri, D.A. Partrick, J.J. Fung, and A. Feldstein Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma J. Surg. Res. 186 2014 29 38
    • (2014) J. Surg. Res. , vol.186 , pp. 29-38
    • Bansal, S.1    Berk, M.2    Alkhouri, N.3    Partrick, D.A.4    Fung, J.J.5    Feldstein, A.6
  • 8
    • 84905403670 scopus 로고    scopus 로고
    • Molecular genetics of clear-cell renal cell carcinoma
    • J. Brugarolas Molecular genetics of clear-cell renal cell carcinoma J. Clin. Oncol. 32 2014 1968 1976
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1968-1976
    • Brugarolas, J.1
  • 9
    • 84896861481 scopus 로고    scopus 로고
    • Cancer death is related to high palmitoleic acid in serum and to polymorphisms in the SCD-1 gene in healthy Swedish men
    • L. Byberg, L. Kilander, E.W. Lemming, K. Michaelsson, and B. Vessby Cancer death is related to high palmitoleic acid in serum and to polymorphisms in the SCD-1 gene in healthy Swedish men Am. J. Clin. Nutr. 99 2014 551 558
    • (2014) Am. J. Clin. Nutr. , vol.99 , pp. 551-558
    • Byberg, L.1    Kilander, L.2    Lemming, E.W.3    Michaelsson, K.4    Vessby, B.5
  • 10
    • 84875465199 scopus 로고    scopus 로고
    • Cancer metabolism: Fatty acid oxidation in the limelight
    • A. Carracedo, L.C. Cantley, and P.P. Pandolfi Cancer metabolism: fatty acid oxidation in the limelight Nat. Rev. Cancer 13 4 2013 227 232
    • (2013) Nat. Rev. Cancer , vol.13 , Issue.4 , pp. 227-232
    • Carracedo, A.1    Cantley, L.C.2    Pandolfi, P.P.3
  • 12
    • 33845263672 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase: A new therapeutic target of liver steatosis
    • P. Dobrzyn, and A. Dobrzyn Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis Drug Dev. Res. 67 2006 643 650
    • (2006) Drug Dev. Res. , vol.67 , pp. 643-650
    • Dobrzyn, P.1    Dobrzyn, A.2
  • 13
    • 84896723424 scopus 로고    scopus 로고
    • Role of lipids in the formation and maintenance of the cutaneous permeability barrier
    • K.R. Feingold, and P.M. Elias Role of lipids in the formation and maintenance of the cutaneous permeability barrier Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1841 2014 280 294
    • (2014) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1841 , pp. 280-294
    • Feingold, K.R.1    Elias, P.M.2
  • 14
    • 43249127067 scopus 로고    scopus 로고
    • Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    • M.T. Flowers, and J.M. Ntambi Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism Curr. Opin. Lipidol. 19 2008 248 256
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 248-256
    • Flowers, M.T.1    Ntambi, J.M.2
  • 15
    • 34248525588 scopus 로고    scopus 로고
    • Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebacous glands and cultured sebocytes
    • W.J. Harrison, J.J. Bull, H. Seltmann, and et al. Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebacous glands and cultured sebocytes J. Invest. Dermatol. 127 2007 1309 1317
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 1309-1317
    • Harrison, W.J.1    Bull, J.J.2    Seltmann, H.3
  • 16
    • 79958815982 scopus 로고    scopus 로고
    • Unique ties between hepatitis C virus replication and intracellular lipids
    • E. Herker, and M. Ott Unique ties between hepatitis C virus replication and intracellular lipids Trends Endocrinol. Metab. 22 2011 241 248
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 241-248
    • Herker, E.1    Ott, M.2
  • 17
    • 77956210076 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells
    • D. Hess, J.W. Chisholm, and R.A. Igal Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells PLoS One 5 2010 e11394
    • (2010) PLoS One , vol.5
    • Hess, D.1    Chisholm, J.W.2    Igal, R.A.3
  • 19
    • 84978017026 scopus 로고    scopus 로고
    • Treatment of neurodegenerative disease by the use of SCD4 inhibitors
    • Hopf, C., Drewes, G, Ruffner, H. 2006. Treatment of neurodegenerative disease by the use of SCD4 inhibitors. WO2006015621.
    • (2006)
    • Hopf, C.1    Drewes, G.2    Ruffner, H.3
  • 20
    • 84921605764 scopus 로고    scopus 로고
    • SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
    • G.-M. Huang, Q.H. Jiang, C. Cai, Q. an, M. u, S. ei, and W. hen SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway Cancer Lett. 358 2015 180 190
    • (2015) Cancer Lett. , vol.358 , pp. 180-190
    • Huang, G.-M.1    Jiang, Q.H.2    Cai, C.3    An, Q.4    U, M.5    Ei, S.6    Hen, W.7
  • 22
    • 77956290719 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1: A novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
    • R.A. Igal Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Carcinogenesis 31 2010 1509 1515
    • (2010) Carcinogenesis , vol.31 , pp. 1509-1515
    • Igal, R.A.1
  • 23
    • 82555167017 scopus 로고    scopus 로고
    • Signaling circuitries controlling stem cell fate: To be or not to be
    • R. Iglesias-Bartolome, and J.S. Gutkind Signaling circuitries controlling stem cell fate: to be or not to be Curr. Opin. Cell Biol. 23 2011 716 723
    • (2011) Curr. Opin. Cell Biol. , vol.23 , pp. 716-723
    • Iglesias-Bartolome, R.1    Gutkind, J.S.2
  • 25
    • 84874090689 scopus 로고    scopus 로고
    • A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis
    • N. Kurikawa, T. Takagi, S. Wakimoto, Y. Uto, H. Terashima, K. Kono, T. Ogata, and J. Ohsumi A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis Biol. Pharm. Bull. 36 2013 259 267
    • (2013) Biol. Pharm. Bull. , vol.36 , pp. 259-267
    • Kurikawa, N.1    Takagi, T.2    Wakimoto, S.3    Uto, Y.4    Terashima, H.5    Kono, K.6    Ogata, T.7    Ohsumi, J.8
  • 28
    • 0028246883 scopus 로고
    • Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues
    • J. Li, S.-F. Ding, N.A. Habib, B.F. Fermor, C.B. Wood, and R.S. Gilmour Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues Int. J. Cancer 57 1994 348 352
    • (1994) Int. J. Cancer , vol.57 , pp. 348-352
    • Li, J.1    Ding, S.-F.2    Habib, N.A.3    Fermor, B.F.4    Wood, C.B.5    Gilmour, R.S.6
  • 30
    • 69949176746 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibitors: Update on patented compound
    • G. Liu Stearoyl-CoA desaturase inhibitors: update on patented compound Expert Opin. Ther. Patents 19 2009 1169 1191
    • (2009) Expert Opin. Ther. Patents , vol.19 , pp. 1169-1191
    • Liu, G.1
  • 31
    • 77949481206 scopus 로고    scopus 로고
    • Recent advances in searoyl-CoA desaturase 1 inhibitors for dyslipidemia and obesity
    • G. Liu Recent advances in searoyl-CoA desaturase 1 inhibitors for dyslipidemia and obesity Curr. Top. Med. Chem. 10 2010 419 433
    • (2010) Curr. Top. Med. Chem. , vol.10 , pp. 419-433
    • Liu, G.1
  • 33
    • 33644861793 scopus 로고    scopus 로고
    • Membrane topology of mouse stearoyl-CoA desaturase 1
    • W.C. Man, M. Miyazaki, K. Chu, and J.M. Ntambi Membrane topology of mouse stearoyl-CoA desaturase 1 J. Biol. Chem. 281 2006 1251 1260
    • (2006) J. Biol. Chem. , vol.281 , pp. 1251-1260
    • Man, W.C.1    Miyazaki, M.2    Chu, K.3    Ntambi, J.M.4
  • 36
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • M. Miyazaki, Y.-C. Kim, M.P. Gray-Keller, A.D. Attie, and J.M. Ntambi The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1 J. Biol. Chem. 275 2000 30132 30138
    • (2000) J. Biol. Chem. , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.-C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 37
    • 0034847971 scopus 로고    scopus 로고
    • Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    • M. Miyazaki, W.C. Man, and J.M. Ntambi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid J. Nutr. 131 2001 2260 2268
    • (2001) J. Nutr. , vol.131 , pp. 2260-2268
    • Miyazaki, M.1    Man, W.C.2    Ntambi, J.M.3
  • 38
    • 0141780830 scopus 로고    scopus 로고
    • Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    • M. Miyazaki, M.J. Jacobsen, W.C. Man, P. Cohen, E. Asilmaz, J.M. Friedman, and J.M. Ntambi Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors J. Biol. Chem. 278 2003 33904 33911
    • (2003) J. Biol. Chem. , vol.278 , pp. 33904-33911
    • Miyazaki, M.1    Jacobsen, M.J.2    Man, W.C.3    Cohen, P.4    Asilmaz, E.5    Friedman, J.M.6    Ntambi, J.M.7
  • 41
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 42
    • 84870472400 scopus 로고    scopus 로고
    • Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases
    • M. Narce, J. Bellenger, M. Rialland, and S. Bellenger Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases Curr. Drug Metabol. 13 2012 1454 1463
    • (2012) Curr. Drug Metabol. , vol.13 , pp. 1454-1463
    • Narce, M.1    Bellenger, J.2    Rialland, M.3    Bellenger, S.4
  • 44
    • 84907992495 scopus 로고    scopus 로고
    • Stearoyl coenzyme A desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication
    • L.N. Nguyen, Y.-S. Lim, L.V. Pham, H.-Y. Shin, Y.-S. Kim, and S.B. Hwang Stearoyl coenzyme A desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication J. Virol. 88 2014 12311 12325
    • (2014) J. Virol. , vol.88 , pp. 12311-12325
    • Nguyen, L.N.1    Lim, Y.-S.2    Pham, L.V.3    Shin, H.-Y.4    Kim, Y.-S.5    Hwang, S.B.6
  • 46
    • 0037832581 scopus 로고    scopus 로고
    • Recent insights into stearoyl-CoA desaturase-1
    • J.M. Ntambi, and M. Miyazaki Recent insights into stearoyl-CoA desaturase-1 Curr. Opin. Lipidol. 14 2003 255 261
    • (2003) Curr. Opin. Lipidol. , vol.14 , pp. 255-261
    • Ntambi, J.M.1    Miyazaki, M.2
  • 47
    • 0029077405 scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • J.M. Ntambi Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol Prog. Lipid Res. 34 1995 139 150
    • (1995) Prog. Lipid Res. , vol.34 , pp. 139-150
    • Ntambi, J.M.1
  • 48
    • 79960632377 scopus 로고    scopus 로고
    • Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia
    • R.M. Oballa, L. Belair, W.C. Black, K.C. Bleasby, C.C. han, C. Desroches, X. Du, R. Gordon, J. Guay, S. Guiral, and et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia J. Med. Chem. 54 2011 5082 5096
    • (2011) J. Med. Chem. , vol.54 , pp. 5082-5096
    • Oballa, R.M.1    Belair, L.2    Black, W.C.3    Bleasby, K.C.4    Han, C.C.5    Desroches, C.6    Du, X.7    Gordon, R.8    Guay, J.9    Guiral, S.10
  • 50
    • 0032509239 scopus 로고    scopus 로고
    • Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant
    • J.F. Oliver, R. lde la, G. ubia, V. Rolli, M.C. Ruiz-Ruiz, M. de, G. urcia, and J.M. Murcia Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant J. Biol. Chem. 273 1998 33533 33539
    • (1998) J. Biol. Chem. , vol.273 , pp. 33533-33539
    • Oliver, J.F.1    Lde La, R.2    Ubia, G.3    Rolli, V.4    Ruiz-Ruiz, M.C.5    De, M.6    Urcia, G.7    Murcia, J.M.8
  • 52
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • A. Paul Nonalcoholic fatty liver disease N. Engl. J. Med. 346 2002 1221 1231
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Paul, A.1
  • 54
    • 77953560365 scopus 로고    scopus 로고
    • Host-virus interactions during hepatitis C virus infection: A complex and dynamic molecular biosystem
    • J. Pezacki, R. Singaravelu, and R. Lyn Host-virus interactions during hepatitis C virus infection: a complex and dynamic molecular biosystem Mol. BioSyst. 6 2010 1131 1142
    • (2010) Mol. BioSyst. , vol.6 , pp. 1131-1142
    • Pezacki, J.1    Singaravelu, R.2    Lyn, R.3
  • 55
    • 84892755312 scopus 로고    scopus 로고
    • An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009-2013)
    • D.A. Powell An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009-2013) Exp. Opin. Ther. Patents 24 2013 155 175
    • (2013) Exp. Opin. Ther. Patents , vol.24 , pp. 155-175
    • Powell, D.A.1
  • 58
    • 40949118437 scopus 로고    scopus 로고
    • Temsirolimus an Inhibitor of Mammalian Target of Rapamycin
    • B.I. Rini Temsirolimus an Inhibitor of Mammalian Target of Rapamycin Clin Cancer Res 14 2008 1286 1290
    • (2008) Clin Cancer Res , vol.14 , pp. 1286-1290
    • Rini, B.I.1
  • 60
    • 84893441702 scopus 로고    scopus 로고
    • Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
    • H. Sampath, and J.M. Ntambi Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance J. Biol. Chem. 289 2014 2482 2488
    • (2014) J. Biol. Chem. , vol.289 , pp. 2482-2488
    • Sampath, H.1    Ntambi, J.M.2
  • 61
    • 67749111842 scopus 로고    scopus 로고
    • Skin specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    • H. Sampath, M.T. Flowers, X. Liu, C.M. Paton, R. Sullivan, and et al. Skin specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity J. Biol. Chem. 284 2009 19961 19973
    • (2009) J. Biol. Chem. , vol.284 , pp. 19961-19973
    • Sampath, H.1    Flowers, M.T.2    Liu, X.3    Paton, C.M.4    Sullivan, R.5
  • 62
    • 21844432112 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
    • N. Scaglia, and R.A. Igal Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells J. Biol. Chem. 280 2005 25339 25349
    • (2005) J. Biol. Chem. , vol.280 , pp. 25339-25349
    • Scaglia, N.1    Igal, R.A.2
  • 63
    • 77954760114 scopus 로고    scopus 로고
    • Anaplastic thyroid carcinoma: Pathogenesis and emerging therapies
    • R.C. Smallridge, and J.A. Copland Anaplastic thyroid carcinoma: pathogenesis and emerging therapies Clin. Oncol. (R. Coll. Radiol.) 22 2010 486 497
    • (2010) Clin. Oncol. (R. Coll. Radiol.) , vol.22 , pp. 486-497
    • Smallridge, R.C.1    Copland, J.A.2
  • 70
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • H. Tilg, and A.R. Moschen Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis Hepatology 52 2010 1836 1846
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 71
    • 0242349259 scopus 로고    scopus 로고
    • β-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages
    • S. Uryu, S. Tokuhiro, and T. Oda β-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages Biochem. Biophys. Res. Commun. 303 2003 302 305
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 302-305
    • Uryu, S.1    Tokuhiro, S.2    Oda, T.3
  • 72
    • 72049095318 scopus 로고    scopus 로고
    • Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl) piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl) amide and its plasma triglyceride-lowering effects in Zucker fatty rats
    • Y. Uto, T. Ogata, Y. Kiyotsuka, Y. Ueno, Y. Miyazawa, H. Kurata, T. Deguchi, N. Watanabe, M. Konishi, R. Okuyama, N. Kurikawa, T. Takagi, S. Wakimoto, and J. Ohsumi Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: identification of 6-[4-(2-methylbenzoyl) piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl) amide and its plasma triglyceride-lowering effects in Zucker fatty rats Bioorg. Med. Chem. Lett. 20 2010 341 345
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 341-345
    • Uto, Y.1    Ogata, T.2    Kiyotsuka, Y.3    Ueno, Y.4    Miyazawa, Y.5    Kurata, H.6    Deguchi, T.7    Watanabe, N.8    Konishi, M.9    Okuyama, R.10    Kurikawa, N.11    Takagi, T.12    Wakimoto, S.13    Ohsumi, J.14
  • 76
    • 34547097746 scopus 로고    scopus 로고
    • Virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • G. Waris, D. Felmlee, F. Negro, A. Siddiqui, and C. Hepatitis virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress J. Virol. 81 2007 8122 8130
    • (2007) J. Virol. , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.2    Negro, F.3    Siddiqui, A.4    Hepatitis, C.5
  • 77
    • 84960825383 scopus 로고    scopus 로고
    • accessed 25.08.15
    • Xenon Pharmaceuticals Web Site. 2015. Available from: http://www.xenon-pharma.com/product-candidates/dermatologic/ (accessed 25.08.15.).
    • (2015)
  • 79
    • 56949099962 scopus 로고    scopus 로고
    • Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma
    • T. Yamashita, M. Honda, H. Takatori, R. Nishino, H. Minato, H. Takamura, T. Ohta, and S. Kaneko Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma J. Hepatol. 50 2009 100 110
    • (2009) J. Hepatol. , vol.50 , pp. 100-110
    • Yamashita, T.1    Honda, M.2    Takatori, H.3    Nishino, R.4    Minato, H.5    Takamura, H.6    Ohta, T.7    Kaneko, S.8
  • 82
    • 0033563109 scopus 로고    scopus 로고
    • Human stearoyl-CoA desaturase alternative transcripts generated single gene tandem polyadenylation sites
    • L. Zhang, L. Ge, S. Parimoo, K. Stenn, and S.M. Prouty Human stearoyl-CoA desaturase alternative transcripts generated single gene tandem polyadenylation sites Biochem. J. 340 1999 255 264
    • (1999) Biochem. J. , vol.340 , pp. 255-264
    • Zhang, L.1    Ge, L.2    Parimoo, S.3    Stenn, K.4    Prouty, S.M.5
  • 84
    • 84903553831 scopus 로고    scopus 로고
    • Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease
    • Z. Zhang, N.A. Dales, and M.D. Winther Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease J. Med. Chem. 57 2014 5039 5056
    • (2014) J. Med. Chem. , vol.57 , pp. 5039-5056
    • Zhang, Z.1    Dales, N.A.2    Winther, M.D.3
  • 86
    • 8844260410 scopus 로고    scopus 로고
    • Acne and sebaceous gland function
    • C.C. Zouboulis Acne and sebaceous gland function Clin. Dermatol. 22 2004 360 366
    • (2004) Clin. Dermatol. , vol.22 , pp. 360-366
    • Zouboulis, C.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.