Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRα-SREBP1c-dependent mechanism

Journal of Diabetes

Volumn 6, Issue 3, 2014, Pages 212-220

  Zhang, Xiaoyan ^a,c   Liu, Jia ^b   Su, Wen ^b   Wu, Jing ^b,d   Wang, Chunjiong ^b   Kong, Xiaomu ^b   Gustafsson, Jan Åke ^e   Ding, Jie ^a   Ma, Xiaosong ^c   Guan, Youfei ^b,c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c Shenzhen University   (China)

^d HEBEI UNITED UNIVERSITY   (China)

^e University of Houston   (United States)

Author keywords

Fatty acid desaturation; Gene knockout mice; Liver X receptor; SCD1; SREBP1c

Indexed keywords

LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; ACYL COENZYME A DESATURASE; FATTY ACID; FLUORINATED HYDROCARBON; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; SCD1 PROTEIN, MOUSE; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDE; TO-901317;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; C57BL MOUSE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG MECHANISM; FATTY ACID DESATURATION; GAS LIQUID CHROMATOGRAPHY; GENE ACTIVATION; GENE ACTIVITY; GENE INDUCTION; GENE OVEREXPRESSION; HOMEOSTASIS; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; AGONISTS; ANIMAL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HEPG2 CELL LINE; HUMAN; IMMUNOBLOTTING; KNOCKOUT MOUSE; LIVER; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; FATTY ACIDS; GENE EXPRESSION; HEP G2 CELLS; HUMANS; HYDROCARBONS, FLUORINATED; IMMUNOBLOTTING; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDES;

EID: 84898600202     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12081     Document Type: Article

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