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Volumn 13, Issue 10, 2012, Pages 1454-1463

Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases

Author keywords

Alcoholic steatohepatitis; Fatty acids; Inflammation; Nonalcoholic steatohepatitis; Obesity metabolic syndrome; Stearoyl CoA desaturase

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACYL COENZYME A DESATURASE 1; ALANINE AMINOTRANSFERASE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTISENSE OLIGONUCLEOTIDE; CCAAT BINDING FACTOR; CD36 ANTIGEN; CONJUGATED LINOLEIC ACID; FAS ANTIGEN; FATTY ACID; INSULIN; INTERLEUKIN 1; LEPTIN; LIVER X RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMEGA 3 FATTY ACID; OXYGENASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PREGNANE X RECEPTOR; ROSIGLITAZONE; SATURATED FATTY ACID; SIRTUIN 1; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STROMELYSIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 84870472400     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012803762693     Document Type: Review
Times cited : (22)

References (102)
  • 1
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J.C.; Horton, J.D.; Hobbs, H.H. Human fatty liver disease: old questions and new insights. Science, 2011, 332, 1519-23.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 2
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon, G.; Baranova, A.; Younossi, Z.M. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther., 2011, 34, 274-85.
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 3
    • 79959848854 scopus 로고    scopus 로고
    • Lipids in the wrong place: Visceral fat and nonalcoholicsteatohepatitis
    • Perseghin, G. Lipids in the wrong place: visceral fat and nonalcoholicsteatohepatitis. Diabetes Care, 2011,34 Suppl 2, S367-70.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Perseghin, G.1
  • 5
    • 79959284653 scopus 로고    scopus 로고
    • Update on fatty liver disease and steatohepatitis
    • Aly, F.Z.; Kleiner, D.E. Update on fatty liver disease and steatohepatitis. Adv. Anat. Pathol., 2011, 18, 294-300.
    • (2011) Adv. Anat. Pathol. , vol.18 , pp. 294-300
    • Aly, F.Z.1    Kleiner, D.E.2
  • 6
    • 79958169116 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A massive problem
    • Day, C.P. Non-alcoholic fatty liver disease: a massive problem. Clin. Med., 2011, 11, 176-8.
    • (2011) Clin. Med. , vol.11 , pp. 176-178
    • Day, C.P.1
  • 10
    • 38849173251 scopus 로고    scopus 로고
    • Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease
    • Mills, S.J.; Harrison, S.A. Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease. Curr. Gastroenterol. Rep., 2005, 7, 32-6.
    • (2005) Curr. Gastroenterol. Rep. , vol.7 , pp. 32-36
    • Mills, S.J.1    Harrison, S.A.2
  • 12
    • 61549111852 scopus 로고    scopus 로고
    • New concepts in the pathogenesis of alcoholic liver disease
    • Albano, E. New concepts in the pathogenesis of alcoholic liver disease. Expert Rev. Gastroenterol. Hepatol., 2008, 2, 749-59.
    • (2008) Expert Rev. Gastroenterol. Hepatol. , vol.2 , pp. 749-759
    • Albano, E.1
  • 14
    • 78149284997 scopus 로고    scopus 로고
    • Role of hepatic desaturases in obesity-related metabolic disorders
    • Bjermo, H.; Riserus, U. Role of hepatic desaturases in obesity-related metabolic disorders. Curr. Opin. Clin. Nutr. Metab. Care, 2010, 13, 703-708.
    • (2010) Curr. Opin. Clin. Nutr. Metab. Care , vol.13 , pp. 703-708
    • Bjermo, H.1    Riserus, U.2
  • 15
    • 77950612089 scopus 로고    scopus 로고
    • A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
    • Buque, X.; Martinez, M. J.; Cano, A.; Miquilena-Colina, M.E.; García-Monzón, C.; Aspichueta, P.; Ochoa, B. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. J. Lipid Res., 2010, 51, 500-513.
    • (2010) J. Lipid Res. , vol.51 , pp. 500-513
    • Buque, X.1    Martinez, M.J.2    Cano, A.3    Miquilena-Colina, M.E.4    García- Monzón, C.5    Aspichueta, P.6    Ochoa, B.7
  • 16
    • 17844383478 scopus 로고    scopus 로고
    • Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    • Biddinger, S. B.; Almind, K.; Miyazaki, M.; Kokkotou, E.; Ntambi, J.M.; Kahn, C.R. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes, 2005 54, 1314-1323.
    • (2005) Diabetes , vol.54 , pp. 1314-1323
    • Biddinger, S.B.1    Almind, K.2    Miyazaki, M.3    Kokkotou, E.4    Ntambi, J.M.5    Kahn, C.R.6
  • 17
    • 77949444189 scopus 로고    scopus 로고
    • Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat
    • Xie, Z.; Li. H.; Wang, K.; Lin, J.; Wang, Q.; Zhao, G.; Jia, W.; Zhang, Q. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Metabolism, 2010, 59, 554-560.
    • (2010) Metabolism , vol.59 , pp. 554-560
    • Xie, Z.1    Li, H.2    Wang, K.3    Lin, J.4    Wang, Q.5    Zhao, G.6    Jia, W.7    Zhang, Q.8
  • 18
    • 33645820583 scopus 로고    scopus 로고
    • Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
    • Linden, D.; William-Olsson, L.; Ahnmark, A.; Ekroos, K.; Hallberg, C.; Sjögren, H.P.; Becker, B.; Svensson, L.; Clapham, J.C.; Oscarsson, J.; Schreyer, S. Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation. FASEB J., 2006, 20, 434-443.
    • (2006) FASEB J. , vol.20 , pp. 434-443
    • Linden, D.1    William-Olsson, L.2    Ahnmark, A.3    Ekroos, K.4    Hallberg, C.5    Sjögren, H.P.6    Becker, B.7    Svensson, L.8    Clapham, J.C.9    Oscarsson, J.10    Schreyer, S.11
  • 21
    • 77955500907 scopus 로고    scopus 로고
    • Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model
    • de Meijer, V. E.; Le, H.D.; Meisel, J.A.; Akhavan, S.M.R.; Pan, A.; Nosé, V.; Puder, M. Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model. Metabolism, 2010, 59, 1092-1105.
    • (2010) Metabolism , vol.59 , pp. 1092-1105
    • Le De Meijer, V.E.H.D.1    Meisel, J.A.2    Akhavan, S.M.R.3    Pan, A.4    Nosé, V.5    Puder, M.6
  • 22
    • 0024444947 scopus 로고
    • Liver microsomal delta 6 and delta 5 linoleic acid desaturation in female BB rats
    • Chanussot, B.; Narce, M.; Poisson, J.P. Liver microsomal delta 6 and delta 5 linoleic acid desaturation in female BB rats. Diabetologia, 1989, 32,786-91.
    • (1989) Diabetologia , vol.32 , pp. 786-791
    • Chanussot, B.1    Narce, M.2    Poisson, J.P.3
  • 23
    • 2942585486 scopus 로고    scopus 로고
    • Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats
    • Fukuchi, S.K.; Hamaguchi, K.; Seike, M.; Himeno, K.; Sakata, T.; Yoshimatsu, H. Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats. Exp. Biol. Med., 2004, 229, 486-493.
    • (2004) Exp. Biol. Med. , vol.229 , pp. 486-493
    • Fukuchi, S.K.1    Hamaguchi, K.2    Seike, M.3    Himeno, K.4    Sakata, T.5    Yoshimatsu, H.6
  • 25
    • 4444358045 scopus 로고    scopus 로고
    • Leptin and the control of metabolism: Role for stearoyl-CoA desaturase-1 (SCD-1)
    • Cohen, P.; Friedman, J. M. "Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J. Nutr., 2004, 134, 2455S-2463S.
    • (2004) J. Nutr. , vol.134
    • Cohen, P.1    Friedman, J.M.2
  • 26
    • 33747034520 scopus 로고    scopus 로고
    • Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    • Biddinger, S. B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R.Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes, 2006, 55, 2032-2041.
    • (2006) Diabetes , vol.55 , pp. 2032-2041
    • Biddinger, S.B.1    Miyazaki, M.2    Boucher, J.3    Ntambi, J.M.4    Kahn, C.R.5
  • 27
    • 77249131862 scopus 로고    scopus 로고
    • Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin
    • Mauvoisin, D.; Prévost, M.; Ducheix, S.; Arnaud, M.P.; Mounier, C.Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin. Mol. Cell. Endocrinol., 2010, 319, 116-128.
    • (2010) Mol. Cell. Endocrinol. , vol.319 , pp. 116-128
    • Mauvoisin, D.1    Prévost, M.2    Ducheix, S.3    Arnaud, M.P.4    Mounier, C.5
  • 30
    • 77956822412 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice
    • Dobrzyn, P.; Dobrzyn, A.; Miyazaki, M.; Ntambi, J.M. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. J. Lipid Res., 2010, 51, 2202-2210.
    • (2010) J. Lipid Res. , vol.51 , pp. 2202-2210
    • Dobrzyn, P.1    Dobrzyn, A.2    Miyazaki, M.3    Ntambi, J.M.4
  • 32
    • 43249127067 scopus 로고    scopus 로고
    • Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    • Flowers, M. T. Ntambi, J. M. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr. Opin. Lipidol., 2008, 19, 248-256.
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 248-256
    • Flowers, M.T.1    Ntambi, J.M.2
  • 33
    • 20144388684 scopus 로고    scopus 로고
    • Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
    • Jiang, G.; Li, Z. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J. Clin. Invest., 2005,115, 1030-1038.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1030-1038
    • Jiang, G.1    Li, Z.2
  • 34
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD-1) in the onset of diet-induced hepatic insulin resistance
    • Gutierrez-Juarez, R.; Pocai. A.; Mulas, C.; Ono, H.; Bhanot, S.; Monia, B.P.; Rossetti, L. Critical role of stearoyl-CoA desaturase-1 (SCD-1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest., 2006, 116, 1686-1695.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3    Ono, H.4    Bhanot, S.5    Monia, B.P.6    Rossetti, L.7
  • 35
    • 67449101455 scopus 로고    scopus 로고
    • Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: Possible role in amelioration of insulin resistance and hepatic steatosis
    • Yokozawa, J., Sasaki. T.; Ohwada, K.; Sasaki, Y.; Ito, J.I.; Saito, T.; Kawata, S. Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: possible role in amelioration of insulin resistance and hepatic steatosis. J. Gastroenterol., 2009, 44, 583-591.
    • (2009) J. Gastroenterol. , vol.44 , pp. 583-591
    • Yokozawa, J.1    Sasaki, T.2    Ohwada, K.3    Sasaki, Y.4    Ito, J.I.5    Saito, T.6    Kawata, S.7
  • 36
    • 79952534308 scopus 로고    scopus 로고
    • Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice
    • Park, H. J.; DiNatale, D.A.; Chung, M.Y.; Park, Y.K.; Lee, J.Y.; Koo, S.I.; O'Connor, M.; Manautou, J.E.; Bruno, R.S. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J. Nutr. Biochem., 2011, 22, 393-400.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 393-400
    • Park, H.J.1    Dinatale, D.A.2    Chung, M.Y.3    Park, Y.K.4    Lee, J.Y.5    Koo, S.I.6    O'Connor, M.7    Manautou, J.E.8    Bruno, R.S.9
  • 37
    • 65549136260 scopus 로고    scopus 로고
    • Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: Role of stearoyl-CoA desaturase
    • Li, Z.Z.; Berk, M.; McIntyre, T.M.; Feldstein, A.E. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J. Biol. Chem., 2009, 284, 5637-5644.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5637-5644
    • Li, Z.Z.1    Berk, M.2    McIntyre, T.M.3    Feldstein, A.E.4
  • 38
    • 68049142428 scopus 로고    scopus 로고
    • Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    • Peter, A.; Weigert, C.; Staiger, H.; Machicao, F.; Schick, F.; Machann, J.; Stefan, N.; Thamer, C.; Häring, H.U.; Schleicher, E. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes, 2009, 58, 1757-1765.
    • (2009) Diabetes , vol.58 , pp. 1757-1765
    • Peter, A.1    Weigert, C.2    Staiger, H.3    MacHicao, F.4    Schick, F.5    MacHann, J.6    Stefan, N.7    Thamer, C.8    Häring, H.U.9    Schleicher, E.10
  • 40
    • 47249090603 scopus 로고    scopus 로고
    • Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention
    • Warensjö, E.; Risérus, U.; Gustafsson, .IB.; Mohsen, R.; Cederholm, T.; Vessby, B. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. Nutr. Metab. Cardiovasc. Dis., 2008, 18, 683-690.
    • (2008) Nutr. Metab. Cardiovasc. Dis. , vol.18 , pp. 683-690
    • Warensjö, E.1    Risérus, U.2    Gustafsson, I.B.3    Mohsen, R.4    Cederholm, T.5    Vessby, B.6
  • 42
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • Kotronen, A.; Seppänen-Laakso, T.; Westerbacka, J.; Kiviluoto, T.; Arola, J.; Ruskeepää, A.L.; Oresic, M.; Yki-Järvinen, H. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes, 2009, 58, 203-208.
    • (2009) Diabetes , vol.58 , pp. 203-208
    • Kotronen, A.1    Seppänen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5    Ruskeepää, A.L.6    Oresic, M.7    Yki-Järvinen, H.8
  • 43
    • 26244436986 scopus 로고    scopus 로고
    • Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men
    • Warensjo, E.; Risérus, U.; Vessby, B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia, 2005, 48, 1999-2005.
    • (2005) Diabetologia , vol.48 , pp. 1999-2005
    • Warensjo, E.1    Risérus, U.2    Vessby, B.3
  • 44
    • 33644881910 scopus 로고    scopus 로고
    • Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
    • Warensjo, E.; Ohrvall, M.; Vessby. B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr. Metab. Cardiovasc. Dis., 2006, 16, 128-136.
    • (2006) Nutr. Metab. Cardiovasc. Dis. , vol.16 , pp. 128-136
    • Warensjo, E.1    Ohrvall, M.2    Vessby, B.3
  • 45
    • 58249092178 scopus 로고    scopus 로고
    • The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents
    • Zhou, Y. E.; Egeland, G.M.; Meltzer, S.J.; Kubow, S. The association of desaturase 9 and plasma fatty acid composition with insulin resistance- associated factors in female adolescents. Metabolism, 2009, 58, 158-166.
    • (2009) Metabolism , vol.58 , pp. 158-166
    • Zhou, Y.E.1    Egeland, G.M.2    Meltzer, S.J.3    Kubow, S.4
  • 46
    • 36048996277 scopus 로고    scopus 로고
    • Long-term predictors of insulin resistance: Role of lifestyle and metabolic factors in middle-aged men
    • Riserus, U.; Arnlöv, J.; Berglund, L. Long-term predictors of insulin resistance: role of lifestyle and metabolic factors in middle-aged men. Diabetes Care, 2007, 30, 2928-2933.
    • (2007) Diabetes Care , vol.30 , pp. 2928-2933
    • Riserus, U.1    Arnlöv, J.2    Berglund, L.3
  • 47
    • 33748477872 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: The SLIM study
    • Corpeleijn, E.; Feskens, E.J.; Jansen, E.H.; Mensink, M.; Saris, W.H.; de Bruin, T.W.; Blaak, E.E. Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia, 2006, 49, 2392-2401.
    • (2006) Diabetologia , vol.49 , pp. 2392-2401
    • Corpeleijn, E.1    Feskens, E.J.2    Jansen, E.H.3    Mensink, M.4    Saris, W.H.5    De Bruin, T.W.6    Blaak, E.E.7
  • 48
    • 34547947590 scopus 로고    scopus 로고
    • Polymorphisms in the SCD-1 gene: Associations with body fat distribution and insulin sensitivity
    • Warensjo, E.; Ingelsson, E.; Lundmark, P.; Lannfelt, L.; Syvänen, A.C.; Vessby, B.; Risérus, U. Polymorphisms in the SCD-1 gene: associations with body fat distribution and insulin sensitivity. Obesity, 2007, 15, 1732-1740.
    • (2007) Obesity , vol.15 , pp. 1732-1740
    • Warensjo, E.1    Ingelsson, E.2    Lundmark, P.3    Lannfelt, L.4    Syvänen, A.C.5    Vessby, B.6    Risérus, U.7
  • 51
    • 65449149413 scopus 로고    scopus 로고
    • Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma
    • Na, T.Y.; Shin, Y.K.; Roh, K.J.; Kang, S.A.; Hong, I.; Oh, S.J.; Seong, J.K.; Park, C.K.; Choi, Y.L.; Lee, M.O. Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology, 2009, 49, 1122-1131.
    • (2009) Hepatology , vol.49 , pp. 1122-1131
    • Na, T.Y.1    Shin, Y.K.2    Roh, K.J.3    Kang, S.A.4    Hong, I.5    Oh, S.J.6    Seong, J.K.7    Park, C.K.8    Choi, Y.L.9    Lee, M.O.10
  • 53
    • 1542410333 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats
    • Levy, J. R.; Clore, J.N.; Stevens, W. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Hepatology, 2004, 39, 608-616.
    • (2004) Hepatology , vol.39 , pp. 608-616
    • Levy, J.R.1    Clore, J.N.2    Stevens, W.3
  • 54
    • 0031781317 scopus 로고    scopus 로고
    • Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid
    • Hagve, T.A.; Woldseth, B; Brox, J.; Narce, M.; Poisson, J.P. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. Scand. J. Clin. Lab. Invest., 1998, 58,187-94.
    • (1998) Scand. J. Clin. Lab. Invest. , vol.58 , pp. 187-194
    • Hagve, T.A.1    Woldseth, B.2    Brox, J.3    Narce, M.4    Poisson, J.P.5
  • 56
    • 0028863637 scopus 로고
    • Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes
    • Narce, M.; Asdrubal, P.; Delachambre, M.C.; Gresti, J.; Poisson, J.P. Influence of spontaneous hypertension on n-3 delta-6-desaturase activity and fatty acid composition of rat hepatocytes. Mol. Cell. Biochem., 1995, 152, 7-12.
    • (1995) Mol. Cell. Biochem. , vol.152 , pp. 7-12
    • Narce, M.1    Asdrubal, P.2    Delachambre, M.C.3    Gresti, J.4    Poisson, J.P.5
  • 57
    • 0033808142 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats
    • Engler, M. M.; Bellenger-Germain, S.H.; Engler, M.B.; Narce, M.M.; Poisson, J.P. Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats. Lipids, 2000, 35, 1011-1015.
    • (2000) Lipids , vol.35 , pp. 1011-1015
    • Engler, M.M.1    Bellenger-Germain, S.H.2    Engler, M.B.3    Narce, M.M.4    Poisson, J.P.5
  • 58
    • 3042819785 scopus 로고    scopus 로고
    • A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension
    • Bellenger, J.; Bellenger, S.; Clément, L.; Mandard, S.; Diot, C.; Poisson, J.P.; Narce, M. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. FASEB J., 2004, 18, 773-775.
    • (2004) FASEB J. , vol.18 , pp. 773-775
    • Bellenger, J.1    Bellenger, S.2    Clément, L.3    Mandard, S.4    Diot, C.5    Poisson, J.P.6    Narce, M.7
  • 60
    • 67349249102 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice
    • Kajikawa, S.; Harada, T.; Kawashima, A.; Imada, K.; Mizuguchi, K. Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice. Prostaglandins Leukot. Essent. Fatty Acids, 2009, 80, 229-238.
    • (2009) Prostaglandins Leukot. Essent. Fatty Acids , vol.80 , pp. 229-238
    • Kajikawa, S.1    Harada, T.2    Kawashima, A.3    Imada, K.4    Mizuguchi, K.5
  • 61
    • 34548527932 scopus 로고    scopus 로고
    • Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats
    • Purushotham, A.; Shrode, G.E.; Wendel, A.A.; Liu, L.F.; Belury, M A. Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats. J. Nutr. Biochem., 2007, 18, 676-684
    • (2007) J. Nutr. Biochem. , vol.18 , pp. 676-684
    • Purushotham, A.1    Shrode, G.E.2    Wendel, A.A.3    Liu, L.F.4    Belury, M.A.5
  • 62
    • 33646441619 scopus 로고    scopus 로고
    • Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (fa/fa) rats
    • Wendel, A. A.; Belury, M. A. Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (fa/fa) rats. Lipids, 2006, 41, 241-247.
    • (2006) Lipids , vol.41 , pp. 241-247
    • Wendel, A.A.1    Belury, M.A.2
  • 63
    • 34447499065 scopus 로고    scopus 로고
    • Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice
    • Liu, L. F., Purushotham A, Wendel AA, Belury MA. Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice. Am. J. Physiol. Gastrointest. Liver Physiol., 2007, 292, G1671-1682.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292
    • Liu, L.F.1    Purushotham, A.2    Wendel, A.A.3    Belury, M.A.4
  • 66
    • 0345601002 scopus 로고    scopus 로고
    • VLDL metabolism in rats is affected by the concentration and source of dietary protein
    • Madani, S.; Prost, J.; Narce, M.; Belleville, J.VLDL metabolism in rats is affected by the concentration and source of dietary protein. J. Nutr., 2003, 133, 4102-4106.
    • (2003) J. Nutr. , vol.133 , pp. 4102-4106
    • Madani, S.1    Prost, J.2    Narce, M.3    Belleville, J.4
  • 67
    • 0027087374 scopus 로고
    • Depletion of delta 9 desaturase (EC 1.14.99.5) enzyme activity in growing rat during dietary protein restriction
    • Narce, M.; Poisson, J.P.; Belleville, J.; Chanussot, B. Depletion of delta 9 desaturase (EC 1.14.99.5) enzyme activity in growing rat during dietary protein restriction. Br. J. Nutr., 1992, 68, 627-637.
    • (1992) Br. J. Nutr. , vol.68 , pp. 627-637
    • Narce, M.1    Poisson, J.P.2    Belleville, J.3    Chanussot, B.4
  • 69
    • 10044240590 scopus 로고    scopus 로고
    • Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver
    • Comte, C.; Bellenger, S.; Bellenger, J.; Tessier, C.; Poisson, J.P.; Narce, M. Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver. Biochimie, 2004, 86, 799-806.
    • (2004) Biochimie , vol.86 , pp. 799-806
    • Comte, C.1    Bellenger, S.2    Bellenger, J.3    Tessier, C.4    Poisson, J.P.5    Narce, M.6
  • 70
    • 79955868038 scopus 로고    scopus 로고
    • An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat
    • Yamazaki, T.; Shiraishi, S. et al. An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat. J. Nutr. Biochem., 2011, 22, 543-553.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 543-553
    • Yamazaki, T.1    Shiraishi, S.2
  • 73
    • 68949091995 scopus 로고    scopus 로고
    • Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones
    • Hwahng, S. H.; Ki, S.H.; Bae, E.J.; Kim, H.E.; Kim, S.G. Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. Hepatology, 2009, 49, 1913-1925.
    • (2009) Hepatology , vol.49 , pp. 1913-1925
    • Hwahng, S.H.1    Ki, S.H.2    Bae, E.J.3    Kim, H.E.4    Kim, S.G.5
  • 74
    • 39749098685 scopus 로고    scopus 로고
    • PXR and LXR in hepatic steatosis, a new dog and an old dog with new tricks
    • Lee, J. H., Zhou J, Xie W. PXR and LXR in hepatic steatosis, a new dog and an old dog with new tricks. Mol. Pharm., 2008, 5, 60-66.
    • (2008) Mol. Pharm. , vol.5 , pp. 60-66
    • Lee, J.H.1    Zhou, J.2    Xie, W.3
  • 75
    • 34247093820 scopus 로고    scopus 로고
    • T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR
    • Mitro, N.; Vargas, L.; Romeo, R.; Koder, A.; Saez, E.T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Lett., 2007, 581, 1721-1726.
    • (2007) FEBS Lett. , vol.581 , pp. 1721-1726
    • Mitro, N.1    Vargas, L.2    Romeo, R.3    Koder, A.4    Saez, E.5
  • 76
    • 80051686720 scopus 로고    scopus 로고
    • ATF4 deficiency protects mice from high-carbohyd.rate diet-induced liver steatosis
    • Li, H.; Meng, Q.; Xiao, F.; Chen, S.; Du, Y.; Yu, J.; Wang, C.; Guo, F. ATF4 deficiency protects mice from high-carbohyd.rate diet-induced liver steatosis. Biochem. J., 2011, 438, 283-289.
    • (2011) Biochem. J. , vol.438 , pp. 283-289
    • Li, H.1    Meng, Q.2    Xiao, F.3    Chen, S.4    Du, Y.5    Yu, J.6    Wang, C.7    Guo, F.8
  • 77
    • 18044388542 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase as a new drug target for obesity treatment
    • Dobrzyn, A.; Ntambi, J. M. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes. Rev., 2005, 6, 169-174.
    • (2005) Obes. Rev. , vol.6 , pp. 169-174
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 78
    • 69949176746 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibitors: Update on patented compounds
    • Liu, G. Stearoyl-CoA desaturase inhibitors: update on patented compounds. Expert Opin. Ther. Pat., 2009, 19, 1169-1191.
    • (2009) Expert Opin. Ther. Pat. , vol.19 , pp. 1169-1191
    • Liu, G.1
  • 79
    • 77952561929 scopus 로고    scopus 로고
    • Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase
    • Dobrzyn, P.; Dobrzyn, A. Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase. Expert Opin. Ther. Pat., 2010, 20, 849-853.
    • (2010) Expert Opin. Ther. Pat. , vol.20 , pp. 849-853
    • Dobrzyn, P.1    Dobrzyn, A.2
  • 80
    • 34948895555 scopus 로고    scopus 로고
    • Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation
    • Li, J. Z.; Ye, J.; Xue, B.; Qi, J.; Zhang, J.; Zhou, Z.; Li, Q.; Wen, Z.; Li, P.; Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes, 2007, 56, 2523-2532.
    • (2007) Diabetes , vol.56 , pp. 2523-2532
    • Li, J.Z.1    Ye, J.2    Xue, B.3    Qi, J.4    Zhang, J.5    Zhou, Z.6    Li, Q.7    Wen, Z.8    Li, P.9
  • 81
    • 37449000478 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats
    • Serrano, A.; Del Arco, I.; Javier, P.F.; Macías, M.; Perez-Valero, V.; Rodríguez de Fonseca, F. The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats. Neuropharmacology, 2008, 54, 226-234.
    • (2008) Neuropharmacology , vol.54 , pp. 226-234
    • Serrano, A.1    Del Arco, I.2    Javier, P.F.3    MacÍas, M.4    Perez-Valero, V.5    Rodríguez De Fonseca, F.6
  • 82
    • 77952426387 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: Considerations for future drug discovery
    • Brown, J. M.; Rudel, L. L. Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery. Curr. Opin. Lipidol., 2010, 21, 192-197.
    • (2010) Curr. Opin. Lipidol. , vol.21 , pp. 192-197
    • Brown, J.M.1    Rudel, L.L.2
  • 84
    • 45549107634 scopus 로고    scopus 로고
    • Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: Longitudinal analyses in middle-aged men
    • Petersson, H.; Basu. S.; Cederholm, T.; Risérus, U. Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men. Br. J. Nutr., 2008, 99, 1186-1189.
    • (2008) Br. J. Nutr. , vol.99 , pp. 1186-1189
    • Petersson, H.1    Basu, S.2    Cederholm, T.3    Risérus, U.4
  • 86
    • 73349117487 scopus 로고    scopus 로고
    • Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
    • Fessler, M. B.; Rudell L.L.; Brown, J.M. Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr. Opin. Lipidol., 2009, 20, 379-385.
    • (2009) Curr. Opin. Lipidol. , vol.20 , pp. 379-385
    • Fessler, M.B.1    Rudell, L.L.2    Brown, J.M.3
  • 88
    • 84860780829 scopus 로고    scopus 로고
    • Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells
    • Minville-Walz, M.; Gresti, J.; Pichon, L.; Bellenger, S.; Bellenger, J.; Narce, M.; Rialland, M. Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells. Genes Nutr. 2012, 7, :209-216.
    • (2012) Genes Nutr , vol.7 , pp. 209-216
    • Minville-Walz, M.1    Gresti, J.2    Pichon, L.3    Bellenger, S.4    Bellenger, J.5    Narce, M.6    Rialland, M.7
  • 90
    • 63149192855 scopus 로고    scopus 로고
    • Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease
    • Zivkovic, A.; Bruce, M.; German, J.; Esfandiari, F.; Halsted, C.H. Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. Alcohol. Clin. Exp. Res., 2009, 33, 751-758.
    • (2009) Alcohol. Clin. Exp. Res. , vol.33 , pp. 751-758
    • Zivkovic, A.1    Bruce, M.2    German, J.3    Esfandiari, F.4    Halsted, C.H.5
  • 91
    • 0034878909 scopus 로고    scopus 로고
    • Effect of ethanol on polyunsaturated fatty acid biosynthesis in hepatocytes from spontaneously hypertensive rats
    • Narce, M.; Poisson, J.P.; Bellenger, J.; Bellenger, S. Effect of ethanol on polyunsaturated fatty acid biosynthesis in hepatocytes from spontaneously hypertensive rats. Alcohol. Clin. Exp. Res., 2001, 25, 1231-1237.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1231-1237
    • Narce, M.1    Poisson, J.P.2    Bellenger, J.3    Bellenger, S.4
  • 94
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    • You, M.; Fischer, M.; Deeg, M.A.; Crabb, D.W. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J. Biol. Chem., 2002, 277, 29342-29347.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 95
    • 33749253713 scopus 로고    scopus 로고
    • Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    • Ji, C.; Chan, C.; Kaplowitz, N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J. Hepatol., 2006, 45, 717-724.
    • (2006) J. Hepatol. , vol.45 , pp. 717-724
    • Ji, C.1    Chan, C.2    Kaplowitz, N.3
  • 96
    • 34548511145 scopus 로고    scopus 로고
    • Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice
    • Yin, H.; Kim, M.; Kim, J.H.; Kong, G.; Kang, K.S.; Kim, H.L.; Yoon, B.I.; Lee, M.O.; Lee, B.H. Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol. Appl. Pharmacol., 2007, 223, 225-233.
    • (2007) Toxicol. Appl. Pharmacol. , vol.223 , pp. 225-233
    • Yin, H.1    Kim, M.2    Kim, J.H.3    Kong, G.4    Kang, K.S.5    Kim, H.L.6    Yoon, B.I.7    Lee, M.O.8    Lee, B.H.9
  • 97
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • You, M.; Matsumoto, M.; Pacold, C.M.; Cho, W.K.; Crabb, D.W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology, 2004,127, 1798-1808.
    • (2004) Gastroenterology , vol.127 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3    Cho, W.K.4    Crabb, D.W.5
  • 98
    • 0037378516 scopus 로고    scopus 로고
    • Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
    • Giandomenico, V.; Simonsson, M.; Grönroos, E.; Ericsson, J. Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol. Cell. Biol., 2003, 23, 2587-2599
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2587-2599
    • Giandomenico, V.1    Simonsson, M.2    Grönroos, E.3    Ericsson, J.4
  • 99
  • 101
    • 40449093056 scopus 로고    scopus 로고
    • Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • You, M.; Cao, Q.; Liang, X.; Ajmo, J.M.; Ness, G.C. Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J. Nutr., 2008, 138, 497-501.
    • (2008) J. Nutr. , vol.138 , pp. 497-501
    • You, M.1    Cao, Q.2    Liang, X.3    Ajmo, J.M.4    Ness, G.C.5


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