Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 37, 2012, Pages 14966-14971

  Brown, Whitney H ^a,b   Gillum, Matthew P ^a,b   Lee, Hui Young ^a,b   Camporez, Joao Paulo G ^b   Zhang, Xian Man ^b   Jeong, Jin Kwon ^b   Alves, Tiago C ^b   Erion, Derek M ^a,b   Guigni, Blas A ^b   Kahn, Mario ^b   Samuel, Varman T ^b   Cravatt, Benjamin F ^c   Diano, Sabrina ^b   Shulman, Gerald I ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Ceramides; Diacylglycerols; T3; T4; TSH

Indexed keywords

ANANDAMIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; DIACYLGLYCEROL; FATTY ACID AMIDASE; GLUCOSE; INSULIN; LIOTHYRONINE; MESSENGER RNA; PALMIDROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE C EPSILON; PROTIRELIN; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; DISEASE PREDISPOSITION; ENERGY EXPENDITURE; GENE DELETION; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; HYPOTHYROIDISM; INSULIN RESISTANCE; LIOTHYRONINE BLOOD LEVEL; LIPID STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYROXINE BLOOD LEVEL;

AMIDOHYDROLASES; ANALYSIS OF VARIANCE; ANIMALS; ARACHIDONIC ACIDS; CHROMATOGRAPHY, LIQUID; ENDOCANNABINOIDS; ENERGY METABOLISM; ETHANOLAMINES; HYPOTHYROIDISM; IMMUNOBLOTTING; INSULIN RESISTANCE; MICE; MICE, KNOCKOUT; PALMITIC ACIDS; POLYMERASE CHAIN REACTION; POLYUNSATURATED ALKAMIDES; PPAR GAMMA; TANDEM MASS SPECTROMETRY; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; THYROXINE; TRIIODOTHYRONINE;

MUS;

EID: 84866296565     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212887109     Document Type: Article

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