Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Lyn, Rodney K ^a,b   Singaravelu, Ragunath ^a,b   Kargman, Stacia ^c   O'Hara, Shifawn ^a   Chan, Helen ^c,e   Oballa, Renata ^c,f   Huang, Zheng ^c,g   Jones, Daniel M ^d   Ridsdale, Andrew ^a   Russell, Rodney S ^d   Partridge, Anthony W ^c,h   Pezacki, John Paul ^a,b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^e Alexion Pharmaceuticals   (Canada)

^f Alexion Pharmaceuticals ^*  (Canada)

^g Lilly China Research and Development Center   (China)

^h Pharmaron Beijing Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; SCD1 PROTEIN, HUMAN; UNSATURATED FATTY ACID;

ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HEPACIVIRUS; HUMAN; MEMBRANE; METABOLISM; TUMOR CELL LINE; VIROLOGY; VIRUS REPLICATION;

CELL LINE, TUMOR; FATTY ACIDS, UNSATURATED; HEPACIVIRUS; HUMANS; MEMBRANES; STEAROYL-COA DESATURASE; VIRUS REPLICATION;

EID: 84897376553     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04549     Document Type: Article

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