메뉴 건너뛰기




Volumn 43, Issue 9, 2016, Pages 881-896

Triterpenes in cancer: significance and their influence

Author keywords

Clinical trials; Ganoderma lucidum; PI3K Akt mTOR pathway; Receptor tyrosine kinase; Triterpenes

Indexed keywords

ACETYL 11 KETO BETA BOSWELLIC ACID; ANTINEOPLASTIC AGENT; ASIATIC ACID; BETULIC ACID; CELASTROL; ERYTHRODIOL; ESCULENTOSIDE; FUNGAL EXTRACT; GLYCYRRHIZIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUPEOL; MAMMALIAN TARGET OF RAPAMYCIN; MASLINIC ACID; MEMBRANE RECEPTOR; NATURAL PRODUCT; OLEANOLIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PLATYCODIN D; PRISTIMERIN; PROTEIN KINASE B; SAIKOSAPONIN A; STAT3 PROTEIN; TOLL LIKE RECEPTOR; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; UVAOL; WITHANOLIDE; TRITERPENE;

EID: 84976276835     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-016-4032-9     Document Type: Review
Times cited : (60)

References (114)
  • 1
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • COI: 1:CAS:528:DC%2BD1cXhtlWlur8%3D, PID: 18234754
    • Croce CM (2008) Oncogenes and cancer. N Engl J Med 358:502–511
    • (2008) N Engl J Med , vol.358 , pp. 502-511
    • Croce, C.M.1
  • 2
    • 84971360233 scopus 로고    scopus 로고
    • Breakthroughs in epigenetics
    • COI: 1:CAS:528:DC%2BC28XmtlCrsLk%3D
    • Anand SS, Gill BS (2015) Breakthroughs in epigenetics. PharmaTutor 3:16–24
    • (2015) PharmaTutor , vol.3 , pp. 16-24
    • Anand, S.S.1    Gill, B.S.2
  • 3
    • 84877797124 scopus 로고    scopus 로고
    • Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents
    • COI: 1:CAS:528:DC%2BC3sXmt1ygu7c%3D, PID: 23373648
    • Negi A, Ramarao P, Kumar R (2013) Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents. Mini Rev Med Chem 13:653–681
    • (2013) Mini Rev Med Chem , vol.13 , pp. 653-681
    • Negi, A.1    Ramarao, P.2    Kumar, R.3
  • 4
    • 0034789517 scopus 로고    scopus 로고
    • Receptor tyrosine kinase signalling as a target for cancer intervention strategies
    • COI: 1:CAS:528:DC%2BD3MXotlCqsL0%3D, PID: 11566607
    • Zwick E, Bange J, Ullrich A (2001) Receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocr Relat Cancer 8:161–173
    • (2001) Endocr Relat Cancer , vol.8 , pp. 161-173
    • Zwick, E.1    Bange, J.2    Ullrich, A.3
  • 5
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • COI: 1:CAS:528:DC%2BC3cXovFartb0%3D, PID: 20602996
    • Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117–1134
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 6
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • COI: 1:CAS:528:DC%2BD3cXns1Cltrs%3D, PID: 11057895
    • Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211–225
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 7
    • 84971253579 scopus 로고    scopus 로고
    • Tilling: versatile reverse genetic tool
    • Negi A, Gill B, Anand SS (2014) Tilling: versatile reverse genetic tool. PharmaTutor 2:26–32
    • (2014) PharmaTutor , vol.2 , pp. 26-32
    • Negi, A.1    Gill, B.2    Anand, S.S.3
  • 8
    • 84941362918 scopus 로고    scopus 로고
    • Growth factors mediated cell signalling in prostate cancer progression: implications in discovery of anti-prostate cancer agents
    • COI: 1:CAS:528:DC%2BC2MXhsVens73O, PID: 26297992
    • Joshi G, Singh PK, Negi A, Rana A, Singh S, Kumar R (2015) Growth factors mediated cell signalling in prostate cancer progression: implications in discovery of anti-prostate cancer agents. Chem Biol Interact 240:120–133
    • (2015) Chem Biol Interact , vol.240 , pp. 120-133
    • Joshi, G.1    Singh, P.K.2    Negi, A.3    Rana, A.4    Singh, S.5    Kumar, R.6
  • 9
    • 84971240326 scopus 로고    scopus 로고
    • Success Stories of enolate form of drugs
    • Negi A, Gill B (2013) Success Stories of enolate form of drugs. PharmaTutor 1:45–53
    • (2013) PharmaTutor , vol.1 , pp. 45-53
    • Negi, A.1    Gill, B.2
  • 10
    • 0031012054 scopus 로고    scopus 로고
    • Plant-derived anticancer agents
    • COI: 1:CAS:528:DyaK2sXitVSrtQ%3D%3D, PID: 9037244
    • Pezzuto JM (1997) Plant-derived anticancer agents. Biochem Pharmacol 53:121–133
    • (1997) Biochem Pharmacol , vol.53 , pp. 121-133
    • Pezzuto, J.M.1
  • 11
    • 0030828993 scopus 로고    scopus 로고
    • Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination
    • COI: 1:CAS:528:DyaK2sXlslyqu78%3D, PID: 9315087
    • Reynolds KA, Wallace KK, Handa S, Brown MS, McArthur HA, Floss HG (1997) Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. J Antibiot 50:701–703
    • (1997) J Antibiot , vol.50 , pp. 701-703
    • Reynolds, K.A.1    Wallace, K.K.2    Handa, S.3    Brown, M.S.4    McArthur, H.A.5    Floss, H.G.6
  • 12
    • 77953533803 scopus 로고    scopus 로고
    • Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXmsF2qt7Y%3D, PID: 20298150
    • Yang H, Dou QP (2010) Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer. Curr Drug Targets 11:733
    • (2010) Curr Drug Targets , vol.11 , pp. 733
    • Yang, H.1    Dou, Q.P.2
  • 13
    • 84861190837 scopus 로고    scopus 로고
    • Anti-glycative potential of triterpenes: a mini-review
    • COI: 1:CAS:528:DC%2BC38XnsFGjtr4%3D
    • Yin M-C (2012) Anti-glycative potential of triterpenes: a mini-review. BioMedicine 2:2–9
    • (2012) BioMedicine , vol.2 , pp. 2-9
    • Yin, M.-C.1
  • 14
    • 34247526984 scopus 로고    scopus 로고
    • Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
    • COI: 1:CAS:528:DC%2BD2sXksFSiu7g%3D, PID: 17446857
    • Liby KT, Yore MM, Sporn MB (2007) Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 7:357–369
    • (2007) Nat Rev Cancer , vol.7 , pp. 357-369
    • Liby, K.T.1    Yore, M.M.2    Sporn, M.B.3
  • 15
    • 67649836518 scopus 로고    scopus 로고
    • Pentacyclic triterpene distribution in various plants–rich sources for a new group of multi-potent plant extracts
    • PID: 19513002
    • Jäger S, Trojan H, Kopp T, Laszczyk MN, Scheffler A (2009) Pentacyclic triterpene distribution in various plants–rich sources for a new group of multi-potent plant extracts. Molecules 14:2016–2031
    • (2009) Molecules , vol.14 , pp. 2016-2031
    • Jäger, S.1    Trojan, H.2    Kopp, T.3    Laszczyk, M.N.4    Scheffler, A.5
  • 16
    • 0036375597 scopus 로고    scopus 로고
    • Structure, mechanism and function of prenyltransferases
    • COI: 1:CAS:528:DC%2BD38XmtF2htbc%3D, PID: 12135472
    • Liang PH, Ko TP, Wang AHJ (2002) Structure, mechanism and function of prenyltransferases. Eur J Biochem 269:3339–3354
    • (2002) Eur J Biochem , vol.269 , pp. 3339-3354
    • Liang, P.H.1    Ko, T.P.2    Wang, A.H.J.3
  • 17
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: spearheading a merger of signaling and therapeutics
    • COI: 1:CAS:528:DC%2BD2sXjt1Slu7w%3D, PID: 17314037
    • Bublil EM, Yarden Y (2007) The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 19:124–134
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 18
    • 84890009448 scopus 로고    scopus 로고
    • Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
    • COI: 1:CAS:528:DC%2BC2cXot1ynsw%3D%3D
    • Singh P, Alex JM, Bast F (2014) Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer. Med Oncol 31:1–14
    • (2014) Med Oncol , vol.31 , pp. 1-14
    • Singh, P.1    Alex, J.M.2    Bast, F.3
  • 19
    • 75149179169 scopus 로고    scopus 로고
    • Metformin associated with lower cancer mortality in type 2 diabetes ZODIAC-16
    • COI: 1:CAS:528:DC%2BC3cXitlaltrw%3D, PID: 19918015
    • Landman GW, Kleefstra N, van Hateren KJ, Groenier KH, Gans RO, Bilo HJ (2010) Metformin associated with lower cancer mortality in type 2 diabetes ZODIAC-16. Diabetes Care 33:322–326
    • (2010) Diabetes Care , vol.33 , pp. 322-326
    • Landman, G.W.1    Kleefstra, N.2    van Hateren, K.J.3    Groenier, K.H.4    Gans, R.O.5    Bilo, H.J.6
  • 21
    • 79952084572 scopus 로고    scopus 로고
    • Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer
    • COI: 1:CAS:528:DC%2BC3cXhsVSht7vO, PID: 22069560
    • Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB (2010) Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins 2:2428–2466
    • (2010) Toxins , vol.2 , pp. 2428-2466
    • Yadav, V.R.1    Prasad, S.2    Sung, B.3    Kannappan, R.4    Aggarwal, B.B.5
  • 22
    • 0033133990 scopus 로고    scopus 로고
    • The PIK-related kinases intercept conventional signaling pathways
    • COI: 1:CAS:528:DyaK1MXjt1Oqs7k%3D, PID: 10322127
    • Kuruvilla FG, Schreiber SL (1999) The PIK-related kinases intercept conventional signaling pathways. Chem Biol 6:R129–R136
    • (1999) Chem Biol , vol.6 , pp. R129-R136
    • Kuruvilla, F.G.1    Schreiber, S.L.2
  • 23
    • 34547793039 scopus 로고    scopus 로고
    • PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation
    • COI: 1:CAS:528:DC%2BD2sXhtVWhsLfP, PID: 17638387
    • Peltier J, O’Neill A, Schaffer DV (2007) PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol 67:1348–1361
    • (2007) Dev Neurobiol , vol.67 , pp. 1348-1361
    • Peltier, J.1    O’Neill, A.2    Schaffer, D.V.3
  • 24
    • 84955614581 scopus 로고    scopus 로고
    • Missing link between microRNA and prostate cancer
    • Gill BS, Alex JM, Kumar S (2016) Missing link between microRNA and prostate cancer. Tumor Biol. doi:10.1007/s13277-016-4900-x
    • (2016) Tumor Biol
    • Gill, B.S.1    Alex, J.M.2    Kumar, S.3
  • 25
    • 84899850988 scopus 로고    scopus 로고
    • Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors
    • COI: 1:CAS:528:DC%2BC2cXnsFWjs78%3D
    • Dienstmann R, Rodon J, Serra V, Tabernero J (2014) Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors. Mol Cancer Therapeut 13:1021–1031
    • (2014) Mol Cancer Therapeut , vol.13 , pp. 1021-1031
    • Dienstmann, R.1    Rodon, J.2    Serra, V.3    Tabernero, J.4
  • 26
    • 0023897684 scopus 로고
    • Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
    • COI: 1:CAS:528:DyaL1cXkvVylsbg%3D, PID: 2833705
    • Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988) Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644–646
    • (1988) Nature , vol.332 , pp. 644-646
    • Whitman, M.1    Downes, C.P.2    Keeler, M.3    Keller, T.4    Cantley, L.5
  • 27
    • 0025201426 scopus 로고
    • Purification and characterization of phosphoinositide 3-kinase from rat liver
    • COI: 1:CAS:528:DyaK3cXlvVOjsL0%3D, PID: 2174051
    • Carpenter C, Duckworth B, Auger K, Cohen B, Schaffhausen B, Cantley L (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704–19711
    • (1990) J Biol Chem , vol.265 , pp. 19704-19711
    • Carpenter, C.1    Duckworth, B.2    Auger, K.3    Cohen, B.4    Schaffhausen, B.5    Cantley, L.6
  • 28
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt a key mediator of cell proliferation, survival and insulin responses?
    • COI: 1:CAS:528:DC%2BD3MXmvFCqs7c%3D, PID: 11686294
    • Lawlor MA, Alessi DR (2001) PKB/Akt a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114:2903–2910
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 30
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • COI: 1:CAS:528:DyaK2sXjsFOjtb8%3D, PID: 9094314
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7:261–269
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 31
    • 0034613381 scopus 로고    scopus 로고
    • Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
    • J-i Okano, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakagawa H (2000) Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem 275:30934–30942
    • (2000) J Biol Chem , vol.275 , pp. 30934-30942
    • Okano, J.-I.1    Gaslightwala, I.2    Birnbaum, M.J.3    Rustgi, A.K.4    Nakagawa, H.5
  • 32
    • 41449088031 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity
    • COI: 1:CAS:528:DC%2BD1cXhtVSmu7s%3D, PID: 18057005
    • Yang P-C, Yang C-H, Huang C-C, Hsu K-S (2008) Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. J Biol Chem 283:2631–2643
    • (2008) J Biol Chem , vol.283 , pp. 2631-2643
    • Yang, P.-C.1    Yang, C.-H.2    Huang, C.-C.3    Hsu, K.-S.4
  • 35
    • 2442464889 scopus 로고    scopus 로고
    • Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
    • COI: 1:CAS:528:DC%2BD2cXivFKms7s%3D, PID: 15077155
    • Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW (2004) Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 23:2934–2949
    • (2004) Oncogene , vol.23 , pp. 2934-2949
    • Pommier, Y.1    Sordet, O.2    Antony, S.3    Hayward, R.L.4    Kohn, K.W.5
  • 36
    • 27844562649 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease
    • COI: 1:CAS:528:DC%2BD2MXht1Wis7vL, PID: 16288294
    • Astrinidis A, Henske EP (2005) Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 24:7475–7481
    • (2005) Oncogene , vol.24 , pp. 7475-7481
    • Astrinidis, A.1    Henske, E.P.2
  • 37
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • COI: 1:CAS:528:DC%2BD3sXhsFGhtro%3D, PID: 12612653
    • Ruggero D, Pandolfi PP (2003) Does the ribosome translate cancer? Nat Rev Cancer 3:179–192
    • (2003) Nat Rev Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 38
    • 0032765047 scopus 로고    scopus 로고
    • Studies of the molecular mechanisms in the regulation of telomerase activity
    • COI: 1:CAS:528:DyaK1MXotVKit7k%3D, PID: 10593857
    • Liu J-P (1999) Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 13:2091–2104
    • (1999) FASEB J , vol.13 , pp. 2091-2104
    • Liu, J.-P.1
  • 39
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • COI: 1:CAS:528:DC%2BD2cXmvFKqsLk%3D, PID: 15314020
    • Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926–1945
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 40
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • COI: 1:CAS:528:DC%2BD2sXotVyqsr0%3D, PID: 17613433
    • Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9–22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 41
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • COI: 1:CAS:528:DC%2BD2cXptFentL8%3D, PID: 15467718
    • Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6:1122–1128
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Rüegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 42
    • 84894038895 scopus 로고    scopus 로고
    • Too sweet for autophagy: hexokinase inhibition of mTORC1 activates autophagy
    • COI: 1:CAS:528:DC%2BC2cXivFCqtr4%3D, PID: 24560270
    • Kundu M (2014) Too sweet for autophagy: hexokinase inhibition of mTORC1 activates autophagy. Mol Cell 53:517–518
    • (2014) Mol Cell , vol.53 , pp. 517-518
    • Kundu, M.1
  • 45
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • COI: 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D, PID: 15122205
    • Bjornsti M-A, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4:335–348
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.-A.1    Houghton, P.J.2
  • 46
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • COI: 1:CAS:528:DC%2BD2MXjtVOqt7Y%3D, PID: 15797377
    • Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O’Reilly T, Natt F, Hall J, Lane HA, Thomas G (2005) The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120:747–759
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3    Zilbermann, F.4    Ruetz, S.5    O’Reilly, T.6    Natt, F.7    Hall, J.8    Lane, H.A.9    Thomas, G.10
  • 47
    • 84937973345 scopus 로고    scopus 로고
    • Differential algorithms-assisted molecular modeling-based identification of mechanistic binding of ganoderic acids
    • COI: 1:CAS:528:DC%2BC2MXhtFGgur%2FP
    • Gill BS, Kumar S (2015) Differential algorithms-assisted molecular modeling-based identification of mechanistic binding of ganoderic acids. Med Chem Res 24:3483–3493
    • (2015) Med Chem Res , vol.24 , pp. 3483-3493
    • Gill, B.S.1    Kumar, S.2
  • 48
    • 53049083867 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor action and resistance in cancer
    • COI: 1:CAS:528:DC%2BD1cXhtF2ku7fJ
    • McConkey DJ, Zhu K (2008) Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Update 11:164–179
    • (2008) Drug Resist Update , vol.11 , pp. 164-179
    • McConkey, D.J.1    Zhu, K.2
  • 49
    • 65649109750 scopus 로고    scopus 로고
    • Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer
    • COI: 1:CAS:528:DC%2BD1MXks1Wis7o%3D, PID: 19355962
    • Rios J, Recio M, Escandell J, Andujar I (2009) Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer. Curr Pharm Des 15:1212–1237
    • (2009) Curr Pharm Des , vol.15 , pp. 1212-1237
    • Rios, J.1    Recio, M.2    Escandell, J.3    Andujar, I.4
  • 50
    • 84881029662 scopus 로고    scopus 로고
    • Cucurbitacins—a promising target for cancer therapy
    • Alghasham AA (2013) Cucurbitacins—a promising target for cancer therapy. Int J Health Sci 7:77–89
    • (2013) Int J Health Sci , vol.7 , pp. 77-89
    • Alghasham, A.A.1
  • 51
    • 33645839013 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs
    • COI: 1:CAS:528:DC%2BD28XislSmsLY%3D, PID: 16529541
    • Klampfer L (2006) Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Curr Cancer Drug Targets 6:107–121
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 107-121
    • Klampfer, L.1
  • 53
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of STAT3 in human prostate tumors and cell lines direct inhibition of STAT3 signaling induces apoptosis of prostate cancer cells
    • COI: 1:CAS:528:DC%2BD38XovFOksLw%3D, PID: 12438264
    • Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R, Bowman T, Falcone R, Fairclough R, Cantor A (2002) Constitutive activation of STAT3 in human prostate tumors and cell lines direct inhibition of STAT3 signaling induces apoptosis of prostate cancer cells. Cancer Res 62:6659–6666
    • (2002) Cancer Res , vol.62 , pp. 6659-6666
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6    Bowman, T.7    Falcone, R.8    Fairclough, R.9    Cantor, A.10
  • 54
    • 0031127782 scopus 로고    scopus 로고
    • Cucurbitacin E targets proliferating endothelia
    • COI: 1:CAS:528:DyaK2sXksVGit78%3D, PID: 9202647
    • Duncan MD, Duncan KL (1997) Cucurbitacin E targets proliferating endothelia. J Surg Res 69:55–60
    • (1997) J Surg Res , vol.69 , pp. 55-60
    • Duncan, M.D.1    Duncan, K.L.2
  • 55
    • 33846420177 scopus 로고    scopus 로고
    • Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of tumor necrosis factor-α in T lymphocytes and macrophages
    • COI: 1:CAS:528:DC%2BD2sXhs1Wkur0%3D, PID: 17065367
    • Escandell JM, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL (2007) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of tumor necrosis factor-α in T lymphocytes and macrophages. J Pharmacol Exp Ther 320:581–590
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 581-590
    • Escandell, J.M.1    Recio, M.C.2    Máñez, S.3    Giner, R.M.4    Cerdá-Nicolás, M.5    Ríos, J.L.6
  • 56
    • 34548693457 scopus 로고    scopus 로고
    • Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
    • COI: 1:CAS:528:DC%2BD2sXhtVaktrvJ, PID: 17855663
    • Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, Guha S, Sethi G, Aggarwal BB (2007) Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5:943–955
    • (2007) Mol Cancer Res , vol.5 , pp. 943-955
    • Pathak, A.K.1    Bhutani, M.2    Nair, A.S.3    Ahn, K.S.4    Chakraborty, A.5    Kadara, H.6    Guha, S.7    Sethi, G.8    Aggarwal, B.B.9
  • 57
    • 0025792319 scopus 로고
    • Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: a summary of the Southwest Oncology Group experience
    • COI: 1:STN:280:DyaK387hvVOntw%3D%3D, PID: 1768676
    • Hersh EM, Metch BS, Muggia FM, Brown TD, Whitehead RP, Budd GT, Rinehart JJ, Crawford ED, Bonnet JD, Behrens BC (1991) Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: a summary of the Southwest Oncology Group experience. J Immunother 10:426–431
    • (1991) J Immunother , vol.10 , pp. 426-431
    • Hersh, E.M.1    Metch, B.S.2    Muggia, F.M.3    Brown, T.D.4    Whitehead, R.P.5    Budd, G.T.6    Rinehart, J.J.7    Crawford, E.D.8    Bonnet, J.D.9    Behrens, B.C.10
  • 58
    • 0031405585 scopus 로고    scopus 로고
    • TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB
    • COI: 1:CAS:528:DyaK1cXjsFaisw%3D%3D, PID: 9430228
    • Schneider P, Thome M, Burns K, Bodmer J-L, Hofmann K, Kataoka T, Holler N, Tschopp J (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 7:831–836
    • (1997) Immunity , vol.7 , pp. 831-836
    • Schneider, P.1    Thome, M.2    Burns, K.3    Bodmer, J.-L.4    Hofmann, K.5    Kataoka, T.6    Holler, N.7    Tschopp, J.8
  • 59
    • 0037276438 scopus 로고    scopus 로고
    • Tumor necrosis factor signaling
    • COI: 1:CAS:528:DC%2BD3sXit12mu7s%3D, PID: 12655295
    • Wajant H, Pfizenmaier K, Scheurich P (2003) Tumor necrosis factor signaling. Cell Death Differ 10:45–65
    • (2003) Cell Death Differ , vol.10 , pp. 45-65
    • Wajant, H.1    Pfizenmaier, K.2    Scheurich, P.3
  • 61
    • 0042835740 scopus 로고    scopus 로고
    • Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors
    • COI: 1:CAS:528:DC%2BD3sXotFCksbc%3D, PID: 12960128
    • Spierings DC, de Vries EG, Timens W, Groen HJ, Boezen HM, de Jong S (2003) Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors. Clin Cancer Res 9:3397–3405
    • (2003) Clin Cancer Res , vol.9 , pp. 3397-3405
    • Spierings, D.C.1    de Vries, E.G.2    Timens, W.3    Groen, H.J.4    Boezen, H.M.5    de Jong, S.6
  • 62
    • 0036449063 scopus 로고    scopus 로고
    • Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily
    • Springer, Berlin
    • O’Neill L (2002) Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. In: Wagner H, Beutler B (eds) Toll-like receptor family members and their ligands. Springer, Berlin, pp 47–61
    • (2002) Toll-like receptor family members and their ligands , pp. 47-61
    • O’Neill, L.1    Wagner, H.2    Beutler, B.3
  • 63
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • COI: 1:CAS:528:DC%2BD2cXlt1Cqur0%3D, PID: 15229469
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499–511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 65
    • 84952066998 scopus 로고    scopus 로고
    • Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling
    • Gill B, Sharma P, Kumar R, Kumar S (2015) Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling. Tumor Biol 37:2789–2804
    • (2015) Tumor Biol , vol.37 , pp. 2789-2804
    • Gill, B.1    Sharma, P.2    Kumar, R.3    Kumar, S.4
  • 66
    • 0345530834 scopus 로고    scopus 로고
    • Programmed cell death: superman meets Dr Death
    • COI: 1:CAS:528:DC%2BD3sXptlGnsLs%3D, PID: 14647296
    • Meier P, Silke J (2003) Programmed cell death: superman meets Dr Death. Nat Cell Biol 5:1035–1038
    • (2003) Nat Cell Biol , vol.5 , pp. 1035-1038
    • Meier, P.1    Silke, J.2
  • 67
    • 84870383878 scopus 로고    scopus 로고
    • Tumor necrosis factor
    • COI: 1:CAS:528:DC%2BC38Xhs1agsr7K, PID: 23085193
    • Chu W-M (2013) Tumor necrosis factor. Cancer Lett 328:222–225
    • (2013) Cancer Lett , vol.328 , pp. 222-225
    • Chu, W.-M.1
  • 68
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • COI: 1:CAS:528:DC%2BD2MXhtlSksrnI, PID: 16355214
    • Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438:967–974
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 69
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • COI: 1:CAS:528:DyaK2MXjs1KnsLk%3D, PID: 7584949
    • Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27–30
    • (1995) Nat Med , vol.1 , pp. 27-30
    • Folkman, J.1
  • 70
    • 0031440035 scopus 로고    scopus 로고
    • Anti-inflammatory actions of pentacyclic triterpenes
    • COI: 1:CAS:528:DyaK1cXisVOl, PID: 9434597
    • Safayhi H, Sailer E (1997) Anti-inflammatory actions of pentacyclic triterpenes. Planta Med 63:487–493
    • (1997) Planta Med , vol.63 , pp. 487-493
    • Safayhi, H.1    Sailer, E.2
  • 71
    • 84925307967 scopus 로고    scopus 로고
    • Maslinic acid enhances signals for the recruitment of macrophages and their differentiation to m1 state
    • Sánchez-Quesada C, López-Biedma A, Gaforio JJ (2015) Maslinic acid enhances signals for the recruitment of macrophages and their differentiation to m1 state. Evid Based Complement Altern Med. doi:10.1155/2015/654721
    • (2015) Evid Based Complement Altern Med
    • Sánchez-Quesada, C.1    López-Biedma, A.2    Gaforio, J.J.3
  • 72
    • 9644279912 scopus 로고    scopus 로고
    • Saikosaponin C induces endothelial cells growth, migration and capillary tube formation
    • COI: 1:CAS:528:DC%2BD2cXhtVCltb7F, PID: 15581913
    • Shyu K-G, Tsai S-C, Wang B-W, Liu Y-C, Lee C-C (2004) Saikosaponin C induces endothelial cells growth, migration and capillary tube formation. Life Sci 76:813–826
    • (2004) Life Sci , vol.76 , pp. 813-826
    • Shyu, K.-G.1    Tsai, S.-C.2    Wang, B.-W.3    Liu, Y.-C.4    Lee, C.-C.5
  • 73
    • 70349554345 scopus 로고    scopus 로고
    • Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study
    • Y-x Zhou, Y-l Huang (2009) Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study. Chin Med J 122:1666–1673
    • (2009) Chin Med J , vol.122 , pp. 1666-1673
    • Zhou, Y.-X.1    Huang, Y.-L.2
  • 74
    • 0036871314 scopus 로고    scopus 로고
    • Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance
    • Kimura Y, Taniguchi M, Baba K (2001) Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22:3309–3318
    • (2001) Anticancer Res , vol.22 , pp. 3309-3318
    • Kimura, Y.1    Taniguchi, M.2    Baba, K.3
  • 75
    • 0042834196 scopus 로고    scopus 로고
    • Betulinic acid suppresses carcinogen-induced NF-κB activation through inhibition of IκBα kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9
    • COI: 1:CAS:528:DC%2BD3sXmvFKjsr8%3D, PID: 12960358
    • Takada Y, Aggarwal BB (2003) Betulinic acid suppresses carcinogen-induced NF-κB activation through inhibition of IκBα kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 171:3278–3286
    • (2003) J Immunol , vol.171 , pp. 3278-3286
    • Takada, Y.1    Aggarwal, B.B.2
  • 76
    • 34047261665 scopus 로고    scopus 로고
    • Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    • COI: 1:CAS:528:DC%2BD2sXivV2nsbw%3D, PID: 17363604
    • Chintharlapalli S, Papineni S, Ramaiah SK, Safe S (2007) Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res 67:2816–2823
    • (2007) Cancer Res , vol.67 , pp. 2816-2823
    • Chintharlapalli, S.1    Papineni, S.2    Ramaiah, S.K.3    Safe, S.4
  • 77
    • 15744404456 scopus 로고    scopus 로고
    • Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells
    • COI: 1:CAS:528:DC%2BD2MXjtlSntrw%3D
    • Hsu Y-L, Kuo P-L, Lin L-T, Lin C-C (2005) Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J Pharm Exp Ther 313:333–344
    • (2005) J Pharm Exp Ther , vol.313 , pp. 333-344
    • Hsu, Y.-L.1    Kuo, P.-L.2    Lin, L.-T.3    Lin, C.-C.4
  • 78
    • 38949133443 scopus 로고    scopus 로고
    • Inhibition of LPS-induced NO and PGE 2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways
    • COI: 1:CAS:528:DC%2BD1cXitVGhs7o%3D, PID: 18279797
    • Yun K-J, Kim J-Y, Kim J-B, Lee K-W, Jeong S-Y, Park H-J, Jung H-J, Cho Y-W, Yun K, Lee K-T (2008) Inhibition of LPS-induced NO and PGE 2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol 8:431–441
    • (2008) Int Immunopharmacol , vol.8 , pp. 431-441
    • Yun, K.-J.1    Kim, J.-Y.2    Kim, J.-B.3    Lee, K.-W.4    Jeong, S.-Y.5    Park, H.-J.6    Jung, H.-J.7    Cho, Y.-W.8    Yun, K.9    Lee, K.-T.10
  • 79
    • 84921647351 scopus 로고    scopus 로고
    • Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways
    • PID: 25617149
    • Zhou C, Liu W, He W, Wang H, Chen Q, Song H (2015) Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways. Int Immunopharmacol 25:49–54
    • (2015) Int Immunopharmacol , vol.25 , pp. 49-54
    • Zhou, C.1    Liu, W.2    He, W.3    Wang, H.4    Chen, Q.5    Song, H.6
  • 80
    • 67651005688 scopus 로고    scopus 로고
    • Acetyl-11-keto-β-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    • COI: 1:CAS:528:DC%2BD1MXosV2msbc%3D, PID: 19567671
    • Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB, Liu M (2009) Acetyl-11-keto-β-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 69:5893–5900
    • (2009) Cancer Res , vol.69 , pp. 5893-5900
    • Pang, X.1    Yi, Z.2    Zhang, X.3    Sung, B.4    Qu, W.5    Lian, X.6    Aggarwal, B.B.7    Liu, M.8
  • 81
    • 33644536397 scopus 로고    scopus 로고
    • Acetyl-11-keto-β-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-κB and NF-κB-regulated gene expression
    • COI: 1:CAS:528:DC%2BD28Xhs1eru70%3D, PID: 16493072
    • Takada Y, Ichikawa H, Badmaev V, Aggarwal BB (2006) Acetyl-11-keto-β-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-κB and NF-κB-regulated gene expression. J Immunol 176:3127–3140
    • (2006) J Immunol , vol.176 , pp. 3127-3140
    • Takada, Y.1    Ichikawa, H.2    Badmaev, V.3    Aggarwal, B.B.4
  • 82
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    • COI: 1:CAS:528:DC%2BC3cXisFWisrw%3D, PID: 20160026
    • Pang X, Yi Z, Zhang J, Lu B, Sung B, Qu W, Aggarwal BB, Liu M (2010) Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res 70:1951–1959
    • (2010) Cancer Res , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6    Aggarwal, B.B.7    Liu, M.8
  • 83
    • 80052081077 scopus 로고    scopus 로고
    • Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression
    • Kim Y, Kang H, Jang S-W, Ko J (2010) Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol 28:175–184
    • (2010) Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol , vol.28 , pp. 175-184
    • Kim, Y.1    Kang, H.2    Jang, S.-W.3    Ko, J.4
  • 84
    • 77953924040 scopus 로고    scopus 로고
    • The in vitro and in vivo experimental evidences disclose the Chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis
    • PID: 20461449
    • Weng C-J, Yen G-C (2010) The in vitro and in vivo experimental evidences disclose the Chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis. Clin Exp Metastasis 27:361–369
    • (2010) Clin Exp Metastasis , vol.27 , pp. 361-369
    • Weng, C.-J.1    Yen, G.-C.2
  • 85
    • 67650995911 scopus 로고    scopus 로고
    • Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD1MXosV2msbk%3D, PID: 19605406
    • Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Song JH, Yin D, Toh M, Xie WD (2009) Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res 69:5876–5884
    • (2009) Cancer Res , vol.69 , pp. 5876-5884
    • Thoennissen, N.H.1    Iwanski, G.B.2    Doan, N.B.3    Okamoto, R.4    Lin, P.5    Abbassi, S.6    Song, J.H.7    Yin, D.8    Toh, M.9    Xie, W.D.10
  • 87
    • 33746048055 scopus 로고    scopus 로고
    • Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression
    • COI: 1:CAS:528:DC%2BD28XmsVamsrg%3D, PID: 16818501
    • Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression. Mol Cancer Ther 5:1434–1445
    • (2006) Mol Cancer Ther , vol.5 , pp. 1434-1445
    • Ichikawa, H.1    Takada, Y.2    Shishodia, S.3    Jayaprakasam, B.4    Nair, M.G.5    Aggarwal, B.B.6
  • 88
    • 85027898766 scopus 로고    scopus 로고
    • Abstract B24: natural withanolides: A new group of anticancer drugs that selectively target the PI3K-mTOR pathway as novel potent therapeutics against colon cancers in vitro and in vivo
    • Subramanian C, White P, Gingrich A, Timmermann BN, Cohen MS (2015) Abstract B24: natural withanolides: A new group of anticancer drugs that selectively target the PI3K-mTOR pathway as novel potent therapeutics against colon cancers in vitro and in vivo. Mol Cancer Ther 14:B24–B24
    • (2015) Mol Cancer Ther , vol.14 , pp. B24
    • Subramanian, C.1    White, P.2    Gingrich, A.3    Timmermann, B.N.4    Cohen, M.S.5
  • 89
    • 27744500461 scopus 로고    scopus 로고
    • Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway
    • COI: 1:CAS:528:DC%2BD2MXhtFCjt7rN, PID: 15958516
    • Saleem M, Kaur S, Kweon M-H, Adhami VM, Afaq F, Mukhtar H (2005) Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. Carcinogenesis 26:1956–1964
    • (2005) Carcinogenesis , vol.26 , pp. 1956-1964
    • Saleem, M.1    Kaur, S.2    Kweon, M.-H.3    Adhami, V.M.4    Afaq, F.5    Mukhtar, H.6
  • 90
    • 3142676732 scopus 로고    scopus 로고
    • Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
    • COI: 1:CAS:528:DC%2BD2cXlt1OksLc%3D, PID: 15122342
    • Saleem M, Afaq F, Adhami VM, Mukhtar H (2004) Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 23:5203–5214
    • (2004) Oncogene , vol.23 , pp. 5203-5214
    • Saleem, M.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 91
    • 84863000261 scopus 로고    scopus 로고
    • Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation
    • COI: 1:CAS:528:DC%2BC38XptVert70%3D, PID: 22669041
    • Mu X, Shi W, Sun L, Li H, Jiang Z, Zhang L (2012) Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation. Molecules 17:6854–6868
    • (2012) Molecules , vol.17 , pp. 6854-6868
    • Mu, X.1    Shi, W.2    Sun, L.3    Li, H.4    Jiang, Z.5    Zhang, L.6
  • 92
    • 84863463881 scopus 로고    scopus 로고
    • The pretreatment of cucumber with methyl jasmonate regulates antioxidant enzyme activities and protects chloroplast and mitochondrial ultrastructure in chilling-stressed leaves
    • COI: 1:CAS:528:DC%2BC38XhtFKnsb3I
    • Li D-M, Guo Y-K, Li Q, Zhang J, Wang X-J, Bai J-G (2012) The pretreatment of cucumber with methyl jasmonate regulates antioxidant enzyme activities and protects chloroplast and mitochondrial ultrastructure in chilling-stressed leaves. Sci Horticult 143:135–143
    • (2012) Sci Horticult , vol.143 , pp. 135-143
    • Li, D.-M.1    Guo, Y.-K.2    Li, Q.3    Zhang, J.4    Wang, X.-J.5    Bai, J.-G.6
  • 93
    • 33646153996 scopus 로고    scopus 로고
    • Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes
    • COI: 1:CAS:528:DC%2BD28XktVegsbg%3D, PID: 16631160
    • Ahn KS, Hahn B-S, Kwack K, Lee EB, Kim YS (2006) Platycodin D-induced apoptosis through nuclear factor-κB activation in immortalized keratinocytes. Eur J Pharmacol 537:1–11
    • (2006) Eur J Pharmacol , vol.537 , pp. 1-11
    • Ahn, K.S.1    Hahn, B.-S.2    Kwack, K.3    Lee, E.B.4    Kim, Y.S.5
  • 94
    • 84884377447 scopus 로고    scopus 로고
    • Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle
    • COI: 1:CAS:528:DC%2BC3sXhs1Sqsb%2FF, PID: 23900420
    • Ogasawara R, Sato K, Higashida K, Nakazato K, Fujita S (2013) Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle. Am J Physiol Endocrinol Metab 305:E760–E765
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E760-E765
    • Ogasawara, R.1    Sato, K.2    Higashida, K.3    Nakazato, K.4    Fujita, S.5
  • 95
    • 67651242243 scopus 로고    scopus 로고
    • Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways
    • COI: 1:CAS:528:DC%2BD1MXpsFChtbg%3D, PID: 19533808
    • Xu Y-H, Zhao L-J, Li Y (2009) Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol WJG 15:2870
    • (2009) World J Gastroenterol WJG , vol.15 , pp. 2870
    • Xu, Y.-H.1    Zhao, L.-J.2    Li, Y.3
  • 97
    • 84903767319 scopus 로고    scopus 로고
    • Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231)
    • COI: 1:CAS:528:DC%2BC2cXhtVOgtrfM, PID: 24888707
    • Elumalai P, Arunkumar R, Benson CS, Sharmila G, Arunakaran J (2014) Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231). Cell Biochem Funct 32:476–484
    • (2014) Cell Biochem Funct , vol.32 , pp. 476-484
    • Elumalai, P.1    Arunkumar, R.2    Benson, C.S.3    Sharmila, G.4    Arunakaran, J.5
  • 99
    • 84937928864 scopus 로고    scopus 로고
    • Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
    • PID: 26191214
    • He S-Q, Gao M, Fu Y-F, Zhang Y-N (2015) Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling. Int J Clin Exp Pathol 8:5175
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 5175
    • He, S.-Q.1    Gao, M.2    Fu, Y.-F.3    Zhang, Y.-N.4
  • 101
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
    • COI: 1:CAS:528:DC%2BD1MXnsVagtbs%3D, PID: 19536107
    • Baselga J, Swain SM (2009) Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 9:463–475
    • (2009) Nat Rev Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 102
    • 84874938231 scopus 로고    scopus 로고
    • β-Eudesmol induces JNK-dependent apoptosis through the mitochondrial pathway in HL60 cells
    • COI: 1:CAS:528:DC%2BC3sXjslSqsL0%3D, PID: 22585533
    • Li Y, Li T, Miao C, Li J, Xiao W, Ma E (2013) β-Eudesmol induces JNK-dependent apoptosis through the mitochondrial pathway in HL60 cells. Phytother Res 27:338–343
    • (2013) Phytother Res , vol.27 , pp. 338-343
    • Li, Y.1    Li, T.2    Miao, C.3    Li, J.4    Xiao, W.5    Ma, E.6
  • 103
    • 84928169049 scopus 로고    scopus 로고
    • Oridonin inhibits mTOR signaling and the growth of lung cancer tumors
    • COI: 1:CAS:528:DC%2BC2cXhs1eisrrP, PID: 25075795
    • Wang Y-Y, Lv Y-F, Lu L, Cai L (2014) Oridonin inhibits mTOR signaling and the growth of lung cancer tumors. Anticancer Drugs 25:1192–1200
    • (2014) Anticancer Drugs , vol.25 , pp. 1192-1200
    • Wang, Y.-Y.1    Lv, Y.-F.2    Lu, L.3    Cai, L.4
  • 104
    • 0024845481 scopus 로고
    • Content of betulin and betulinic acid, antitumor agents of Zizyphus species
    • COI: 1:CAS:528:DyaK3cXht1GitLo%3D
    • Maurya S, Devi S, Pandey V, Khosa R (1989) Content of betulin and betulinic acid, antitumor agents of Zizyphus species. Fitoterapia 60:468–469
    • (1989) Fitoterapia , vol.60 , pp. 468-469
    • Maurya, S.1    Devi, S.2    Pandey, V.3    Khosa, R.4
  • 105
    • 84890672850 scopus 로고    scopus 로고
    • Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea
    • PID: 24279741
    • Sánchez-Quesada C, López-Biedma A, Warleta F, Campos M, Beltrán G, Gaforio JJ (2013) Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea. J Agric Food Chem 61:12173–12182
    • (2013) J Agric Food Chem , vol.61 , pp. 12173-12182
    • Sánchez-Quesada, C.1    López-Biedma, A.2    Warleta, F.3    Campos, M.4    Beltrán, G.5    Gaforio, J.J.6
  • 106
    • 56349099145 scopus 로고    scopus 로고
    • Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway
    • COI: 1:CAS:528:DC%2BD1cXhsVWnu7jL, PID: 18790561
    • Reyes-Zurita FJ, Rufino-Palomares EE, Lupiáñez JA, Cascante M (2009) Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. Cancer Lett 273:44–54
    • (2009) Cancer Lett , vol.273 , pp. 44-54
    • Reyes-Zurita, F.J.1    Rufino-Palomares, E.E.2    Lupiáñez, J.A.3    Cascante, M.4
  • 107
    • 81255158024 scopus 로고    scopus 로고
    • Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B
    • COI: 1:CAS:528:DC%2BC3MXhsV2rt7vN, PID: 21970807
    • Huang L, Guan T, Qian Y, Huang M, Tang X, Li Y, Sun H (2011) Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B. Eur J Pharmacol 672:169–174
    • (2011) Eur J Pharmacol , vol.672 , pp. 169-174
    • Huang, L.1    Guan, T.2    Qian, Y.3    Huang, M.4    Tang, X.5    Li, Y.6    Sun, H.7
  • 108
    • 67650109645 scopus 로고    scopus 로고
    • Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation
    • PID: 19543395
    • Martín R, Ibeas E, Carvalho-Tavares J, Hernández M, Ruiz-Gutierrez V, Nieto ML (2009) Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. PLoS One 4:e5975
    • (2009) PLoS One , vol.4
    • Martín, R.1    Ibeas, E.2    Carvalho-Tavares, J.3    Hernández, M.4    Ruiz-Gutierrez, V.5    Nieto, M.L.6
  • 109
    • 80053897594 scopus 로고    scopus 로고
    • Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice
    • COI: 1:CAS:528:DC%2BC3MXht12itrrE, PID: 21708244
    • Lu J, D-m Wu, Zheng Y-l HuB, Cheng W, Z-f Zhang, Shan Q (2011) Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. Brain Behav Immun 25:1658–1667
    • (2011) Brain Behav Immun , vol.25 , pp. 1658-1667
    • Lu, J.1    Wu, D.-M.2    Zheng, H.B.3    Cheng, W.4    Zhang, Z.-F.5    Shan, Q.6
  • 110
    • 84867015860 scopus 로고    scopus 로고
    • Glycyrrhizin regulates CD4+ T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway
    • C-t Tu, Li J, F-p Wang, Li L, J-y Wang, Jiang W (2012) Glycyrrhizin regulates CD4+ T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway. Int Immunopharmacol 14:410–421
    • (2012) Int Immunopharmacol , vol.14 , pp. 410-421
    • Tu, C.-T.1    Li, J.2    Wang, F.-P.3    Li, L.4    Wang, J.Y.5    Jiang, W.6
  • 111
    • 2942569380 scopus 로고    scopus 로고
    • Effects of esculentoside A on production of interleukin-1, 2, and prostaglandin E ~ 2
    • COI: 1:CAS:528:DC%2BD2cXkvVyqt7c%3D, PID: 15169638
    • Xiao Z-Y, Zheng Q-Y, Jiang Y-Y, Zhou B, Yin M, Wang H-B, Zhang J-P (2004) Effects of esculentoside A on production of interleukin-1, 2, and prostaglandin E ~ 2. Acta Pharmacol Sin 25:817–821
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 817-821
    • Xiao, Z.-Y.1    Zheng, Q.-Y.2    Jiang, Y.-Y.3    Zhou, B.4    Yin, M.5    Wang, H.-B.6    Zhang, J.-P.7
  • 112
    • 8444237366 scopus 로고    scopus 로고
    • Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-κB signaling
    • COI: 1:CAS:528:DC%2BD2cXhtVentrbE, PID: 15489214
    • Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D (2004) Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-κB signaling. Nutr Cancer 49:209–216
    • (2004) Nutr Cancer , vol.49 , pp. 209-216
    • Jiang, J.1    Slivova, V.2    Harvey, K.3    Valachovicova, T.4    Sliva, D.5
  • 113
    • 77950818771 scopus 로고    scopus 로고
    • Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression
    • COI: 1:CAS:528:DC%2BC3cXptFKntL8%3D, PID: 20360625
    • Chen N-H, Liu J-W, Zhong J-J (2010) Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol Rep 62:150–163
    • (2010) Pharmacol Rep , vol.62 , pp. 150-163
    • Chen, N.-H.1    Liu, J.-W.2    Zhong, J.-J.3
  • 114
    • 38849178686 scopus 로고    scopus 로고
    • Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1
    • COI: 1:CAS:528:DC%2BD1cXhs1aisb8%3D, PID: 18024477
    • Weng C-J, Chau C-F, Hsieh Y-S, Yang S-F, Yen G-C (2008) Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1. Carcinogenesis 29:147–156
    • (2008) Carcinogenesis , vol.29 , pp. 147-156
    • Weng, C.-J.1    Chau, C.-F.2    Hsieh, Y.-S.3    Yang, S.-F.4    Yen, G.-C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.