Signal transduction pathways activated by the IL-1 receptor/Toll-like receptor superfamily

Current Topics in Microbiology and Immunology

Volumn 270, Issue , 2002, Pages 47-61

  O'Neill, L A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; IRAK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAK 1 PROTEIN; TOLL LIKE RECEPTOR; TOLLIP PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

GENE INDUCTION; GRAM NEGATIVE BACTERIUM; HOST; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; MICROORGANISM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0036449063     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59430-4_3     Document Type: Review

References (79)

1. Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S (1998) Targetted disruption of the MyD88 gene results in loss of IL-1 and IL-18-mediated function. Immunity 9:143-150
2. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:696-712
3. Anderson KV, Bokla L, Nusslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 42:791-798
4. Aliprantis, AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A (1999) Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 285:736-739
5. Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG (2000) Toll-like receptor 2-mediated NF-κB requires a Rac1-dependent pathway. Nature Immunol 1:533-540
6. Bowie, A, Kiss-Toth E, Symons JA, Smith GL, Dower SK, O'Neill LA (2000) A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci USA 97:10162-10167
7. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL (1999) Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285:732-736
8. Bulut, Y, Faure E, Thomas L, Equils O, Arditi M (2001) Coperation of TLR-2 and -6 for cellular activation by soluble tuberculosis factor and Borellia burdoferi outer surface protein A lipoprotein: Role of Toll-interacting protein and IL-1 receptor signalling molecules in Toll-like receptor 2 signalling. J Immunol 167:987-994
9. Burns, K, Martinon F, Esslinger C, Pahl H, Schneider P, Bodmer JL, Di Marco F, French L, Tschopp J (1998) MyD88: An adapter protein involved in interleukin-1 signalling. J Biol Chem 273:12203-12209
10. Burns, K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (2000) Tollip, a new component of the IL-1RI pathway links IRAK to the IL-1 receptor. Nature Cell Biol 2:364-351
11. Cao Z, Henzel WJ, Gao X (1996a) IRAK: A kinase associated with the interleukin-1 receptor. Science 271:1128-1131
12. Cao Z., Xiong J, Takeuchi M, Kurama T, Goeddel DV (1996b) Traf-6 is a signal transducer for interleukin-1. Nature 383:443-446
13. Caunt CJ, Kiss-Toth E, Carlotti F, Chapman R, Qwarnstrom EE (2001) Ras controls tumor necrosis factor receptor-associated factor (TRAF)6-dependent induction of nuclear factor-κ b. Selective regulation through receptor signaling components. J Biol Chem 276:6280-6288
14. Chen CY, Del Gatto-Konczak F, Wu Z, Karin M (1998) Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science 280:1945-1949
15. Dunn E, Sims JE, Nicklin MJ, O'Neill LA (2001) Annotating genes with potential roles in the immune system: Six new members of the IL-1 family. Trends in Immunol 22:533-536
16. Da Silva Correia J, Soldau K, Christen U, Tobias PS, Ulevitch RJ (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR-4 and ND2. J Biol Chem 276:21129-21135
17. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (2001) Mal (MyD88 adapter-like) is required for TLR-4 signal transduction. Nature 413:78-83
18. Gay NJ, Keith F (1991) Drosophila Toll and IL-1 receptor. Nature 351:355-356
19. Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL (2001) Cutting edge: Bacterial flagellin activates basolaterally expressed TLR-5 to induce epithelial proinflammatory gene expression. J Immunol 167:1882-1885
20. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-1103
21. Heguy A, Baldari CT, Macchia G, Telford JL, Melli M (1992) Amino acids conserved in the interleukin-1 receptors (IL-1Rs) and the Drosophila Toll protein are essential for IL-1R signal transduction. J Biol Chem 267:2605-2609
22. Hedengren M, Asling B, Dushay MS, Ando I, Ekengren S, Wihlborg M, Hultmark D (1999) Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Mol Cell 4:1-20
23. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S (2000) A Toll-liker receptor recognises bacterial DNA. Nature 408:740-745
24. Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN (2001) Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69:1477-82
25. Horng T, Barton GM, Medzhitov R (2001) TIRAP: An adapter molecule in Toll signalling. Nature Immunol 2:835-841
26. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752
27. Huang Q, Liu D, Majewski, P, Schulte LC, Korn JM, Young RA, Lander ES and Hacohen N (2001) The plasticity of dendritic cell responses to pathogens and their components. Science 294:870-875
28. Huang WY, Valles S, Qwarnstrom EE (2001) Translocation of the IL-1 receptor to focal adhesions is regulated through the C-terminal end of the cytoplasmic domain. Cell Biol Int 25:309-317
29. Janssens, S et al (2002) Regulation of interleukin-1-induced NF-κB activation by alternative splicing of MyD88. Current Biol (in press)
30. Jefferies C, O'Neill LAJ (2000) Racl regulated IL-1-induced NF-κB in an I-κB-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression. J Biol Chem 275:3114-3120
31. Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA (2001) Transactivation by the p65 subunit of NF-κB in response to IL-1 involves MyD88, IRAK, Traf-6 and Racl. Mol Cell Biol 21:4544-4552
32. Jones BW, Means TK, Heldwein KA, Keen MA, Hill PJ, Belisle JT, Fenton MJ (2001) Different Toll-like receptor agonists induce distinct macrophage responses. J Leukoc Biol 69:1036-1044
33. Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S (2001) Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 166:5688-5694
34. Kawai, T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115-150
35. Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, Hoshino K, Akira S (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167:5887-5894
36. Kidd S (1992) Characterisation of the Drosophila cactus locus and analysis of interaction between cactus and dorsal proteins. Cell 71:623-635
37. Li X, Commane M, Burns C, Vithalani K, Cao Z, Stark G (1999) Mutant cells that do not respond to IL-1 reveal a novel role for IL-1 receptor-associated kinase. Mol Cell Biol 19:4643-4652
38. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent anti-fungal response in Drosophila adults. Cell 86:973-983
39. Levashina EA, Langley E, Green C, Gubb D, Ashburner M, Hoffmann JA, Reichhart JM (1999) Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 285:1917-1919
40. Letsou A, Alexander S, Orth K, Wasserman SA (1991) Genetic and molecular characterisation of tube, a Drosophila gene maternally required for embryonic dorsoventral polatiry. Proc Natl Acad Sci USA 88:810-814
41. Lord KA, Hoffman-Liebermann B, Liebermann DA (1990) Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene 5:1095-1097
42. MacGillivray MK, Cruz TF, McCulloch CA (2000) The recruitment of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1beta-induced ERK activation. J Biol Chem 275:23509-23515
43. Mahtani KR, Brook M, Dean JL, Sully G, Saklatvala J, Clark AR (2001) Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 21:6461-6469
44. Mansell A, Reinicke A, Worrall DM, O'Neill LAJ (2002) The serine protease inhibitor anti-thrombin-III inhibits LPS-mediated NF-κB activation by TLR-4. FEBS Lett 508:313-317
45. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397
46. Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA Jr (1998) MyD88 is an adapter in the hToll/Il-1 receptor family signalling pathways. Mol Cell 2:253-258
47. Muzio M, Li J, Feng P, Dixit V (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278:1612-1615
48. Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T, Inoue J (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 1999 4:353-362
49. O'Neill LAJ (2000) the interleukin-1 receptor / Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Science's Signal Transduction Knowledge Environment. http://www.stke.org/cgi/content/full/OC.sigtrans;2000/44/rel
50. O'Neill LAJ, Greene C (1998) Signal transduction pathways activated by the IL-1 receptor family: Ancient signalling machinery in mammals, insects and plants. J Leuk Biol 63:650-657
51. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A (2000) The reportoire for pattern recognition of pathogens by the innate immune system is defined by co-operation between Toll-like receptors. Proc Natl Acad Sci USA 97:13766-13771
52. Palsson EM, Popoff M, Thelestam M, O'Neill LA (2000) Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1. J Biol Chem 275:7818-7825
53. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085-2088
54. Pujol N, Link EM, Liu LX, Kurz CL, Alloing G, Tan M, Ray KP, Solari R, Johnson CD, Ewbank JJ (2001) A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Curr Biol 11:809-821
55. Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (2001) IRAK-mediated translocation of Traf-6 and TAB2 in the interleukin-1-induced activation of NF-κB. J Biol Chem 276:41661-41667
56. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D (1999) Endotoxin-tolerent mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189:615-625
57. Re F, Strominger JL (2001) Toll-like receptor 2 (tlr2) and tlr4 differentially activate human dendritic cells. J Biol Chem 276:37692-37699
58. Ridley SH, Sarsfield SJ, Lee JC, Bigg HF, Cawston TE, Taylor DJ, DeWitt DL, Saklatvala J (1997) Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol 158:3165-3173
59. Roth S, Stein D, Nusslein-Volhard C (1989) A gradient of nuclear localisation of the dorsal protein determines dorsoventral patterns in the Drosophila embryo. Cell 59:1189-1202
60. Schreuder H, Tardif C, Trump-Kallmeyer S, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW (1997) A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature 386:194-200
61. Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ (1999) Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor-2. J Biol Chem 274:17406-17409
62. Shelton CA, Wasserman, SA (1993) pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell 72:515-525
63. Sims JE, March CJ, Cosman D, Widmer MB, MacDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, Dower SK (1988) cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241:585-589
64. Sims JE, Dower SK (1994) Interleukin-1 receptors. Eur Cyt Netw 5:539-546
65. Sizemore N, Leung S, Stark GR (1999) Activation of PI 3-kinase in response to IL-1 leads to phosphorylation and activation of the NF-kappa p65/RelA subunit. Mol Cell Biol 19:4798-4805
66. Takaesu, G., Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (2001) Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK-1 by inducing TAB2 translocafion in the IL-1 signalling pathway. Mol Cell Biol 21:2475-2484
67. Takeuchi, O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S (1999) Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11:443-451
68. Takeuchi, O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Muhlradt PF, Akira S (2000) Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor-2- and MyD88-dependent signalling pathway. J Immunol 164:554-557
69. Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S (2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13:933-940
70. Thomas JA, Allen JL, Tsen M, Dubnicoff T, Danao J, Liao XC, Cao Z, Wasserman SA (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol 163:978-984
71. Underhill, D, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, Aderem A (1999) Toll-like receptor-2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401:1477-1482
72. Volpe, F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (1997) The IL-1 receptor accessory protein is responsible for the recruitment of the interluakin-1 receptor associated kinase to the IL-1/IL-1 receptor complex. FEBS Lett 419:41-44
73. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346-351
74. Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z (1997) MyD88: An adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837-847
75. Wu LP, Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 395:93-97
76. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274:19403-19410
77. Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111-115
78. Yamin TT and Miller DK (1997) The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J Biol Chem 272:21540-21547
79. Yang RB, Mark MR, Gurney AL, Godowski PJ (1999) Signaling events induced by lipopolysaccharide-activated toll-like receptor. J Immunol 163:639-643