Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

International Immunopharmacology

Volumn 8, Issue 3, 2008, Pages 431-441

  Yun, Kyung Jin ^a   Kim, Ji Yeon ^a   Kim, Jong Bin ^a   Lee, Kyung Won ^a   Jeong, Seo Young ^a   Park, Hee Juhn ^b   Jung, Hyun Ju ^b   Cho, Young Wuk ^c   Yun, Kijoo ^d   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Sangji University   (South Korea)

^c Biomedical Science Institute   (South Korea)

^d Gangneung Wonju National University   (South Korea)

Author keywords

Asiatic acid; Lipopolysaccharide; Mitogen activated protein kinases; Nitric oxide; Nuclear factor B; Prostaglandin E2

Indexed keywords

AGLYCONE; ASIATIC ACID; ASIATICOSIDE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INHIBITORY KAPPA B ALPHA; INHIBITORY KAPPA B KINASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; PROTEIN KINASE; PROTEIN P50; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL NUCLEUS; CELL VIABILITY; CENTELLA ASIATICA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; MACROPHAGE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTO-ONCOGENE PROTEINS C-RAF; TRITERPENES;

EID: 38949133443     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.11.003     Document Type: Article

References (53)

1. Rao A.V., and Gurfinkel D.M. The bioactivity of saponins: triterpenoid and steroidal glycosides. Drug Metab Drug Interac 17 (2000) 211-235
2. Coldren C.D., Hashim P., Ali J.M., Oh S.K., Sinskey A.J., and Rha C. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med 69 (2003) 725-732
3. Lee Y.S., Jin D.Q., Beak S.M., Lee E.S., and Kim J.A. Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes. Eur J Pharmacol 476 (2003) 173-178
4. Jew S.S., Yoo C.H., Lim D.Y., Kim H., Mook-Jung I., Jung M.W., et al. Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity. Bioorg Med Chem Lett 10 (2000) 119-121
5. Lee M.K., Kim S.R., Sung S.H., Lim D., Kim H., Choi H., et al. Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity. Res Commun Mol Pathol Pharmacol 108 (2000) 75-86
6. Dong M.S., Jung S.H., Kim H.J., Kim J.R., Zhao L.X., Lee E.S., et al. Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6. Arch Pharm Res 27 (2004) 512-517
7. 2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Cancer Lett 186 (2002) 83-91
8. Maquart F.X., Chastang F., Simeon A., Birembaut P., Gillery P., and Wegrowski Y. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 9 (1999) 289-296
9. Mook-Jung I., Shin J.E., Yun S.H., Huh K., Koh J.Y., Park H.K., et al. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res 58 (1999) 417-425
10. Medzhitov R., and Janeway Jr. C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91 (1997) 295-298
11. Grahames C.B., Michel A.D., Chessell I.P., and Humphrey P.P. Pharmacological characterization of ATP-and LPS-induced IL-1beta release in human monocytes. Br J Pharmacol 127 (1999) 1915-1921
12. Mehta V.B., Hart J., and Wewers M.D. ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem 276 (2001) 3820-3826
13. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 8 (1990) 253-278
14. Lee S.H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267 (1992) 25934-25938
15. Ignarro L.J. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol 53 (2002) 503-514
16. West N.E., Qian H., Guzik T.J., Black E., Cai S., George S.E., et al. Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: effects on vascular smooth muscle cell differentiation and superoxide production. Circulation 104 (2001) 1526-1532
17. Heba G., Krzeminski T., Porc M., Grzyb J., and Dembinska-Kiec A. Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats. J Physiol Pharmacol 52 (2001) 39-52
18. Salvemini D., Ischiropoulos H., and Cuzzocrea S. Roles of nitric oxide and superoxide in inflammation. Methods Mol Biol 225 (2003) 291-303
19. Funk C.D., Funk L.B., Kennedy M.E., Pong A.S., and Fitzgerald G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 5 (1991) 2304-2312
20. Subbaramaiah K., and Dannenberg A.J. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 24 (2003) 96-102
21. Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat Rev, Immunol 2 (2002) 725-734
22. 2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells. J Biol Chem 272 (1997) 25941-25950
23. Karin M., and Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signaling. Semin Immunol 12 (2000) 85-98
24. Doyle S., Vaidya S., O'Connell R., Dadgostar H., Dempsey P., Wu T., et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17 (2002) 251-263
25. Triantafilou M., and Triantafilou K. Sepsis: molecular mechanisms underlying lipopolysaccharide recognition. Expert Rev Mol Med 6 (2004) 1-18
26. Su B., and Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol 8 (1996) 402-411
27. Zang M., Hayne C., and Luo Z. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem 277 (2002) 4395-4405
28. Whitmarsh A.J., and Davis R.J. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci 23 (1998) 481-485
29. Jung H.J., Park H.J., Kim R.G., Shin K.M., Ha J., Choi J.W., et al. In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus. Planta Med 69 (2003) 610-616
30. Kim D.H., Lee K.T., Bae E.A., Han M.J., and Park H.J. Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation to in vitro cytotoxicity. Arch Pharm Res 22 (1999) 30-34
31. Jung HJ, Nam JH, Lee KT, Choi J, Kim WB, Chung WY, et al. Structure-activity relationships of polyhydroxyursane-type triterpenoids on the cytoprotective and anti-inflammatory effects. Nat Prod Sci 2007;13:152-9.
32. Won J.H., Im H.T., Kim Y.H., Yun K.J., Park H.J., Choi J.W., et al. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. Br J Pharmacol 148 (2006) 216-225
33. Janssen-Heininger Y.M., Poynter M.E., and Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28 (2000) 1317-1327
34. Ghosh S., and Karin M. Missing pieces in the NF-κB puzzle. Cell 109 (2002) S81-S96
35. Bian Z.M., Elner S.G., Yoshida A., and Elner V.M. Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade. Exp Eye Res 76 (2003) 573-583
36. Chakravortty D., Kato Y., Sugiyama T., Koide N., Mu M.M., Yoshida T., et al. The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production inRAW267.4macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J Immunol 166 (2001) 2011-2017
37. 2. Acta Pharmacol Sin 25 (2004) 817-821
38. Jeong H.G., and Kim J.Y. Induction of inducible nitric oxide synthase expression by 18beta-glycyrrhetinic acid in macrophages. FEBS Lett 513 (2002) 208-212
39. Marquez Martin A., de la Puerta Vazquez R., Fernandez-Arche A., and Ruiz-Gutierrez V. Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. Free Radic Res 40 (2006) 295-302
40. Caballero-George C., Vanderheyden P.M., Okamoto Y., Masaki T., Mbwambo Z., Apers S., et al. Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. Phytother Res 18 (2004) 729-736
41. Barnes P.J., and Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336 (1997) 1066-1071
42. Brown K., Park S., Kanno T., Franzoso G., and Siebenlist U. Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci USA 90 (1993) 2532-2536
43. Rodriguez M.S., Thompson J., Hay R.T., and Dargemont C. Nuclear retention of IkappaB alpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem 274 (1999) 9108-9115
44. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13 (2001) 85-94
45. Ruland J., and Mak T.W. Transducing signals from antigen receptors to nuclear factor kappaB. Immunol Rev 193 (2003) 93-100
46. Chen C.C., and Wang J.K. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol 55 (1999) 481-488
47. Bhat N.R., Zhang P., Lee J.C., and Hogan E.L. Extracellular signal regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18 (1998) 1633-1641
48. Ajizian S.J., English B.K., and Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J Infect Dis 179 (1999) 939-944
49. Hambleton J., Weinstein S.L., Lem L., and DeFranco A.L. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 93 (1996) 2774-2778
50. Liu Q., Fan J., McMahon M., Prince A.M., and Zhang P. Role of the oncogenic Raf-1 in orchestration of discrete nuclear factor-kappaB-activating pathways. Mol Cell Biol Res Commun 4 (2001) 381-389
51. Kyriakis J.M., App H., Zhang X.F., Banerjee P., Brautigan D.L., Rapp U.R., et al. Raf-1 activates MAP kinase-kinase. Nature 358 (1992) 417-421
52. O'Nell L. The role of MyD88-like adapters in Toll-like receptor signal transduction. Biochem Soc Trans 28 (2000) 557-563
53. Horng T., Barton G.M., Flavell R.A., and Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for toll-like receptors. Nature 420 (2002) 329-333