Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B

European Journal of Pharmacology

Volumn 672, Issue 1-3, 2011, Pages 169-174

  Huang, Longfei ^a   Guan, Teng ^a   Qian, Yisong ^a   Huang, Menghao ^a   Tang, Xuzhen ^a   Li, Yunman ^a   Sun, Hongbin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Astrocyte; LPS; Maslinic acid; NF B; Pentacyclic triterpene

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MASLINIC ACID; NITRIC OXIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BIOLOGICAL AGENTS; CELL NUCLEUS; CELLS, CULTURED; CEREBRAL CORTEX; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 81255158024     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.175     Document Type: Article

References (32)

1. E. Ambrosini, and F. Aloisi Chemokines and glial cells: a complex network in the central nervous system Neurochem. Res. 29 2004 1017 1038 (Pubitemid 39011351)
2. C.H. Chen, M.T. Sheu, T.F. Chen, Y.C. Wang, W.C. Hou, D.Z. Liu, T.C. Chung, and Y.C. Liang Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways Biochem. Pharmacol. 72 2006 1001 1009
3. 15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138 (Pubitemid 13203451)
4. W.S. Griffin Perispinal etanercept: potential as an Alzheimer therapeutic J. Neuroinflammation 5 2008 3
5. T. Guan, Y. Li, H. Sun, X. Tang, and Y. Qian Effects of maslinic acid, a natural triterpene, on glycogen metabolism in cultured cortical astrocytes Planta Med. 75 2009 1141 1143
6. U.K. Hanisch Microglia as a source and target of cytokines Glia 40 2002 140 155
7. M.S. Hayden, and S. Ghosh Signaling to NF-kappaB Genes Dev. 18 2004 2195 2224
8. B. Kaltschmidt, T. Sparna, and C. Kaltschmidt Activation of NF-kappa B by reactive oxygen intermediates in the nervous system Antioxid. Redox Signal. 1 1999 129 144 (Pubitemid 129619770)
9. C. Li, Z. Yang, C. Zhai, W. Qiu, D. Li, Z. Yi, L. Wang, J. Tang, M. Qian, J. Luo, and M. Liu Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway Mol. Cancer 9 2010 73
10. S.T. Lin, Y. Wang, Y. Xue, D.C. Feng, Y. Xu, and L.Y. Xu Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF- kappaB signaling pathway Mol. Cell. Biochem. 315 2008 41 49
11. S.M. Lucas, N.J. Rothwell, and R.M. Gibson The role of inflammation in CNS injury and disease Br. J. Pharmacol. 147 Suppl 1 2006 S232 S240 (Pubitemid 43077281)
12. A. Marquez Martin, R. de la Puerta Vazquez, A. Fernandez-Arche, and V. Ruiz-Gutierrez Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages Free. Radic. Res. 40 2006 295 302 (Pubitemid 43245445)
13. B. Mayer, and B. Hemmens Biosynthesis and action of nitric oxide in mammalian cells Trends Biochem. Sci. 22 1997 477 481 (Pubitemid 27515914)
14. K.D. McCarthy, and J. de Vellis Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J. Cell Biol 85 1980 890 902 (Pubitemid 10007455)
15. M.P. Montilla, A. Agil, M.C. Navarro, M.I. Jimenez, A. Garcia-Granados, A. Parra, and M.M. Cabo Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea Planta Med. 69 2003 472 474 (Pubitemid 36774194)
16. R.E. Mrak, and W.S. Griffin Glia and their cytokines in progression of neurodegeneration Neurobiol. Aging 26 2005 349 354 (Pubitemid 40082718)
17. C. Nathan, and Q.W. Xie Regulation of biosynthesis of nitric oxide J. Biol. Chem. 269 1994 13725 13728 (Pubitemid 24191108)
18. T.C. Nichols NF-kappaB and reperfusion injury Drug News Perspect. 17 2004 99 104
19. Y. Qian, T. Guan, X. Tang, L. Huang, M. Huang, Y. Li, H. Sun, R. Yu, and F. Zhang Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid Eur. J. Pharmacol. 651 2011 59 65
20. A. Salminen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors Prog. Neurobiol. 87 2009 181 194
21. G. Sethi, B. Sung, and B.B. Aggarwal Nuclear factor-kappaB activation: from bench to bedside Exp. Biol. Med. (Maywood) 233 2008 21 31
22. I.M. Shah, I.M. Macrae, and M. Di Napoli Neuroinflammation and neuroprotective strategies in acute ischaemic stroke - from bench to bedside Curr. Mol. Med. 9 2009 336 354
23. W.H. Shen, C.Y. Zhang, and G.Y. Zhang Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia Acta Pharmacol. Sin. 24 2003 311 315
24. M.V. Sofroniew Reactive astrocytes in neural repair and protection Neuroscientist 11 2005 400 407 (Pubitemid 41339226)
25. K. Sriram, and J.P. O'Callaghan Divergent roles for tumor necrosis factor-alpha in the brain J. Neuroimmune Pharmacol. 2 2007 140 153
26. C. Szabo, and C. Thiemermann Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury Shock 2 1994 145 155
27. Y. Takei, and R. Laskey Interpreting crosstalk between TNF-alpha and NGF: potential implications for disease Trends Mol. Med. 14 2008 381 388
28. L.J. Van Eldik, W.L. Thompson, H. Ralay Ranaivo, H.A. Behanna, and D. Martin Watterson Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches Int. Rev. Neurobiol. 82 2007 277 296
29. J.R. Vane, J.A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, J. Croxtall, and D.A. Willoughby Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation Proc. Natl. Acad. Sci. U. S. A. 91 1994 2046 2050 (Pubitemid 24092039)
30. A. Volterra, and J. Meldolesi Astrocytes, from brain glue to communication elements: the revolution continues Nat. Rev. Neurosci. 6 2005 626 640 (Pubitemid 41059337)
31. K.K. Wu Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators Prostaglandins Leukot. Essent. Fatty Acids 72 2005 89 93 (Pubitemid 40051225)
32. D.Y. Zhu, Q. Deng, H.H. Yao, D.C. Wang, Y. Deng, and G.Q. Liu Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice Life Sci. 71 2002 1985 1996