Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

Brain, Behavior, and Immunity

Volumn 25, Issue 8, 2011, Pages 1658-1667

  Lu, Jun ^a   Wu, Dong mei ^a,b   Zheng, Yuan lin ^a   Hu, Bin ^a   Cheng, Wei ^b   Zhang, Zi feng ^a   Shan, Qun ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b CHINA UNIVERSITY OF MINING AND TECHNOLOGY   (China)

Author keywords

Cognitive impairments; Endoplasmic reticulum stress; High fat diet; I B kinase nuclear factor B mediated inflammation; Insulin signaling; Ursolic acid

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; URSOLIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; HIPPOCAMPUS; INFLAMMATION; LIPID DIET; MALE; MAZE TEST; MEMORY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; COGNITION DISORDERS; CYCLOOXYGENASE INHIBITORS; DIET, HIGH-FAT; DIETARY FATS; ENDOPLASMIC RETICULUM STRESS; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; I-KAPPA B KINASE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INSULIN; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NF-KAPPA B; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOR SERINE-THREONINE KINASES; TRITERPENES;

EID: 80053897594     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.06.009     Document Type: Article

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