Cucurbitacin e induces autophagy via downregulating mTORC1 signaling and upregulating AMPK activity

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Zha, Qing Bing ^a   Zhang, Xiao Yu ^a   Lin, Qiu Ru ^a   Xu, Li Hui ^a   Zhao, Gao Xiang ^a   Pan, Hao ^a   Zhou, Dan ^a   Ouyang, Dong Yun ^a   Liu, Ze Huan ^a   He, Xian Hui ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; CUCURBITACIN; CUCURBITACIN E; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ATG5 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 5; LAMP2 PROTEIN, HUMAN; MAP1LC3A PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; S6 KINASE; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE; TRITERPENE; ULK1 PROTEIN, HUMAN;

ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LYSOSOME; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; MCF-7 CELL LINE; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOMES; MCF-7 CELLS; MICROTUBULE-ASSOCIATED PROTEINS; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRITERPENES;

EID: 84929346834     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124355     Document Type: Article

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