Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of tumor necrosis factor-α in T lymphocytes and macrophages

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 2, 2007, Pages 581-590

  Escandell, José M ^a   Recio, M Carmen ^a   Máñez, Salvador ^a   Giner, Rosa M ^a   Cerdá Nicolás, Miguel ^a   Ríos, José Luis ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CUCURBITACIN R; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; PLANT EXTRACT; PROSTAGLANDIN E2; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE INJURY; CELL FREE SYSTEM; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG INHIBITION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; JOINT RADIOGRAPHY; LYMPHOCYTE; MACROPHAGE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; CELL LINE; DINOPROSTONE; FEMALE; HUMANS; MACROPHAGES; MICE; PANCREATIC ELASTASE; RATS; RATS, INBRED LEW; STAT3 TRANSCRIPTION FACTOR; SUPEROXIDES; T-LYMPHOCYTES; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33846420177     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107003     Document Type: Article

References (40)

1. Abramson SB, Amin AR, Clancy RM, and Attur M (2001) The role of nitric oxide in tissue destruction. Best Pract Res Clin Rheumatol 15:831-845.
2. Amin AR, Attur M, and Abramson SB (1999) Nitric oxide synthase and cyclooxygenases: distribution, regulation and intervention in arthritis. Curr Opin Rheumatol 11:202-209.
3. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324.
4. Baslund B, Tvede N, Danneskiold-Samsoe B, Larsson P, Panayi G, Petersen J, Petersen LJ, Beurskens FJM, Schuurman J, van de Winkel JGJ, et al. (2005) Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 52:2686-2692.
5. Bombini G, Canetti C, Rocha FAC, and Cunha FQ (2004) Tumour necrosis factor-α mediates neutrophil migration to the knee synovial cavity during immune inflammation. Eur J Pharmacol 496:197-204.
6. Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, and Lee DM (2006) Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med 203:837-842.
7. Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS, and Currie MG (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 273:15-24.
8. Cuzzocrea S, Mazzon E, Bevilaqua C, Costantino G, Britti D, Mazullo G, De Sarro A, and Caputi AP (2000) Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. Br J Pharmacol 131:1399-1407.
9. Escandell JM, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, and Ríos JL (2006) Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis. Eur J Pharmacol 532:145-154.
10. Fahmi H (2004) mPGES-1 as a novel target for arthritis. Curr Opin Rheumatol 16:623-627.
11. Graness A, Poli V, and Goppelt-Struebe M (2006) STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I. Biochem Pharmacol 72:32-41.
12. Issekutz AC, Meager A, Otterness I, and Issekutz TB (1994) The role of tumour necrosis factor-α and IL-1 in polymorphonuclear leukocyte and T lymphocyte recruitment to joint inflammation in adjuvant arthritis. Clin Exp Immunol 97:26-32.
13. Jayaprakasam B, Seeram NP, and Nair MG (2003) Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 189:11-16.
14. Kim ND, Chou RC, Seung E, Tager AM, and Luster AD (2006) A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med 203:829-835.
15. Liu H and Pope RM (2003) The role of apoptosis in rheumatoid arthritis. Curr Opin Pharmacol 3:317-322.
16. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, and Wahl SM (1993) Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 178:749-754.
17. McCartney-Francis N, Song X, Mizel DE, and Wahl SM (2001) Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease. J Immunol 166:2734-2740.
18. Muhl H and Pfeilschifter J (2004) Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention. Eur J Pharmacol 500:63-71.
19. Musza LL, Speight P, McElhiney S, Barrow CJ, Gillum AM, Cooper R, and Killar LM (1994) Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides. J Nat Prod 57:1498-1502.
20. Oh H, Mun YJ, Im SJ, Lee SY, Song HJ, Lee HS, and Woo WH (2002) Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta Med 68:832-833.
21. Panossian A, Gabrielian E, and Wagner H (1999) On the mechanism of action of plant adaptogens with particular reference to cucurbitacin R diglucoside. Phytomedicine 6:147-155.
22. Park CS, Lim KJ, Baek SH, Sohn HO, Lee DW, Yun HY, Baek KJ, Lee HS, and Kwon NS (2001) 23,24-Dihydrocucurbitacin D inhibits nitric oxide generation from murine macrophages by blocking nuclear factor-κB activation. FASEB J 15:A197.
23. Park CS, Lim KJ, Baek SH, Sohn HO, Lee DW, Yun HY, Baek KJ, Lee HS, and Kwon NS (2004a) Inhibition of nitric oxide generation by 23,24- dihydrocucurbitacin D in mouse peritoneal macrophages. J Pharmacol Exp Ther 309:705-710.
24. Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, Song HS, Kim GJ, Oh GT, and Hong JT (2004b) Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of nuclear factor-κB through interaction with the p50 subunit. Arthritis Rheum 50:3104-3515.
25. Peters RR, Baier Krepsky P, Siqueira-Junior JM, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M, Castro da Rocha FA, and Ribeiro-do-Valle RM (2003) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci 73:2185-2197.
26. Peters RR, Farias MR, and Ribeiro-do-Valle RM (1997) Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata. Planta Med 63:525-528.
27. Recio MC, Prieto M, Bonucelli M, Orsi C, Máñez S, Giner RM, and Ríos JL (2004) Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med 70:414-420.
28. Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato ABP, Poole S, Ferreira SH, and Cunha FQ (2000) Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol 387:111-118.
29. Rioja I, Bush KA, Buckton JB, Dickson MC, and Life PF (2004) Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment. Clin Exp Immunol 137:65-73.
30. Ríos JL, Escandell JM, and Recio MC (2005) New insight on the bioactivity of cucurbitacins, in Studies in Natural Products Chemistry: Bioactive Natural Products (Atta-Ur-Rahman ed) vol 32, pp 429-469, Elsevier Science, Amsterdam.
31. Ríos JL, Giner RM, Jiménez MJ, Wickman G, and Hancke JL (1990) A study on the anti-inflammatory activity of Cayaponia tayuya root. Fitoterapia 61:275-278.
32. Salvemini D, Ischiropoulos H, and Cuzzocrea S (2003) Roles of nitric oxide and superoxide in inflammation, in Methods in Molecular Biology: Inflammation Protocols (Winyard PG and Willoughby DA eds) pp 291-303, Humana Press, Totowa, NJ.
33. Scheller J, Ohnesorge N, and Rose-John S (2006) Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand J Immunol 63:321-329.
34. Skapenko A, Leipe J, Lipsky PE, and Schulze-Koops H (2005) The role of the T cell in autoimmune inflammation. Arthritis Res Ther 7:S4-S14.
35. Solomon S, Kassahn D, and Illges H (2005) The role of the complement and the Fcγ R system I the pathogenesis of arthritis. Arthritis Res Ther 7:129-135.
36. Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, and Sebti SM (2005) Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 24:3236-3245.
37. Taurog JD, Argentieri DC, and McReynolds RA (1988) Adjuvant arthritis. Methods Enzymol 162:339-355.
38. Tremblay GM, Janelle MF, and Bourbonnais Y (2003) Anti-inflammatory activity of neutrophil elastase inhibitors. Curr Opin Investig Drugs 4:556-565.
39. Wahl SM, McCartney-Francis N, Chan J, Dionne R, Ta L, and Orenstein JM (2003) Nitric oxide in experimental joint inflammation: benefit or detriment? Cells Tissues Organs 174:26-33.
40. Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, et al. (2004) Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 10:48-54.