Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231)

Cell Biochemistry and Function

Volumn 32, Issue 5, 2014, Pages 476-484

  Elumalai, Perumal ^a   Arunkumar, Ramachandran ^a   Benson, Chellakkan Selvanesan ^a   Sharmila, Govindaraj ^a   Arunakaran, Jagadeesan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Breast cancer; Cell cycle; Cell proliferation; IGF I signalling; Nimbolide

Indexed keywords

BETA CATENIN; CELL CYCLE PROTEIN; CYCLINE; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYC PROTEIN; NIMBOLIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21; RAF PROTEIN; RAS PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR BETA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; IGFBP3 PROTEIN, HUMAN; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, HUMAN; LIMONOID; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MORPHOLINE DERIVATIVE; MYC PROTEIN, HUMAN; PTEN PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL PROLIFERATION; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; DRUG EFFECTS; FEMALE; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMONES; DOWN-REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LIMONINS; MCF-7 CELLS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; PTEN PHOSPHOHYDROLASE; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 84903767319     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.3040     Document Type: Article

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