Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 5, 2015, Pages 5175-5181

  He, Si Qi ^a   Gao, Meng ^a   Fu, Yun Feng ^a   Zhang, Ya Nan ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

AKT; Glycyrrhizic acid; Leukemia; MTOR; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; GLYCYRRHIZIC ACID; MTOR PROTEIN, HUMAN; PROTEIN KINASE B; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CELL PROLIFERATION; CELL SIZE; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; FEMALE; HUMAN; LEUKEMIA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLYCYRRHIZIC ACID; HUMANS; LEUKEMIA; MICE, INBRED BALB C; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937928864     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Zhao XF, Gojo, York T, Ning Y, Baer MR. Diagnosis of biphenotypic acute leukemia: a paradigmatic approach. Int J Clin Exp Pathol 2009; 3: 75-86.
2. C Chiarini F, Lonetti A, Teti G, Orsini E, Bressanin D, Cappellini A, Ricci F, Tazzari PL, Ognibene A, Falconi M, Pagliaro P, Iacobucci I, Martinelli G, Amadori S, McCubrey JA, Martelli AM. A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia. Oncotarget 2012; 3: 1615-28.
3. Li S, Zhu JH, Cao LP, Sun Q, Liu HD, Li WD, Li JS, Hang CH. Growth inhibitory in vitro effects of glycyrrhizic acid in U251 glioblastoma cell line. Neurol Sci 2014; 35: 1115-20.
4. Raphael TJ, Kuttan G. Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. Immunopharmacol Immunotoxico 2008; 30: 243-55.
5. H Hibasami H, Iwase H, Yoshioka K, Takahashi H. Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells. Int J Mol Med 2006; 17: 215-19.
6. Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, Luo HB, Yang DP, Chen YL, Shen JG, Chen JP. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat 2012; 134: 943-55.
7. Chueh FS, Hsiao YT, Chang SJ, Wu PP, Yang JS, Lin JJ, Chung JG, Lai TY. Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase-and mitochondria-dependent pathways. Oncol Rep 2012; 28: 2069-76.
8. Meng XG, Yue SW. Dexamethasone disrupts cytoskeleton organization and migration of T47D human breast cancer cells by modulating the AKT/mTOR/RhoA pathway. Asian Pac J Cancer Prev 2014; 15: 10245-10250.
9. Bai HW, Badaboina S, Park CH, Choi BY, Na YH, Chung BY. Centipedegrass extract induces apoptosis through the activation of caspases and the downregulation of PI3K/Akt and MAPK phosphorylation in leukemia cells. Int J Mol Med 2015; 35: 511-8.
10. Qiu XM, Bai X, Jiang HF, He P, Wang JH. 20-(s)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/Akt pathways. Anticancer Drugs 2014; 25: 1072-1080.
11. Zeng D, Wang J, Kong P, Chang C, Li J, Li J. Ginsenoside Rg3 inhibits HIF-1a and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways. Int J Clin Exp Pathol 2014; 7: 2172-2178.
12. Sakamoto KM, Grant S, Saleiro D, Crispino JD, Hijiya N, Giles F, Platanias L, Eklund EA. Targeting novel signaling pathways for resistant acute myeloid leukemia. Mol Genet Metab 2014; S1096-7192: 00379-5.
13. Wu CH, Chen AZ, Yen GC. Protective effects of glycyrrhizic acid and 18β-glycyrrhetinic acid against cisplatin-induced nephrotoxicity in BALB/c mice. J Agric Food Chem 2015; [Epub ahead of print].
14. Jia X, Yang W, Han J, Xiong H. Effects of lentivirus mediated STAT3 silencing on human chronic myeloid leukemia cells and leukemia mice. Int J Clin Exp Med 2014; 7: 4031-4037.
15. Jordan NJ, Dutkowski CM, Barrow D, Mottram HJ, Hutcheson IR, Nicholson RI, Guichard SM, Gee JM. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Res 2014; 16: R12.